FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13602

FusionGeneSummary for FMN1_PATL2

check button Fusion gene summary
Fusion gene informationFusion gene name: FMN1_PATL2
Fusion gene ID: 13602
HgeneTgene
Gene symbol

FMN1

PATL2

Gene ID

342184

197135

Gene nameformin 1PAT1 homolog 2
SynonymsFMN|LDOOMD4|Pat1a|hPat1a
Cytomap

15q13.3

15q21.1

Type of geneprotein-codingprotein-coding
Descriptionformin-1formin (limb deformity)limb deformity protein homologprotein PAT1 homolog 2PAT1-like protein 2protein PAT1 homolog aprotein associated with topoisomerase II homolog 2
Modification date2018051920180523
UniProtAcc

Q68DA7

C9JE40

Ensembl transtripts involved in fusion geneENST00000334528, ENST00000561249, 
ENST00000559047, ENST00000558197, 
ENST00000559150, ENST00000320930, 
ENST00000560775, ENST00000434130, 
ENST00000560780, ENST00000558573, 
Fusion gene scores* DoF score9 X 6 X 5=2702 X 1 X 2=4
# samples 92
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: FMN1 [Title/Abstract] AND PATL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A92D-01AFMN1chr15

33357158

-PATL2chr15

44968763

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334528ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000334528ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000334528ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000334528ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-intronENST00000561249ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000561249ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000561249ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000561249ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-intronENST00000559047ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000559047ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000559047ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
5CDS-5UTRENST00000559047ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-intronENST00000558197ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000558197ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000558197ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000558197ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-intronENST00000559150ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000559150ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000559150ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000559150ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-intronENST00000320930ENST00000560775FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000320930ENST00000434130FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000320930ENST00000560780FMN1chr15

33357158

-PATL2chr15

44968763

-
intron-5UTRENST00000320930ENST00000558573FMN1chr15

33357158

-PATL2chr15

44968763

-

Top

FusionProtFeatures for FMN1_PATL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMN1

Q68DA7

PATL2

C9JE40

Plays a role in the formation of adherens junction andthe polymerization of linear actin cables. {ECO:0000250}. RNA-binding protein that acts as a translationalrepressor. {ECO:0000250|UniProtKB:Q4V7K4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FMN1_PATL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FMN1_PATL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FMN1PRPF40A, NUP85, LLGL2, CDH1, CYP2S1, NAPGPATL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FMN1_PATL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FMN1_PATL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource