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Fusion gene ID: 13697 |
FusionGeneSummary for FNDC3B_TPRG1 |
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Fusion gene information | Fusion gene name: FNDC3B_TPRG1 | Fusion gene ID: 13697 | Hgene | Tgene | Gene symbol | FNDC3B | TPRG1 | Gene ID | 64778 | 285386 |
Gene name | fibronectin type III domain containing 3B | tumor protein p63 regulated 1 | |
Synonyms | FAD104|PRO4979|YVTM2421 | FAM79B | |
Cytomap | 3q26.31 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104 | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180519 | 20180403 | |
UniProtAcc | Q53EP0 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000415807, ENST00000336824, ENST00000416957, ENST00000392699, ENST00000421757, ENST00000423424, ENST00000476794, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 22 X 10 X 13=2860 | 12 X 6 X 6=432 |
# samples | 24 | 13 | |
** MAII score | log2(24/2860*10)=-3.57490883605723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FNDC3B [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-C5-A8ZZ-01A | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000415807 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000415807 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000415807 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000336824 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000336824 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000336824 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000416957 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000416957 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000416957 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000392699 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000392699 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000392699 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000421757 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000421757 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000421757 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000423424 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
Frame-shift | ENST00000423424 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
5CDS-intron | ENST00000423424 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
intron-3CDS | ENST00000476794 | ENST00000433971 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
intron-3CDS | ENST00000476794 | ENST00000345063 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
intron-intron | ENST00000476794 | ENST00000488841 | FNDC3B | chr3 | 171830380 | + | TPRG1 | chr3 | 189028175 | + |
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FusionProtFeatures for FNDC3B_TPRG1 |
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Hgene | Tgene |
FNDC3B | TPRG1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FNDC3B_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FNDC3B_TPRG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FNDC3B | ELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1 | TPRG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FNDC3B_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FNDC3B_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FNDC3B | C0022578 | Keratoconus | 1 | CTD_human |
Hgene | FNDC3B | C0339573 | Glaucoma, Primary Open Angle | 1 | CTD_human |