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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13870

FusionGeneSummary for FRAS1_MOB1B

check button Fusion gene summary
Fusion gene informationFusion gene name: FRAS1_MOB1B
Fusion gene ID: 13870
HgeneTgene
Gene symbol

FRAS1

MOB1B

Gene ID

80144

92597

Gene nameFraser extracellular matrix complex subunit 1MOB kinase activator 1B
SynonymsFRASRS1MATS2|MOB4A|MOBKL1A
Cytomap

4q21.21

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionextracellular matrix protein FRAS1Fraser syndrome 1MOB kinase activator 1BMOB1 Mps One Binder homolog BMOB1, Mps One Binder kinase activator-like 1Amob1 homolog 1Amob1Amps one binder kinase activator-like 1A
Modification date2018051920180519
UniProtAcc

Q86XX4

Q7L9L4

Ensembl transtripts involved in fusion geneENST00000264899, ENST00000325942, 
ENST00000264895, 
ENST00000309395, 
ENST00000396051, ENST00000511449, 
Fusion gene scores* DoF score10 X 7 X 8=5602 X 2 X 2=8
# samples 102
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FRAS1 [Title/Abstract] AND MOB1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMOB1B

GO:0031952

regulation of protein autophosphorylation

15197186

TgeneMOB1B

GO:0035329

hippo signaling

19739119


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A14Q-01AFRAS1chr4

79373508

+MOB1Bchr4

71888084

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000264899ENST00000309395FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
intron-intronENST00000264899ENST00000396051FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
intron-3UTRENST00000264899ENST00000511449FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
intron-intronENST00000325942ENST00000309395FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
intron-intronENST00000325942ENST00000396051FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
intron-3UTRENST00000325942ENST00000511449FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
5CDS-intronENST00000264895ENST00000309395FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
5CDS-intronENST00000264895ENST00000396051FRAS1chr4

79373508

+MOB1Bchr4

71888084

+
5CDS-3UTRENST00000264895ENST00000511449FRAS1chr4

79373508

+MOB1Bchr4

71888084

+

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FusionProtFeatures for FRAS1_MOB1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRAS1

Q86XX4

MOB1B

Q7L9L4

Activator of LATS1/2 in the Hippo signaling pathwaywhich plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS1/2 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Stimulates the kinase activity ofSTK38L. {ECO:0000269|PubMed:15067004,ECO:0000269|PubMed:19739119}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRAS1_MOB1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRAS1_MOB1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRAS1KLK11, TAZ, NXPH2, SUSD4, KLK5, ZPBP2, PVRIG, QPCT, PTPRK, CHST8, WNT4, LIPH, GPHA2, ZFP41, DKKL1, DEFA5, PSG8, ZNF408, SCGB1D1, ST8SIA4, MGAT4C, GML, IFNE, LRRTM1, ADAMTS4, PRG3, XAGE1B, FCGR1A, OS9, LYZL1, LRRC4C, SLAMF1, TRIM25MOB1BLATS1, LATS2, STK3, STK38, APP, STK38L, ANKRD28, ANKRD52, CRLF3, DOCK6, DOCK7, DOCK8, DST, IPO11, LRCH1, LRCH2, LRCH3, MAP4K4, MOB2, PPP6C, PPP6R1, PPP6R2, PPP6R3, PTPN14, RASSF2, RASSF5, SAV1, STK4, TNIP1, NT5C2, CCDC53, MOB1A, SKI, CYLD, HSD17B10, SOD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRAS1_MOB1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FRAS1_MOB1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRAS1C0024433Macrostomia1CTD_human
HgeneFRAS1C0265233Cryptophthalmos syndrome1CTD_human;ORPHANET