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Fusion gene ID: 13804 |
FusionGeneSummary for FOXN2_SPTBN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXN2_SPTBN1 | Fusion gene ID: 13804 | Hgene | Tgene | Gene symbol | FOXN2 | SPTBN1 | Gene ID | 3344 | 6711 |
| Gene name | forkhead box N2 | spectrin beta, non-erythrocytic 1 | |
| Synonyms | HTLF | ELF|HEL102|SPTB2|betaSpII | |
| Cytomap | 2p16.3 | 2p16.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein N2human T-cell leukemia virus enhancer factor | spectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P32314 | Q01082 | |
| Ensembl transtripts involved in fusion gene | ENST00000340553, | ENST00000356805, ENST00000333896, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 13 X 13 X 6=1014 |
| # samples | 4 | 15 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/1014*10)=-2.75702324650746 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FOXN2 [Title/Abstract] AND SPTBN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-60-2715-01A | FOXN2 | chr2 | 48573890 | + | SPTBN1 | chr2 | 54849437 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340553 | ENST00000356805 | FOXN2 | chr2 | 48573890 | + | SPTBN1 | chr2 | 54849437 | + |
| In-frame | ENST00000340553 | ENST00000333896 | FOXN2 | chr2 | 48573890 | + | SPTBN1 | chr2 | 54849437 | + |
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FusionProtFeatures for FOXN2_SPTBN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXN2 | SPTBN1 |
| Binds to the purine-rich region in HTLV-I LTR. | Fodrin, which seems to be involved in secretion,interacts with calmodulin in a calcium-dependent manner and isthus candidate for the calcium-dependent movement of thecytoskeleton at the membrane. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 2197_2307 | 279 | 2156 | Domain | PH |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 2197_2307 | 292 | 2365 | Domain | PH |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1063_1166 | 279 | 2156 | Repeat | Spectrin 8 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1170_1258 | 279 | 2156 | Repeat | Spectrin 9 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1276_1376 | 279 | 2156 | Repeat | Spectrin 10 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1381_1482 | 279 | 2156 | Repeat | Spectrin 11 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1486_1590 | 279 | 2156 | Repeat | Spectrin 12 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1592_1696 | 279 | 2156 | Repeat | Spectrin 13 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1698_1801 | 279 | 2156 | Repeat | Spectrin 14 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1805_1907 | 279 | 2156 | Repeat | Spectrin 15 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1914_2014 | 279 | 2156 | Repeat | Spectrin 16 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 2018_2097 | 279 | 2156 | Repeat | Spectrin 17 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 303_411 | 279 | 2156 | Repeat | Spectrin 1 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 423_525 | 279 | 2156 | Repeat | Spectrin 2 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 530_636 | 279 | 2156 | Repeat | Spectrin 3 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 639_742 | 279 | 2156 | Repeat | Spectrin 4 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 745_847 | 279 | 2156 | Repeat | Spectrin 5 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 850_952 | 279 | 2156 | Repeat | Spectrin 6 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 957_1060 | 279 | 2156 | Repeat | Spectrin 7 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1063_1166 | 292 | 2365 | Repeat | Spectrin 8 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1170_1258 | 292 | 2365 | Repeat | Spectrin 9 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1276_1376 | 292 | 2365 | Repeat | Spectrin 10 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1381_1482 | 292 | 2365 | Repeat | Spectrin 11 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1486_1590 | 292 | 2365 | Repeat | Spectrin 12 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1592_1696 | 292 | 2365 | Repeat | Spectrin 13 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1698_1801 | 292 | 2365 | Repeat | Spectrin 14 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1805_1907 | 292 | 2365 | Repeat | Spectrin 15 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1914_2014 | 292 | 2365 | Repeat | Spectrin 16 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 2018_2097 | 292 | 2365 | Repeat | Spectrin 17 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 303_411 | 292 | 2365 | Repeat | Spectrin 1 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 423_525 | 292 | 2365 | Repeat | Spectrin 2 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 530_636 | 292 | 2365 | Repeat | Spectrin 3 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 639_742 | 292 | 2365 | Repeat | Spectrin 4 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 745_847 | 292 | 2365 | Repeat | Spectrin 5 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 850_952 | 292 | 2365 | Repeat | Spectrin 6 |
| Tgene | >SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 957_1060 | 292 | 2365 | Repeat | Spectrin 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FOXN2 | chr2:48573890 | chr2:54849437 | ENST00000340553 | + | 3 | 7 | 112_208 | 179 | 432 | DNA binding | Fork-head |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 173_278 | 279 | 2156 | Domain | Calponin-homology (CH) 2 |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 54_158 | 279 | 2156 | Domain | Calponin-homology (CH) 1 |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 173_278 | 292 | 2365 | Domain | Calponin-homology (CH) 2 |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 54_158 | 292 | 2365 | Domain | Calponin-homology (CH) 1 |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 2_275 | 279 | 2156 | Region | Note=Actin-binding |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 2_275 | 292 | 2365 | Region | Note=Actin-binding |
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FusionGeneSequence for FOXN2_SPTBN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000356805_chr2_54849437_+_2252aa MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKATLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEG DDVPSFGPACYQNPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKV LDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGW IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKE VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS DLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD CQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKA QRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV QTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVT DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHV TMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD KHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDK FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI DKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEE EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQ SAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKH VFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKK >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000333896_chr2_54849437_+_2056aa MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKATLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEG DDVPSFGPACYQNPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKV LDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAA YEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGV EDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGW IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKE VAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS DLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD CQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKA QRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV QTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVT DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED YAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHV TMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD KHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDK FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI DKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000356805_chr2_54849437_+_6756nt ATGGGTCCAGTAATTGGAATGACTCCAGATAAGAGAGCTGAAACCCCAGGAGCTGAAAAGATTGCAGGATTAAGCCAGATTTACAAAATG GGAAGCTTGCCTGAAGCTGTTGATGCTGCCAGGCCGAAGGCCACTCTAGTGGACAGTGAGTCAGCAGATGATGAACTCACAAACTTGAAC TGGCTTCATGAAAGCACTAATCTTCTAACAAACTTCAGCCTCGGAAGTGAGGGTCTTCCAATTGTTAGTCCATTGTATGACATAGAGGGA GATGATGTGCCATCCTTTGGACCAGCTTGCTACCAGAACCCAGAAAAAAAATCAGCGACTTCAAAGCCCCCATACTCCTTTAGTCTTCTC ATTTATATGGCCATTGAGCACTCTCCAAATAAATGTTTGCCTGTCAAAGAAATTTATAGCTGGATTCTGGACCATTTTCCATATTTTGCT ACTGCACCAACAGGCTGGAAGAATTCTGTTCGACATAATCTGTCCCTGAATAAATGTTTTCAGAAAGTGGAAAGAAGCCATGGCAAGGTG CTTGACAATGCTATTGAAACAGAAAAAATGATTGAAAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATC ATTCTGAACAATCGCAAATTTGCCAATTCACTGGTCGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCA CCCAAATTTACTGAGAAGGGGAACTTGGAAGTGCTGCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCC CGGGAGGGGAAGCTCATCTCTGACATCAACAAGGCCTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAG CTCATAAGACAGGAGAAACTGGAACAGCTCGCCCGCAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGT CTGGTGTCTCAGGACAACTTTGGGTTTGACCTTCCTGCAGTTGAGGCCGCCACAAAAAAGCACGAGGCCATTGAGACAGACATTGCCGCA TACGAGGAGCGTGTGCAGGCTGTGGTAGCCGTGGCCAGGGAGCTCGAGGCCGAGAATTACCACGACATCAAGCGCATCACAGCGAGGAAG GACAATGTCATCCGGCTCTGGGAATACCTACTGGAACTGCTCAGGGCCCGGAGACAGCGGCTCGAGATGAACCTGGGGCTGCAGAAGATA TTCCAGGAAATGCTCTACATTATGGACTGGATGGATGAAATGAAGGTGCTAGTATTGTCTCAAGACTATGGCAAACACTTACTTGGTGTG GAAGACCTGTTACAGAAGCACACCCTGGTTGAAGCAGACATTGGCATCCAGGCAGAGCGGGTGAGAGGTGTCAATGCCTCCGCCCAGAAG TTCGCAACAGACGGGGAAGGTTACAAGCCCTGTGACCCCCAGGTGATCCGAGACCGCGTGGCCCACATGGAGTTCTGTTATCAAGAGCTT TGCCAGCTGGCGGCTGAGCGCAGGGCCCGTCTGGAAGAGTCCCGCCGCCTCTGGAAGTTCTTCTGGGAGATGGCAGAAGAGGAAGGCTGG ATACGGGAGAAGGAGAAGATCCTGTCCTCGGACGATTACGGGAAAGACCTGACCAGCGTCATGCGCCTGCTCAGCAAGCACCGGGCGTTC GAGGACGAGATGAGCGGCCGCAGTGGCCACTTTGAGCAGGCCATCAAGGAAGGCGAAGACATGATCGCGGAGGAGCACTTCGGGTCGGAG AAGATCCGTGAGAGGATCATTTACATCCGGGAGCAGTGGGCCAACCTAGAGCAGCTCTCGGCCATTCGGAAGAAGCGCCTGGAGGAGGCC TCCCTGCTGCACCAGTTCCAGGCAGATGCTGATGACATTGATGCCTGGATGCTGGACATCCTCAAGATTGTCTCCAGCAGCGACGTGGGC CACGATGAGTATTCCACACAGTCTCTGGTCAAGAAACACAAGGACGTGGCGGAAGAGATCGCCAATTACAGGCCCACCCTTGACACGCTG CACGAACAAGCCAGCGCCCTCCCCCAGGAGCATGCCGAGTCTCCAGACGTGAGGGGCAGGCTGTCGGGCATCGAGGAGCGGTATAAGGAG GTGGCAGAGCTGACGCGGCTGCGGAAGCAGGCACTCCAGGACACTCTGGCCCTGTACAAGATGTTCAGCGAGGCTGATGCCTGTGAGCTC TGGATCGACGAGAAGGAGCAGTGGCTCAACAACATGCAGATCCCAGAGAAGCTGGAGGATCTGGAGGTCATCCAGCACAGATTTGAGAGC CTAGAACCAGAAATGAACAACCAGGCTTCCCGGGTTGCAGTGGTGAACCAGATTGCACGCCAGCTGATGCACAGCGGCCACCCAAGTGAG AAGGAAATCAAAGCCCAGCAGGACAAACTCAACACAAGGTGGAGCCAGTTCAGAGAACTGGTTGACAGGAAGAAGGATGCCCTCCTGTCT GCCCTGAGCATCCAGAACTACCACCTCGAGTGCAATGAAACCAAATCCTGGATTCGGGAAAAGACCAAGGTCATCGAGTCCACCCAGGAC CTGGGCAATGACCTGGCTGGCGTCATGGCCCTGCAGCGCAAGCTGACCGGCATGGAGCGGGACTTGGTGGCCATTGAGGCAAAGCTGAGT GACCTGCAGAAGGAGGCGGAGAAGCTGGAGTCCGAGCACCCCGACCAGGCCCAGGCCATCCTGTCTCGGCTGGCCGAGATCAGCGACGTG TGGGAGGAGATGAAGACCACCCTGAAAAACCGAGAGGCCTCCCTGGGAGAGGCCAGCAAGCTGCAGCAGTTCCTACGGGACTTGGACGAC TTCCAGTCCTGGCTCTCTAGGACCCAGACAGCGATCGCCTCGGAGGACATGCCAAACACCCTGACCGAGGCTGAGAAGCTGCTCACGCAG CACGAGAACATCAAGAACGAGATCGACAACTACGAGGAGGACTACCAGAAGATGAGGGACATGGGCGAGATGGTCACCCAGGGGCAGACC GATGCCCAGTACATGTTTCTGCGGCAGCGGCTGCAGGCCCTGGACACTGGATGGAACGAGCTCCACAAGATGTGGGAGAACAGACAAAAT CTCCTATCCCAGTCACATGCCTACCAGCAGTTCCTCAGAGACACGAAGCAAGCCGAAGCCTTTCTTAACAACCAGGAGTATGTTCTGGCT CACACTGAAATGCCTACCACCTTGGAAGGAGCTGAAGCAGCAATTAAAAAGCAAGAGGACTTCATGACCACCATGGACGCCAATGAGGAG AAGATCAATGCTGTGGTGGAGACTGGCCGGAGGCTGGTGAGCGATGGGAACATCAACTCAGATCGCATCCAGGAGAAGGTGGACTCTATT GATGACAGACATAGGAAGAATCGTGAGACAGCCAGTGAACTTTTGATGAGGTTGAAGGACAACAGGGATCTACAGAAATTCCTGCAAGAT TGTCAAGAGCTGTCTCTCTGGATCAATGAGAAGATGCTCACAGCCCAGGACATGTCTTACGATGAAGCCAGAAATCTGCACAGTAAATGG TTGAAGCATCAAGCATTTATGGCAGAACTTGCATCCAACAAAGAATGGCTTGACAAAATCGAGAAGGAAGGAATGCAGCTCATTTCAGAA AAGCCTGAGACGGAAGCTGTGGTGAAGGAGAAACTCACTGGTTTACATAAAATGTGGGAAGTCCTTGAATCCACTACCCAGACAAAGGCC CAGCGGCTCTTTGATGCAAACAAGGCCGAACTTTTCACCCAGAGCTGTGCAGATCTAGACAAATGGCTGCACGGCCTGGAGAGTCAGATT CAGTCTGATGACTATGGCAAAGACCTGACCAGTGTCAATATCCTGCTGAAAAAGCAACAGATGCTGGAGAATCAGATGGAAGTGCGGAAG AAGGAGATCGAAGAGCTCCAAAGCCAAGCCCAGGCCCTGAGTCAGGAAGGGAAGAGCACCGACGAGGTAGACAGCAAGCGCCTCACCGTG CAGACCAAGTTCATGGAGTTGCTGGAGCCCTTGAACGAGAGGAAGCATAACCTGCTGGCCTCCAAAGAGATCCATCAGTTCAACAGGGAT GTGGAGGACGAGATCTTGTGGGTTGGAGAGAGGATGCCTTTGGCAACTTCCACGGATCATGGCCACAACCTCCAGACTGTGCAGCTGTTA ATAAAGAAAAATCAGACCCTCCAGAAAGAAATCCAGGGGCACCAGCCTCGCATTGACGACATCTTTGAGAGGAGCCAAAACATCGTCACT GACAGCAGCAGCCTCAGCGCTGAGGCCATCAGACAGAGGCTTGCCGACCTGAAGCAGCTGTGGGGTCTCCTCATTGAGGAGACAGAGAAA CGCCACAGGCGGCTGGAGGAGGCGCACAGGGCCCAGCAGTACTACTTTGACGCTGCTGAGGCCGAAGCCTGGATGAGCGAGCAGGAGCTG TACATGATGTCAGAGGAGAAGGCCAAGGATGAGCAGAGTGCTGTCTCCATGTTGAAGAAGCACCAGATCTTAGAACAAGCTGTGGAGGAC TATGCAGAGACCGTGCATCAGCTCTCCAAGACCAGCCGGGCCCTGGTGGCCGACAGCCATCCTGAAAGTGAGCGCATTAGCATGCGGCAG TCCAAAGTGGATAAACTGTACGCTGGTCTGAAAGACCTTGCTGAAGAGAGAAGAGGCAAGCTGGATGAGAGACACAGGTTATTCCAGCTC AACCGGGAGGTGGACGACCTGGAGCAGTGGATCGCTGAGAGGGAGGTGGTCGCAGGGTCCCATGAACTGGGACAGGACTATGAGCATGTC ACGATGTTACAAGAACGATTCCGGGAGTTTGCCCGAGACACCGGGAACATTGGGCAGGAGCGCGTGGACACGGTCAATCACCTGGCAGAT GAGCTCATCAACTCTGGACATTCAGATGCCGCCACCATCGCTGAATGGAAGGATGGCCTCAATGAAGCCTGGGCCGACCTCCTGGAGCTC ATTGACACAAGAACACAGATTCTTGCCGCTTCCTATGAACTGCACAAGTTTTACCACGATGCCAAGGAGATCTTTGGGCGTATACAGGAC AAACACAAGAAACTCCCTGAGGAGCTTGGGAGAGATCAGAACACAGTGGAGACCTTACAGAGAATGCACACTACATTTGAGCATGACATC CAGGCTCTGGGCACACAGGTGAGGCAGCTGCAGGAGGATGCAGCCCGCCTCCAGGCGGCCTATGCGGGTGACAAGGCCGACGATATCCAG AAGCGCGAGAACGAGGTCCTGGAAGCCTGGAAGTCCCTCCTGGACGCCTGTGAGAGCCGCAGGGTGCGGCTGGTGGACACAGGGGACAAG TTCCGCTTCTTCAGCATGGTGCGCGACCTCATGCTCTGGATGGAGGATGTCATCCGGCAGATCGAGGCCCAGGAGAAGCCAAGGGATGTA TCATCTGTTGAACTCTTAATGAATAATCATCAAGGCATCAAAGCTGAAATTGATGCACGTAATGACAGTTTCACAACCTGCATTGAACTT GGGAAATCCCTGTTGGCGAGAAAACACTATGCATCTGAGGAGATCAAGGAAAAATTACTGCAGTTGACGGAAAAGAGGAAAGAAATGATC GACAAGTGGGAAGACCGATGGGAATGGTTAAGACTGATTCTGGAGGTCCATCAGTTCTCAAGAGACGCCAGTGTGGCCGAGGCCTGGCTG CTTGGACAGGAGCCGTACCTATCCAGCCGAGAGATAGGCCAGAGCGTGGACGAGGTGGAGAAGCTCATCAAGCGCCACGAGGCATTTGAA AAGTCTGCAGCAACCTGGGATGAGAGGTTCTCTGCCCTGGAAAGGCTGACTACATTGGAGTTACTGGAAGTGCGCAGACAGCAAGAGGAA GAGGAGAGGAAGAGGCGGCCGCCTTCTCCCGAGCCGAGCACGAAGGTTTCAGAGGAAGCCGAGTCCCAGCAGCAGTGGGATACTTCAAAA GGAGAACAAGTTTCCCAAAACGGTTTGCCAGCTGAACAGGGATCTCCACGGATGGCAGAAACGGTGGACACAAGCGAAATGGTCAACGGC GCTACAGAACAAAGGACGAGCTCTAAAGAGTCCAGCCCCATCCCCTCCCCGACCTCTGATCGTAAAGCCAAGACTGCCCTCCCAGCCCAG AGTGCCGCCACCTTACCAGCCAGAACCCAGGAGACACCTTCGGCCCAGATGGAAGGCTTCCTCAATCGGAAACACGAGTGGGAGGCCCAC AATAAGAAAGCCTCAAGCAGGTCCTGGCACAATGTTTATTGTGTCATAAATAACCAAGAAATGGGTTTCTACAAAGATGCAAAGACTGCT GCTTCTGGAATTCCCTACCACAGCGAGGTCCCTGTGAGTTTGAAAGAAGCTGTCTGCGAAGTGGCCCTTGATTACAAAAAGAAGAAACAC GTATTCAAGCTAAGACTAAATGATGGCAATGAGTACCTCTTCCAAGCCAAAGACGATGAGGAAATGAACACATGGATCCAGGCTATCTCT TCCGCCATCTCCTCTGATAAACACGAGGTGTCTGCCAGCACCCAGAGCACGCCAGCATCCAGCCGCGCGCAGACCCTCCCCACCAGCGTC GTCACCATCACCAGCGAGTCCAGTCCCGGCAAGCGGGAAAAGGACAAAGAGAAAGACAAAGAGAAGCGGTTCAGCCTTTTTGGCAAAAAG >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000333896_chr2_54849437_+_6168nt ATGGGTCCAGTAATTGGAATGACTCCAGATAAGAGAGCTGAAACCCCAGGAGCTGAAAAGATTGCAGGATTAAGCCAGATTTACAAAATG GGAAGCTTGCCTGAAGCTGTTGATGCTGCCAGGCCGAAGGCCACTCTAGTGGACAGTGAGTCAGCAGATGATGAACTCACAAACTTGAAC TGGCTTCATGAAAGCACTAATCTTCTAACAAACTTCAGCCTCGGAAGTGAGGGTCTTCCAATTGTTAGTCCATTGTATGACATAGAGGGA GATGATGTGCCATCCTTTGGACCAGCTTGCTACCAGAACCCAGAAAAAAAATCAGCGACTTCAAAGCCCCCATACTCCTTTAGTCTTCTC ATTTATATGGCCATTGAGCACTCTCCAAATAAATGTTTGCCTGTCAAAGAAATTTATAGCTGGATTCTGGACCATTTTCCATATTTTGCT ACTGCACCAACAGGCTGGAAGAATTCTGTTCGACATAATCTGTCCCTGAATAAATGTTTTCAGAAAGTGGAAAGAAGCCATGGCAAGGTG CTTGACAATGCTATTGAAACAGAAAAAATGATTGAAAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATC ATTCTGAACAATCGCAAATTTGCCAATTCACTGGTCGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCA CCCAAATTTACTGAGAAGGGGAACTTGGAAGTGCTGCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCC CGGGAGGGGAAGCTCATCTCTGACATCAACAAGGCCTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAG CTCATAAGACAGGAGAAACTGGAACAGCTCGCCCGCAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGT CTGGTGTCTCAGGACAACTTTGGGTTTGACCTTCCTGCAGTTGAGGCCGCCACAAAAAAGCACGAGGCCATTGAGACAGACATTGCCGCA TACGAGGAGCGTGTGCAGGCTGTGGTAGCCGTGGCCAGGGAGCTCGAGGCCGAGAATTACCACGACATCAAGCGCATCACAGCGAGGAAG GACAATGTCATCCGGCTCTGGGAATACCTACTGGAACTGCTCAGGGCCCGGAGACAGCGGCTCGAGATGAACCTGGGGCTGCAGAAGATA TTCCAGGAAATGCTCTACATTATGGACTGGATGGATGAAATGAAGGTGCTAGTATTGTCTCAAGACTATGGCAAACACTTACTTGGTGTG GAAGACCTGTTACAGAAGCACACCCTGGTTGAAGCAGACATTGGCATCCAGGCAGAGCGGGTGAGAGGTGTCAATGCCTCCGCCCAGAAG TTCGCAACAGACGGGGAAGGTTACAAGCCCTGTGACCCCCAGGTGATCCGAGACCGCGTGGCCCACATGGAGTTCTGTTATCAAGAGCTT TGCCAGCTGGCGGCTGAGCGCAGGGCCCGTCTGGAAGAGTCCCGCCGCCTCTGGAAGTTCTTCTGGGAGATGGCAGAAGAGGAAGGCTGG ATACGGGAGAAGGAGAAGATCCTGTCCTCGGACGATTACGGGAAAGACCTGACCAGCGTCATGCGCCTGCTCAGCAAGCACCGGGCGTTC GAGGACGAGATGAGCGGCCGCAGTGGCCACTTTGAGCAGGCCATCAAGGAAGGCGAAGACATGATCGCGGAGGAGCACTTCGGGTCGGAG AAGATCCGTGAGAGGATCATTTACATCCGGGAGCAGTGGGCCAACCTAGAGCAGCTCTCGGCCATTCGGAAGAAGCGCCTGGAGGAGGCC TCCCTGCTGCACCAGTTCCAGGCAGATGCTGATGACATTGATGCCTGGATGCTGGACATCCTCAAGATTGTCTCCAGCAGCGACGTGGGC CACGATGAGTATTCCACACAGTCTCTGGTCAAGAAACACAAGGACGTGGCGGAAGAGATCGCCAATTACAGGCCCACCCTTGACACGCTG CACGAACAAGCCAGCGCCCTCCCCCAGGAGCATGCCGAGTCTCCAGACGTGAGGGGCAGGCTGTCGGGCATCGAGGAGCGGTATAAGGAG GTGGCAGAGCTGACGCGGCTGCGGAAGCAGGCACTCCAGGACACTCTGGCCCTGTACAAGATGTTCAGCGAGGCTGATGCCTGTGAGCTC TGGATCGACGAGAAGGAGCAGTGGCTCAACAACATGCAGATCCCAGAGAAGCTGGAGGATCTGGAGGTCATCCAGCACAGATTTGAGAGC CTAGAACCAGAAATGAACAACCAGGCTTCCCGGGTTGCAGTGGTGAACCAGATTGCACGCCAGCTGATGCACAGCGGCCACCCAAGTGAG AAGGAAATCAAAGCCCAGCAGGACAAACTCAACACAAGGTGGAGCCAGTTCAGAGAACTGGTTGACAGGAAGAAGGATGCCCTCCTGTCT GCCCTGAGCATCCAGAACTACCACCTCGAGTGCAATGAAACCAAATCCTGGATTCGGGAAAAGACCAAGGTCATCGAGTCCACCCAGGAC CTGGGCAATGACCTGGCTGGCGTCATGGCCCTGCAGCGCAAGCTGACCGGCATGGAGCGGGACTTGGTGGCCATTGAGGCAAAGCTGAGT GACCTGCAGAAGGAGGCGGAGAAGCTGGAGTCCGAGCACCCCGACCAGGCCCAGGCCATCCTGTCTCGGCTGGCCGAGATCAGCGACGTG TGGGAGGAGATGAAGACCACCCTGAAAAACCGAGAGGCCTCCCTGGGAGAGGCCAGCAAGCTGCAGCAGTTCCTACGGGACTTGGACGAC TTCCAGTCCTGGCTCTCTAGGACCCAGACAGCGATCGCCTCGGAGGACATGCCAAACACCCTGACCGAGGCTGAGAAGCTGCTCACGCAG CACGAGAACATCAAGAACGAGATCGACAACTACGAGGAGGACTACCAGAAGATGAGGGACATGGGCGAGATGGTCACCCAGGGGCAGACC GATGCCCAGTACATGTTTCTGCGGCAGCGGCTGCAGGCCCTGGACACTGGATGGAACGAGCTCCACAAGATGTGGGAGAACAGACAAAAT CTCCTATCCCAGTCACATGCCTACCAGCAGTTCCTCAGAGACACGAAGCAAGCCGAAGCCTTTCTTAACAACCAGGAGTATGTTCTGGCT CACACTGAAATGCCTACCACCTTGGAAGGAGCTGAAGCAGCAATTAAAAAGCAAGAGGACTTCATGACCACCATGGACGCCAATGAGGAG AAGATCAATGCTGTGGTGGAGACTGGCCGGAGGCTGGTGAGCGATGGGAACATCAACTCAGATCGCATCCAGGAGAAGGTGGACTCTATT GATGACAGACATAGGAAGAATCGTGAGACAGCCAGTGAACTTTTGATGAGGTTGAAGGACAACAGGGATCTACAGAAATTCCTGCAAGAT TGTCAAGAGCTGTCTCTCTGGATCAATGAGAAGATGCTCACAGCCCAGGACATGTCTTACGATGAAGCCAGAAATCTGCACAGTAAATGG TTGAAGCATCAAGCATTTATGGCAGAACTTGCATCCAACAAAGAATGGCTTGACAAAATCGAGAAGGAAGGAATGCAGCTCATTTCAGAA AAGCCTGAGACGGAAGCTGTGGTGAAGGAGAAACTCACTGGTTTACATAAAATGTGGGAAGTCCTTGAATCCACTACCCAGACAAAGGCC CAGCGGCTCTTTGATGCAAACAAGGCCGAACTTTTCACCCAGAGCTGTGCAGATCTAGACAAATGGCTGCACGGCCTGGAGAGTCAGATT CAGTCTGATGACTATGGCAAAGACCTGACCAGTGTCAATATCCTGCTGAAAAAGCAACAGATGCTGGAGAATCAGATGGAAGTGCGGAAG AAGGAGATCGAAGAGCTCCAAAGCCAAGCCCAGGCCCTGAGTCAGGAAGGGAAGAGCACCGACGAGGTAGACAGCAAGCGCCTCACCGTG CAGACCAAGTTCATGGAGTTGCTGGAGCCCTTGAACGAGAGGAAGCATAACCTGCTGGCCTCCAAAGAGATCCATCAGTTCAACAGGGAT GTGGAGGACGAGATCTTGTGGGTTGGAGAGAGGATGCCTTTGGCAACTTCCACGGATCATGGCCACAACCTCCAGACTGTGCAGCTGTTA ATAAAGAAAAATCAGACCCTCCAGAAAGAAATCCAGGGGCACCAGCCTCGCATTGACGACATCTTTGAGAGGAGCCAAAACATCGTCACT GACAGCAGCAGCCTCAGCGCTGAGGCCATCAGACAGAGGCTTGCCGACCTGAAGCAGCTGTGGGGTCTCCTCATTGAGGAGACAGAGAAA CGCCACAGGCGGCTGGAGGAGGCGCACAGGGCCCAGCAGTACTACTTTGACGCTGCTGAGGCCGAAGCCTGGATGAGCGAGCAGGAGCTG TACATGATGTCAGAGGAGAAGGCCAAGGATGAGCAGAGTGCTGTCTCCATGTTGAAGAAGCACCAGATCTTAGAACAAGCTGTGGAGGAC TATGCAGAGACCGTGCATCAGCTCTCCAAGACCAGCCGGGCCCTGGTGGCCGACAGCCATCCTGAAAGTGAGCGCATTAGCATGCGGCAG TCCAAAGTGGATAAACTGTACGCTGGTCTGAAAGACCTTGCTGAAGAGAGAAGAGGCAAGCTGGATGAGAGACACAGGTTATTCCAGCTC AACCGGGAGGTGGACGACCTGGAGCAGTGGATCGCTGAGAGGGAGGTGGTCGCAGGGTCCCATGAACTGGGACAGGACTATGAGCATGTC ACGATGTTACAAGAACGATTCCGGGAGTTTGCCCGAGACACCGGGAACATTGGGCAGGAGCGCGTGGACACGGTCAATCACCTGGCAGAT GAGCTCATCAACTCTGGACATTCAGATGCCGCCACCATCGCTGAATGGAAGGATGGCCTCAATGAAGCCTGGGCCGACCTCCTGGAGCTC ATTGACACAAGAACACAGATTCTTGCCGCTTCCTATGAACTGCACAAGTTTTACCACGATGCCAAGGAGATCTTTGGGCGTATACAGGAC AAACACAAGAAACTCCCTGAGGAGCTTGGGAGAGATCAGAACACAGTGGAGACCTTACAGAGAATGCACACTACATTTGAGCATGACATC CAGGCTCTGGGCACACAGGTGAGGCAGCTGCAGGAGGATGCAGCCCGCCTCCAGGCGGCCTATGCGGGTGACAAGGCCGACGATATCCAG AAGCGCGAGAACGAGGTCCTGGAAGCCTGGAAGTCCCTCCTGGACGCCTGTGAGAGCCGCAGGGTGCGGCTGGTGGACACAGGGGACAAG TTCCGCTTCTTCAGCATGGTGCGCGACCTCATGCTCTGGATGGAGGATGTCATCCGGCAGATCGAGGCCCAGGAGAAGCCAAGGGATGTA TCATCTGTTGAACTCTTAATGAATAATCATCAAGGCATCAAAGCTGAAATTGATGCACGTAATGACAGTTTCACAACCTGCATTGAACTT GGGAAATCCCTGTTGGCGAGAAAACACTATGCATCTGAGGAGATCAAGGAAAAATTACTGCAGTTGACGGAAAAGAGGAAAGAAATGATC GACAAGTGGGAAGACCGATGGGAATGGTTAAGACTGATTCTGGAGGTCCATCAGTTCTCAAGAGACGCCAGTGTGGCCGAGGCCTGGCTG CTTGGACAGGAGCCGTACCTATCCAGCCGAGAGATAGGCCAGAGCGTGGACGAGGTGGAGAAGCTCATCAAGCGCCACGAGGCATTTGAA AAGTCTGCAGCAACCTGGGATGAGAGGTTCTCTGCCCTGGAAAGGCTGACTACATTGGAGTTACTGGAAGTGCGCAGACAGCAAGAGGAA GAGGAGAGGAAGAGGCGGCCGCCTTCTCCCGAGCCGAGCACGAAGGTTTCAGAGGAAGCCGAGTCCCAGCAGCAGTGGGATACTTCAAAA GGAGAACAAGTTTCCCAAAACGGTTTGCCAGCTGAACAGGGATCTCCACGGGTTAGTTACCGCTCTCAAACCTACCAAAACTACAAAAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000356805_chr2_54849437_+_8123nt CGCGTCTTCCCGGAGGCGACTGCTGGAAGCTGCAGGGAACAGCTGCGGTGCTCTGCCATATTGTGTCTTCCCCGGCCGGTCCCTCGCCTC CCGGCCGAGCTGACGTTGGTTGAAGCCATGGATAACAGAACCCACAGATGCAGAGGGCTGACTGTACAAGTCTGTCAAAAAACCAAACTG CTGGTTGGCTAATAATTGGTCACTGTATGACTTATAGTACAGGTGATATTACTTCTGATTCTAGATGAACTGTAAGAGTAAATGGGTCCA GTAATTGGAATGACTCCAGATAAGAGAGCTGAAACCCCAGGAGCTGAAAAGATTGCAGGATTAAGCCAGATTTACAAAATGGGAAGCTTG CCTGAAGCTGTTGATGCTGCCAGGCCGAAGGCCACTCTAGTGGACAGTGAGTCAGCAGATGATGAACTCACAAACTTGAACTGGCTTCAT GAAAGCACTAATCTTCTAACAAACTTCAGCCTCGGAAGTGAGGGTCTTCCAATTGTTAGTCCATTGTATGACATAGAGGGAGATGATGTG CCATCCTTTGGACCAGCTTGCTACCAGAACCCAGAAAAAAAATCAGCGACTTCAAAGCCCCCATACTCCTTTAGTCTTCTCATTTATATG GCCATTGAGCACTCTCCAAATAAATGTTTGCCTGTCAAAGAAATTTATAGCTGGATTCTGGACCATTTTCCATATTTTGCTACTGCACCA ACAGGCTGGAAGAATTCTGTTCGACATAATCTGTCCCTGAATAAATGTTTTCAGAAAGTGGAAAGAAGCCATGGCAAGGTGCTTGACAAT GCTATTGAAACAGAAAAAATGATTGAAAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATCATTCTGAAC AATCGCAAATTTGCCAATTCACTGGTCGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCACCCAAATTT ACTGAGAAGGGGAACTTGGAAGTGCTGCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCCCGGGAGGGG AAGCTCATCTCTGACATCAACAAGGCCTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAGCTCATAAGA CAGGAGAAACTGGAACAGCTCGCCCGCAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGTCTGGTGTCT CAGGACAACTTTGGGTTTGACCTTCCTGCAGTTGAGGCCGCCACAAAAAAGCACGAGGCCATTGAGACAGACATTGCCGCATACGAGGAG CGTGTGCAGGCTGTGGTAGCCGTGGCCAGGGAGCTCGAGGCCGAGAATTACCACGACATCAAGCGCATCACAGCGAGGAAGGACAATGTC ATCCGGCTCTGGGAATACCTACTGGAACTGCTCAGGGCCCGGAGACAGCGGCTCGAGATGAACCTGGGGCTGCAGAAGATATTCCAGGAA ATGCTCTACATTATGGACTGGATGGATGAAATGAAGGTGCTAGTATTGTCTCAAGACTATGGCAAACACTTACTTGGTGTGGAAGACCTG TTACAGAAGCACACCCTGGTTGAAGCAGACATTGGCATCCAGGCAGAGCGGGTGAGAGGTGTCAATGCCTCCGCCCAGAAGTTCGCAACA GACGGGGAAGGTTACAAGCCCTGTGACCCCCAGGTGATCCGAGACCGCGTGGCCCACATGGAGTTCTGTTATCAAGAGCTTTGCCAGCTG GCGGCTGAGCGCAGGGCCCGTCTGGAAGAGTCCCGCCGCCTCTGGAAGTTCTTCTGGGAGATGGCAGAAGAGGAAGGCTGGATACGGGAG AAGGAGAAGATCCTGTCCTCGGACGATTACGGGAAAGACCTGACCAGCGTCATGCGCCTGCTCAGCAAGCACCGGGCGTTCGAGGACGAG ATGAGCGGCCGCAGTGGCCACTTTGAGCAGGCCATCAAGGAAGGCGAAGACATGATCGCGGAGGAGCACTTCGGGTCGGAGAAGATCCGT GAGAGGATCATTTACATCCGGGAGCAGTGGGCCAACCTAGAGCAGCTCTCGGCCATTCGGAAGAAGCGCCTGGAGGAGGCCTCCCTGCTG CACCAGTTCCAGGCAGATGCTGATGACATTGATGCCTGGATGCTGGACATCCTCAAGATTGTCTCCAGCAGCGACGTGGGCCACGATGAG TATTCCACACAGTCTCTGGTCAAGAAACACAAGGACGTGGCGGAAGAGATCGCCAATTACAGGCCCACCCTTGACACGCTGCACGAACAA GCCAGCGCCCTCCCCCAGGAGCATGCCGAGTCTCCAGACGTGAGGGGCAGGCTGTCGGGCATCGAGGAGCGGTATAAGGAGGTGGCAGAG CTGACGCGGCTGCGGAAGCAGGCACTCCAGGACACTCTGGCCCTGTACAAGATGTTCAGCGAGGCTGATGCCTGTGAGCTCTGGATCGAC GAGAAGGAGCAGTGGCTCAACAACATGCAGATCCCAGAGAAGCTGGAGGATCTGGAGGTCATCCAGCACAGATTTGAGAGCCTAGAACCA GAAATGAACAACCAGGCTTCCCGGGTTGCAGTGGTGAACCAGATTGCACGCCAGCTGATGCACAGCGGCCACCCAAGTGAGAAGGAAATC AAAGCCCAGCAGGACAAACTCAACACAAGGTGGAGCCAGTTCAGAGAACTGGTTGACAGGAAGAAGGATGCCCTCCTGTCTGCCCTGAGC ATCCAGAACTACCACCTCGAGTGCAATGAAACCAAATCCTGGATTCGGGAAAAGACCAAGGTCATCGAGTCCACCCAGGACCTGGGCAAT GACCTGGCTGGCGTCATGGCCCTGCAGCGCAAGCTGACCGGCATGGAGCGGGACTTGGTGGCCATTGAGGCAAAGCTGAGTGACCTGCAG AAGGAGGCGGAGAAGCTGGAGTCCGAGCACCCCGACCAGGCCCAGGCCATCCTGTCTCGGCTGGCCGAGATCAGCGACGTGTGGGAGGAG ATGAAGACCACCCTGAAAAACCGAGAGGCCTCCCTGGGAGAGGCCAGCAAGCTGCAGCAGTTCCTACGGGACTTGGACGACTTCCAGTCC TGGCTCTCTAGGACCCAGACAGCGATCGCCTCGGAGGACATGCCAAACACCCTGACCGAGGCTGAGAAGCTGCTCACGCAGCACGAGAAC ATCAAGAACGAGATCGACAACTACGAGGAGGACTACCAGAAGATGAGGGACATGGGCGAGATGGTCACCCAGGGGCAGACCGATGCCCAG TACATGTTTCTGCGGCAGCGGCTGCAGGCCCTGGACACTGGATGGAACGAGCTCCACAAGATGTGGGAGAACAGACAAAATCTCCTATCC CAGTCACATGCCTACCAGCAGTTCCTCAGAGACACGAAGCAAGCCGAAGCCTTTCTTAACAACCAGGAGTATGTTCTGGCTCACACTGAA ATGCCTACCACCTTGGAAGGAGCTGAAGCAGCAATTAAAAAGCAAGAGGACTTCATGACCACCATGGACGCCAATGAGGAGAAGATCAAT GCTGTGGTGGAGACTGGCCGGAGGCTGGTGAGCGATGGGAACATCAACTCAGATCGCATCCAGGAGAAGGTGGACTCTATTGATGACAGA CATAGGAAGAATCGTGAGACAGCCAGTGAACTTTTGATGAGGTTGAAGGACAACAGGGATCTACAGAAATTCCTGCAAGATTGTCAAGAG CTGTCTCTCTGGATCAATGAGAAGATGCTCACAGCCCAGGACATGTCTTACGATGAAGCCAGAAATCTGCACAGTAAATGGTTGAAGCAT CAAGCATTTATGGCAGAACTTGCATCCAACAAAGAATGGCTTGACAAAATCGAGAAGGAAGGAATGCAGCTCATTTCAGAAAAGCCTGAG ACGGAAGCTGTGGTGAAGGAGAAACTCACTGGTTTACATAAAATGTGGGAAGTCCTTGAATCCACTACCCAGACAAAGGCCCAGCGGCTC TTTGATGCAAACAAGGCCGAACTTTTCACCCAGAGCTGTGCAGATCTAGACAAATGGCTGCACGGCCTGGAGAGTCAGATTCAGTCTGAT GACTATGGCAAAGACCTGACCAGTGTCAATATCCTGCTGAAAAAGCAACAGATGCTGGAGAATCAGATGGAAGTGCGGAAGAAGGAGATC GAAGAGCTCCAAAGCCAAGCCCAGGCCCTGAGTCAGGAAGGGAAGAGCACCGACGAGGTAGACAGCAAGCGCCTCACCGTGCAGACCAAG TTCATGGAGTTGCTGGAGCCCTTGAACGAGAGGAAGCATAACCTGCTGGCCTCCAAAGAGATCCATCAGTTCAACAGGGATGTGGAGGAC GAGATCTTGTGGGTTGGAGAGAGGATGCCTTTGGCAACTTCCACGGATCATGGCCACAACCTCCAGACTGTGCAGCTGTTAATAAAGAAA AATCAGACCCTCCAGAAAGAAATCCAGGGGCACCAGCCTCGCATTGACGACATCTTTGAGAGGAGCCAAAACATCGTCACTGACAGCAGC AGCCTCAGCGCTGAGGCCATCAGACAGAGGCTTGCCGACCTGAAGCAGCTGTGGGGTCTCCTCATTGAGGAGACAGAGAAACGCCACAGG CGGCTGGAGGAGGCGCACAGGGCCCAGCAGTACTACTTTGACGCTGCTGAGGCCGAAGCCTGGATGAGCGAGCAGGAGCTGTACATGATG TCAGAGGAGAAGGCCAAGGATGAGCAGAGTGCTGTCTCCATGTTGAAGAAGCACCAGATCTTAGAACAAGCTGTGGAGGACTATGCAGAG ACCGTGCATCAGCTCTCCAAGACCAGCCGGGCCCTGGTGGCCGACAGCCATCCTGAAAGTGAGCGCATTAGCATGCGGCAGTCCAAAGTG GATAAACTGTACGCTGGTCTGAAAGACCTTGCTGAAGAGAGAAGAGGCAAGCTGGATGAGAGACACAGGTTATTCCAGCTCAACCGGGAG GTGGACGACCTGGAGCAGTGGATCGCTGAGAGGGAGGTGGTCGCAGGGTCCCATGAACTGGGACAGGACTATGAGCATGTCACGATGTTA CAAGAACGATTCCGGGAGTTTGCCCGAGACACCGGGAACATTGGGCAGGAGCGCGTGGACACGGTCAATCACCTGGCAGATGAGCTCATC AACTCTGGACATTCAGATGCCGCCACCATCGCTGAATGGAAGGATGGCCTCAATGAAGCCTGGGCCGACCTCCTGGAGCTCATTGACACA AGAACACAGATTCTTGCCGCTTCCTATGAACTGCACAAGTTTTACCACGATGCCAAGGAGATCTTTGGGCGTATACAGGACAAACACAAG AAACTCCCTGAGGAGCTTGGGAGAGATCAGAACACAGTGGAGACCTTACAGAGAATGCACACTACATTTGAGCATGACATCCAGGCTCTG GGCACACAGGTGAGGCAGCTGCAGGAGGATGCAGCCCGCCTCCAGGCGGCCTATGCGGGTGACAAGGCCGACGATATCCAGAAGCGCGAG AACGAGGTCCTGGAAGCCTGGAAGTCCCTCCTGGACGCCTGTGAGAGCCGCAGGGTGCGGCTGGTGGACACAGGGGACAAGTTCCGCTTC TTCAGCATGGTGCGCGACCTCATGCTCTGGATGGAGGATGTCATCCGGCAGATCGAGGCCCAGGAGAAGCCAAGGGATGTATCATCTGTT GAACTCTTAATGAATAATCATCAAGGCATCAAAGCTGAAATTGATGCACGTAATGACAGTTTCACAACCTGCATTGAACTTGGGAAATCC CTGTTGGCGAGAAAACACTATGCATCTGAGGAGATCAAGGAAAAATTACTGCAGTTGACGGAAAAGAGGAAAGAAATGATCGACAAGTGG GAAGACCGATGGGAATGGTTAAGACTGATTCTGGAGGTCCATCAGTTCTCAAGAGACGCCAGTGTGGCCGAGGCCTGGCTGCTTGGACAG GAGCCGTACCTATCCAGCCGAGAGATAGGCCAGAGCGTGGACGAGGTGGAGAAGCTCATCAAGCGCCACGAGGCATTTGAAAAGTCTGCA GCAACCTGGGATGAGAGGTTCTCTGCCCTGGAAAGGCTGACTACATTGGAGTTACTGGAAGTGCGCAGACAGCAAGAGGAAGAGGAGAGG AAGAGGCGGCCGCCTTCTCCCGAGCCGAGCACGAAGGTTTCAGAGGAAGCCGAGTCCCAGCAGCAGTGGGATACTTCAAAAGGAGAACAA GTTTCCCAAAACGGTTTGCCAGCTGAACAGGGATCTCCACGGATGGCAGAAACGGTGGACACAAGCGAAATGGTCAACGGCGCTACAGAA CAAAGGACGAGCTCTAAAGAGTCCAGCCCCATCCCCTCCCCGACCTCTGATCGTAAAGCCAAGACTGCCCTCCCAGCCCAGAGTGCCGCC ACCTTACCAGCCAGAACCCAGGAGACACCTTCGGCCCAGATGGAAGGCTTCCTCAATCGGAAACACGAGTGGGAGGCCCACAATAAGAAA GCCTCAAGCAGGTCCTGGCACAATGTTTATTGTGTCATAAATAACCAAGAAATGGGTTTCTACAAAGATGCAAAGACTGCTGCTTCTGGA ATTCCCTACCACAGCGAGGTCCCTGTGAGTTTGAAAGAAGCTGTCTGCGAAGTGGCCCTTGATTACAAAAAGAAGAAACACGTATTCAAG CTAAGACTAAATGATGGCAATGAGTACCTCTTCCAAGCCAAAGACGATGAGGAAATGAACACATGGATCCAGGCTATCTCTTCCGCCATC TCCTCTGATAAACACGAGGTGTCTGCCAGCACCCAGAGCACGCCAGCATCCAGCCGCGCGCAGACCCTCCCCACCAGCGTCGTCACCATC ACCAGCGAGTCCAGTCCCGGCAAGCGGGAAAAGGACAAAGAGAAAGACAAAGAGAAGCGGTTCAGCCTTTTTGGCAAAAAGAAATGAACT CCTTTCCTTCACCTCCTGCCCTTCTCTTACCTTTTCAGTGAAATTCCAGCATGCAAGCTCAGAACCAACACATTACTCTCTGTGCCTAAT GTTCCTCAATGTGGTTGATTTTTTTTTTTTTTTAATTTATAGAGCATTTCGGGGGGGGTGGGGGAAACACACCTAAACACTTTATCTCCA AGTTACAAAAGTTTGAGGTGCAGAGGGAAGGCCAGATTTTTTTTTTAATGAAATTATATAGATTAGATCTCAGTATTTAAACTGTTCCTC AATTTTGTGAGGCTGTGTTGGAAATAACCCGCCTCTAGTGCTGTTGGTATGCAAGGCAGCGGTGCTTAATCAATATTTCCTGTGCTCACC AGAGGCAAAATGTACCAATATCCTGACACCATTCTCTCTCCATTTACTTCTGGTGGTTACCCTGACTCTTGACTCTTAGAAGTGCCCGAG ATGGGGCTAACCTTTATTAAACAGATCGCATATTATGATCTTGCTGCAGCCACAGTGCAGCTCCACATTAACTCTACAGACCAAACCATT TGTATCTGGCATCACTTACTAACACACGACATGCGGCTTTTCTGCATCAACTGCTATGACGGTTAAGAATGTCAGTATACAAGAAGGAAT AGAAAACTGATACTGTTTTAAATAATCTGTAATTTCAATTTTTTTTTTTTGCTGAAATACATTATATTGTACGTTTGAGATAATTCTAGT ACAAAGTATAATAAAACTAGATGTATAATAAACCCTTTAAATCATTGGTAAGTGTACAAGTGGTGGAACTGAAGCATTTACTGGACAAAG TAATGTTACTCTAATGGTTACTTGCTCGTGCGTTGCCACACTGTGTTATAATTTGCTTCATTTCCTTGCTATTTGATACATAGTGTGCAT TTCTCTGTCACTGTAACTATTGTAATGACAAATTTTCATCTTACTGCACAATCAAAATGACATTGATAGGAATGAACTCCAGAGGCTGGG CCTGAACAGGGAGGTGGTCGCTCAGGCCTGGTGCTCAGTCGTACGACCTGTACCTCTCAACTTTTGCCCTATCTGTTAAATATATGCTAT >In-frame_FOXN2_ENST00000340553_chr2_48573890_+_SPTBN1_ENST00000333896_chr2_54849437_+_8651nt CGCGTCTTCCCGGAGGCGACTGCTGGAAGCTGCAGGGAACAGCTGCGGTGCTCTGCCATATTGTGTCTTCCCCGGCCGGTCCCTCGCCTC CCGGCCGAGCTGACGTTGGTTGAAGCCATGGATAACAGAACCCACAGATGCAGAGGGCTGACTGTACAAGTCTGTCAAAAAACCAAACTG CTGGTTGGCTAATAATTGGTCACTGTATGACTTATAGTACAGGTGATATTACTTCTGATTCTAGATGAACTGTAAGAGTAAATGGGTCCA GTAATTGGAATGACTCCAGATAAGAGAGCTGAAACCCCAGGAGCTGAAAAGATTGCAGGATTAAGCCAGATTTACAAAATGGGAAGCTTG CCTGAAGCTGTTGATGCTGCCAGGCCGAAGGCCACTCTAGTGGACAGTGAGTCAGCAGATGATGAACTCACAAACTTGAACTGGCTTCAT GAAAGCACTAATCTTCTAACAAACTTCAGCCTCGGAAGTGAGGGTCTTCCAATTGTTAGTCCATTGTATGACATAGAGGGAGATGATGTG CCATCCTTTGGACCAGCTTGCTACCAGAACCCAGAAAAAAAATCAGCGACTTCAAAGCCCCCATACTCCTTTAGTCTTCTCATTTATATG GCCATTGAGCACTCTCCAAATAAATGTTTGCCTGTCAAAGAAATTTATAGCTGGATTCTGGACCATTTTCCATATTTTGCTACTGCACCA ACAGGCTGGAAGAATTCTGTTCGACATAATCTGTCCCTGAATAAATGTTTTCAGAAAGTGGAAAGAAGCCATGGCAAGGTGCTTGACAAT GCTATTGAAACAGAAAAAATGATTGAAAAGTATGAATCACTTGCCTCTGACCTTCTGGAATGGATTGAACAAACCATCATCATTCTGAAC AATCGCAAATTTGCCAATTCACTGGTCGGGGTTCAACAGCAGCTTCAGGCATTCAACACTTACCGCACTGTGGAGAAACCACCCAAATTT ACTGAGAAGGGGAACTTGGAAGTGCTGCTCTTCACCATTCAGAGCAAGATGAGGGCCAACAACCAGAAGGTCTACATGCCCCGGGAGGGG AAGCTCATCTCTGACATCAACAAGGCCTGGGAAAGACTGGAAAAAGCGGAACACGAAAGAGAACTGGCTTTGCGGAATGAGCTCATAAGA CAGGAGAAACTGGAACAGCTCGCCCGCAGATTTGATCGCAAGGCAGCTATGAGGGAGACTTGGCTGAGCGAAAACCAGCGTCTGGTGTCT CAGGACAACTTTGGGTTTGACCTTCCTGCAGTTGAGGCCGCCACAAAAAAGCACGAGGCCATTGAGACAGACATTGCCGCATACGAGGAG CGTGTGCAGGCTGTGGTAGCCGTGGCCAGGGAGCTCGAGGCCGAGAATTACCACGACATCAAGCGCATCACAGCGAGGAAGGACAATGTC ATCCGGCTCTGGGAATACCTACTGGAACTGCTCAGGGCCCGGAGACAGCGGCTCGAGATGAACCTGGGGCTGCAGAAGATATTCCAGGAA ATGCTCTACATTATGGACTGGATGGATGAAATGAAGGTGCTAGTATTGTCTCAAGACTATGGCAAACACTTACTTGGTGTGGAAGACCTG TTACAGAAGCACACCCTGGTTGAAGCAGACATTGGCATCCAGGCAGAGCGGGTGAGAGGTGTCAATGCCTCCGCCCAGAAGTTCGCAACA GACGGGGAAGGTTACAAGCCCTGTGACCCCCAGGTGATCCGAGACCGCGTGGCCCACATGGAGTTCTGTTATCAAGAGCTTTGCCAGCTG GCGGCTGAGCGCAGGGCCCGTCTGGAAGAGTCCCGCCGCCTCTGGAAGTTCTTCTGGGAGATGGCAGAAGAGGAAGGCTGGATACGGGAG AAGGAGAAGATCCTGTCCTCGGACGATTACGGGAAAGACCTGACCAGCGTCATGCGCCTGCTCAGCAAGCACCGGGCGTTCGAGGACGAG ATGAGCGGCCGCAGTGGCCACTTTGAGCAGGCCATCAAGGAAGGCGAAGACATGATCGCGGAGGAGCACTTCGGGTCGGAGAAGATCCGT GAGAGGATCATTTACATCCGGGAGCAGTGGGCCAACCTAGAGCAGCTCTCGGCCATTCGGAAGAAGCGCCTGGAGGAGGCCTCCCTGCTG CACCAGTTCCAGGCAGATGCTGATGACATTGATGCCTGGATGCTGGACATCCTCAAGATTGTCTCCAGCAGCGACGTGGGCCACGATGAG TATTCCACACAGTCTCTGGTCAAGAAACACAAGGACGTGGCGGAAGAGATCGCCAATTACAGGCCCACCCTTGACACGCTGCACGAACAA GCCAGCGCCCTCCCCCAGGAGCATGCCGAGTCTCCAGACGTGAGGGGCAGGCTGTCGGGCATCGAGGAGCGGTATAAGGAGGTGGCAGAG CTGACGCGGCTGCGGAAGCAGGCACTCCAGGACACTCTGGCCCTGTACAAGATGTTCAGCGAGGCTGATGCCTGTGAGCTCTGGATCGAC GAGAAGGAGCAGTGGCTCAACAACATGCAGATCCCAGAGAAGCTGGAGGATCTGGAGGTCATCCAGCACAGATTTGAGAGCCTAGAACCA GAAATGAACAACCAGGCTTCCCGGGTTGCAGTGGTGAACCAGATTGCACGCCAGCTGATGCACAGCGGCCACCCAAGTGAGAAGGAAATC AAAGCCCAGCAGGACAAACTCAACACAAGGTGGAGCCAGTTCAGAGAACTGGTTGACAGGAAGAAGGATGCCCTCCTGTCTGCCCTGAGC ATCCAGAACTACCACCTCGAGTGCAATGAAACCAAATCCTGGATTCGGGAAAAGACCAAGGTCATCGAGTCCACCCAGGACCTGGGCAAT GACCTGGCTGGCGTCATGGCCCTGCAGCGCAAGCTGACCGGCATGGAGCGGGACTTGGTGGCCATTGAGGCAAAGCTGAGTGACCTGCAG AAGGAGGCGGAGAAGCTGGAGTCCGAGCACCCCGACCAGGCCCAGGCCATCCTGTCTCGGCTGGCCGAGATCAGCGACGTGTGGGAGGAG ATGAAGACCACCCTGAAAAACCGAGAGGCCTCCCTGGGAGAGGCCAGCAAGCTGCAGCAGTTCCTACGGGACTTGGACGACTTCCAGTCC TGGCTCTCTAGGACCCAGACAGCGATCGCCTCGGAGGACATGCCAAACACCCTGACCGAGGCTGAGAAGCTGCTCACGCAGCACGAGAAC ATCAAGAACGAGATCGACAACTACGAGGAGGACTACCAGAAGATGAGGGACATGGGCGAGATGGTCACCCAGGGGCAGACCGATGCCCAG TACATGTTTCTGCGGCAGCGGCTGCAGGCCCTGGACACTGGATGGAACGAGCTCCACAAGATGTGGGAGAACAGACAAAATCTCCTATCC CAGTCACATGCCTACCAGCAGTTCCTCAGAGACACGAAGCAAGCCGAAGCCTTTCTTAACAACCAGGAGTATGTTCTGGCTCACACTGAA ATGCCTACCACCTTGGAAGGAGCTGAAGCAGCAATTAAAAAGCAAGAGGACTTCATGACCACCATGGACGCCAATGAGGAGAAGATCAAT GCTGTGGTGGAGACTGGCCGGAGGCTGGTGAGCGATGGGAACATCAACTCAGATCGCATCCAGGAGAAGGTGGACTCTATTGATGACAGA CATAGGAAGAATCGTGAGACAGCCAGTGAACTTTTGATGAGGTTGAAGGACAACAGGGATCTACAGAAATTCCTGCAAGATTGTCAAGAG CTGTCTCTCTGGATCAATGAGAAGATGCTCACAGCCCAGGACATGTCTTACGATGAAGCCAGAAATCTGCACAGTAAATGGTTGAAGCAT CAAGCATTTATGGCAGAACTTGCATCCAACAAAGAATGGCTTGACAAAATCGAGAAGGAAGGAATGCAGCTCATTTCAGAAAAGCCTGAG ACGGAAGCTGTGGTGAAGGAGAAACTCACTGGTTTACATAAAATGTGGGAAGTCCTTGAATCCACTACCCAGACAAAGGCCCAGCGGCTC TTTGATGCAAACAAGGCCGAACTTTTCACCCAGAGCTGTGCAGATCTAGACAAATGGCTGCACGGCCTGGAGAGTCAGATTCAGTCTGAT GACTATGGCAAAGACCTGACCAGTGTCAATATCCTGCTGAAAAAGCAACAGATGCTGGAGAATCAGATGGAAGTGCGGAAGAAGGAGATC GAAGAGCTCCAAAGCCAAGCCCAGGCCCTGAGTCAGGAAGGGAAGAGCACCGACGAGGTAGACAGCAAGCGCCTCACCGTGCAGACCAAG TTCATGGAGTTGCTGGAGCCCTTGAACGAGAGGAAGCATAACCTGCTGGCCTCCAAAGAGATCCATCAGTTCAACAGGGATGTGGAGGAC GAGATCTTGTGGGTTGGAGAGAGGATGCCTTTGGCAACTTCCACGGATCATGGCCACAACCTCCAGACTGTGCAGCTGTTAATAAAGAAA AATCAGACCCTCCAGAAAGAAATCCAGGGGCACCAGCCTCGCATTGACGACATCTTTGAGAGGAGCCAAAACATCGTCACTGACAGCAGC AGCCTCAGCGCTGAGGCCATCAGACAGAGGCTTGCCGACCTGAAGCAGCTGTGGGGTCTCCTCATTGAGGAGACAGAGAAACGCCACAGG CGGCTGGAGGAGGCGCACAGGGCCCAGCAGTACTACTTTGACGCTGCTGAGGCCGAAGCCTGGATGAGCGAGCAGGAGCTGTACATGATG TCAGAGGAGAAGGCCAAGGATGAGCAGAGTGCTGTCTCCATGTTGAAGAAGCACCAGATCTTAGAACAAGCTGTGGAGGACTATGCAGAG ACCGTGCATCAGCTCTCCAAGACCAGCCGGGCCCTGGTGGCCGACAGCCATCCTGAAAGTGAGCGCATTAGCATGCGGCAGTCCAAAGTG GATAAACTGTACGCTGGTCTGAAAGACCTTGCTGAAGAGAGAAGAGGCAAGCTGGATGAGAGACACAGGTTATTCCAGCTCAACCGGGAG GTGGACGACCTGGAGCAGTGGATCGCTGAGAGGGAGGTGGTCGCAGGGTCCCATGAACTGGGACAGGACTATGAGCATGTCACGATGTTA CAAGAACGATTCCGGGAGTTTGCCCGAGACACCGGGAACATTGGGCAGGAGCGCGTGGACACGGTCAATCACCTGGCAGATGAGCTCATC AACTCTGGACATTCAGATGCCGCCACCATCGCTGAATGGAAGGATGGCCTCAATGAAGCCTGGGCCGACCTCCTGGAGCTCATTGACACA AGAACACAGATTCTTGCCGCTTCCTATGAACTGCACAAGTTTTACCACGATGCCAAGGAGATCTTTGGGCGTATACAGGACAAACACAAG