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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 13675

FusionGeneSummary for FNDC3A_RB1

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3A_RB1
Fusion gene ID: 13675
HgeneTgene
Gene symbol

FNDC3A

RB1

Gene ID

22862

5925

Gene namefibronectin type III domain containing 3ARB transcriptional corepressor 1
SynonymsFNDC3|HUGO|bA203I16.1|bA203I16.5OSRC|PPP1R130|RB|p105-Rb|pRb|pp110
Cytomap

13q14.2

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblastsretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas
Modification date2018051920180523
UniProtAcc

Q9Y2H6

P06400

Ensembl transtripts involved in fusion geneENST00000492622, ENST00000541916, 
ENST00000398316, 
ENST00000267163, 
ENST00000484879, 
Fusion gene scores* DoF score8 X 7 X 6=3367 X 5 X 5=175
# samples 98
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3A [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

TgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

TgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-C8-A12K-01AFNDC3Achr13

49688867

+RB1chr13

49037867

+
TCGARVCESCTCGA-C5-A3HE-01AFNDC3Achr13

49551053

+RB1chr13

48881416

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000492622ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000492622ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
In-frameENST00000541916ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000541916ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
In-frameENST00000398316ENST00000267163FNDC3Achr13

49688867

+RB1chr13

49037867

+
5CDS-intronENST00000398316ENST00000484879FNDC3Achr13

49688867

+RB1chr13

49037867

+
intron-3CDSENST00000492622ENST00000267163FNDC3Achr13

49551053

+RB1chr13

48881416

+
intron-intronENST00000492622ENST00000484879FNDC3Achr13

49551053

+RB1chr13

48881416

+
5UTR-3CDSENST00000541916ENST00000267163FNDC3Achr13

49551053

+RB1chr13

48881416

+
5UTR-intronENST00000541916ENST00000484879FNDC3Achr13

49551053

+RB1chr13

48881416

+
intron-3CDSENST00000398316ENST00000267163FNDC3Achr13

49551053

+RB1chr13

48881416

+
intron-intronENST00000398316ENST00000484879FNDC3Achr13

49551053

+RB1chr13

48881416

+

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FusionProtFeatures for FNDC3A_RB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3A

Q9Y2H6

RB1

P06400

Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927870_876702929MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+22468_133281143Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+42668_133841199Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+42668_133841199Compositional biasNote=Pro-rich
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+2241046_1151281143DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224268_369281143DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224373_465281143DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224469_562281143DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224566_660281143DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224664_757281143DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224761_851281143DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224861_950281143DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+224951_1045281143DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+4261046_1151841199DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426268_369841199DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426373_465841199DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426469_562841199DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426566_660841199DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426664_757841199DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426761_851841199DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426861_950841199DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+426951_1045841199DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+4261046_1151841199DomainFibronectin type-III 9
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426268_369841199DomainFibronectin type-III 1
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426373_465841199DomainFibronectin type-III 2
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426469_562841199DomainFibronectin type-III 3
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426566_660841199DomainFibronectin type-III 4
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426664_757841199DomainFibronectin type-III 5
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426761_851841199DomainFibronectin type-III 6
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426861_950841199DomainFibronectin type-III 7
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+426951_1045841199DomainFibronectin type-III 8
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000398316+2241177_1197281143TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000492622+4261177_1197841199TransmembraneHelical
HgeneFNDC3Achr13:49688867chr13:49037867ENST00000541916+4261177_1197841199TransmembraneHelical
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+192710_18702929Compositional biasNote=Poly-Ala
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+192720_29702929Compositional biasNote=Poly-Pro
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927373_579702929RegionNote=Domain A
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927373_771702929RegionNote=Pocket%3B binds T and E1A
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927580_639702929RegionNote=Spacer
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927640_771702929RegionNote=Domain B


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FusionGeneSequence for FNDC3A_RB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_311aa
MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSM
YGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR
IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGS

>In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_311aa
MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSM
YGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR
IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGS

>In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_255aa
MSGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRL
KTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_933nt
ATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGA
ACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCT
GCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATG
TATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACA
TTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATT
TTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGG
ATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGA
TCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTG
CTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGT
AAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGAT

>In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_933nt
ATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGA
ACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCT
GCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATG
TATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACA
TTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATT
TTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGG
ATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGA
TCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTG
CTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGT
AAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGAT

>In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_765nt
ATGAGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATG
ATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCT
GTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTG
AAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGT
TCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAA
ATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAAC
AGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAA
GCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_3153nt
CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG
AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC
AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT
GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT
CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA
GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC
CTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAG
CATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATA
ACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTC
GAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAG
AAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGA
AAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCT
TTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTA
CTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGAC
ACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAG
CTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGAT
TGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAA
GAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTT
TTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGAC
TGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATT
TTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCA
TATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTA
AATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGT
GTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATAC
AAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTAT
TCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTAT
CTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCAT
TATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTC
CCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCT
TCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTG
TGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTG
CATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCC
AGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAA
AACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGG
TCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAGAAGATAACTCTCCTAGTATCTCA

>In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_2921nt
TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC
ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT
GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT
GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGT
GAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGAT
CAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCAC
CAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACAT
CTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATC
AATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGA
AGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGA
GTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAA
CAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTT
TCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAA
GCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCC
TCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTG
CCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAA
ATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTA
GAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTG
CTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGA
ACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAA
TTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGC
ACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTT
TTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGT
CTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACA
TTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATT
AAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGA
GATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAA
AGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATG
ACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCT
GGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTT
CAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGT
CTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTA

>In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_2767nt
AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG
AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATG
TGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTT
CAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAA
ACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCA
CCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATG
ACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGC
GACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCA
GATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAA
ATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGT
CTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCA
GATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCAT
TTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGA
TAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTT
TAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAA
CTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATA
CTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACA
GATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTG
GTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGG
ACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGAC
TGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTT
TGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGT
CTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTAT
CTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAAC
TATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTT
TGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTA
TTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGT
TTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGT
GTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTT
ACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAG


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FusionGenePPI for FNDC3A_RB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNDC3AELAVL1, APP, SPINT2, TMEM51, KCNK16, DLK1, HERC2, EVC2, TMEM17, HNRNPD, SORT1, NIPSNAP1, SMC3, VAPA, SYNCRIP, FAM46A, RBM45, CEP170P1, BAG6, CENPU, FPR2, SYT3, IL27RA, CD1E, FADS3, CLEC2D, PDGFRB, PCDHGA5, GRAMD1B, GRPR, SLC22A16, AP3S1, TRIM25RB1CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRB1chr13:49688867chr13:49037867ENST00000267163+1927763_928702929LIMD1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3A_RB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRB1P06400DB00071Insulin PorkRetinoblastoma-associated proteinbiotechapproved
TgeneRB1P06400DB00030Insulin HumanRetinoblastoma-associated proteinbiotechapproved|investigational

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RelatedDiseases for FNDC3A_RB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRB1C0035335Retinoblastoma9CTD_human;HPO;UNIPROT
TgeneRB1C1458155Mammary Neoplasms3CTD_human
TgeneRB1C0149925Small cell carcinoma of lung2CTD_human;ORPHANET
TgeneRB1C2239176Liver carcinoma2CTD_human
TgeneRB1C0001624Adrenal Gland Neoplasms1CTD_human
TgeneRB1C0007117Basal cell carcinoma1CTD_human
TgeneRB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRB1C0007786Brain Ischemia1CTD_human
TgeneRB1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneRB1C0024667Animal Mammary Neoplasms1CTD_human
TgeneRB1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneRB1C0027627Neoplasm Metastasis1CTD_human
TgeneRB1C0027659Neoplasms, Experimental1CTD_human
TgeneRB1C0029463Osteosarcoma1CTD_human;HPO
TgeneRB1C0030297Pancreatic Neoplasm1CTD_human
TgeneRB1C0036920Sezary Syndrome1CTD_human
TgeneRB1C0038325Stevens-Johnson Syndrome1CTD_human
TgeneRB1C0206686Adrenocortical carcinoma1CTD_human
TgeneRB1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneRB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human