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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13580

FusionGeneSummary for FLOT1_TTC19

check button Fusion gene summary
Fusion gene informationFusion gene name: FLOT1_TTC19
Fusion gene ID: 13580
HgeneTgene
Gene symbol

FLOT1

TTC19

Gene ID

10211

54902

Gene nameflotillin 1tetratricopeptide repeat domain 19
Synonyms-2010204O13Rik|MC3DN2
Cytomap

6p21.33

17p12

Type of geneprotein-codingprotein-coding
Descriptionflotillin-1integral membrane component of caveolaetetratricopeptide repeat protein 19, mitochondrialTPR repeat protein 19
Modification date2018052220180523
UniProtAcc

O75955

Q6DKK2

Ensembl transtripts involved in fusion geneENST00000376389, ENST00000456573, 
ENST00000470643, ENST00000420604, 
ENST00000436822, ENST00000492441, 
ENST00000383382, ENST00000460694, 
ENST00000553223, ENST00000470163, 
ENST00000383562, ENST00000496175, 
ENST00000490802, ENST00000430843, 
ENST00000444632, ENST00000466680, 
ENST00000261647, ENST00000486880, 
ENST00000497842, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FLOT1 [Title/Abstract] AND TTC19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA481472FLOT1chr6

2027969

+TTC19chr17

15932006

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000376389ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000376389ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000376389ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000456573ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000456573ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000456573ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000470643ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000470643ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000470643ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000420604ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000420604ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000420604ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000436822ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000436822ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000436822ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000492441ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000492441ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000492441ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000383382ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000383382ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000383382ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000460694ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000460694ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000460694ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000553223ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000553223ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000553223ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000470163ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000470163ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000470163ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000383562ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000383562ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000383562ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000496175ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000496175ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000496175ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000490802ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000490802ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000490802ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000430843ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000430843ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000430843ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000444632ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000444632ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000444632ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000466680ENST00000261647FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-3UTRENST00000466680ENST00000486880FLOT1chr6

2027969

+TTC19chr17

15932006

+
intron-intronENST00000466680ENST00000497842FLOT1chr6

2027969

+TTC19chr17

15932006

+

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FusionProtFeatures for FLOT1_TTC19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLOT1

O75955

TTC19

Q6DKK2

May act as a scaffolding protein within caveolarmembranes, functionally participating in formation of caveolae orcaveolae-like vesicles. Required for the preservation of the structural andfunctional integrity of mitochondrial respiratory complex III byallowing the physiological turnover of the Rieske protein UQCRFS1(PubMed:21278747, PubMed:28673544). Involved in the clearance ofUQCRFS1 N-terminal fragments, which are produced uponincorporation of UQCRFS1 into the complex III and whose presenceis detrimental for its catalytic activity (PubMed:28673544).{ECO:0000269|PubMed:21278747, ECO:0000269|PubMed:28673544}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLOT1_TTC19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLOT1_TTC19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLOT1_TTC19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FLOT1_TTC19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLOT1C0034362Q Fever1CTD_human
TgeneTTC19C0021359Infertility1CTD_human
TgeneTTC19C0027765nervous system disorder1CTD_human
TgeneTTC19C0524851Neurodegenerative Disorders1CTD_human;HPO
TgeneTTC19C0751830Gait Disorders, Neurologic1CTD_human