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Fusion gene ID: 13818 |
FusionGeneSummary for FOXO1_PDGFRB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXO1_PDGFRB | Fusion gene ID: 13818 | Hgene | Tgene | Gene symbol | FOXO1 | PDGFRB | Gene ID | 2308 | 5159 |
| Gene name | forkhead box O1 | platelet derived growth factor receptor beta | |
| Synonyms | FKH1|FKHR|FOXO1A | CD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT | |
| Cytomap | 13q14.11 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein O1forkhead box protein O1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma | platelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q12778 | P09619 | |
| Ensembl transtripts involved in fusion gene | ENST00000379561, ENST00000473775, | ENST00000261799, ENST00000523456, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 6 X 7 X 3=126 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FOXO1 [Title/Abstract] AND PDGFRB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FOXO1 | GO:0009267 | cellular response to starvation | 20543840 |
| Hgene | FOXO1 | GO:0032873 | negative regulation of stress-activated MAPK cascade | 19696738 |
| Hgene | FOXO1 | GO:0043066 | negative regulation of apoptotic process | 10871843 |
| Hgene | FOXO1 | GO:0045893 | positive regulation of transcription, DNA-templated | 7862145|10871843|12228231 |
| Hgene | FOXO1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10871843|12228231 |
| Hgene | FOXO1 | GO:0071455 | cellular response to hyperoxia | 20543840 |
| Tgene | PDGFRB | GO:0007165 | signal transduction | 10821867 |
| Tgene | PDGFRB | GO:0010863 | positive regulation of phospholipase C activity | 1653029 |
| Tgene | PDGFRB | GO:0018108 | peptidyl-tyrosine phosphorylation | 1653029|2536956|2850496 |
| Tgene | PDGFRB | GO:0030335 | positive regulation of cell migration | 17470632 |
| Tgene | PDGFRB | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 7691811 |
| Tgene | PDGFRB | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | 17470632 |
| Tgene | PDGFRB | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 1314164 |
| Tgene | PDGFRB | GO:0046777 | protein autophosphorylation | 1314164|2536956|2850496 |
| Tgene | PDGFRB | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 1314164|2536956 |
| Tgene | PDGFRB | GO:0060326 | cell chemotaxis | 2554309|17991872 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KICH | TCGA-KM-8443-01A | FOXO1 | chr13 | 41239720 | - | PDGFRB | chr5 | 149499686 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379561 | ENST00000261799 | FOXO1 | chr13 | 41239720 | - | PDGFRB | chr5 | 149499686 | - |
| 5CDS-intron | ENST00000379561 | ENST00000523456 | FOXO1 | chr13 | 41239720 | - | PDGFRB | chr5 | 149499686 | - |
| intron-3CDS | ENST00000473775 | ENST00000261799 | FOXO1 | chr13 | 41239720 | - | PDGFRB | chr5 | 149499686 | - |
| intron-intron | ENST00000473775 | ENST00000523456 | FOXO1 | chr13 | 41239720 | - | PDGFRB | chr5 | 149499686 | - |
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FusionProtFeatures for FOXO1_PDGFRB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXO1 | PDGFRB |
| Transcription factor that is the main target of insulinsignaling and regulates metabolic homeostasis in response tooxidative stress. Binds to the insulin response element (IRE) withconsensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator ofredox balance and osteoblast numbers and controls bone mass.Orchestrates the endocrine function of the skeleton in regulatingglucose metabolism. Acts synergistically with ATF4 to suppressosteocalcin/BGLAP activity, increasing glucose levels andtriggering glucose intolerance and insulin insensitivity. Alsosuppresses the transcriptional activity of RUNX2, an upstreamactivator of osteocalcin/BGLAP. In hepatocytes, promotesgluconeogenesis by acting together with PPARGC1A and CEBPA toactivate the expression of genes such as IGFBP1, G6PC and PCK1.Important regulator of cell death acting downstream of CDK1,PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediatesinsulin action on adipose tissue. Regulates the expression ofadipogenic genes such as PPARG during preadipocyte differentiationand, adipocyte size and adipose tissue-specific gene expression inresponse to excessive calorie intake. Regulates thetranscriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell deathinduction in response to starvation or oxidative stress in atranscription-independent manner. Mediates the function of MLIP incardiomyocytes hypertrophy and cardiac remodeling (By similarity).{ECO:0000250|UniProtKB:G3V7R4, ECO:0000250|UniProtKB:Q9R1E0,ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:12228231,ECO:0000269|PubMed:15220471, ECO:0000269|PubMed:15890677,ECO:0000269|PubMed:18356527, ECO:0000269|PubMed:19221179,ECO:0000269|PubMed:20543840, ECO:0000269|PubMed:21245099}. | Tyrosine-protein kinase that acts as cell-surfacereceptor for homodimeric PDGFB and PDGFD and for heterodimersformed by PDGFA and PDGFB, and plays an essential role in theregulation of embryonic development, cell proliferation, survival,differentiation, chemotaxis and migration. Plays an essential rolein blood vessel development by promoting proliferation, migrationand recruitment of pericytes and smooth muscle cells toendothelial cells. Plays a role in the migration of vascularsmooth muscle cells and the formation of neointima at vascularinjury sites. Required for normal development of thecardiovascular system. Required for normal recruitment ofpericytes (mesangial cells) in the kidney glomerulus, and fornormal formation of a branched network of capillaries in kidneyglomeruli. Promotes rearrangement of the actin cytoskeleton andthe formation of membrane ruffles. Binding of its cognate ligands- homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB orhomodimeric PDGFD -leads to the activation of several signalingcascades; the response depends on the nature of the bound ligandand is modulated by the formation of heterodimers between PDGFRAand PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL,SHC1 and NCK1. Activation of PLCG1 leads to the production of thecellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activationof protein kinase C. Phosphorylation of PIK3R1, the regulatorysubunit of phosphatidylinositol 3-kinase, leads to the activationof the AKT1 signaling pathway. Phosphorylation of SHC1, or of theC-terminus of PTPN11, creates a binding site for GRB2, resultingin the activation of HRAS, RAF1 and down-stream MAP kinases,including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylationand activation of SRC family kinases. Promotes phosphorylation ofPDCD6IP/ALIX and STAM. Receptor signaling is down-regulated byprotein phosphatases that dephosphorylate the receptor and itsdown-stream effectors, and by rapid internalization of theactivated receptor. {ECO:0000269|PubMed:11297552,ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164,ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029,ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866,ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858,ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854,ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309,ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772,ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273,ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233,ECO:0000269|PubMed:8195171}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 120_130 | 210 | 1440 | Compositional bias | Note=Poly-Pro |
| Hgene | FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 152_155 | 210 | 1440 | Compositional bias | Note=Poly-Ser |
| Hgene | FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 91_102 | 210 | 1440 | Compositional bias | Note=Poly-Ala |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 159_235 | 210 | 1440 | DNA binding | Fork-head |
| Hgene | >FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 211_218 | 210 | 1440 | Region | Note=DNA-binding |
| Hgene | >FOXO1 | chr13:41239720 | chr5:149499686 | ENST00000379561 | - | 1 | 3 | 234_237 | 210 | 1440 | Region | Note=DNA-binding |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 129_210 | 862 | 1107 | Domain | Note=Ig-like C2-type 2 |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 214_309 | 862 | 1107 | Domain | Note=Ig-like C2-type 3 |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 331_403 | 862 | 1107 | Domain | Note=Ig-like C2-type 4 |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 33_120 | 862 | 1107 | Domain | Note=Ig-like C2-type 1 |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 416_524 | 862 | 1107 | Domain | Note=Ig-like C2-type 5 |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 600_962 | 862 | 1107 | Domain | Protein kinase |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 606_614 | 862 | 1107 | Nucleotide binding | ATP |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 33_532 | 862 | 1107 | Topological domain | Extracellular |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 554_1106 | 862 | 1107 | Topological domain | Cytoplasmic |
| Tgene | PDGFRB | chr13:41239720 | chr5:149499686 | ENST00000261799 | - | 17 | 23 | 533_553 | 862 | 1107 | Transmembrane | Helical |
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FusionGeneSequence for FOXO1_PDGFRB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FOXO1_ENST00000379561_chr13_41239720_-_PDGFRB_ENST00000261799_chr5_149499686_-_455aa MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSV AAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKR LTLSQIYEWMVKSVPYFKDKGDSNSSAGWKTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAV QPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FOXO1_ENST00000379561_chr13_41239720_-_PDGFRB_ENST00000261799_chr5_149499686_-_1365nt ATGGCCGAGGCGCCTCAGGTGGTGGAGATCGACCCGGACTTCGAGCCGCTGCCCCGGCCGCGCTCGTGCACCTGGCCGCTGCCCAGGCCG GAGTTTAGCCAGTCCAACTCGGCCACCTCCAGCCCGGCGCCGTCGGGCAGCGCGGCTGCCAACCCCGACGCCGCGGCGGGCCTGCCCTCG GCCTCGGCTGCCGCTGTCAGCGCCGACTTCATGAGCAACCTGAGCTTGCTGGAGGAGAGCGAGGACTTCCCGCAGGCGCCCGGCTCCGTG GCGGCGGCGGTGGCGGCGGCGGCCGCCGCGGCCGCCACCGGGGGGCTGTGCGGGGACTTCCAGGGCCCGGAGGCGGGCTGCCTGCACCCA GCGCCACCGCAGCCCCCGCCGCCCGGGCCGCTGTCGCAGCACCCGCCGGTGCCCCCCGCCGCCGCTGGGCCGCTCGCGGGGCAGCCGCGC AAGAGCAGCTCGTCCCGCCGCAACGCGTGGGGCAACCTGTCCTACGCCGACCTCATCACCAAGGCCATCGAGAGCTCGGCGGAGAAGCGG CTCACGCTGTCGCAGATCTACGAGTGGATGGTCAAGAGCGTGCCCTACTTCAAGGATAAGGGTGACAGCAACAGCTCGGCGGGCTGGAAG ACCTTTTTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAGCGACGTGTGGTCCTTCGGGATCCTG CTCTGGGAGATCTTCACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAACGGGGTTACCGC ATGGCCCAGCCTGCCCATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAAGTTTGAGATTCGGCCCCCCTTCTCC CAGCTGGTGCTGCTTCTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGATGAGGAGTTTCTGAGGAGTGACCAC CCAGCCATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACACCAGCTCCGTCCTCTATACTGCCGTG CAGCCCAATGAGGGTGACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGTTCCCCC AGCCTAGCCAGCTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCTGGAGCCCCAGGACGAACCAGAGCCA GAGCCCCAGCTTGAGCTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGGGCGGAAGCAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FOXO1_ENST00000379561_chr13_41239720_-_PDGFRB_ENST00000261799_chr5_149499686_-_3676nt GCAGCCGCCACATTCAACAGGCAGCAGCGCAGCGGGCGCGCCGCTGGGGAGAGCAAGCGGCCCGCGGCGTCCGTCCGTCCTTCCGTCCGC GGCCCTGTCAGCTGGAGCGCGGCGCAGGCTCTGCCCCGGCCCGGCGGCTCTGGCCGGCCGTCCAGTCCGTGCGGCGGACCCCGAGGAGCC TCGATGTGGATGGCCCCGCGAAGTTAAGTTCTGGGCTCGCGCTTCCACTCCGCCGCGCCTTCCTCCCAGTTTCCGTCCGCTCGCCGCACC GGCTTCGTTCCCCCAAATCTCGGACCGTCCCTTCGCGCCCCCTCCCCGTCCGCCCCCAGTGCTGCGTTCTCCCCCTCTTGGCTCTCCTGC GGCTGGGGGAGGGGCGGGGGTCACCATGGCCGAGGCGCCTCAGGTGGTGGAGATCGACCCGGACTTCGAGCCGCTGCCCCGGCCGCGCTC GTGCACCTGGCCGCTGCCCAGGCCGGAGTTTAGCCAGTCCAACTCGGCCACCTCCAGCCCGGCGCCGTCGGGCAGCGCGGCTGCCAACCC CGACGCCGCGGCGGGCCTGCCCTCGGCCTCGGCTGCCGCTGTCAGCGCCGACTTCATGAGCAACCTGAGCTTGCTGGAGGAGAGCGAGGA CTTCCCGCAGGCGCCCGGCTCCGTGGCGGCGGCGGTGGCGGCGGCGGCCGCCGCGGCCGCCACCGGGGGGCTGTGCGGGGACTTCCAGGG CCCGGAGGCGGGCTGCCTGCACCCAGCGCCACCGCAGCCCCCGCCGCCCGGGCCGCTGTCGCAGCACCCGCCGGTGCCCCCCGCCGCCGC TGGGCCGCTCGCGGGGCAGCCGCGCAAGAGCAGCTCGTCCCGCCGCAACGCGTGGGGCAACCTGTCCTACGCCGACCTCATCACCAAGGC CATCGAGAGCTCGGCGGAGAAGCGGCTCACGCTGTCGCAGATCTACGAGTGGATGGTCAAGAGCGTGCCCTACTTCAAGGATAAGGGTGA CAGCAACAGCTCGGCGGGCTGGAAGACCTTTTTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTACACCACCCTGAG CGACGTGTGGTCCTTCGGGATCCTGCTCTGGGAGATCTTCACCTTGGGTGGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTA CAATGCCATCAAACGGGGTTACCGCATGGCCCAGCCTGCCCATGCCTCCGACGAGATCTATGAGATCATGCAGAAGTGCTGGGAAGAGAA GTTTGAGATTCGGCCCCCCTTCTCCCAGCTGGTGCTGCTTCTCGAGAGACTGTTGGGCGAAGGTTACAAAAAGAAGTACCAGCAGGTGGA TGAGGAGTTTCTGAGGAGTGACCACCCAGCCATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCTCCCCTGGACAC CAGCTCCGTCCTCTATACTGCCGTGCAGCCCAATGAGGGTGACAACGACTATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGA CGAGGGCCCACTGGAGGGTTCCCCCAGCCTAGCCAGCTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGTGACAGCCCCCT GGAGCCCCAGGACGAACCAGAGCCAGAGCCCCAGCTTGAGCTCCAGGTGGAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTG CCCTGCGCCTCGGGCGGAAGCAGAGGATAGCTTCCTGTAGGGGGCTGGCCCCTACCCTGCCCTGCCTGAAGCTCCCCCCCTGCCAGCACC CAGCATCTCCTGGCCTGGCCTGACCGGGCTTCCTGTCAGCCAGGCTGCCCTTATCAGCTGTCCCCTTCTGGAAGCTTTCTGCTCCTGACG TGTTGTGCCCCAAACCCTGGGGCTGGCTTAGGAGGCAAGAAAACTGCAGGGGCCGTGACCAGCCCTCTGCCTCCAGGGAGGCCAACTGAC TCTGAGCCAGGGTTCCCCCAGGGAACTCAGTTTTCCCATATGTAAAATGGGAAAGTTAGGCTTGATGACCCAGAATCTAGGATTCTCTCC CTGGCTGACAGGTGGGGAGACCGAATCCCTCCCTGGGAAGATTCTTGGAGTTACTGAGGTGGTAAATTAACTTTTTTCTGTTCAGCCAGC TACCCCTCAAGGAATCATAGCTCTCTCCTCGCACTTTTATCCACCCAGGAGCTAGGGAAGAGACCCTAGCCTCCCTGGCTGCTGGCTGAG CTAGGGCCTAGCCTTGAGCAGTGTTGCCTCATCCAGAAGAAAGCCAGTCTCCTCCCTATGATGCCAGTCCCTGCGTTCCCTGGCCCGAGC TGGTCTGGGGCCATTAGGCAGCCTAATTAATGCTGGAGGCTGAGCCAAGTACAGGACACCCCCAGCCTGCAGCCCTTGCCCAGGGCACTT GGAGCACACGCAGCCATAGCAAGTGCCTGTGTCCCTGTCCTTCAGGCCCATCAGTCCTGGGGCTTTTTCTTTATCACCCTCAGTCTTAAT CCATCCACCAGAGTCTAGAAGGCCAGACGGGCCCCGCATCTGTGATGAGAATGTAAATGTGCCAGTGTGGAGTGGCCACGTGTGTGTGCC AGTATATGGCCCTGGCTCTGCATTGGACCTGCTATGAGGCTTTGGAGGAATCCCTCACCCTCTCTGGGCCTCAGTTTCCCCTTCAAAAAA TGAATAAGTCGGACTTATTAACTCTGAGTGCCTTGCCAGCACTAACATTCTAGAGTATTCCAGGTGGTTGCACATTTGTCCAGATGAAGC AAGGCCATATACCCTAAACTTCCATCCTGGGGGTCAGCTGGGCTCCTGGGAGATTCCAGATCACACATCACACTCTGGGGACTCAGGAAC CATGCCCCTTCCCCAGGCCCCCAGCAAGTCTCAAGAACACAGCTGCACAGGCCTTGACTTAGAGTGACAGCCGGTGTCCTGGAAAGCCCC CAGCAGCTGCCCCAGGGACATGGGAAGACCACGGGACCTCTTTCACTACCCACGATGACCTCCGGGGGTATCCTGGGCAAAAGGGACAAA GAGGGCAAATGAGATCACCTCCTGCAGCCCACCACTCCAGCACCTGTGCCGAGGTCTGCGTCGAAGACAGAATGGACAGTGAGGACAGTT ATGTCTTGTAAAAGACAAGAAGCTTCAGATGGGTACCCCAAGAAGGATGTGAGAGGTGGGCGCTTTGGAGGTTTGCCCCTCACCCACCAG CTGCCCCATCCCTGAGGCAGCGCTCCATGGGGGTATGGTTTTGTCACTGCCCAGACCTAGCAGTGACATCTCATTGTCCCCAGCCCAGTG GGCATTGGAGGTGCCAGGGGAGTCAGGGTTGTAGCCAAGACGCCCCCGCACGGGGAGGGTTGGGAAGGGGGTGCAGGAAGCTCAACCCCT CTGGGCACCAACCCTGCATTGCAGGTTGGCACCTTACTTCCCTGGGATCCCCAGAGTTGGTCCAAGGAGGGAGAGTGGGTTCTCAATACG GTACCAAAGATATAATCACCTAGGTTTACAAATATTTTTAGGACTCACGTTAACTCACATTTATACAGCAGAAATGCTATTTTGTATGCT |
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FusionGenePPI for FOXO1_PDGFRB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FOXO1 | AR, SMAD3, SMAD4, CREBBP, YWHAG, YWHAZ, TSC2, ESR1, CEBPB, HOXA5, HNF4A, RFWD2, PARP1, HOXA11, LRPPRC, SKP2, PML, SIRT1, AKT1, SIRT2, ATG7, STUB1, NLK, MDM2, RARA, FSHR, IRF3, FHL2, EP300, MST1, YWHAQ, NCOA1, PIK3R3, TENC1, XPO1, CCNB1, CDKN1A, GSK3B, FOXO1, FOXO4, RECQL, FOXO3B, CUX1, DLX5, HOXD13, SATB1, SATB2, SMARCA4, SETD7, MORF4L2, SNX17, RB1, DNAJC9, FOXO6, PRKACA, CRY1, PITX1, SIRT7, ATM | PDGFRB | KRTAP4-12, GRB2, PTPN11, PDGFRA, PDGFRB, VAV1, VAV2, VAV3, PLCG1, COPA, NCK2, CRK, GRB14, NCK1, RAF1, SLC9A3R1, SH3KBP1, ITGB3, SHC1, S1PR1, CAV1, CAV3, EIF2AK2, SNX1, SNX2, SNX4, EGFR, PIK3R1, RASA1, PDCD6IP, SRC, ADRBK1, MFGE8, NEDD4, ETV6, IRF8, SLA, SH2B2, TNK2, ERRFI1, HSP90AA1, TRIP6, KLHL12, PDGFB, NTRK1, MYO1E, BCLAF1, ZZEF1, FGD6, FOXK1, PIK3R3, PTEN, STAT5A, STAT3, CBLB, DEPDC1, ATR, FOXK2, ANKLE2, ACVR2B, UBB, ABCD4, NOP9, FNDC3A, HUS1, TYW1, CGRRF1, HELLS, PDE3B, BMPR1A, CTDNEP1, LACC1, PPM1L, TPTE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOXO1_PDGFRB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PDGFRB | P09619 | DB00619 | Imatinib | Platelet-derived growth factor receptor beta | small molecule | approved |
| Tgene | PDGFRB | P09619 | DB06589 | Pazopanib | Platelet-derived growth factor receptor beta | small molecule | approved |
| Tgene | PDGFRB | P09619 | DB08896 | Regorafenib | Platelet-derived growth factor receptor beta | small molecule | approved |
| Tgene | PDGFRB | P09619 | DB00102 | Becaplermin | Platelet-derived growth factor receptor beta | biotech | approved|investigational |
| Tgene | PDGFRB | P09619 | DB00398 | Sorafenib | Platelet-derived growth factor receptor beta | small molecule | approved|investigational |
| Tgene | PDGFRB | P09619 | DB01254 | Dasatinib | Platelet-derived growth factor receptor beta | small molecule | approved|investigational |
| Tgene | PDGFRB | P09619 | DB01268 | Sunitinib | Platelet-derived growth factor receptor beta | small molecule | approved|investigational |
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RelatedDiseases for FOXO1_PDGFRB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FOXO1 | C0022578 | Keratoconus | 1 | CTD_human |
| Hgene | FOXO1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | PDGFRB | C3554321 | BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 4 | 3 | UNIPROT |
| Tgene | PDGFRB | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Tgene | PDGFRB | C0036341 | Schizophrenia | 2 | PSYGENET |
| Tgene | PDGFRB | C0432284 | Infantile myofibromatosis | 2 | ORPHANET;UNIPROT |
| Tgene | PDGFRB | C0004782 | Basal Ganglia Diseases | 1 | CTD_human |
| Tgene | PDGFRB | C0006663 | Calcinosis | 1 | CTD_human |
| Tgene | PDGFRB | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | PDGFRB | C1866182 | Penttinen-Aula syndrome | 1 | ORPHANET;UNIPROT |
| Tgene | PDGFRB | C4225270 | KOSAKI OVERGROWTH SYNDROME | 1 | UNIPROT |
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