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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13603

FusionGeneSummary for FMN1_SNAP23

check button Fusion gene summary
Fusion gene informationFusion gene name: FMN1_SNAP23
Fusion gene ID: 13603
HgeneTgene
Gene symbol

FMN1

SNAP23

Gene ID

342184

8773

Gene nameformin 1synaptosome associated protein 23
SynonymsFMN|LDHsT17016|SNAP-23|SNAP23A|SNAP23B
Cytomap

15q13.3

15q15.1-q15.2

Type of geneprotein-codingprotein-coding
Descriptionformin-1formin (limb deformity)limb deformity protein homologsynaptosomal-associated protein 23synaptosomal-associated protein, 23kDsynaptosomal-associated protein, 23kDasynaptosome associated protein 23kDavesicle-membrane fusion protein SNAP-23
Modification date2018051920180527
UniProtAcc

Q68DA7

O00161

Ensembl transtripts involved in fusion geneENST00000334528, ENST00000561249, 
ENST00000559047, ENST00000558197, 
ENST00000559150, ENST00000320930, 
ENST00000249647, ENST00000566141, 
ENST00000564153, ENST00000349777, 
ENST00000567094, ENST00000397138, 
Fusion gene scores* DoF score9 X 6 X 5=2706 X 6 X 4=144
# samples 96
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FMN1 [Title/Abstract] AND SNAP23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-DA-A95W-06AFMN1chr15

33256308

-SNAP23chr15

42804031

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334528ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000334528ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000334528ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000334528ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000334528ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000334528ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000561249ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000561249ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000561249ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000561249ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000561249ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000561249ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000559047ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000559047ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000559047ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000559047ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-5UTRENST00000559047ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
5CDS-intronENST00000559047ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000558197ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000558197ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000558197ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000558197ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000558197ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000558197ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000559150ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000559150ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000559150ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000559150ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000559150ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000559150ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000320930ENST00000249647FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000320930ENST00000566141FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000320930ENST00000564153FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000320930ENST00000349777FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-5UTRENST00000320930ENST00000567094FMN1chr15

33256308

-SNAP23chr15

42804031

+
intron-intronENST00000320930ENST00000397138FMN1chr15

33256308

-SNAP23chr15

42804031

+

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FusionProtFeatures for FMN1_SNAP23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMN1

Q68DA7

SNAP23

O00161

Plays a role in the formation of adherens junction andthe polymerization of linear actin cables. {ECO:0000250}. Essential component of the high affinity receptor forthe general membrane fusion machinery and an important regulatorof transport vesicle docking and fusion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FMN1_SNAP23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FMN1_SNAP23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FMN1PRPF40A, NUP85, LLGL2, CDH1, CYP2S1, NAPGSNAP23SNAPIN, ABI2, ABI3, SCGN, FXR2, NAPA, STX11, STX18, SNTG1, VAMP7, STXBP5, STX1A, STX2, STX3, STX4, VAMP2, VAMP3, VAMP8, STXBP3, STX5, STX1B, KIF5B, STX12, CFTR, SCAMP1, SCAMP2, ITSN1, STX6, NSF, MATR3, WASH2P, ELAVL1, CEP97, CCP110, SCFD1, ILF2, PSAP, C12orf57, UBQLN2, FAM3C, SRSF1, SYNCRIP, YES1, ANXA3, HNRNPAB, FN1, SNAP23, VAMP5, NAPB, ZDHHC17, CCDC8, ABCE1, STX7, STX19, KRAS, TMEM17, TMEM216, PTAR1, CDH1, DUSP22, STXBP6, CHMP2A, VAMP4, GJB7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FMN1_SNAP23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FMN1_SNAP23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSNAP23C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneSNAP23C0151744Myocardial Ischemia1CTD_human