FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1357

FusionGeneSummary for AKAP8_RPL28

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP8_RPL28
Fusion gene ID: 1357
HgeneTgene
Gene symbol

AKAP8

RPL28

Gene ID

10270

6158

Gene nameA-kinase anchoring protein 8ribosomal protein L28
SynonymsAKAP 95|AKAP-8|AKAP-95|AKAP95L28
Cytomap

19p13.12

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDa60S ribosomal protein L28large ribosomal subunit protein eL28
Modification date2018052320180525
UniProtAcc

O43823

P46779

Ensembl transtripts involved in fusion geneENST00000269701, ENST00000344063, 
ENST00000431533, ENST00000428193, 
ENST00000558815, ENST00000560583, 
ENST00000560055, ENST00000559463, 
ENST00000558131, ENST00000558752, 
ENST00000458349, 
Fusion gene scores* DoF score5 X 5 X 4=1008 X 8 X 4=256
# samples 511
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP8 [Title/Abstract] AND RPL28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A8PJ-01AAKAP8chr19

15466118

-RPL28chr19

55897718

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000269701ENST00000344063AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000431533AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000428193AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000558815AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000560583AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000560055AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000559463AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000558131AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-5UTRENST00000269701ENST00000558752AKAP8chr19

15466118

-RPL28chr19

55897718

+
intron-intronENST00000269701ENST00000458349AKAP8chr19

15466118

-RPL28chr19

55897718

+

Top

FusionProtFeatures for AKAP8_RPL28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP8

O43823

RPL28

P46779

Anchoring protein that mediates the subcellularcompartmentation of cAMP-dependent protein kinase (PKA type II)(PubMed:9473338). Acts as an anchor for a PKA-signaling complexonto mitotic chromosomes, which is required for maintenance ofchromosomes in a condensed form throughout mitosis. Recruitscondensin complex subunit NCAPD2 to chromosomes required forchromatin condensation; the function appears to be independentfrom PKA-anchoring (PubMed:10601332, PubMed:10791967,PubMed:11964380). May help to deliver cyclin D/E to CDK4 tofacilitate cell cycle progression (PubMed:14641107). Required forcell cycle G2/M transition and histone deacetylation duringmitosis. In mitotic cells recruits HDAC3 to the vicinity ofchromatin leading to deacetylation and subsequent phosphorylationat 'Ser-10' of histone H3; in this function may act redundantlywith AKAP8L (PubMed:16980585). Involved in nuclear retention ofRPS6KA1 upon ERK activation thus inducing cell proliferation(PubMed:22130794). May be involved in regulation of DNAreplication by acting as scaffold for MCM2 (PubMed:12740381).Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and isinvolved in transcriptional regulation. In a teratocarcinoma cellline is involved in retinoic acid-mediated induction ofdevelopmental genes implicating H3 'Lys-4' methylation(PubMed:23995757). May be involved in recruitment of active CASP3to the nucleus in apoptotic cells (PubMed:16227597). May act as acarrier protein of GJA1 for its transport to the nucleus(PubMed:26880274). Seems to involved in modulation of rDNAtranscription. Preferentially binds GC-rich DNA in vitro andassociates to GC-rich ribosomal RNA promoters (PubMed:26683827).Involved in modulation of Toll-like receptor signaling. Requiredfor the cAMP-dependent suppression of TNF-alpha in early stages ofLPS-induced macrophage activation; the function probablyimplicates targeting of PKA to NFKB1 (By similarity).{ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0,ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967,ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585,ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827,ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107,ECO:0000305|PubMed:9473338}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AKAP8_RPL28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for AKAP8_RPL28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP8MCM2, CCND3, CCND1, CCND2, PRKAR2A, AMY1A, DDX5, TADA2A, MYC, ELAVL1, HNRNPA1, CUL3, COPS5, CAND1, LRRK2, ESR1, BARD1, CSNK2A1, HDAC11, HIPK4, RPA3, RPA2, RPA1, NXF1, CCDC8, EZH2, RNF2, BMI1, ILK, CLEC11A, FBXW11, EEF1D, EEF1B2, RUVBL1, RUVBL2, TUBB4B, EWSR1, MATR3, FOXA3, FOXC2, FOXE1, FOXG1, FOXJ2, CRY2, FOXP3, FOXS1, CDC5L, C11orf30, BRCA1, TESRPL28MAGEB2, UBC, DCC, ARRB2, TDRD3, CUL2, CDK2, CUL1, COPS5, CAND1, ESR1, MAGOH, EIF4A3, PA2G4, FN1, SMAD4, UBL4A, ITGA4, PAN2, MAP2K5, FBXO6, TARDBP, GTF2I, RPL8, RPS10, RPS18, RPS19, RPS23, RPS29, RPS2, RPS3A, RPS3, GRSF1, TP53, PCSK9, CCNDBP1, BRCA1, CCDC8, RNF2, RPL23A, RPL13, RPL14, RPL19, RPL21, RPL23, RPL3, RPL34, RPL36, RPL5, RPL7, RPLP0, RPS11, RPS14, RPS15, RPS15A, RPS16, RPS25, RPL35, RPL38, RPLP1, RPLP2, RPS6, XPO1, HNRNPU, KIF11, MCM2, RC3H1, C3orf17, ZNF746, HIST1H1D, HIST1H1A, HIST1H1C, PTPRK, KLHL21, FAT4, ZDBF2, GSG2, FAT3, SIPA1L2, KIAA0020, TRO, KIAA0232, CDC42BPA, TUBB3, RPL18A, IFFO1, RRP8, CELSR2, FREM2, RBM34, AKAP11, PLCH1, RPL4, RPL26L1, PPAN-P2RY11, POLE2, GLYR1, ZNF354A, WHSC1, ZCCHC7, C1QBP, FTSJ3, POLE, ZNF644, BRIX1, RPL32, PTPRD, RPL30, RPL27, TUBA4A, DKC1, RPL18, GPR98, RPL6, ZNF184, CENPU, GPRASP2, RBM28, SDCBP, RPL7A, PEX14, ZNF865, KLHL15, RPS8, NCL, CYLD, INO80B, COX15, DNM1L, PDHA1, SOAT1, VDAC1, FOXA1, TRIM25, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AKAP8_RPL28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AKAP8_RPL28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP8C0041696Unipolar Depression1PSYGENET
HgeneAKAP8C1269683Major Depressive Disorder1PSYGENET
TgeneRPL28C0043094Weight Gain1CTD_human