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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13709

FusionGeneSummary for FNIP2_JAG2

check button Fusion gene summary
Fusion gene informationFusion gene name: FNIP2_JAG2
Fusion gene ID: 13709
HgeneTgene
Gene symbol

FNIP2

JAG2

Gene ID

57600

3714

Gene namefolliculin interacting protein 2jagged 2
SynonymsFNIPL|MAPO1HJ2|SER2
Cytomap

4q32.1

14q32.33

Type of geneprotein-codingprotein-coding
Descriptionfolliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 proteinprotein jagged-2
Modification date2018051920180522
UniProtAcc

Q9P278

Q9Y219

Ensembl transtripts involved in fusion geneENST00000264433, ENST00000379346, 
ENST00000505445, 
ENST00000331782, 
ENST00000347004, 
Fusion gene scores* DoF score9 X 5 X 6=2702 X 2 X 1=4
# samples 92
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: FNIP2 [Title/Abstract] AND JAG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFNIP2

GO:0000122

negative regulation of transcription by RNA polymerase II

21209915

HgeneFNIP2

GO:0001932

regulation of protein phosphorylation

18663353

HgeneFNIP2

GO:0006468

protein phosphorylation

18663353

HgeneFNIP2

GO:0031334

positive regulation of protein complex assembly

25126726

HgeneFNIP2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19914239

TgeneJAG2

GO:0030154

cell differentiation

11700865

TgeneJAG2

GO:0030217

T cell differentiation

10383933

TgeneJAG2

GO:0042127

regulation of cell proliferation

10383933

TgeneJAG2

GO:0045061

thymic T cell selection

10383933


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW368093FNIP2chr4

159750868

+JAG2chr14

105612312

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000264433ENST00000331782FNIP2chr4

159750868

+JAG2chr14

105612312

-
intron-3CDSENST00000264433ENST00000347004FNIP2chr4

159750868

+JAG2chr14

105612312

-
intron-3CDSENST00000379346ENST00000331782FNIP2chr4

159750868

+JAG2chr14

105612312

-
intron-3CDSENST00000379346ENST00000347004FNIP2chr4

159750868

+JAG2chr14

105612312

-
intron-3CDSENST00000505445ENST00000331782FNIP2chr4

159750868

+JAG2chr14

105612312

-
intron-3CDSENST00000505445ENST00000347004FNIP2chr4

159750868

+JAG2chr14

105612312

-

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FusionProtFeatures for FNIP2_JAG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNIP2

Q9P278

JAG2

Q9Y219

Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1 (PubMed:27353360). May play a role in the signaltransduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energyand/or nutrient sensing through the AMPK and mTOR signalingpathways (PubMed:18403135). May regulate phosphorylation ofRPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3,ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}. Putative Notch ligand involved in the mediation of Notchsignaling. Involved in limb development (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNIP2_JAG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNIP2_JAG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNIP2_JAG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FNIP2_JAG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneJAG2C0017636Glioblastoma1CTD_human
TgeneJAG2C0036341Schizophrenia1PSYGENET
TgeneJAG2C0039075Syndactyly1CTD_human
TgeneJAG2C0376634Craniofacial Abnormalities1CTD_human
TgeneJAG2C0751674Lymphangioleiomyomatosis1CTD_human
TgeneJAG2C0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneJAG2C1458155Mammary Neoplasms1CTD_human