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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13604

FusionGeneSummary for FMN1_SNRPN

check button Fusion gene summary
Fusion gene informationFusion gene name: FMN1_SNRPN
Fusion gene ID: 13604
HgeneTgene
Gene symbol

FMN1

SNRPN

Gene ID

342184

6638

Gene nameformin 1small nuclear ribonucleoprotein polypeptide N
SynonymsFMN|LDHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-N
Cytomap

15q13.3

15q11.2

Type of geneprotein-codingprotein-coding
Descriptionformin-1formin (limb deformity)limb deformity protein homologsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing protein
Modification date2018051920180523
UniProtAcc

Q68DA7

P63162

Ensembl transtripts involved in fusion geneENST00000334528, ENST00000561249, 
ENST00000559047, ENST00000558197, 
ENST00000559150, ENST00000320930, 
ENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
Fusion gene scores* DoF score9 X 6 X 5=2707 X 10 X 2=140
# samples 911
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/140*10)=-0.347923303420307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FMN1 [Title/Abstract] AND SNRPN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-05-4398-01AFMN1chr15

33300215

-SNRPNchr15

25131663

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334528ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000334528ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000334528ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-3UTRENST00000334528ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000334528ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000334528ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000334528ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000334528ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000334528ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000561249ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000561249ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000561249ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-3UTRENST00000561249ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000561249ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000561249ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000561249ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000561249ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000561249ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000559047ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000559047ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-5UTRENST00000559047ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-3UTRENST00000559047ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000559047ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000559047ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000559047ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000559047ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
5CDS-intronENST00000559047ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000558197ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000558197ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000558197ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-3UTRENST00000558197ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000558197ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000558197ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000558197ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000558197ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000558197ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000559150ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000559150ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000559150ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-3UTRENST00000559150ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000559150ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000559150ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000559150ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000559150ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000559150ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000320930ENST00000400098FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000320930ENST00000400100FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-5UTRENST00000320930ENST00000400097FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-3UTRENST00000320930ENST00000553597FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000320930ENST00000390687FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000320930ENST00000346403FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000320930ENST00000554227FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000320930ENST00000577565FMN1chr15

33300215

-SNRPNchr15

25131663

+
intron-intronENST00000320930ENST00000444203FMN1chr15

33300215

-SNRPNchr15

25131663

+

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FusionProtFeatures for FMN1_SNRPN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMN1

Q68DA7

SNRPN

P63162

Plays a role in the formation of adherens junction andthe polymerization of linear actin cables. {ECO:0000250}. May be involved in tissue-specific alternative RNAprocessing events.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FMN1_SNRPN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FMN1_SNRPN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FMN1PRPF40A, NUP85, LLGL2, CDH1, CYP2S1, NAPGSNRPNARL4D, LRIF1, SH3GL3, TP53, SNRPD3, MEPCE, HCFC1, GEMIN2, GTF2I, UPF1, ADAR, MAFG, KEAP1, ZBTB1, RBFOX1, CTBP1, EZH2, SUZ12, RNF2, SNRPA1, SFN, NTRK1, KRAS, GAN, ESR1, CRBN, SNRPG, SNRPE, SART3, SNRPF, CMTR2, RNPC3, ZRSR2, ZMAT5, FARP1, SNRNP35, PDCD7, DPP8, SNRNP48, TGS1, CLNS1A, SNRPB2, TUT1, LSM11, SNRPD1, SLC4A1AP, SNRPD2, PRPF3, PRMT5, SNRNP70, SNRNP27, SNRPA, TOE1, SF3A2, SYF2, PRKRIP1, PAXBP1, CSTF1, EAPP, WBP4, TFIP11, GEMIN8, SKAP2, GEMIN5, RIOK1, PRPF4, SF3B1, HTATSF1, SNRPC, DDX23, SF3A3, SNRNP200, XAB2, WDR77, AQR, SNUPN, SF3A1, COPRS, SF3B2, PRPF6, PRPF8, CRNKL1, DHX35, TXNL4A, TSSC4, AKAP7, CRTAP, CCDC12, DGCR14, NOL7, CDC40, SF3B4, LSM6, CWF19L2, LSM8, GPATCH11, PRPF31, EPB41L3, LSM4, LSM2, CD2BP2, WDR83, GPATCH1, BUD31, RBM42, ISY1, NHP2L1, TRA2A, SF3B5, EFTUD2, COIL, NCL, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FMN1_SNRPN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FMN1_SNRPN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource