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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13573

FusionGeneSummary for FLNB_GON4L

check button Fusion gene summary
Fusion gene informationFusion gene name: FLNB_GON4L
Fusion gene ID: 13573
HgeneTgene
Gene symbol

FLNB

GON4L

Gene ID

2317

54856

Gene namefilamin Bgon-4 like
SynonymsABP-278|ABP-280|AOI|FH1|FLN-B|FLN1L|LRS1|SCT|TABP|TAPGON-4|GON4|YARP
Cytomap

3p14.3

1q22

Type of geneprotein-codingprotein-coding
Descriptionfilamin-BABP-280 homologLarsen syndrome 1 (autosomal dominant)actin binding protein 278actin-binding-like proteinbeta-filaminfilamin B, betafilamin homolog 1filamin-3thyroid autoantigenGON-4-like protein2610100B20RikYY1AP related proteinYY1AP-related protein1gon-4 homolog
Modification date2018052220180523
UniProtAcc

O75369

Q3T8J9

Ensembl transtripts involved in fusion geneENST00000490882, ENST00000429972, 
ENST00000295956, ENST00000358537, 
ENST00000357272, ENST00000348383, 
ENST00000493452, ENST00000419752, 
ENST00000484981, 		ENST00000437809, 
ENST00000368331, ENST00000271883, 
ENST00000361040, ENST00000471341, 
Fusion gene scores* DoF score8 X 11 X 8=7047 X 6 X 6=252
# samples 178
** MAII scorelog2(17/704*10)=-2.0500406824996
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLNB [Title/Abstract] AND GON4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-8485-01AFLNBchr3

57994583

+GON4Lchr1

155737332

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000490882ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000490882ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000490882ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000490882ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000490882ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000429972ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000429972ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000429972ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000429972ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000429972ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000295956ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000295956ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000295956ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000295956ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000295956ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000358537ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000358537ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000358537ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000358537ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000358537ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000357272ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000357272ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000357272ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000357272ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000357272ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000348383ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000348383ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000348383ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
Frame-shiftENST00000348383ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
5CDS-5UTRENST00000348383ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000493452ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000493452ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000493452ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000493452ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-5UTRENST00000493452ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000419752ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000419752ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000419752ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000419752ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-5UTRENST00000419752ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000484981ENST00000437809FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000484981ENST00000368331FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000484981ENST00000271883FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-3CDSENST00000484981ENST00000361040FLNBchr3

57994583

+GON4Lchr1

155737332

-
intron-5UTRENST00000484981ENST00000471341FLNBchr3

57994583

+GON4Lchr1

155737332

-

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FusionProtFeatures for FLNB_GON4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLNB

O75369

GON4L

Q3T8J9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLNB_GON4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLNB_GON4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FLNBNPHP1, PSEN1, PSEN2, FLNA, ITGB1, ITGB3, ITGB6, FBLIM1, TSHR, GP1BA, OTUD1, G3BP1, PLEKHO1, RAD21, SIRT7, ISG15, ASB2, RAC1, MAP3K1, MAPK8, CDK2, HNRNPA0, VCP, ZC3H4, NUP210, HNRNPM, CSTB, SEPT9, ESR1, MDC1, FMNL1, VCAM1, FN1, SMURF2, MLH1, ITGA4, NPM1, DCTN2, DCTN3, TXNL1, UBR4, FLNC, LEO1, MAD1L1, PSMD12, PSMD3, SQSTM1, TRIM55, CUL7, OBSL1, CCDC8, SUZ12, RNF2, SIRT6, ABCE1, HSPB1, AP1G1, BASP1, EIF4EBP1, AHNAK, AP1B1, ARFIP1, DCPS, MAP4, NUP50, SEPT6, TARDBP, GGA1, NMD3, RSU1, SEC13, TLDC1, UFD1L, VBP1, MAP2K4, PTEN, MED4, CAPZA2, DBN1, MYH9, PPP1CB, RALA, IQGAP1, SYNPO, ITGB3BP, LIMA1, ANLN, MYO19, MYO18A, MCM2, MCM5, CDC73, TSC22D2, CDH1, HSPB7, ARRB2, TRIM25, BRCA1, TESGON4LDHX16, PNKD, HIST1H2BA, KRAS, HIST1H2BG, CRAMP1L, H2AFX, ASB3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLNB_GON4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FLNB_GON4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLNBC0175778Larsen syndrome2UNIPROT
HgeneFLNBC0036341Schizophrenia1PSYGENET
HgeneFLNBC0265283Atelosteogenesis, type 11CTD_human;ORPHANET;UNIPROT
HgeneFLNBC0432201Boomerang dysplasia1CTD_human;ORPHANET;UNIPROT
HgeneFLNBC1848934SPONDYLOCARPOTARSAL SYNOSTOSIS SYNDROME1CTD_human;ORPHANET
HgeneFLNBC2931648Larsen syndrome, dominant type1CTD_human;ORPHANET
HgeneFLNBC3668942Atelosteogenesis Type 31CTD_human;ORPHANET;UNIPROT
TgeneGON4LC3714756Intellectual Disability1CTD_human