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Fusion gene ID: 13709 |
FusionGeneSummary for FNIP2_JAG2 |
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Fusion gene information | Fusion gene name: FNIP2_JAG2 | Fusion gene ID: 13709 | Hgene | Tgene | Gene symbol | FNIP2 | JAG2 | Gene ID | 57600 | 3714 |
Gene name | folliculin interacting protein 2 | jagged 2 | |
Synonyms | FNIPL|MAPO1 | HJ2|SER2 | |
Cytomap | 4q32.1 | 14q32.33 | |
Type of gene | protein-coding | protein-coding | |
Description | folliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 protein | protein jagged-2 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9P278 | Q9Y219 | |
Ensembl transtripts involved in fusion gene | ENST00000264433, ENST00000379346, ENST00000505445, | ENST00000331782, ENST00000347004, | |
Fusion gene scores | * DoF score | 9 X 5 X 6=270 | 2 X 2 X 1=4 |
# samples | 9 | 2 | |
** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: FNIP2 [Title/Abstract] AND JAG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FNIP2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21209915 |
Hgene | FNIP2 | GO:0001932 | regulation of protein phosphorylation | 18663353 |
Hgene | FNIP2 | GO:0006468 | protein phosphorylation | 18663353 |
Hgene | FNIP2 | GO:0031334 | positive regulation of protein complex assembly | 25126726 |
Hgene | FNIP2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19914239 |
Tgene | JAG2 | GO:0030154 | cell differentiation | 11700865 |
Tgene | JAG2 | GO:0030217 | T cell differentiation | 10383933 |
Tgene | JAG2 | GO:0042127 | regulation of cell proliferation | 10383933 |
Tgene | JAG2 | GO:0045061 | thymic T cell selection | 10383933 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW368093 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000264433 | ENST00000331782 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
intron-3CDS | ENST00000264433 | ENST00000347004 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
intron-3CDS | ENST00000379346 | ENST00000331782 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
intron-3CDS | ENST00000379346 | ENST00000347004 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
intron-3CDS | ENST00000505445 | ENST00000331782 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
intron-3CDS | ENST00000505445 | ENST00000347004 | FNIP2 | chr4 | 159750868 | + | JAG2 | chr14 | 105612312 | - |
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FusionProtFeatures for FNIP2_JAG2 |
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Hgene | Tgene |
FNIP2 | JAG2 |
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1 (PubMed:27353360). May play a role in the signaltransduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energyand/or nutrient sensing through the AMPK and mTOR signalingpathways (PubMed:18403135). May regulate phosphorylation ofRPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3,ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}. | Putative Notch ligand involved in the mediation of Notchsignaling. Involved in limb development (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FNIP2_JAG2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FNIP2_JAG2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FNIP2_JAG2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FNIP2_JAG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | JAG2 | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | JAG2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | JAG2 | C0039075 | Syndactyly | 1 | CTD_human |
Tgene | JAG2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Tgene | JAG2 | C0751674 | Lymphangioleiomyomatosis | 1 | CTD_human |
Tgene | JAG2 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
Tgene | JAG2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |