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Fusion gene ID: 13704 |
FusionGeneSummary for FNIP1_IL5 |
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Fusion gene information | Fusion gene name: FNIP1_IL5 | Fusion gene ID: 13704 | Hgene | Tgene | Gene symbol | FNIP1 | IL5 | Gene ID | 96459 | 3567 |
Gene name | folliculin interacting protein 1 | interleukin 5 | |
Synonyms | - | EDF|IL-5|TRF | |
Cytomap | 5q31.1 | 5q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | folliculin-interacting protein 1 | interleukin-5B-cell differentiation factor IT-cell replacing factorcolony-stimulating factor, eosinophileosinophil differentiation factor | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q8TF40 | P05113 | |
Ensembl transtripts involved in fusion gene | ENST00000307968, ENST00000307954, ENST00000510461, ENST00000511848, | ENST00000231454, | |
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 2 X 2 X 2=8 |
# samples | 8 | 2 | |
** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FNIP1 [Title/Abstract] AND IL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FNIP1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21209915 |
Hgene | FNIP1 | GO:0001932 | regulation of protein phosphorylation | 18663353 |
Hgene | FNIP1 | GO:0031334 | positive regulation of protein complex assembly | 25126726 |
Hgene | FNIP1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19914239 |
Tgene | IL5 | GO:0071803 | positive regulation of podosome assembly | 15220135 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FJ-A3ZF-01A | FNIP1 | chr5 | 131132523 | - | IL5 | chr5 | 131878818 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000307968 | ENST00000231454 | FNIP1 | chr5 | 131132523 | - | IL5 | chr5 | 131878818 | - |
In-frame | ENST00000307954 | ENST00000231454 | FNIP1 | chr5 | 131132523 | - | IL5 | chr5 | 131878818 | - |
In-frame | ENST00000510461 | ENST00000231454 | FNIP1 | chr5 | 131132523 | - | IL5 | chr5 | 131878818 | - |
In-frame | ENST00000511848 | ENST00000231454 | FNIP1 | chr5 | 131132523 | - | IL5 | chr5 | 131878818 | - |
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FusionProtFeatures for FNIP1_IL5 |
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Hgene | Tgene |
FNIP1 | IL5 |
Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1. Competes with the activating co-chaperone AHSA1 forbinding to HSP90AA1, thereby providing a reciprocal regulatorymechanism for chaperoning of client proteins (PubMed:27353360).May be involved in energy and/or nutrient sensing through the AMPKand mTOR signaling pathways (PubMed:17028174). May regulatephosphorylation of RPS6KB1 (PubMed:18663353).{ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}. | Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000307968 | - | 1 | 17 | 96_99 | 30 | 1139 | Compositional bias | Note=Poly-Ser |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000510461 | - | 1 | 18 | 96_99 | 30 | 1167 | Compositional bias | Note=Poly-Ser |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000511848 | - | 1 | 13 | 96_99 | 30 | 509 | Compositional bias | Note=Poly-Ser |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000307968 | - | 1 | 17 | 1102_1157 | 30 | 1139 | Domain | dDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000307968 | - | 1 | 17 | 37_478 | 30 | 1139 | Domain | uDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000307968 | - | 1 | 17 | 486_1092 | 30 | 1139 | Domain | cDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000510461 | - | 1 | 18 | 1102_1157 | 30 | 1167 | Domain | dDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000510461 | - | 1 | 18 | 37_478 | 30 | 1167 | Domain | uDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000510461 | - | 1 | 18 | 486_1092 | 30 | 1167 | Domain | cDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000511848 | - | 1 | 13 | 1102_1157 | 30 | 509 | Domain | dDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000511848 | - | 1 | 13 | 37_478 | 30 | 509 | Domain | uDENN FNIP1/2-type |
Hgene | >FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000511848 | - | 1 | 13 | 486_1092 | 30 | 509 | Domain | cDENN FNIP1/2-type |
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FusionGeneSequence for FNIP1_IL5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_FNIP1_ENST00000307968_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_117aa MAPTLFQKLFSKRTGLGAPGRDARDPDCGFRLXGFLFLYIKITNCALKKSFREXAHWRVKLCKGVLWKDYSKTCPXXRNTLTAKKKSVEK >In-frame_FNIP1_ENST00000307954_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_117aa MAPTLFQKLFSKRTGLGAPGRDARDPDCGFRLXGFLFLYIKITNCALKKSFREXAHWRVKLCKGVLWKDYSKTCPXXRNTLTAKKKSVEK >In-frame_FNIP1_ENST00000510461_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_117aa MAPTLFQKLFSKRTGLGAPGRDARDPDCGFRLXGFLFLYIKITNCALKKSFREXAHWRVKLCKGVLWKDYSKTCPXXRNTLTAKKKSVEK >In-frame_FNIP1_ENST00000511848_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_117aa MAPTLFQKLFSKRTGLGAPGRDARDPDCGFRLXGFLFLYIKITNCALKKSFREXAHWRVKLCKGVLWKDYSKTCPXXRNTLTAKKKSVEK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_FNIP1_ENST00000307968_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_353nt ATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCGGGTTC AGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAGTCAAA CTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGGAGAAG >In-frame_FNIP1_ENST00000307954_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_353nt ATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCGGGTTC AGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAGTCAAA CTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGGAGAAG >In-frame_FNIP1_ENST00000510461_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_353nt ATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCGGGTTC AGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAGTCAAA CTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGGAGAAG >In-frame_FNIP1_ENST00000511848_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_353nt ATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCGGGTTC AGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAGTCAAA CTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGGAGAAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_FNIP1_ENST00000307968_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_720nt ATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCGGGTTC AGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAGTCAAA CTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGGAGAAG AAAGACGGAGAGTAAACCAATTCCTAGACTACCTGCAAGAGTTTCTTGGTGTAATGAACACCGAGTGGATAATAGAAAGTTGAGACTAAA CTGGTTTGTTGCAGCCAAAGATTTTGGAGGAGAAGGACATTTTACTGCAGTGAGAATGAGGGCCAAGAAAGAGTCAGGCCTTAATTTTCA GTATAATTTAACTTCAGAGGGAAAGTAAATATTTCAGGCATACTGACACTTTGCCAGAAAGCATAAAATTCTTAAAATATATTTCAGATA TCAGAATCATTGAAGTATTTTCCTCCAGGCAAAATTGATATACTTTTTTCTTATTTAACTTAACATTCTGTAAAATGTCTGTTAACTTAA TAGTATTTATGAAATGGTTAAGAATTTGGTAAATTAGTATTTATTTAATGTTATGTTGTGTTCTAATAAAACAAAAATAGACAACTGTTC >In-frame_FNIP1_ENST00000307954_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_749nt GGAGCGACCCCTGCCTGGCCGTGGCTAGCATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCC GCGACGCCCGGGACCCAGATTGCGGGTTCAGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTT TCAGGGAATAGGCACACTGGAGAGTCAAACTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACAT TGACGGCCAAAAAAAAAAGTGTGGAGAAGAAAGACGGAGAGTAAACCAATTCCTAGACTACCTGCAAGAGTTTCTTGGTGTAATGAACAC CGAGTGGATAATAGAAAGTTGAGACTAAACTGGTTTGTTGCAGCCAAAGATTTTGGAGGAGAAGGACATTTTACTGCAGTGAGAATGAGG GCCAAGAAAGAGTCAGGCCTTAATTTTCAGTATAATTTAACTTCAGAGGGAAAGTAAATATTTCAGGCATACTGACACTTTGCCAGAAAG CATAAAATTCTTAAAATATATTTCAGATATCAGAATCATTGAAGTATTTTCCTCCAGGCAAAATTGATATACTTTTTTCTTATTTAACTT AACATTCTGTAAAATGTCTGTTAACTTAATAGTATTTATGAAATGGTTAAGAATTTGGTAAATTAGTATTTATTTAATGTTATGTTGTGT >In-frame_FNIP1_ENST00000510461_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_816nt ATATGACTGAGGCGCCCATGGGGGTGGCGGGGCGGCTGTAGGAGCAGGGGCCTAGCAAGCGCCCAGCGGAGCGACCCCTGCCTGGCCGTG GCTAGCATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGC GGGTTCAGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGA GTCAAACTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTG GAGAAGAAAGACGGAGAGTAAACCAATTCCTAGACTACCTGCAAGAGTTTCTTGGTGTAATGAACACCGAGTGGATAATAGAAAGTTGAG ACTAAACTGGTTTGTTGCAGCCAAAGATTTTGGAGGAGAAGGACATTTTACTGCAGTGAGAATGAGGGCCAAGAAAGAGTCAGGCCTTAA TTTTCAGTATAATTTAACTTCAGAGGGAAAGTAAATATTTCAGGCATACTGACACTTTGCCAGAAAGCATAAAATTCTTAAAATATATTT CAGATATCAGAATCATTGAAGTATTTTCCTCCAGGCAAAATTGATATACTTTTTTCTTATTTAACTTAACATTCTGTAAAATGTCTGTTA ACTTAATAGTATTTATGAAATGGTTAAGAATTTGGTAAATTAGTATTTATTTAATGTTATGTTGTGTTCTAATAAAACAAAAATAGACAA >In-frame_FNIP1_ENST00000511848_chr5_131132523_-_IL5_ENST00000231454_chr5_131878818_-_815nt TATGACTGAGGCGCCCATGGGGGTGGCGGGGCGGCTGTAGGAGCAGGGGCCTAGCAAGCGCCCAGCGGAGCGACCCCTGCCTGGCCGTGG CTAGCATGGCCCCTACGCTGTTCCAGAAGCTCTTCAGCAAGAGGACCGGGCTGGGCGCGCCCGGCCGCGACGCCCGGGACCCAGATTGCG GGTTCAGACTCTGAGGATTCCTGTTCCTGTACATAAAAATCACCAACTGTGCACTGAAGAAATCTTTCAGGGAATAGGCACACTGGAGAG TCAAACTGTGCAAGGGGGTACTGTGGAAAGACTATTCAAAAACTTGTCCTTAATAAAGAAATACATTGACGGCCAAAAAAAAAAGTGTGG AGAAGAAAGACGGAGAGTAAACCAATTCCTAGACTACCTGCAAGAGTTTCTTGGTGTAATGAACACCGAGTGGATAATAGAAAGTTGAGA CTAAACTGGTTTGTTGCAGCCAAAGATTTTGGAGGAGAAGGACATTTTACTGCAGTGAGAATGAGGGCCAAGAAAGAGTCAGGCCTTAAT TTTCAGTATAATTTAACTTCAGAGGGAAAGTAAATATTTCAGGCATACTGACACTTTGCCAGAAAGCATAAAATTCTTAAAATATATTTC AGATATCAGAATCATTGAAGTATTTTCCTCCAGGCAAAATTGATATACTTTTTTCTTATTTAACTTAACATTCTGTAAAATGTCTGTTAA CTTAATAGTATTTATGAAATGGTTAAGAATTTGGTAAATTAGTATTTATTTAATGTTATGTTGTGTTCTAATAAAACAAAAATAGACAAC |
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FusionGenePPI for FNIP1_IL5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FNIP1 | HSP90AA1, PRKAA1, PRKAB1, PRKAG1, FLCN, PRKAA2, FBXW11, COPS5, BTRC, HSPA5, GABARAP, HSPA1B, STIP1, CDC37, PTGES3, NR3C1, CDK4, BRAF, FNIP1, FNIP2, TRIM25 | IL5 | IL5RA, IL5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000307968 | - | 1 | 17 | 929_1166 | 30 | 1139 | HSP90AA1 |
Hgene | FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000510461 | - | 1 | 18 | 929_1166 | 30 | 1167 | HSP90AA1 |
Hgene | FNIP1 | chr5:131132523 | chr5:131878818 | ENST00000511848 | - | 1 | 13 | 929_1166 | 30 | 509 | HSP90AA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FNIP1_IL5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IL5 | P05113 | DB01411 | Pranlukast | Interleukin-5 | small molecule | approved|investigational |
Tgene | IL5 | P05113 | DB06602 | Reslizumab | Interleukin-5 | biotech | approved|investigational |
Tgene | IL5 | P05113 | DB06612 | Mepolizumab | Interleukin-5 | biotech | approved|investigational |
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RelatedDiseases for FNIP1_IL5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IL5 | C0004096 | Asthma | 2 | CTD_human |
Tgene | IL5 | C0011615 | Dermatitis, Atopic | 2 | CTD_human |
Tgene | IL5 | C0014457 | Eosinophilia | 2 | CTD_human |
Tgene | IL5 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | IL5 | C0014324 | Entamoebiasis | 1 | CTD_human |
Tgene | IL5 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
Tgene | IL5 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Tgene | IL5 | C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |