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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13633

FusionGeneSummary for FN1_CDKN1B

check button Fusion gene summary
Fusion gene informationFusion gene name: FN1_CDKN1B
Fusion gene ID: 13633
HgeneTgene
Gene symbol

FN1

CDKN1B

Gene ID

2335

1027

Gene namefibronectin 1cyclin dependent kinase inhibitor 1B
SynonymsCIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCFCDKN4|KIP1|MEN1B|MEN4|P27KIP1
Cytomap

2q35

12p13.1

Type of geneprotein-codingprotein-coding
Descriptionfibronectincold-insoluble globulinmigration-stimulating factorcyclin-dependent kinase inhibitor 1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)
Modification date2018052720180523
UniProtAcc

P02751

P46527

Ensembl transtripts involved in fusion geneENST00000421182, ENST00000357867, 
ENST00000323926, ENST00000336916, 
ENST00000354785, ENST00000357009, 
ENST00000346544, ENST00000345488, 
ENST00000359671, ENST00000446046, 
ENST00000443816, ENST00000432072, 
ENST00000356005, ENST00000490833, 
ENST00000426059, 		ENST00000477087, 
ENST00000228872, ENST00000396340, 
Fusion gene scores* DoF score20 X 22 X 6=26404 X 4 X 2=32
# samples 244
** MAII scorelog2(24/2640*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FN1 [Title/Abstract] AND CDKN1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

HgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

HgeneFN1

GO:0010628

positive regulation of gene expression

25834989

HgeneFN1

GO:0018149

peptide cross-linking

3997886

HgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneFN1

GO:0035987

endodermal cell differentiation

23154389

HgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

HgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

HgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

HgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

HgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

HgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989

TgeneCDKN1B

GO:0000082

G1/S transition of mitotic cell cycle

10208428

TgeneCDKN1B

GO:0008285

negative regulation of cell proliferation

19266349

TgeneCDKN1B

GO:0010942

positive regulation of cell death

19266349

TgeneCDKN1B

GO:0030308

negative regulation of cell growth

10208428

TgeneCDKN1B

GO:0033673

negative regulation of kinase activity

19170105

TgeneCDKN1B

GO:0042326

negative regulation of phosphorylation

10208428

TgeneCDKN1B

GO:0045732

positive regulation of protein catabolic process

19056892

TgeneCDKN1B

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

28666995

TgeneCDKN1B

GO:0045892

negative regulation of transcription, DNA-templated

19170105

TgeneCDKN1B

GO:0045930

negative regulation of mitotic cell cycle

19266349

TgeneCDKN1B

GO:0048102

autophagic cell death

12698196

TgeneCDKN1B

GO:0071285

cellular response to lithium ion

19056892

TgeneCDKN1B

GO:0071850

mitotic cell cycle arrest

19266349


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG925834FN1chr2

216283967

-CDKN1Bchr12

12874585

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000421182ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000421182ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000421182ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000357867ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000357867ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000357867ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000323926ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000323926ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000323926ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000336916ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000336916ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000336916ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000354785ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000354785ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000354785ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000357009ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000357009ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000357009ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000346544ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000346544ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000346544ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000345488ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000345488ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000345488ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000359671ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000359671ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000359671ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000446046ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000446046ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000446046ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000443816ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000443816ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000443816ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000432072ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000432072ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000432072ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000356005ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000356005ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000356005ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
intron-intronENST00000490833ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
intron-3UTRENST00000490833ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
intron-intronENST00000490833ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000426059ENST00000477087FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-3UTRENST00000426059ENST00000228872FN1chr2

216283967

-CDKN1Bchr12

12874585

+
5CDS-intronENST00000426059ENST00000396340FN1chr2

216283967

-CDKN1Bchr12

12874585

+

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FusionProtFeatures for FN1_CDKN1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FN1

P02751

CDKN1B

P46527

Important regulator of cell cycle progression. Inhibitsthe kinase activity of CDK2 bound to cyclin A, but has littleinhibitory activity on CDK2 bound to SPDYA (PubMed:28666995).Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexesand is involved in the assembly, stability, and modulation ofCCND1-CDK4 complex activation. Acts either as an inhibitor or anactivator of cyclin type D-CDK4 complexes depending on itsphosphorylation state and/or stoichometry.{ECO:0000269|PubMed:10831586, ECO:0000269|PubMed:12244301,ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:17254966,ECO:0000269|PubMed:19075005, ECO:0000269|PubMed:28666995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FN1_CDKN1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FN1_CDKN1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FN1_CDKN1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
HgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational

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RelatedDiseases for FN1_CDKN1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFN1C0020538Hypertensive disease2CTD_human;HPO
HgeneFN1C0000786Spontaneous abortion1CTD_human
HgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
HgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
HgeneFN1C0010346Crohn Disease1CTD_human
HgeneFN1C0011849Diabetes Mellitus1CTD_human
HgeneFN1C0011881Diabetic Nephropathy1CTD_human
HgeneFN1C0017636Glioblastoma1CTD_human
HgeneFN1C0017668Focal glomerulosclerosis1CTD_human
HgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
HgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneFN1C0027626Neoplasm Invasiveness1CTD_human
HgeneFN1C0034069Pulmonary Fibrosis1CTD_human
HgeneFN1C0036341Schizophrenia1PSYGENET
HgeneFN1C0085762Alcohol abuse1PSYGENET
HgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
HgeneFN1C0345967Malignant mesothelioma1CTD_human
HgeneFN1C1458155Mammary Neoplasms1CTD_human
HgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT
TgeneCDKN1BC0024121Lung Neoplasms3CTD_human
TgeneCDKN1BC0033578Prostatic Neoplasms2CTD_human
TgeneCDKN1BC0021841Intestinal Neoplasms1CTD_human
TgeneCDKN1BC0022665Kidney Neoplasm1CTD_human
TgeneCDKN1BC0023903Liver neoplasms1CTD_human
TgeneCDKN1BC0025500Mesothelioma1CTD_human
TgeneCDKN1BC0032019Pituitary Neoplasms1CTD_human
TgeneCDKN1BC0034885Rectal Neoplasms1CTD_human
TgeneCDKN1BC0036920Sezary Syndrome1CTD_human
TgeneCDKN1BC0038356Stomach Neoplasms1CTD_human
TgeneCDKN1BC0042138Uterine Neoplasms1CTD_human
TgeneCDKN1BC0079487Helicobacter Infections1CTD_human
TgeneCDKN1BC0206669Hepatocellular Adenoma1CTD_human
TgeneCDKN1BC0206754Neuroendocrine Tumors1CTD_human
TgeneCDKN1BC0263454Chloracne1CTD_human
TgeneCDKN1BC0282612Prostatic Intraepithelial Neoplasias1CTD_human
TgeneCDKN1BC0919267ovarian neoplasm1CTD_human
TgeneCDKN1BC1458155Mammary Neoplasms1CTD_human
TgeneCDKN1BC2239176Liver carcinoma1CTD_human