AAACTCCCTGAGGAGCTTGGGAGAGATCAGAACACAGTGGAGACCTTACAGAGAATGCACACTACATTTGAGCATGACATCCAGGCTCTG GGCACACAGGTGAGGCAGCTGCAGGAGGATGCAGCCCGCCTCCAGGCGGCCTATGCGGGTGACAAGGCCGACGATATCCAGAAGCGCGAG AACGAGGTCCTGGAAGCCTGGAAGTCCCTCCTGGACGCCTGTGAGAGCCGCAGGGTGCGGCTGGTGGACACAGGGGACAAGTTCCGCTTC TTCAGCATGGTGCGCGACCTCATGCTCTGGATGGAGGATGTCATCCGGCAGATCGAGGCCCAGGAGAAGCCAAGGGATGTATCATCTGTT GAACTCTTAATGAATAATCATCAAGGCATCAAAGCTGAAATTGATGCACGTAATGACAGTTTCACAACCTGCATTGAACTTGGGAAATCC CTGTTGGCGAGAAAACACTATGCATCTGAGGAGATCAAGGAAAAATTACTGCAGTTGACGGAAAAGAGGAAAGAAATGATCGACAAGTGG GAAGACCGATGGGAATGGTTAAGACTGATTCTGGAGGTCCATCAGTTCTCAAGAGACGCCAGTGTGGCCGAGGCCTGGCTGCTTGGACAG GAGCCGTACCTATCCAGCCGAGAGATAGGCCAGAGCGTGGACGAGGTGGAGAAGCTCATCAAGCGCCACGAGGCATTTGAAAAGTCTGCA GCAACCTGGGATGAGAGGTTCTCTGCCCTGGAAAGGCTGACTACATTGGAGTTACTGGAAGTGCGCAGACAGCAAGAGGAAGAGGAGAGG AAGAGGCGGCCGCCTTCTCCCGAGCCGAGCACGAAGGTTTCAGAGGAAGCCGAGTCCCAGCAGCAGTGGGATACTTCAAAAGGAGAACAA GTTTCCCAAAACGGTTTGCCAGCTGAACAGGGATCTCCACGGGTTAGTTACCGCTCTCAAACCTACCAAAACTACAAAAACTTTAATAGC AGACGGACAGCCAGTGACCAGCCATGGTCTGGACTGTGAAGTTCACTACCATTTGTCAAGAATCACCCTTTCCAAATCCTCTGGGTTTTG ACTTTTTGGCTTCCACTTCACCCAAAATGTTAAAATTTTTACTTAATTCATAGCCTTCCTTGGTTTCATATTTGTTTGCATTTAATTCAT GTTTGAGTCTCTTAACTGATGGATGCCCACTTGCCTTAAAGCAGCATACTTATTTTTTGTTTATTTATTGTGAGCTTTTTACTTTATTAA GATTTTACAGCGAAACCCTTACATGAGTAATTGAAATGAAATTAAATGAGATTACAGCATAATGAAGAAGAAAACTAGAATCTAACAGGT ATGACACATTCAGTTATTCTAACAGGGCACAGTACTGTGCTATATGTAGCCGCCTTTACAGATGTTATTAACCTATAGTAGTTTACTATT AACTAGGAAGACTGGTGTATGAGGAGGGAGACATTCTGTAATAAGATTAAAACCTAAAGTCAGCTGTGTAACATTCCATGAAAGATGCAT TCATTTATTGAAGATGACAAAAAAGGGAGTCAGATATATTCTGGAAGCTATTTTAATTTTAGGCACACAATCTCATACATTTTGAGACCC TTGGGTCATTTATTACTTTTTACAAACTAGTTCCTCTCTTTTTTTCTGCCAAGTCCTGAATTGAAAACTGTAGGCTTCCTTGCACAGATG TTGCAGCCAGCCTCAGGAGTAAAGTGCCCGCTGACTGCTGCCGCCACCTCTGTCTCGCTCCCTGTCAGTGCTGCTGGCACGTGGGACGCG GCAGGTGACAGCCGTTCTCAGCATGTTTTAGAAGCTTGCCTCACAGACTTCCATGCCTCTCCATTCAGCCGATGACTTCAGGGTGTCAAA CTGTTTTAATTTTTCAAACAAATGGAACAGAAGCCATTGTGGTTCATCCTGATTACTTGAACGTTGCACTTGGTGGACCGTGCCTGGGAG CGCTCGCATGCCCCCTGGCTTCAGAAGTCATGTCAGTGTCTCTGTAGACAAACTCCACTGTACATCTTGGATTAATCTTCTGATTCATTG TTCATTTTCTCAAGACTTTTTGTGGAATTCTCTGATAAAGGAAGCTTTTAGGATGGTATCTATCAGGCCACCAGCAGGAATTGAAAATGT TTTCACAAAAATCCTTTTCCTTAGAAATAAAAGCTGGTGACAGAGATGGTTTCCTTGTACCGATAAAAACAAAACCAAATCCATATTATA CATCAAAACCTTGTGAGACATTCACTTGCTCTTTTGCCATATTTAGATGTGTCAGTGGAATCAGAAACCTGTTTTGATATGTGTTCTCTA TGAGTTAAGTCTGATTTGTCTTTTTATTTCATGATGCATGTCTTTTTTTTCTTTTGTCAGGATAACGTCATATAGCATCTTGTTTGTTTT TCCTTATCTCTATGTACATATCTATCTACTTCTGACTGTAGATGGGTATATAGATAGATGCCAAGCTTCTTATGTTCTGGGGGTAGTATG CATCATTATTGGGTCTCTGCCTTAAAACACATCAAAATTCATTTTAGACAAAAAAACTTCTGCTTTGTCTTTGGTCATTAGGGAGCTCTA ATGTGTGTTTGTGGCTCCAAGTTACATTTTGTGTTTCATTGATCTATATGTATATATGTGATGTTTTCATATATATATGTGTGTGTGTTT AAATTTTGTATCATCAGGACTGACACCCAATTTGACACTTTTTGTATCTAGAAGACCCTCCAAAAAAGGAACCACATAAGCACACAAGAA AAGAGTGCTATGATGTTCTTAGCATTTGCTATCATGCCTATTTTTATCTAGATTTTTAAATGTAGCTTGTCATAACAAAATTTTAATTAC AATTGGCTTGTATGAGAAGAAAAAGTATTTTTATTGTTTTGAGTGATGACGCAGAGACTCAGTGAACTTGAAAATAGCATTGCTTCGTGC ACTTTGAATACCAATCAGGTGTTTTCTGTGCTACTAGTTGTCACGTTGCATTCATGTTCACCTCCTGATTTAAGTATCTCGGGTGTGCCC AGCCACTAAAGCACTCTGGACTAATCGCTAAAGAGAAGCAACGTGGGGGGTGGGGTTGCGAGGGATGTGTTCACATGTACCCATCATTTG ATCATAGCACTGTGATTGCTTTTGATGTGTGTCTCTAGTGGTGTGCTGTCTGTTGGCATGCTTAAAGCACATGTCCATTAAAATTCATTT |
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FusionGenePPI for FOXN2_SPTBN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FOXN2 | USP7, ELAVL1, UBC, FBXW11, FOXA2, RFX1, HCFC1, SKP1, BTRC, PSMD8, RFX2, PCBP1 | SPTBN1 | EPB41L3, DCTN1, NF2, GRIA2, CTNNA1, SNCA, PJA1, MAPK14, MEF2C, STAT1, PLCB1, PYGO1, PACSIN1, SREBF2, GRB2, PLEKHA5, APC, CEBPA, SRRM2, AGO3, CDC5L, DISC1, CEP63, TRAF3IP1, SH3BP5, TNIK, ARRB2, SIRT7, CUL3, CDK2, CUL1, COPS5, NEDD8, GRK5, CBL, UBASH3B, PIK3R2, SHC1, AP2M1, SPTAN1, RBM8A, NENF, RABL2A, CDH2, DDX19A, SOD1, PSMA7, TXN2, POU2F1, DBN1, PRKCDBP, HSPA5, ESR1, EIF4A3, MAGOH, SMURF1, FN1, SMAD9, ZNF512B, UBL4A, SMAD3, ANK1, TPM1, TGFBR1, SMAD2, SMAD4, MYBL2, SVIL, PAN2, KIAA0101, FBXO6, EIF2B2, MOB4, TNKS1BP1, RPA1, RPA2, RPA3, TUBG1, WEE1, HSPB1, UNK, NCAPD3, MCM5, NXF1, NTRK1, PTEN, EWSR1, HIST1H3E, ADD1, CAPZA2, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, PDLIM7, KATNA1, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, SNW1, FBXW7, THAP3, SPTBN1, GLTSCR2, SEPT8, COPB1, ZNF251, STXBP1, GOLGA6L10, EIF3H, CDH1, PDP1, PPM1B, PTP4A2, STYXL1, CYLD, TRIM25, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000333896 | + | 6 | 31 | 1563_2093 | 279 | 2156 | ANK2 |
| Tgene | SPTBN1 | chr2:48573890 | chr2:54849437 | ENST00000356805 | + | 7 | 36 | 1563_2093 | 292 | 2365 | ANK2 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOXN2_SPTBN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | SPTBN1 | Q01082 | DB01373 | Calcium | Spectrin beta chain, non-erythrocytic 1 | small molecule | approved|nutraceutical |
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RelatedDiseases for FOXN2_SPTBN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SPTBN1 | C0043094 | Weight Gain | 1 | CTD_human |
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