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Fusion gene ID: 13857 |
FusionGeneSummary for FOXRED2_IFT27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXRED2_IFT27 | Fusion gene ID: 13857 | Hgene | Tgene | Gene symbol | FOXRED2 | IFT27 | Gene ID | 80020 | 11020 |
| Gene name | FAD dependent oxidoreductase domain containing 2 | intraflagellar transport 27 | |
| Synonyms | ERFAD | BBS19|RABL4|RAYL | |
| Cytomap | 22q12.3 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FAD-dependent oxidoreductase domain-containing protein 2ER flavoprotein associated with degradationendoplasmic reticulum flavoprotein associated with degradation | intraflagellar transport protein 27 homologRAB, member of RAS oncogene family-like 4rab-like protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IWF2 | Q9BW83 | |
| Ensembl transtripts involved in fusion gene | ENST00000397224, ENST00000216187, ENST00000366463, ENST00000397223, | ENST00000340630, ENST00000453009, ENST00000433985, ENST00000476548, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FOXRED2 [Title/Abstract] AND IFT27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-VQ-A8E2-01A | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397224 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000397224 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000397224 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-intron | ENST00000397224 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| Frame-shift | ENST00000216187 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000216187 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000216187 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-intron | ENST00000216187 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| intron-3CDS | ENST00000366463 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| intron-5UTR | ENST00000366463 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| intron-5UTR | ENST00000366463 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| intron-intron | ENST00000366463 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| In-frame | ENST00000397223 | ENST00000340630 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000397223 | ENST00000453009 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-5UTR | ENST00000397223 | ENST00000433985 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
| 5CDS-intron | ENST00000397223 | ENST00000476548 | FOXRED2 | chr22 | 36897288 | - | IFT27 | chr22 | 37163906 | - |
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FusionProtFeatures for FOXRED2_IFT27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXRED2 | IFT27 |
| Probable flavoprotein which may function in endoplasmicreticulum associated degradation (ERAD). May bind non-nativeproteins in the endoplasmic reticulum and target them to theubiquitination machinery for subsequent degradation.{ECO:0000269|PubMed:19706418}. | Small GTPase-like component of the intraflagellartransport (IFT) complex B that promotes the exit of the BBSomecomplex from cilia via its interaction with ARL6(PubMed:25443296). Not involved in entry of the BBSome complexinto cilium. Prevents aggregation of GTP-free ARL6(PubMed:25443296). Required for hedgehog signaling. Forms asubcomplex within the IFT complex B with IFT25 (By similarity).{ECO:0000250|UniProtKB:A8HN58, ECO:0000269|PubMed:25443296}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | - | 0 | 7 | 123_126 | 11 | 186 | Nucleotide binding | GTP |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | - | 0 | 7 | 12_19 | 11 | 186 | Nucleotide binding | GTP |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000340630 | - | 0 | 7 | 64_68 | 11 | 186 | Nucleotide binding | GTP |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | - | 0 | 7 | 123_126 | 11 | 187 | Nucleotide binding | GTP |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | - | 0 | 7 | 12_19 | 11 | 187 | Nucleotide binding | GTP |
| Tgene | >IFT27 | chr22:36897288 | chr22:37163906 | ENST00000433985 | - | 0 | 7 | 64_68 | 11 | 187 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000216187 | - | 5 | 9 | 681_684 | 405 | 685 | Motif | Prevents secretion from ER |
| Hgene | >FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000397223 | - | 4 | 8 | 681_684 | 405 | 685 | Motif | Prevents secretion from ER |
| Hgene | >FOXRED2 | chr22:36897288 | chr22:37163906 | ENST00000397224 | - | 5 | 9 | 681_684 | 405 | 685 | Motif | Prevents secretion from ER |
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FusionGeneSequence for FOXRED2_IFT27 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FOXRED2_ENST00000397224_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_580aa MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPRHRKLISINKRYTGKAN AEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFV ATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTY QLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAF GKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDS VELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVLVGNKTDLAGRRAVDSAEARAWALGQGL >In-frame_FOXRED2_ENST00000397223_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_580aa MGLSAAAPLWGPPGLLLAIALHPALSVPPRRDYCVLGAGPAGLQMAYFLQRAGRDYAVFERAPRPGSFFTRYPRHRKLISINKRYTGKAN AEFNLRHDWNSLLSHDPRLLFRHYSRAYFPDARDMVRYLGDFADTLGLRVQYNTTIAHVTLDKDRQAWNGHYFILTDQKGQVHQCSVLFV ATGLSVPNQVDFPGSEYAEGYESVSVDPEDFVGQNVLILGRGNSAFETAENILGVTNFIHMLSRSRVRLSWATHYVGDLRAINNGLLDTY QLKSLDGLLESDLTDLAILKDSKGKFHVTPKFFLEEANTNQSADSITLPQDDNDNFAMRVPYDRVIRCLGWNFDFSIFNKSLRLNSGNAF GKKYPLIRASYESKGSRGLFILGTASHSVDYRKSAGGFIHGFRYTDPAVGKTALAQIFRSDGAHFQKSYTLTTGMDLVVKTVPVPDTGDS VELFIFDSAGKELFSEMLDKLWESPNVLCLVYDVTNEESFNNCSKWLEKARSQAPGISLPGVLVGNKTDLAGRRAVDSAEARAWALGQGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FOXRED2_ENST00000397224_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_1740nt ATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCGCTGTCGGTGCCCCCGCGC CGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTTCGAG CGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGGTACACGGGCAAGGCTAAC GCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTTCCCC GACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACCACCATCGCCCACGTCACT CTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTTTGTA GCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTGTCCGTGGACCCTGAGGAC TTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTATCCAT ATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAATGGCCTGCTGGATACCTAC CAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCACCCCG AAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGACAACTTTGCCATGCGCGTG CCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGCATTC GGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACTGCCAGCCACTCGGTGGAC TACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTGGCACAGATCTTCCGCAGT GATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTTCCTGACACGGGAGACAGT GTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGTCCCAATGTCTTATGTCTC GTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCTCCAGGCATCTCTCTCCCA GGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGGGCGCTGGGCCAGGGCCTG GAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTCCACCAGCTGTACCGGGAG >In-frame_FOXRED2_ENST00000397223_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_1740nt ATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCGCTGTCGGTGCCCCCGCGC CGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTTCGAG CGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGGTACACGGGCAAGGCTAAC GCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTTCCCC GACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACCACCATCGCCCACGTCACT CTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTTTGTA GCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTGTCCGTGGACCCTGAGGAC TTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTATCCAT ATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAATGGCCTGCTGGATACCTAC CAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCACCCCG AAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGACAACTTTGCCATGCGCGTG CCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGCATTC GGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACTGCCAGCCACTCGGTGGAC TACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTGGCACAGATCTTCCGCAGT GATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTTCCTGACACGGGAGACAGT GTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGTCCCAATGTCTTATGTCTC GTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCTCCAGGCATCTCTCTCCCA GGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGGGCGCTGGGCCAGGGCCTG GAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTCCACCAGCTGTACCGGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FOXRED2_ENST00000397224_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_1943nt ATTGGTCCGGGCGCGAGGGGCGGAGCCGCCGCGGAGCAAGCGAGCCAAGCGCGGCCTCATTAGACCACGGGTTGCAGCCGGAGCGGCTGG GAGGATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCGCTGTCGGTGCCCCC GCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGCGACTACGCAGTGTT CGAGCGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGGTACACGGGCAAGGC TAACGCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTACTCGCGTGCCTACTT CCCCGACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACCACCATCGCCCACGT CACTCTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAGTGCAGCGTCCTCTT TGTAGCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTGTCCGTGGACCCTGA GGACTTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGTGTCACAAACTTTAT CCATATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAATGGCCTGCTGGATAC CTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGCAAGTTCCATGTCAC CCCGAAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGACAACTTTGCCATGCG CGTGCCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTTAACTCGGGAAATGC ATTCGGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACTGCCAGCCACTCGGT GGACTACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTGGCACAGATCTTCCG CAGTGATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTTCCTGACACGGGAGA CAGTGTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGTCCCAATGTCTTATG TCTCGTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCTCCAGGCATCTCTCT CCCAGGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGGGCGCTGGGCCAGGG CCTGGAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTCCACCAGCTGTACCG GGAGAAGGTGGAGGTTTTCCGGGCCCTGGCATGACGAGCTGGAGCAGATCGTGCTGCACAACCGGAGAAGACAGAATTACCTCTGCTCTT >In-frame_FOXRED2_ENST00000397223_chr22_36897288_-_IFT27_ENST00000340630_chr22_37163906_-_1957nt TGACCCAGATTGCAGTGAGAGTTCCCGCAGGCCCCGCCTCTTTCTGGGCCTCGTGTCTCCCAGCCGCCGGGCCGGGTGCGAGGCCTTACC CCTCTGATCTGCTGCAGGATGGGCCTCTCCGCTGCGGCCCCGTTGTGGGGTCCCCCGGGGCTGCTCCTGGCCATCGCCCTGCACCCAGCG CTGTCGGTGCCCCCGCGCCGGGACTACTGCGTGCTGGGCGCTGGGCCCGCGGGCCTGCAGATGGCCTACTTCCTGCAGCGCGCTGGACGC GACTACGCAGTGTTCGAGCGGGCCCCGCGGCCCGGCAGCTTCTTCACACGCTACCCGCGGCACCGCAAGCTCATCAGCATCAACAAGCGG TACACGGGCAAGGCTAACGCCGAGTTCAACCTCCGCCACGACTGGAACTCTCTGCTCAGCCACGACCCCCGGCTGCTCTTCAGACACTAC TCGCGTGCCTACTTCCCCGACGCCCGCGACATGGTGCGCTACCTGGGTGACTTCGCGGACACGCTGGGGCTCCGTGTCCAGTACAACACC ACCATCGCCCACGTCACTCTGGACAAGGACCGACAGGCCTGGAATGGCCACTACTTCATCCTAACTGACCAGAAGGGCCAGGTGCATCAG TGCAGCGTCCTCTTTGTAGCCACTGGTTTATCAGTCCCCAACCAGGTTGACTTCCCTGGCTCCGAATATGCAGAGGGTTACGAGTCCGTG TCCGTGGACCCTGAGGACTTTGTAGGCCAGAATGTGCTGATCCTGGGTCGTGGGAACTCGGCCTTTGAGACAGCAGAGAACATCTTGGGT GTCACAAACTTTATCCATATGCTCAGCCGCTCCCGGGTCCGTCTGTCCTGGGCCACCCACTACGTTGGAGACCTCAGAGCCATCAACAAT GGCCTGCTGGATACCTACCAGCTCAAGTCCCTGGACGGGCTGCTCGAGTCTGACCTGACGGATCTGGCCATCCTGAAGGACAGCAAAGGC AAGTTCCATGTCACCCCGAAATTCTTCCTGGAAGAAGCCAACACCAACCAGAGTGCCGACTCCATCACCCTCCCCCAGGACGACAATGAC AACTTTGCCATGCGCGTGCCCTATGACCGGGTAATCCGCTGCCTGGGCTGGAACTTTGACTTCTCCATTTTCAATAAGTCCCTCAGACTT AACTCGGGAAATGCATTCGGCAAGAAGTACCCGCTGATTCGAGCTAGCTACGAATCCAAAGGAAGCCGGGGTCTGTTTATCCTGGGTACT GCCAGCCACTCGGTGGACTACCGGAAATCTGCTGGGGGCTTCATCCACGGATTCCGATACACAGACCCAGCAGTGGGCAAGACCGCCCTG GCACAGATCTTCCGCAGTGATGGAGCCCATTTCCAGAAAAGCTACACCCTGACAACAGGAATGGATTTGGTGGTGAAGACAGTGCCAGTT CCTGACACGGGAGACAGTGTGGAACTCTTCATTTTTGACTCTGCTGGCAAGGAGCTGTTTTCGGAAATGCTGGATAAATTGTGGGAGAGT CCCAATGTCTTATGTCTCGTCTATGATGTGACCAATGAAGAATCCTTCAACAACTGCAGCAAGTGGCTGGAGAAGGCTCGGTCACAGGCT CCAGGCATCTCTCTCCCAGGTGTTTTAGTTGGGAACAAGACAGACCTGGCCGGCAGACGAGCAGTGGACTCAGCTGAGGCCCGGGCATGG GCGCTGGGCCAGGGCCTGGAATGTTTTGAAACATCCGTGAAAGAGATGGAAAACTTCGAAGCCCCTTTCCACTGCCTTGCCAAGCAGTTC CACCAGCTGTACCGGGAGAAGGTGGAGGTTTTCCGGGCCCTGGCATGACGAGCTGGAGCAGATCGTGCTGCACAACCGGAGAAGACAGAA |
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FusionGenePPI for FOXRED2_IFT27 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FOXRED2 | SEL1L, OS9, DNAJC10, RPN1, FBXO6, TXNDC16, VDAC1, DPY30, EMD, GALK1, NIPSNAP1, CASK, RPL10, ACTG2, CANX, LIN7C, GANAB, USH2A, VDAC2, FLNA, KRT18, PRKDC, RAB9A, SLC25A10, ACTA1, ERLEC1, NDUFAF3, RBM45, MIPEP, FEM1B, CBWD3, TOMM40 | IFT27 | HSPB11, PRDX5, GOLGA2, LCA5, SCLT1, UBXN10, SBF1, TTC30A, IFT46, IFT74, IFT22, IFT88, TTC26, SMC6, RHBDD2, IFT172, IFT81, IFT80, TTC30B, IFT52 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOXRED2_IFT27 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOXRED2_IFT27 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IFT27 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | IFT27 | C3889475 | BARDET-BIEDL SYNDROME 19 | 1 | UNIPROT |
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