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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13869

FusionGeneSummary for FRAS1_MGST2

check button Fusion gene summary
Fusion gene informationFusion gene name: FRAS1_MGST2
Fusion gene ID: 13869
HgeneTgene
Gene symbol

FRAS1

MGST2

Gene ID

80144

4258

Gene nameFraser extracellular matrix complex subunit 1microsomal glutathione S-transferase 2
SynonymsFRASRS1GST2|MGST-II
Cytomap

4q21.21

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionextracellular matrix protein FRAS1Fraser syndrome 1microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II
Modification date2018051920180523
UniProtAcc

Q86XX4

Q99735

Ensembl transtripts involved in fusion geneENST00000264899, ENST00000325942, 
ENST00000264895, 
ENST00000515137, 
ENST00000265498, ENST00000506797, 
Fusion gene scores* DoF score10 X 7 X 8=5607 X 4 X 6=168
# samples 108
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FRAS1 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMGST2

GO:0006629

lipid metabolic process

9278457

TgeneMGST2

GO:0006750

glutathione biosynthetic process

8703034

TgeneMGST2

GO:0019370

leukotriene biosynthetic process

8703034|9092565|23409838

TgeneMGST2

GO:0046466

membrane lipid catabolic process

23409838


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-29-A5NZ-01AFRAS1chr4

79322041

+MGST2chr4

140616351

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000264899ENST00000515137FRAS1chr4

79322041

+MGST2chr4

140616351

+
intron-3UTRENST00000264899ENST00000265498FRAS1chr4

79322041

+MGST2chr4

140616351

+
intron-intronENST00000264899ENST00000506797FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-3UTRENST00000325942ENST00000515137FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-3UTRENST00000325942ENST00000265498FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-intronENST00000325942ENST00000506797FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-3UTRENST00000264895ENST00000515137FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-3UTRENST00000264895ENST00000265498FRAS1chr4

79322041

+MGST2chr4

140616351

+
5CDS-intronENST00000264895ENST00000506797FRAS1chr4

79322041

+MGST2chr4

140616351

+

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FusionProtFeatures for FRAS1_MGST2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FRAS1

Q86XX4

MGST2

Q99735

Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FRAS1_MGST2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FRAS1_MGST2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FRAS1KLK11, TAZ, NXPH2, SUSD4, KLK5, ZPBP2, PVRIG, QPCT, PTPRK, CHST8, WNT4, LIPH, GPHA2, ZFP41, DKKL1, DEFA5, PSG8, ZNF408, SCGB1D1, ST8SIA4, MGAT4C, GML, IFNE, LRRTM1, ADAMTS4, PRG3, XAGE1B, FCGR1A, OS9, LYZL1, LRRC4C, SLAMF1, TRIM25MGST2MGST2, RELL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FRAS1_MGST2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMGST2Q99735DB00143GlutathioneMicrosomal glutathione S-transferase 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for FRAS1_MGST2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFRAS1C0024433Macrostomia1CTD_human
HgeneFRAS1C0265233Cryptophthalmos syndrome1CTD_human;ORPHANET