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Fusion gene ID: 13890 |
FusionGeneSummary for FRMD4A_MCM10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRMD4A_MCM10 | Fusion gene ID: 13890 | Hgene | Tgene | Gene symbol | FRMD4A | MCM10 | Gene ID | 55691 | 55388 |
| Gene name | FERM domain containing 4A | minichromosome maintenance 10 replication initiation factor | |
| Synonyms | CCAFCA|FRMD4|bA295P9.4 | CNA43|DNA43|PRO2249 | |
| Cytomap | 10p13 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FERM domain-containing protein 4AFERM domain containing 4 | protein MCM10 homologMCM10 minichromosome maintenance deficient 10homolog of yeast MCM10hsMCM10minichromosome maintenance complex component 10 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9P2Q2 | Q7L590 | |
| Ensembl transtripts involved in fusion gene | ENST00000358621, ENST00000357447, ENST00000378503, ENST00000342409, ENST00000493380, ENST00000475141, ENST00000492155, | ENST00000378714, ENST00000484800, ENST00000378694, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FRMD4A [Title/Abstract] AND MCM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-5525-01A | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shit | ENST00000358621 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000358621 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000358621 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| In-frame | ENST00000357447 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| In-frame | ENST00000357447 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| In-frame | ENST00000357447 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000378503 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000378503 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000378503 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000342409 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000342409 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| Frame-shit | ENST00000342409 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000493380 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000493380 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000493380 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000475141 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000475141 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000475141 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000492155 | ENST00000378714 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000492155 | ENST00000484800 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
| intron-3CDS | ENST00000492155 | ENST00000378694 | FRMD4A | chr10 | 13900847 | - | MCM10 | chr10 | 13214376 | + |
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FusionProtFeatures for FRMD4A_MCM10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRMD4A | MCM10 |
| Scaffolding protein that regulates epithelial cellpolarity by connecting ARF6 activation with the PAR3 complex (Bysimilarity). Plays a redundant role with FRMD4B in epithelialpolarization (By similarity). May regulate MAPT secretion byactivating ARF6-signaling (PubMed:27044754).{ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRMD4A_MCM10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378714_chr10_13214376_+_795aa MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQRN_GICKSK_RPYKSS_K_QQLNRQQAQPVCKNPLRSLPGHLLRRGEFREFRS QHAFLRSLMSLRYQEPRGWLEHQRLHLQIPKAHLQG_QVHPPNPYRRFLGTNLVG_LEVKLWGPQEVLGKRLNPSVWKPSLVCGSGGLET PPQK_TRK_PAEN_SDCLRSRKRWPERSWKK_IG_HLGLT_RRLRHRV_IVEKPSATGN_MIFVT_HNVCPCSTLEKFTKRSGRRSRGLS _GSSMPTP_SPRMVQRRCVTLSIILRRS_LWVKLLTWEPVKPRRRMESRARRL_ICVTVSTVSTMSRLSTRSSAQSVRICSPPSLEDEFQ RSLPAEAPASKNGCAKMAFTTEGFLLPRMQLQLQQLWLLRRRFKPL_VIWLLRAQT_SSRKHGKNSEYPRRACLALRSSRN_WTCRRVEP GT_NNI_PKPQLQGLWGAQNQPSSPSRPQHS_SNRSSGCWR_GEGNQKKYRSDFCRAQVKLRAQLCHLHQDSPLLSLHGQDPSSPGWREP RPQ_RPSWGEVSWKEMMFSFMMSHHHQDQN_VL_QKPKS_LLSPN_GQKARFLQKQTQTALRRNKRTLRTSWR_RNV_KKTPCFLLKLRM NWSLPGKKGENNLPIWNLRNFRKS_KQNQNTQAS_KRPRLRCRSATLSHW_KKNKWKKR_ETSEK_SAVS_HARRAPIPTSSCWRPASVS >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000484800_chr10_13214376_+_796aa MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQRN_GICKSK_RPYKSS_K_QQLNRQQAQPVCKNPL_RSLPGHLLRRGEFREFR SQHAFLRSLMSLRYQEPRGWLEHQRLHLQIPKAHLQG_QVHPPNPYRRFLGTNLVG_LEVKLWGPQEVLGKRLNPSVWKPSLVCGSGGLE TPPQK_TRK_PAEN_SDCLRSRKRWPERSWKK_IG_HLGLT_RRLRHRV_IVEKPSATGN_MIFVT_HNVCPCSTLEKFTKRSGRRSRGL S_GSSMPTP_SPRMVQRRCVTLSIILRRS_LWVKLLTWEPVKPRRRMESRARRL_ICVTVSTVSTMSRLSTRSSAQSVRICSPPSLEDEF QRSLPAEAPASKNGCAKMAFTTEGFLLPRMQLQLQQLWLLRRRFKPL_VIWLLRAQT_SSRKHGKNSEYPRRACLALRSSRN_WTCRRVE PGT_NNI_PKPQLQGLWGAQNQPSSPSRPQHS_SNRSSGCWR_GEGNQKKYRSDFCRAQVKLRAQLCHLHQDSPLLSLHGQDPSSPGWRE PRPQ_RPSWGEVSWKEMMFSFMMSHHHQDQN_VL_QKPKS_LLSPN_GQKARFLQKQTQTALRRNKRTLRTSWR_RNV_KKTPCFLLKLR MNWSLPGKKGENNLPIWNLRNFRKS_KQNQNTQAS_KRPRLRCRSATLSHW_KKNKWKKR_ETSEK_SAVS_HARRAPIPTSSCWRPASV >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378694_chr10_13214376_+_776aa MAVQLVPDSALGLLMMTEGRRCQVHLLDDRKLELLVQRN_GICKSK_RPYKSS_K_QQLNRQQAQPVCKNPLRSLPGHLLRRGEFREFRS QHAFLRSLMSLRYQEPRGWLEHQRLHLQIPKAHLQG_QVHPPNPYRRFLGTNLVG_LEVKLWGPQEVLGKRLNPSVWKPSLVCGSGGLET PPQK_TRK_PAEN_SDCLRSRKRWPERSWKK_IG_HLGLT_RRLRHRV_IVEKPSATGN_MIFVT_HNVCPCSTLEKFTKRSGRRSRGLS _GSSMPTP_SPRMVQRRCVTLSIILRRS_LWVKLLTWEPVKPRRRMESRARRL_ICVTVSTVSTMSRLSTRSSAQSVRICSPPSLEDEFQ RSLPAEAPASKNGCAKMAFTTEGFLLPRMQLQLQQLWLLRRRFKPL_VIWLLRAQT_SSRKHGKNSEYPRRACLALRSSRN_WTCRRVEP GT_NNI_PKPQLQGLWGAQNQPSSPSRPQHS_SNRSSGCWR_GEGNQKKYRSDFCRAQVKLRAQLCHLHQDSPLLSLHGQDPSSPGWREP RPQ_RPSWGEVSWKEMMFSFMMSHHHQDQN_VL_QKPKS_LLSPN_GQKARFLQKQTQTALRRNKRTLRTSWR_RNV_KKTPCFLLKLRM NWSLPGKKGENNLPIWNLRNFRKS_KQNQNTQAS_KRPRLRCRSATLSHW_KKNKWKKR_ETSEK_SAVS_HARRAPIPTSSCWRPASVS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378714_chr10_13214376_+_2387nt ATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTTGATGACAGG AAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAACAATTAAAC AGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGAGAATTCAGGAGT CAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCACCTCCAGATCCCA AAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAACTAGAGGTCAAA TTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGCGGCCTCGAGTAT CCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAGAGAAGCTGGAAG AAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCATATGGAAACTGA ATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGCAGGGGACTGTCG TAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGAAGGTCTTAATTA TGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGCGTGACTGTGAGT ACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAGGACGAATTCCAA AGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTGCCTCGTATGCAG CTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACTTGATCATCCAGG AAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGACGTGTGGAGCCA GGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCTCGGCCTCAGCAC TCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGAGCTCAAGTGAAG TTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGCTGGAGGGAGCCC CGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCACCAAGACCAAAAC TGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAAACCCAAACAGCA TTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTCAAGCTGAGGATG AATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAGCAAAATCAAAAC ACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGGAAGAAAAGATGA GAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCTGCGTCAGTGAGC AGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACAGACTCCCGAACA AGCACTGCAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGAAAAGACTGGTCCAAAGATAGGAGGAGAAACTCTGT >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000484800_chr10_13214376_+_2390nt ATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTTGATGACAGG AAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAACAATTAAAC AGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGTAGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGAGAATTCAGG AGTCAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCACCTCCAGATC CCAAAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAACTAGAGGTC AAATTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGCGGCCTCGAG TATCCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAGAGAAGCTGG AAGAAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCATATGGAAAC TGAATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGCAGGGGACTG TCGTAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGAAGGTCTTAA TTATGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGCGTGACTGTG AGTACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAGGACGAATTC CAAAGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTGCCTCGTATG CAGCTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACTTGATCATCC AGGAAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGACGTGTGGAG CCAGGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCTCGGCCTCAG CACTCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGAGCTCAAGTG AAGTTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGCTGGAGGGAG CCCCGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCACCAAGACCAA AACTGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAAACCCAAACA GCATTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTCAAGCTGAGG ATGAATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAGCAAAATCAA AACACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGGAAGAAAAGA TGAGAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCTGCGTCAGTG AGCAGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACAGACTCCCGA ACAAGCACTGCAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGAAAAGACTGGTCCAAAGATAGGAGGAGAAACTC >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378694_chr10_13214376_+_2330nt ATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTTGATGACAGG AAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAACAATTAAAC AGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGAGAATTCAGGAGT CAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCACCTCCAGATCCCA AAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAACTAGAGGTCAAA TTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGCGGCCTCGAGTAT CCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAGAGAAGCTGGAAG AAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCATATGGAAACTGA ATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGCAGGGGACTGTCG TAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGAAGGTCTTAATTA TGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGCGTGACTGTGAGT ACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAGGACGAATTCCAA AGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTGCCTCGTATGCAG CTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACTTGATCATCCAGG AAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGACGTGTGGAGCCA GGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCTCGGCCTCAGCAC TCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGAGCTCAAGTGAAG TTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGCTGGAGGGAGCCC CGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCACCAAGACCAAAAC TGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAAACCCAAACAGCA TTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTCAAGCTGAGGATG AATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAGCAAAATCAAAAC ACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGGAAGAAAAGATGA GAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCTGCGTCAGTGAGC AGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACAGACTCCCGAACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378714_chr10_13214376_+_4550nt GAACGCTCACAGAACAGGCAGTGCAATTCCATGTTCCTCTTAAGTATGTTAGCCCTACCGGGAGCTGAGCTGGCCAGTCTACTTGGAGAG GAAAAGTAGATCTGGGGAAGGTGGAAGGGTCAGTTCCTAAGTGACTTCCTCCTCGGGGATGGTAAGGGCATTTGCTGATCTCCAGTGACT GCCTGGTGCCTCATGGTCAGACTCGGCTGTCTCACTCCCAGATATCTGATTTTGCAAAAAGGGACACACCTATCTGCAGCAAAGAAGACA CTGACCAGATTGCGAGCGGTGCTTTTGGATGCTCTGTAGCCACCCGGGGCCCAGGAGGACTGACTCGGCAGCAGGATTCGTGCATGGGAA TCGGAGACCATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTT GATGACAGGAAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAA CAATTAAACAGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGAGAA TTCAGGAGTCAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCACCTC CAGATCCCAAAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAACTA GAGGTCAAATTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGCGGC CTCGAGTATCCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAGAGA AGCTGGAAGAAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCATAT GGAAACTGAATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGCAGG GGACTGTCGTAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGAAGG TCTTAATTATGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGCGTG ACTGTGAGTACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAGGAC GAATTCCAAAGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTGCCT CGTATGCAGCTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACTTGA TCATCCAGGAAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGACGT GTGGAGCCAGGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCTCGG CCTCAGCACTCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGAGCT CAAGTGAAGTTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGCTGG AGGGAGCCCCGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCACCAA GACCAAAACTGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAAACC CAAACAGCATTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTCAAG CTGAGGATGAATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAGCAA AATCAAAACACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGGAAG AAAAGATGAGAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCTGCG TCAGTGAGCAGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACAGAC TCCCGAACAAGCACTGCAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGAAAAGACTGGTCCAAAGATAGGAGGAG AAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGACATTTTCCCACAGACTTCCTG GCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGATTGACGCCGTCAAAAACAAATGCTTGTTAAGCC CATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAGTGGAAAACCAAGTTATCATTG TCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCAAAAATTGGAAGGTAAACAGAGAGCTATGTTTC TGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCAGAGGCAAAAGAATTTGGCTTA ATTCTCACTCCAGGTAAGTAGCTTAACTTCTGGGCTTCAGTTTTCTCATCTGTAAAATCAGGAAGATTGGACTAAGTGATCCTGAAATGT ATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTCCCATCTAGATAATGATGATCACATAGTCTTGATGTACGGACATTAAAAGCC AGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCACTGAATCACTTTGCATTTCAGTTTATATATATA GAGAGAAAGAAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTAAAATCTCATATTATTTTTTTTTTAATTTTTTT ATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGCGGCACACTGCAGCCTTGGCTTCCCTGGGCTCA AGCAGTCCTCCCACCTCAGTCTCCCAAATAGCTAGGACTACAGGCGTGCGTGACCAAGCCCAGCTAATTTTTGCATTTTTTGTAGAGATG GGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTGAGCACTAGCAATCCACCCACCTCTGTTTCCAAAAAAAAAAAAAAAATGAAA GGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCTGGGCAACCTGGTTTTCCAAATATCATTTGACC TAAGTGAATGTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAAGCTTGAGCTGTAGCTAAAAGTAATTTAGGTTT CCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGATGGTTGATTTAGGTTTTCAAAAGCTAGAAATAA AATTTACATGCCTTAGATTTCATAAAATTCTGCTCTAATTGGGTGGAAGGTGCTGTATCTAACTTGTGTTCCTCCTAAGGTTATGTCCTA ATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAAGGTTGCTTTTCTTTTTAATTTTTTCTAACAAAGAAAAGAATAAAGTATTTA TTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGATTTATTTATCTCATTAACTTAAAACAGCTATG TGTATGAAATAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTTTCTTATGGGAAAAACAATGTTCTTGTTTGAAC AGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATATGCTTGTAAAGGCTGAGGGTGAGCTGTATCTGG >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000484800_chr10_13214376_+_3185nt GAACGCTCACAGAACAGGCAGTGCAATTCCATGTTCCTCTTAAGTATGTTAGCCCTACCGGGAGCTGAGCTGGCCAGTCTACTTGGAGAG GAAAAGTAGATCTGGGGAAGGTGGAAGGGTCAGTTCCTAAGTGACTTCCTCCTCGGGGATGGTAAGGGCATTTGCTGATCTCCAGTGACT GCCTGGTGCCTCATGGTCAGACTCGGCTGTCTCACTCCCAGATATCTGATTTTGCAAAAAGGGACACACCTATCTGCAGCAAAGAAGACA CTGACCAGATTGCGAGCGGTGCTTTTGGATGCTCTGTAGCCACCCGGGGCCCAGGAGGACTGACTCGGCAGCAGGATTCGTGCATGGGAA TCGGAGACCATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTT GATGACAGGAAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAA CAATTAAACAGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGTAGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGA GAATTCAGGAGTCAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCAC CTCCAGATCCCAAAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAA CTAGAGGTCAAATTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGC GGCCTCGAGTATCCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAG AGAAGCTGGAAGAAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCA TATGGAAACTGAATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGC AGGGGACTGTCGTAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGA AGGTCTTAATTATGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGC GTGACTGTGAGTACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAG GACGAATTCCAAAGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTG CCTCGTATGCAGCTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACT TGATCATCCAGGAAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGA CGTGTGGAGCCAGGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCT CGGCCTCAGCACTCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGA GCTCAAGTGAAGTTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGC TGGAGGGAGCCCCGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCAC CAAGACCAAAACTGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAA ACCCAAACAGCATTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTC AAGCTGAGGATGAATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAG CAAAATCAAAACACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGG AAGAAAAGATGAGAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCT GCGTCAGTGAGCAGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACA GACTCCCGAACAAGCACTGCAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGAAAAGACTGGTCCAAAGATAGGAG GAGAAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGACATTTTCCCACAGACTTC CTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGATTGACGCCGTCAAAAACAAATGCTTGTTAA GCCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAGTGGAAAACCAAGTTATCA TTGTCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCAAAAATTGGAAGGTAAACAGAGAGCTATGT TTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCAGAGGCAAAAGAATTTGGC >In-frame_FRMD4A_ENST00000357447_chr10_13900847_-_MCM10_ENST00000378694_chr10_13214376_+_4643nt GAACGCTCACAGAACAGGCAGTGCAATTCCATGTTCCTCTTAAGTATGTTAGCCCTACCGGGAGCTGAGCTGGCCAGTCTACTTGGAGAG GAAAAGTAGATCTGGGGAAGGTGGAAGGGTCAGTTCCTAAGTGACTTCCTCCTCGGGGATGGTAAGGGCATTTGCTGATCTCCAGTGACT GCCTGGTGCCTCATGGTCAGACTCGGCTGTCTCACTCCCAGATATCTGATTTTGCAAAAAGGGACACACCTATCTGCAGCAAAGAAGACA CTGACCAGATTGCGAGCGGTGCTTTTGGATGCTCTGTAGCCACCCGGGGCCCAGGAGGACTGACTCGGCAGCAGGATTCGTGCATGGGAA TCGGAGACCATGGCAGTGCAGCTGGTGCCCGACTCAGCTCTCGGCCTGCTGATGATGACGGAGGGCCGCCGATGTCAAGTACATCTTCTT GATGACAGGAAGCTGGAACTCCTAGTACAGAGGAATTAAGGAATTTGCAAGAGCAAATGAAGGCCTTACAAGAGCAGCTAAAAGTAACAA CAATTAAACAGACAGCAAGCCCAGCCCGTCTGCAAAAATCCCCTGAGAAGTCTCCCCGGCCACCTCTTAAGGAGAGGAGAGTTCAGAGAA TTCAGGAGTCAACATGCTTTTCTGCGGAGCTTGATGTCCCTGCGCTACCAAGAACCAAGAGGGTGGCTCGAACACCAAAGGCTTCACCTC CAGATCCCAAAAGCTCATCTTCAAGGATGACAAGTGCACCCTCCCAACCCCTACAGACGATTTCTCGGAACAAACCTAGTGGGATAACTA GAGGTCAAATTGTGGGGACCCCAGGAAGTTCTGGGGAAACGACTCAACCCATCTGTGTGGAAGCCTTCTCTGGTCTGCGGCTCAGGCGGC CTCGAGTATCCTCCACAGAAATGAACAAGAAAATGACCGGCCGAAAACTGATCAGACTGTCTCAGATCAAGGAAAAGATGGCCAGAGAGA AGCTGGAAGAAATAGATTGGGTGACATTTGGGGTTATATTGAAGAAGGTTACGCCACAGAGTGTGAATAGTGGAAAAACCTTCAGCATAT GGAAACTGAATGATCTTCGTGACCTGACACAATGTGTGTCCTTGTTCTTATTTGGAGAAGTTCACAAAGCGCTCTGGAAGACGGAGCAGG GGACTGTCGTAGGGATCCTCAATGCCAACCCCATGAAGCCCAAGGATGGTTCAGAGGAGGTGTGTTTATCTATCGATCATCCTCAGAAGG TCTTAATTATGGGTGAAGCTCTTGACCTGGGAACCTGTAAAGCCAAGAAGAAGAATGGAGAGCCGTGCACGCAGACTGTGAATTTGCGTG ACTGTGAGTACTGTCAGTACCATGTCCAGGCTCAGTACAAGAAGCTCAGCGCAAAGCGTGCGGATCTGCAGTCCACCTTCTCTGGAGGAC GAATTCCAAAGAAGTTTGCCCGCAGAGGCACCAGCCTCAAAGAACGGCTGTGCCAAGATGGCTTTTACTACGGAGGGGTTTCTTCTGCCT