	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13685

FusionGeneSummary for FNDC3B_KLF13

Fusion gene summary

Fusion gene information	Fusion gene name: FNDC3B_KLF13
	Fusion gene ID: 13685
		Hgene	Tgene
	Gene symbol	FNDC3B	KLF13
	Gene ID	64778	51621
	Gene name	fibronectin type III domain containing 3B	Kruppel like factor 13
	Synonyms	FAD104\|PRO4979\|YVTM2421	BTEB3\|FKLF2\|NSLP1\|RFLAT-1\|RFLAT1
	Cytomap	3q26.31	15q13.3
	Type of gene	protein-coding	protein-coding
	Description	fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104	Krueppel-like factor 13BTE-binding protein 3RANTES factor of late activated T lymphocytes-1basic transcription element binding protein 3novel Sp1-like zinc finger transcription factor 1transcription factor BTEB3transcription factor NSLP1
	Modification date	20180519	20180523
	UniProtAcc	Q53EP0	Q9Y2Y9
	Ensembl transtripts involved in fusion gene	ENST00000415807, ENST00000336824, ENST00000416957, ENST00000392699, ENST00000421757, ENST00000423424, ENST00000476794,	ENST00000307145, ENST00000560473, ENST00000500533,
Fusion gene scores	* DoF score	22 X 10 X 13=2860	2 X 2 X 2=8
	# samples	24	2
	** MAII score	log2(24/2860*10)=-3.57490883605723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: FNDC3B [Title/Abstract] AND KLF13 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	HNSC	TCGA-CQ-A4C7-01A	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000415807	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000415807	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000415807	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000336824	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000336824	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000336824	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000416957	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000416957	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000416957	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000392699	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000392699	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000392699	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000421757	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000421757	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000421757	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000423424	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000423424	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
5CDS-intron	ENST00000423424	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
intron-intron	ENST00000476794	ENST00000307145	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
intron-intron	ENST00000476794	ENST00000560473	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+
intron-intron	ENST00000476794	ENST00000500533	FNDC3B	chr3	171851336	+	KLF13	chr15	31727573	+

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FusionProtFeatures for FNDC3B_KLF13

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FNDC3B Q53EP0	KLF13 Q9Y2Y9
	Represses transcription by binding to the BTE site, aGC-rich DNA element, in competition with the activator SP1. Italso represses transcription by interacting with the corepressorSin3A and HDAC1. Activates RANTES expression in T-cells.{ECO:0000269\|PubMed:11477107}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for FNDC3B_KLF13

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNDC3B_KLF13

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
FNDC3B	ELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1	KLF13	SIN3A, CREBBP, SERPINH1, KAT2B, PCBD1, SREBF1, SREBF2, EP300, SH3KBP1, CHCHD10

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for FNDC3B_KLF13

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FNDC3B_KLF13

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FNDC3B	C0022578	Keratoconus	1	CTD_human
Hgene	FNDC3B	C0339573	Glaucoma, Primary Open Angle	1	CTD_human
Tgene	KLF13	C0014175	Endometriosis	1	CTD_human

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Fusion gene ID: 13685

FusionGeneSummary for FNDC3B_KLF13

FusionProtFeatures for FNDC3B_KLF13

FusionGeneSequence for FNDC3B_KLF13

FusionGenePPI for FNDC3B_KLF13

RelatedDrugs for FNDC3B_KLF13

RelatedDiseases for FNDC3B_KLF13