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Fusion gene ID: 13675 |
FusionGeneSummary for FNDC3A_RB1 |
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Fusion gene information | Fusion gene name: FNDC3A_RB1 | Fusion gene ID: 13675 | Hgene | Tgene | Gene symbol | FNDC3A | RB1 | Gene ID | 22862 | 5925 |
Gene name | fibronectin type III domain containing 3A | RB transcriptional corepressor 1 | |
Synonyms | FNDC3|HUGO|bA203I16.1|bA203I16.5 | OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 | |
Cytomap | 13q14.2 | 13q14.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblasts | retinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9Y2H6 | P06400 | |
Ensembl transtripts involved in fusion gene | ENST00000492622, ENST00000541916, ENST00000398316, | ENST00000267163, ENST00000484879, | |
Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 7 X 5 X 5=175 |
# samples | 9 | 8 | |
** MAII score | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FNDC3A [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RB1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
Tgene | RB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10783144|12065415|19223331 |
Tgene | RB1 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 25100735 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-C8-A12K-01A | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
TCGA | RV | CESC | TCGA-C5-A3HE-01A | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000492622 | ENST00000267163 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
5CDS-intron | ENST00000492622 | ENST00000484879 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
In-frame | ENST00000541916 | ENST00000267163 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
5CDS-intron | ENST00000541916 | ENST00000484879 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
In-frame | ENST00000398316 | ENST00000267163 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
5CDS-intron | ENST00000398316 | ENST00000484879 | FNDC3A | chr13 | 49688867 | + | RB1 | chr13 | 49037867 | + |
intron-3CDS | ENST00000492622 | ENST00000267163 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
intron-intron | ENST00000492622 | ENST00000484879 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
5UTR-3CDS | ENST00000541916 | ENST00000267163 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
5UTR-intron | ENST00000541916 | ENST00000484879 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
intron-3CDS | ENST00000398316 | ENST00000267163 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
intron-intron | ENST00000398316 | ENST00000484879 | FNDC3A | chr13 | 49551053 | + | RB1 | chr13 | 48881416 | + |
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FusionProtFeatures for FNDC3A_RB1 |
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Hgene | Tgene |
FNDC3A | RB1 |
Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 870_876 | 702 | 929 | Motif | Nuclear localization signal |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 68_133 | 28 | 1143 | Compositional bias | Note=Pro-rich |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 68_133 | 84 | 1199 | Compositional bias | Note=Pro-rich |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 68_133 | 84 | 1199 | Compositional bias | Note=Pro-rich |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 1046_1151 | 28 | 1143 | Domain | Fibronectin type-III 9 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 268_369 | 28 | 1143 | Domain | Fibronectin type-III 1 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 373_465 | 28 | 1143 | Domain | Fibronectin type-III 2 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 469_562 | 28 | 1143 | Domain | Fibronectin type-III 3 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 566_660 | 28 | 1143 | Domain | Fibronectin type-III 4 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 664_757 | 28 | 1143 | Domain | Fibronectin type-III 5 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 761_851 | 28 | 1143 | Domain | Fibronectin type-III 6 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 861_950 | 28 | 1143 | Domain | Fibronectin type-III 7 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 951_1045 | 28 | 1143 | Domain | Fibronectin type-III 8 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 1046_1151 | 84 | 1199 | Domain | Fibronectin type-III 9 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 268_369 | 84 | 1199 | Domain | Fibronectin type-III 1 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 373_465 | 84 | 1199 | Domain | Fibronectin type-III 2 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 469_562 | 84 | 1199 | Domain | Fibronectin type-III 3 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 566_660 | 84 | 1199 | Domain | Fibronectin type-III 4 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 664_757 | 84 | 1199 | Domain | Fibronectin type-III 5 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 761_851 | 84 | 1199 | Domain | Fibronectin type-III 6 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 861_950 | 84 | 1199 | Domain | Fibronectin type-III 7 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 951_1045 | 84 | 1199 | Domain | Fibronectin type-III 8 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 1046_1151 | 84 | 1199 | Domain | Fibronectin type-III 9 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 268_369 | 84 | 1199 | Domain | Fibronectin type-III 1 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 373_465 | 84 | 1199 | Domain | Fibronectin type-III 2 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 469_562 | 84 | 1199 | Domain | Fibronectin type-III 3 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 566_660 | 84 | 1199 | Domain | Fibronectin type-III 4 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 664_757 | 84 | 1199 | Domain | Fibronectin type-III 5 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 761_851 | 84 | 1199 | Domain | Fibronectin type-III 6 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 861_950 | 84 | 1199 | Domain | Fibronectin type-III 7 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 951_1045 | 84 | 1199 | Domain | Fibronectin type-III 8 |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000398316 | + | 2 | 24 | 1177_1197 | 28 | 1143 | Transmembrane | Helical |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000492622 | + | 4 | 26 | 1177_1197 | 84 | 1199 | Transmembrane | Helical |
Hgene | >FNDC3A | chr13:49688867 | chr13:49037867 | ENST00000541916 | + | 4 | 26 | 1177_1197 | 84 | 1199 | Transmembrane | Helical |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 10_18 | 702 | 929 | Compositional bias | Note=Poly-Ala |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 20_29 | 702 | 929 | Compositional bias | Note=Poly-Pro |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 373_579 | 702 | 929 | Region | Note=Domain A |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 373_771 | 702 | 929 | Region | Note=Pocket%3B binds T and E1A |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 580_639 | 702 | 929 | Region | Note=Spacer |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 640_771 | 702 | 929 | Region | Note=Domain B |
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FusionGeneSequence for FNDC3A_RB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_311aa MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSM YGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGS >In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_311aa MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSM YGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLR IPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGS >In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_255aa MSGPAQVPMMSPNGSVPPIYVPPGYAPQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRL KTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCN |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_933nt ATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGA ACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCT GCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATG TATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACA TTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATT TTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGG ATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGA TCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTG CTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGT AAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGAT >In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_933nt ATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGA ACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCT GCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATG TATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACA TTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATT TTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGG ATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGA TCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTG CTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGT AAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGAT >In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_765nt ATGAGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATG ATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCT GTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTG AAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGT TCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAA ATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAAC AGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAA GCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_FNDC3A_ENST00000492622_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_3153nt CTCCCGGCTCCGTAGTAAGCATGGCGGCGGCGGCGTTCGTGGTCCCTCGGGTGAAACAGAAAGCGGGAGCTACGCGGAGAGGGAGCGAAG AGCGGGGCTGAGGCGGCGGCGTCACTGCCAGGAAACAACCCCAACAGTCAGCGCGCCGGCGGCCGCGGCGGCCCTGAGAGCTGACTCTGC AGCTGAGGTAGAGAGACAACGATCAGGAACCCTAAGAAGAGGCGCCAGAGGAGCCGCCTTCTGCCTCAGAACGGCGTGACTCGGAGAATT GGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACCACTACTGGATACAACTCAGATCTTAAGTAGTGATATTT CTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCTGGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAA GAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTC CTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAG CATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATA ACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTC GAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAG AAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGA AAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCT TTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTA CTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGAC ACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAG CTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGAT TGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAA GAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTT TTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGAC TGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATT TTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCA TATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTA AATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGT GTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATAC AAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTAT TCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTAT CTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCAT TATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTC CCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCT TCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTG TGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTG CATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCC AGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAA AACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGG TCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAGAAGATAACTCTCCTAGTATCTCA >In-frame_FNDC3A_ENST00000541916_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_2921nt TTGACACGGCTTTGGAAACGACGTCATGTGTTAGAATTGGAGCGTTATTCAGTATATTAATGTCTTATTGATAATGGCAGAACATCCACC ACTACTGGATACAACTCAGATCTTAAGTAGTGATATTTCTCTTTTGTCTGCCCCTATTGTAAGTGCAGATGGAACACAACAGGTTATTCT GGTACAAGTTAACCCAGGAGAAGCATTTACAATAAGAAGAGAAGATGGACAGTTTCAGTGCATTACAGGTCCTGCTCAGGTTCCAATGAT GTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATGTGTTCCATGTATGGCATATGCAAAGT GAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACGTGTTTTGAT CAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCAC CAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACAT CTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATC AATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGA AGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGA GTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAA CAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTT TCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAA GCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCC TCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTG CCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAA ATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTA GAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTG CTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGA ACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAA TTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGC ACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTT TTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGT CTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACA TTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATT AAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGA GATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAA AGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATG ACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCT GGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTT CAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGT CTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTA >In-frame_FNDC3A_ENST00000398316_chr13_49688867_+_RB1_ENST00000267163_chr13_49037867_+_2767nt AGCCGTTCTCCAATTAAAGCTGTTAACGTGTACTACGCTGTTTCCTTGTTGGATTTTCTTGTTCTCTGCTGCTACTGTAAAAACGAAATG AGTGGTCCTGCTCAGGTTCCAATGATGTCCCCAAATGGTTCTGTGCCTCCTATCTATGTGCCTCCTGGATATGCCCCACAGATTATGATG TGTTCCATGTATGGCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTAACAGCATACAAGGATCTTCCTCATGCTGTT CAGGAGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAA ACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCA CCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATG ACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGC GACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCA GATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAA ATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGT CTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCA GATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCAT TTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGA TAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTT TAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAA CTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATA CTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACA GATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTG GTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGG ACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGAC TGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTT TGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGT CTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTAT CTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAAC TATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTT TGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTA TTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGT TTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGT GTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTT ACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAG |
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FusionGenePPI for FNDC3A_RB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FNDC3A | ELAVL1, APP, SPINT2, TMEM51, KCNK16, DLK1, HERC2, EVC2, TMEM17, HNRNPD, SORT1, NIPSNAP1, SMC3, VAPA, SYNCRIP, FAM46A, RBM45, CEP170P1, BAG6, CENPU, FPR2, SYT3, IL27RA, CD1E, FADS3, CLEC2D, PDGFRB, PCDHGA5, GRAMD1B, GRPR, SLC22A16, AP3S1, TRIM25 | RB1 | CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | RB1 | chr13:49688867 | chr13:49037867 | ENST00000267163 | + | 19 | 27 | 763_928 | 702 | 929 | LIMD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FNDC3A_RB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | RB1 | P06400 | DB00071 | Insulin Pork | Retinoblastoma-associated protein | biotech | approved |
Tgene | RB1 | P06400 | DB00030 | Insulin Human | Retinoblastoma-associated protein | biotech | approved|investigational |
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RelatedDiseases for FNDC3A_RB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RB1 | C0035335 | Retinoblastoma | 9 | CTD_human;HPO;UNIPROT |
Tgene | RB1 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
Tgene | RB1 | C0149925 | Small cell carcinoma of lung | 2 | CTD_human;ORPHANET |
Tgene | RB1 | C2239176 | Liver carcinoma | 2 | CTD_human |
Tgene | RB1 | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
Tgene | RB1 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
Tgene | RB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | RB1 | C0007786 | Brain Ischemia | 1 | CTD_human |
Tgene | RB1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | RB1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | RB1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | RB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | RB1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | RB1 | C0029463 | Osteosarcoma | 1 | CTD_human;HPO |
Tgene | RB1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
Tgene | RB1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
Tgene | RB1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Tgene | RB1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Tgene | RB1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | RB1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |