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Fusion gene ID: 13866 |
FusionGeneSummary for FRAS1_DCK |
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Fusion gene information | Fusion gene name: FRAS1_DCK | Fusion gene ID: 13866 | Hgene | Tgene | Gene symbol | FRAS1 | DCK | Gene ID | 80144 | 1633 |
Gene name | Fraser extracellular matrix complex subunit 1 | deoxycytidine kinase | |
Synonyms | FRASRS1 | - | |
Cytomap | 4q21.21 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | extracellular matrix protein FRAS1Fraser syndrome 1 | deoxycytidine kinasedeoxynucleoside kinase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86XX4 | P27707 | |
Ensembl transtripts involved in fusion gene | ENST00000264899, ENST00000325942, ENST00000264895, | ENST00000286648, ENST00000504952, ENST00000504730, | |
Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 2 X 2 X 2=8 |
# samples | 10 | 2 | |
** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FRAS1 [Title/Abstract] AND DCK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DCK | GO:0006220 | pyrimidine nucleotide metabolic process | 12808445 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A14Q-01A | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000264899 | ENST00000286648 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
intron-3CDS | ENST00000264899 | ENST00000504952 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
intron-3CDS | ENST00000264899 | ENST00000504730 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
intron-3CDS | ENST00000325942 | ENST00000286648 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
intron-3CDS | ENST00000325942 | ENST00000504952 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
intron-3CDS | ENST00000325942 | ENST00000504730 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
Frame-shift | ENST00000264895 | ENST00000286648 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
Frame-shift | ENST00000264895 | ENST00000504952 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
Frame-shift | ENST00000264895 | ENST00000504730 | FRAS1 | chr4 | 79373508 | + | DCK | chr4 | 71888084 | + |
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FusionProtFeatures for FRAS1_DCK |
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Hgene | Tgene |
FRAS1 | DCK |
Required for the phosphorylation of thedeoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) anddeoxyadenosine (dA). Has broad substrate specificity, and does notdisplay selectivity based on the chirality of the substrate. It isalso an essential enzyme for the phosphorylation of numerousnucleoside analogs widely employed as antiviral andchemotherapeutic agents. {ECO:0000269|PubMed:18377927,ECO:0000269|PubMed:20614893}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRAS1_DCK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRAS1_DCK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FRAS1 | KLK11, TAZ, NXPH2, SUSD4, KLK5, ZPBP2, PVRIG, QPCT, PTPRK, CHST8, WNT4, LIPH, GPHA2, ZFP41, DKKL1, DEFA5, PSG8, ZNF408, SCGB1D1, ST8SIA4, MGAT4C, GML, IFNE, LRRTM1, ADAMTS4, PRG3, XAGE1B, FCGR1A, OS9, LYZL1, LRRC4C, SLAMF1, TRIM25 | DCK | DDX19B, GOLM1, MED19, RXRG, DCK, ELAVL1, TFEC, ADSS, CHMP4A, CHRAC1, CBX3, EFHD2, HSPE1, IDH1, PTMS, RANBP1, RBBP7, TALDO1, THOP1, TYMS, DGUOK, NTRK1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRAS1_DCK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | DCK | P27707 | DB01073 | Fludarabine | Deoxycytidine kinase | small molecule | approved |
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RelatedDiseases for FRAS1_DCK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FRAS1 | C0024433 | Macrostomia | 1 | CTD_human |
Hgene | FRAS1 | C0265233 | Cryptophthalmos syndrome | 1 | CTD_human;ORPHANET |