CGTATGCAGCTTCAATTGCAGCAGCTGTGGCTCCTAAGAAGAAGATTCAAACCACTCTGAGTAATCTGGTTGTTAAGGGCACAAACTTGA TCATCCAGGAAACACGGCAAAAACTCGGAATACCCCAGAAGAGCCTGTCTTGCTCTGAGGAGTTCAAGGAACTGATGGACCTGCCGACGT GTGGAGCCAGGAACTTAAAACAACATTTAGCCAAAGCCACAGCTTCAGGGATTATGGGGAGCCCAAAACCAGCCATCAAGTCCATCTCGG CCTCAGCACTCTTGAAGCAACAGAAGCAGCGGATGTTGGAGATGAGGAGAAGGAAATCAGAAGAAATACAGAAGCGATTTCTGCAGAGCT CAAGTGAAGTTGAGAGCCCAGCTGTGCCATCTTCATCAAGACAGCCCCCTGCTCAGCCTCCACGGACAGGATCCGAGTTCCCCAGGCTGG AGGGAGCCCCGGCCACAATGACGCCCAAGCTGGGGCGAGGTGTCTTGGAAGGAGATGATGTTCTCTTTTATGATGAGTCACCACCACCAA GACCAAAACTGAGTGCTTTAGCAGAAGCCAAAAAGTTAGCTGCTATCACCAAATTAAGGGCAAAAGGCCAGGTTCTTACAAAAACAAACC CAAACAGCATTAAGAAGAAACAAAAGGACCCTCAGGACATCCTGGAGGTGAAGGAACGTGTAGAAAAAAACACCATGTTTTCTTCTCAAG CTGAGGATGAATTGGAGCCTGCCAGGAAAAAAAGGAGAGAACAACTTGCCTATCTGGAATCTGAGGAATTTCAGAAAATCCTAAAAGCAA AATCAAAACACACAGGCATCCTGAAAGAGGCCGAGGCTGAGATGCAGGAGCGCTACTTTGAGCCACTGGTGAAAAAAGAACAAATGGAAG AAAAGATGAGAAACATCAGAGAAGTGAAGTGCCGTGTCGTGACATGCAAGACGTGCGCCTATACCCACTTCAAGCTGCTGGAGACCTGCG TCAGTGAGCAGCATGAATACCACTGGCATGATGGTGTGAAGAGGTTTTTCAAATGTCCCTGTGGAAACAGAAGCATCTCCTTGGACAGAC TCCCGAACAAGCACTGCAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGTATGCCATTTGCGTACTAATTTTTGAC TCCTTTTAGTGACCCATGCTAATAATGTGGAACCATCTCCTATTAAAATATTTTCATTTTTCTAGGAAAAGACTGGTCCAAAGATAGGAG GAGAAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGACATTTTCCCACAGACTTC CTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGATTGACGCCGTCAAAAACAAATGCTTGTTAA GCCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAGTGGAAAACCAAGTTATCA TTGTCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCAAAAATTGGAAGGTAAACAGAGAGCTATGT TTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCAGAGGCAAAAGAATTTGGC TTAATTCTCACTCCAGGTAAGTAGCTTAACTTCTGGGCTTCAGTTTTCTCATCTGTAAAATCAGGAAGATTGGACTAAGTGATCCTGAAA TGTATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTCCCATCTAGATAATGATGATCACATAGTCTTGATGTACGGACATTAAAA GCCAGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCACTGAATCACTTTGCATTTCAGTTTATATAT ATAGAGAGAAAGAAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTAAAATCTCATATTATTTTTTTTTTAATTTT TTTATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGCGGCACACTGCAGCCTTGGCTTCCCTGGGC TCAAGCAGTCCTCCCACCTCAGTCTCCCAAATAGCTAGGACTACAGGCGTGCGTGACCAAGCCCAGCTAATTTTTGCATTTTTTGTAGAG ATGGGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTGAGCACTAGCAATCCACCCACCTCTGTTTCCAAAAAAAAAAAAAAAATG AAAGGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCTGGGCAACCTGGTTTTCCAAATATCATTTG ACCTAAGTGAATGTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAAGCTTGAGCTGTAGCTAAAAGTAATTTAGG TTTCCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGATGGTTGATTTAGGTTTTCAAAAGCTAGAAA TAAAATTTACATGCCTTAGATTTCATAAAATTCTGCTCTAATTGGGTGGAAGGTGCTGTATCTAACTTGTGTTCCTCCTAAGGTTATGTC CTAATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAAGGTTGCTTTTCTTTTTAATTTTTTCTAACAAAGAAAAGAATAAAGTAT TTATTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGATTTATTTATCTCATTAACTTAAAACAGCT ATGTGTATGAAATAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTTTCTTATGGGAAAAACAATGTTCTTGTTTG AACAGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATATGCTTGTAAAGGCTGAGGGTGAGCTGTATC |
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FusionGenePPI for FRMD4A_MCM10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FRMD4A | HNRNPA1, TRAF3IP1, YEATS4, WDR83 | MCM10 | KRT15, CEP70, HOOK2, ZBTB43, CCDC85B, CALCOCO2, CEP72, DPPA2, TRIM37, NINL, MCM6, CCND3, ZBTB8A, MCM7, ORC2, RPAP1, IKBKG, DDB1, RBX1, CUL4A, VPRBP, APP, ORC4, CDC45, MCM2, CDC7, MCM3, CDC5L, CDC6, CCND1, CDK6, ORC3, CDKN2A, CDKN1A, GOLGA2, TEX264, TMEM171, MCMBP, MCM4, SIRT1, NTRK1, HIST1H2BG, PCM1, TNIP1, POLR2G, SUPT5H, OFD1, CCDC14, USP37, YWHAE, IKZF5, CAV3, KLHL40, TPH1, RELL2, CACNG5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRMD4A_MCM10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRMD4A_MCM10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FRMD4A | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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