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Fusion gene ID: 13602 |
FusionGeneSummary for FMN1_PATL2 |
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Fusion gene information | Fusion gene name: FMN1_PATL2 | Fusion gene ID: 13602 | Hgene | Tgene | Gene symbol | FMN1 | PATL2 | Gene ID | 342184 | 197135 |
Gene name | formin 1 | PAT1 homolog 2 | |
Synonyms | FMN|LD | OOMD4|Pat1a|hPat1a | |
Cytomap | 15q13.3 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | formin-1formin (limb deformity)limb deformity protein homolog | protein PAT1 homolog 2PAT1-like protein 2protein PAT1 homolog aprotein associated with topoisomerase II homolog 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q68DA7 | C9JE40 | |
Ensembl transtripts involved in fusion gene | ENST00000334528, ENST00000561249, ENST00000559047, ENST00000558197, ENST00000559150, ENST00000320930, | ENST00000560775, ENST00000434130, ENST00000560780, ENST00000558573, | |
Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 2 X 1 X 2=4 |
# samples | 9 | 2 | |
** MAII score | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: FMN1 [Title/Abstract] AND PATL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-VQ-A92D-01A | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000334528 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000334528 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000334528 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000334528 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-intron | ENST00000561249 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000561249 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000561249 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000561249 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-intron | ENST00000559047 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000559047 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000559047 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
5CDS-5UTR | ENST00000559047 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-intron | ENST00000558197 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000558197 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000558197 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000558197 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-intron | ENST00000559150 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000559150 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000559150 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000559150 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-intron | ENST00000320930 | ENST00000560775 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000320930 | ENST00000434130 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000320930 | ENST00000560780 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
intron-5UTR | ENST00000320930 | ENST00000558573 | FMN1 | chr15 | 33357158 | - | PATL2 | chr15 | 44968763 | - |
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FusionProtFeatures for FMN1_PATL2 |
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Hgene | Tgene |
FMN1 | PATL2 |
Plays a role in the formation of adherens junction andthe polymerization of linear actin cables. {ECO:0000250}. | RNA-binding protein that acts as a translationalrepressor. {ECO:0000250|UniProtKB:Q4V7K4}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FMN1_PATL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FMN1_PATL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FMN1 | PRPF40A, NUP85, LLGL2, CDH1, CYP2S1, NAPG | PATL2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FMN1_PATL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FMN1_PATL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |