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Fusion gene ID: 13864 |
FusionGeneSummary for FRAS1_ART3 |
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Fusion gene information | Fusion gene name: FRAS1_ART3 | Fusion gene ID: 13864 | Hgene | Tgene | Gene symbol | FRAS1 | ART3 | Gene ID | 80144 | 419 |
Gene name | Fraser extracellular matrix complex subunit 1 | ADP-ribosyltransferase 3 | |
Synonyms | FRASRS1 | ARTC3 | |
Cytomap | 4q21.21 | 4q21.1|4p15.1-p14 | |
Type of gene | protein-coding | protein-coding | |
Description | extracellular matrix protein FRAS1Fraser syndrome 1 | ecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86XX4 | Q13508 | |
Ensembl transtripts involved in fusion gene | ENST00000264899, ENST00000325942, ENST00000264895, | ENST00000341029, ENST00000355810, ENST00000349321, ENST00000513494, | |
Fusion gene scores | * DoF score | 10 X 7 X 8=560 | 3 X 2 X 3=18 |
# samples | 10 | 3 | |
** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FRAS1 [Title/Abstract] AND ART3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCS | TCGA-NG-A4VU-01A | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000264899 | ENST00000341029 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000264899 | ENST00000355810 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000264899 | ENST00000349321 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
5CDS-intron | ENST00000264899 | ENST00000513494 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000325942 | ENST00000341029 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000325942 | ENST00000355810 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000325942 | ENST00000349321 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
5CDS-intron | ENST00000325942 | ENST00000513494 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000264895 | ENST00000341029 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000264895 | ENST00000355810 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
Frame-shift | ENST00000264895 | ENST00000349321 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
5CDS-intron | ENST00000264895 | ENST00000513494 | FRAS1 | chr4 | 78987170 | + | ART3 | chr4 | 77033539 | + |
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FusionProtFeatures for FRAS1_ART3 |
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Hgene | Tgene |
FRAS1 | ART3 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FRAS1_ART3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FRAS1_ART3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FRAS1 | KLK11, TAZ, NXPH2, SUSD4, KLK5, ZPBP2, PVRIG, QPCT, PTPRK, CHST8, WNT4, LIPH, GPHA2, ZFP41, DKKL1, DEFA5, PSG8, ZNF408, SCGB1D1, ST8SIA4, MGAT4C, GML, IFNE, LRRTM1, ADAMTS4, PRG3, XAGE1B, FCGR1A, OS9, LYZL1, LRRC4C, SLAMF1, TRIM25 | ART3 | ALCAM, PRKCD, MDN1, ATP12A, PIGO, RAB39B, DDX19B, CHD1L, DYNC2LI1, PAM, NAGLU, ARSK, HSPA12A, GPD1L, ITGA7, MGAT5, CBWD3, POGLUT1, SPG7, PSEN2, MAP2K2, SCAMP2, GALNT7, ITGA8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FRAS1_ART3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FRAS1_ART3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FRAS1 | C0024433 | Macrostomia | 1 | CTD_human |
Hgene | FRAS1 | C0265233 | Cryptophthalmos syndrome | 1 | CTD_human;ORPHANET |