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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13531

FusionGeneSummary for FKBP6_RNF167

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP6_RNF167
Fusion gene ID: 13531
HgeneTgene
Gene symbol

FKBP6

RNF167

Gene ID

8468

26001

Gene nameFK506 binding protein 6ring finger protein 167
SynonymsFKBP365730408C10Rik|LP2254|RING105
Cytomap

7q11.23

17p13.2

Type of geneprotein-codingprotein-coding
Descriptioninactive peptidyl-prolyl cis-trans isomerase FKBP636 kDa FKBPFK506 binding protein 6, 36kDaPPIase FKBP6immunophilin FKBP36inactive PPIase FKBP6peptidyl-prolyl cis-trans isomerase FKBP6rotamaseE3 ubiquitin-protein ligase RNF167RING-type E3 ubiquitin transferase RNF167
Modification date2018052220180523
UniProtAcc

O75344

Q9H6Y7

Ensembl transtripts involved in fusion geneENST00000431982, ENST00000413573, 
ENST00000252037, 		ENST00000571816, 
ENST00000572430, ENST00000262482, 
ENST00000575111, ENST00000576229, 
ENST00000570492, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 4 X 3=48
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FKBP6 [Title/Abstract] AND RNF167 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF167

GO:0000209

protein polyubiquitination

16314844


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA679431FKBP6chr7

72722427

-RNF167chr17

4844166

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000431982ENST00000571816FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000431982ENST00000572430FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000431982ENST00000262482FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000431982ENST00000575111FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-intronENST00000431982ENST00000576229FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-3UTRENST00000431982ENST00000570492FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000413573ENST00000571816FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000413573ENST00000572430FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000413573ENST00000262482FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000413573ENST00000575111FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-intronENST00000413573ENST00000576229FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-3UTRENST00000413573ENST00000570492FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000252037ENST00000571816FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000252037ENST00000572430FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000252037ENST00000262482FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-5UTRENST00000252037ENST00000575111FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-intronENST00000252037ENST00000576229FKBP6chr7

72722427

-RNF167chr17

4844166

+
intron-3UTRENST00000252037ENST00000570492FKBP6chr7

72722427

-RNF167chr17

4844166

+

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FusionProtFeatures for FKBP6_RNF167


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP6

O75344

RNF167

Q9H6Y7

Co-chaperone required during spermatogenesis to represstransposable elements and prevent their mobilization, which isessential for the germline integrity. Acts via the piRNA metabolicprocess, which mediates the repression of transposable elementsduring meiosis by forming complexes composed of piRNAs and Piwiproteins and govern the methylation and subsequent repression oftransposons. Acts as a co-chaperone via its interaction with HSP90and is required for the piRNA amplification process, the secondarypiRNA biogenesis. May be required together with HSP90 in removalof 16 nucleotide ping-pong by-products from Piwi complexes,possibly facilitating turnover of Piwi complexes (By similarity).{ECO:0000250}. May act as an E3 ubiquitin-protein ligase, or as part ofthe E3 complex, which accepts ubiquitin from specific E2ubiquitin-conjugating enzymes, such as UBE2E1, and then transfersit to substrates, such as SLC22A18. May play a role in growthregulation involved in G1/S transition.{ECO:0000269|PubMed:16314844}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP6_RNF167


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP6_RNF167


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP6_RNF167


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP6_RNF167


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource