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Fusion gene ID: 1368 |
FusionGeneSummary for AKAP9_SEC61G |
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Fusion gene information | Fusion gene name: AKAP9_SEC61G | Fusion gene ID: 1368 | Hgene | Tgene | Gene symbol | AKAP9 | SEC61G | Gene ID | 10142 | 23480 |
Gene name | A-kinase anchoring protein 9 | Sec61 translocon gamma subunit | |
Synonyms | AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO | SSS1 | |
Cytomap | 7q21.2 | 7p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ | protein transport protein Sec61 subunit gammaSec61 gamma subunitprotein transport protein SEC61 gamma subunit | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q99996 | P60059 | |
Ensembl transtripts involved in fusion gene | ENST00000356239, ENST00000358100, ENST00000359028, ENST00000394564, ENST00000491695, | ENST00000395535, ENST00000352861, ENST00000415949, ENST00000450622, | |
Fusion gene scores | * DoF score | 12 X 12 X 7=1008 | 2 X 2 X 2=8 |
# samples | 22 | 2 | |
** MAII score | log2(22/1008*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: AKAP9 [Title/Abstract] AND SEC61G [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AKAP9 | GO:1903358 | regulation of Golgi organization | 27666745 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | GBM | TCGA-14-1823-01A | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000356239 | ENST00000395535 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000356239 | ENST00000352861 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000356239 | ENST00000415949 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000356239 | ENST00000450622 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000358100 | ENST00000395535 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000358100 | ENST00000352861 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000358100 | ENST00000415949 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000358100 | ENST00000450622 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000359028 | ENST00000395535 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000359028 | ENST00000352861 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000359028 | ENST00000415949 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000359028 | ENST00000450622 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000394564 | ENST00000395535 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000394564 | ENST00000352861 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000394564 | ENST00000415949 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
5CDS-5UTR | ENST00000394564 | ENST00000450622 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
intron-5UTR | ENST00000491695 | ENST00000395535 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
intron-5UTR | ENST00000491695 | ENST00000352861 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
intron-5UTR | ENST00000491695 | ENST00000415949 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
intron-5UTR | ENST00000491695 | ENST00000450622 | AKAP9 | chr7 | 91570461 | + | SEC61G | chr7 | 54825287 | - |
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FusionProtFeatures for AKAP9_SEC61G |
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Hgene | Tgene |
AKAP9 | SEC61G |
Necessary for protein translocation in the endoplasmicreticulum. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AKAP9_SEC61G |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AKAP9_SEC61G |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AKAP9 | TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1 | SEC61G | AURKA, TUBGCP3, SFTPC, CREB3, SEC61A1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AKAP9_SEC61G |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKAP9_SEC61G |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AKAP9 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | AKAP9 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Hgene | AKAP9 | C2678483 | Long Qt Syndrome 11 | 1 | CTD_human;UNIPROT |