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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1359

FusionGeneSummary for AKAP9_AKAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP9_AKAP9
Fusion gene ID: 1359
HgeneTgene
Gene symbol

AKAP9

AKAP9

Gene ID

10142

10142

Gene nameA-kinase anchoring protein 9A-kinase anchoring protein 9
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAOAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap

7q21.2

7q21.2

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2018052320180523
UniProtAcc

Q99996

Q99996

Ensembl transtripts involved in fusion geneENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 		ENST00000356239, 
ENST00000358100, ENST00000359028, 
ENST00000394564, ENST00000491695, 
Fusion gene scores* DoF score12 X 12 X 7=10087 X 9 X 5=315
# samples 2214
** MAII scorelog2(22/1008*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/315*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP9 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM930492AKAP9chr7

91732433

+AKAP9chr7

91725926

+
ChiTaRS3.1BM685013AKAP9chr7

91725926

-AKAP9chr7

91732433

-
ChiTaRS3.1BQ187681AKAP9chr7

91732433

+AKAP9chr7

91725926

+
ChiTaRS3.1CB177531AKAP9chr7

91630522

+AKAP9chr7

91622250

+
ChiTaRS3.1BU743167AKAP9chr7

91725926

-AKAP9chr7

91732433

-
ChiTaRS3.1BQ183998AKAP9chr7

91725926

-AKAP9chr7

91732433

-
ChiTaRS3.1BU072746AKAP9chr7

91630522

+AKAP9chr7

91622250

+
ChiTaRS3.1BQ184576AKAP9chr7

91725926

-AKAP9chr7

91732433

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000356239ENST00000356239AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000356239ENST00000358100AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000356239ENST00000359028AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000356239ENST00000394564AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000356239ENST00000491695AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000358100ENST00000356239AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000358100ENST00000358100AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000358100ENST00000359028AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000358100ENST00000394564AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000358100ENST00000491695AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000359028ENST00000356239AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000359028ENST00000358100AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000359028ENST00000359028AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000359028ENST00000394564AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000359028ENST00000491695AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000394564ENST00000356239AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000394564ENST00000358100AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000394564ENST00000359028AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000394564ENST00000394564AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000394564ENST00000491695AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000491695ENST00000356239AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000491695ENST00000358100AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000491695ENST00000359028AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000491695ENST00000394564AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000491695ENST00000491695AKAP9chr7

91732433

+AKAP9chr7

91725926

+
intron-intronENST00000356239ENST00000356239AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000356239ENST00000358100AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000356239ENST00000359028AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000356239ENST00000394564AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000356239ENST00000491695AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000358100ENST00000356239AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000358100ENST00000358100AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000358100ENST00000359028AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000358100ENST00000394564AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000358100ENST00000491695AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000359028ENST00000356239AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000359028ENST00000358100AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000359028ENST00000359028AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000359028ENST00000394564AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000359028ENST00000491695AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000394564ENST00000356239AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000394564ENST00000358100AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000394564ENST00000359028AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000394564ENST00000394564AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000394564ENST00000491695AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000491695ENST00000356239AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000491695ENST00000358100AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000491695ENST00000359028AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000491695ENST00000394564AKAP9chr7

91725926

-AKAP9chr7

91732433

-
intron-intronENST00000491695ENST00000491695AKAP9chr7

91725926

-AKAP9chr7

91732433

-
In-frameENST00000356239ENST00000356239AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000356239ENST00000358100AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000356239ENST00000359028AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000356239ENST00000394564AKAP9chr7

91630522

+AKAP9chr7

91622250

+
5CDS-intronENST00000356239ENST00000491695AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000358100ENST00000356239AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000358100ENST00000358100AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000358100ENST00000359028AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000358100ENST00000394564AKAP9chr7

91630522

+AKAP9chr7

91622250

+
5CDS-intronENST00000358100ENST00000491695AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000359028ENST00000356239AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000359028ENST00000358100AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000359028ENST00000359028AKAP9chr7

91630522

+AKAP9chr7

91622250

+
In-frameENST00000359028ENST00000394564AKAP9chr7

91630522

+AKAP9chr7

91622250

+
5CDS-intronENST00000359028ENST00000491695AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000394564ENST00000356239AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000394564ENST00000358100AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000394564ENST00000359028AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000394564ENST00000394564AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-intronENST00000394564ENST00000491695AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000491695ENST00000356239AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000491695ENST00000358100AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000491695ENST00000359028AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-3CDSENST00000491695ENST00000394564AKAP9chr7

91630522

+AKAP9chr7

91622250

+
intron-intronENST00000491695ENST00000491695AKAP9chr7

91630522

+AKAP9chr7

91622250

+

Top

FusionProtFeatures for AKAP9_AKAP9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

AKAP9

Q99996


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501088_1173-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501241_1268-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501324_1380-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501422_1447-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150152_902-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501573_1647-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501845_2443-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502532_2549-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502591_2764-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503061_3088-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503120_3466-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503583_3685-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150932_1010-783908Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491088_1173-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491241_1268-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491324_1380-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491422_1447-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149152_902-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491573_1647-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491845_2443-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492532_2549-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492591_2764-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493061_3088-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493120_3466-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493583_3685-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149932_1010-753858Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501088_1173-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501241_1268-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501324_1380-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501422_1447-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150152_902-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501573_1647-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501845_2443-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502532_2549-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502591_2764-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503061_3088-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503120_3466-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503583_3685-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150932_1010-753912Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501834_2760-783908Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150191_280-783908Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150309_998-783908Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503722_3726-783908Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491834_2760-753858Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149191_280-753858Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149309_998-753858Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493722_3726-753858Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501834_2760-753912Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150191_280-753912Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150309_998-753912Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503722_3726-753912Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502542_2555-783908RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492542_2555-753858RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502542_2555-753912RegionNote=PKA-RII subunit binding domain


Top

FusionGeneSequence for AKAP9_AKAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AKAP9_AKAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP9_AKAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP9_AKAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP9C0037274Dermatologic disorders1CTD_human
HgeneAKAP9C0311375Arsenic Poisoning1CTD_human
HgeneAKAP9C2678483Long Qt Syndrome 111CTD_human;UNIPROT
TgeneAKAP9C0037274Dermatologic disorders1CTD_human
TgeneAKAP9C0311375Arsenic Poisoning1CTD_human
TgeneAKAP9C2678483Long Qt Syndrome 111CTD_human;UNIPROT