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Fusion gene ID: 13868 |
FusionGeneSummary for FRAS1_MGMT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FRAS1_MGMT | Fusion gene ID: 13868 | Hgene | Tgene | Gene symbol | FRAS1 | MGMT | Gene ID | 80144 | 4255 |
| Gene name | Fraser extracellular matrix complex subunit 1 | O-6-methylguanine-DNA methyltransferase | |
| Synonyms | FRASRS1 | - | |
| Cytomap | 4q21.21 | 10q26.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | extracellular matrix protein FRAS1Fraser syndrome 1 | methylated-DNA--protein-cysteine methyltransferase6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferaseO6-methylguanine-DNA methyltransferasemethylguanine-DNA methyltransferase | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q86XX4 | P16455 | |
| Ensembl transtripts involved in fusion gene | ENST00000264899, ENST00000325942, ENST00000264895, | ENST00000306010, ENST00000462672, | |
| Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 8 X 3 X 5=120 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FRAS1 [Title/Abstract] AND MGMT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MGMT | GO:0043066 | negative regulation of apoptotic process | 24147153 |
| Tgene | MGMT | GO:2000781 | positive regulation of double-strand break repair | 24147153 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-DI-A2QY-01A | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000264899 | ENST00000306010 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| intron-intron | ENST00000264899 | ENST00000462672 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| Frame-shift | ENST00000325942 | ENST00000306010 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| 5CDS-intron | ENST00000325942 | ENST00000462672 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| Frame-shift | ENST00000264895 | ENST00000306010 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
| 5CDS-intron | ENST00000264895 | ENST00000462672 | FRAS1 | chr4 | 79343154 | + | MGMT | chr10 | 131334505 | + |
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FusionProtFeatures for FRAS1_MGMT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FRAS1 | MGMT |
| Involved in the cellular defense against the biologicaleffects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT)in DNA. Repairs the methylated nucleobase in DNA bystoichiometrically transferring the methyl group to a cysteineresidue in the enzyme. This is a suicide reaction: the enzyme isirreversibly inactivated. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRAS1_MGMT |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRAS1_MGMT |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FRAS1 | KLK11, TAZ, NXPH2, SUSD4, KLK5, ZPBP2, PVRIG, QPCT, PTPRK, CHST8, WNT4, LIPH, GPHA2, ZFP41, DKKL1, DEFA5, PSG8, ZNF408, SCGB1D1, ST8SIA4, MGAT4C, GML, IFNE, LRRTM1, ADAMTS4, PRG3, XAGE1B, FCGR1A, OS9, LYZL1, LRRC4C, SLAMF1, TRIM25 | MGMT | CSNK2A1, CSNK2A2, PRKACA, PRKCA, ESR1, CREBBP, EP300, SMC1A, HIST1H4A, HIST1H2AM, H2BFM, HIST3H3, MCM3, MSH2, TOP1, PRKDC, XRCC6, DDX5, DDX24, USP19, RNF8, PSME2, UBB, PSMD9, FBXO2, FBXO27, HSP90AA1, HSP90AB1, CDK12, CDK10, PRKCH, PRPF4, CDKL5, SET, PTPN4, YWHAZ, KPNB1, WNT9B, PABPC3, ANP32E, NCL, HNRNPA2B1, HNRNPC, RPS15A, RPLP1, EIF3H, EEF1A1, EEF1A2, EEF1B2, SLC25A4, SLC25A6, PKM, TTPA, IL25, FBL, TUBB4B, TUBA1C, ANXA1, ANXA2, ACTB, MYO7A, VIM, PHB, SRP9, SSRP1, PCNA, CDK2, CDK1, CCNB1, CDKN1A, MCM2, ORC1, POLD1, BRCA2, FANCA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRAS1_MGMT |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MGMT | P16455 | DB01593 | Zinc | Methylated-DNA--protein-cysteine methyltransferase | small molecule | approved|investigational |
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RelatedDiseases for FRAS1_MGMT |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FRAS1 | C0024433 | Macrostomia | 1 | CTD_human |
| Hgene | FRAS1 | C0265233 | Cryptophthalmos syndrome | 1 | CTD_human;ORPHANET |
| Tgene | MGMT | C0017638 | Glioma | 3 | CTD_human |
| Tgene | MGMT | C0017636 | Glioblastoma | 2 | CTD_human |
| Tgene | MGMT | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Tgene | MGMT | C0023418 | leukemia | 1 | CTD_human |
| Tgene | MGMT | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | MGMT | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Tgene | MGMT | C0027540 | Necrosis | 1 | CTD_human |
| Tgene | MGMT | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | MGMT | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | MGMT | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
| Tgene | MGMT | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
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