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Fusion gene ID: 13528 |
FusionGeneSummary for FKBP5_VPS54 |
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Fusion gene information | Fusion gene name: FKBP5_VPS54 | Fusion gene ID: 13528 | Hgene | Tgene | Gene symbol | FKBP5 | VPS54 | Gene ID | 2289 | 51542 |
Gene name | FK506 binding protein 5 | VPS54, GARP complex subunit | |
Synonyms | AIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10 | HCC8|PPP1R164|SLP-8p|VPS54L|WR|hVps54L | |
Cytomap | 6p21.31 | 2p15-p14 | |
Type of gene | protein-coding | protein-coding | |
Description | peptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogen-regulated protein 6p | vacuolar protein sorting-associated protein 54hepatocellular carcinoma protein 8protein phosphatase 1, regulatory subunit 164tumor antigen HOM-HCC-8tumor antigen SLP-8pvacuolar protein sorting 54 homolog | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q13451 | Q9P1Q0 | |
Ensembl transtripts involved in fusion gene | ENST00000539068, ENST00000536438, ENST00000357266, ENST00000540787, ENST00000542713, | ENST00000409558, ENST00000272322, ENST00000354504, | |
Fusion gene scores | * DoF score | 9 X 10 X 6=540 | 5 X 5 X 4=100 |
# samples | 12 | 5 | |
** MAII score | log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FKBP5 [Title/Abstract] AND VPS54 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FKBP5 | GO:0061077 | chaperone-mediated protein folding | 11350175 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-EJ-5532-01A | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000539068 | ENST00000409558 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000539068 | ENST00000272322 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000539068 | ENST00000354504 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000536438 | ENST00000409558 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000536438 | ENST00000272322 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000536438 | ENST00000354504 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000357266 | ENST00000409558 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000357266 | ENST00000272322 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000357266 | ENST00000354504 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000540787 | ENST00000409558 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000540787 | ENST00000272322 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000540787 | ENST00000354504 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000542713 | ENST00000409558 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000542713 | ENST00000272322 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
intron-3CDS | ENST00000542713 | ENST00000354504 | FKBP5 | chr6 | 35543526 | - | VPS54 | chr2 | 64124724 | - |
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FusionProtFeatures for FKBP5_VPS54 |
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Hgene | Tgene |
FKBP5 | VPS54 |
Immunophilin protein with PPIase and co-chaperoneactivities. Component of unligated steroid receptorsheterocomplexes through interaction with heat-shock protein 90(HSP90). Plays a role in the intracellular trafficking ofheterooligomeric forms of steroid hormone receptors maintainingthe complex into the cytoplasm when unliganded. | Acts as component of the GARP complex that is involvedin retrograde transport from early and late endosomes to thetrans-Golgi network (TGN). The GARP complex is required for themaintenance of the cycling of mannose 6-phosphate receptorsbetween the TGN and endosomes, this cycling is necessary forproper lysosomal sorting of acid hydrolases such as CTSD(PubMed:18367545). Within the GARP complex, required to tether thecomplex to the TGN. Not involved in endocytic recycling(PubMed:25799061). {ECO:0000269|PubMed:18367545,ECO:0000269|PubMed:25799061}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FKBP5_VPS54 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FKBP5_VPS54 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FKBP5 | MAP3K1, IKBKE, ESR1, FES, HSF1, PGR, HSP90AA1, USP49, PHLPP1, CDK9, STK11, STIP1, IKBKB, RIPK3, AKT1, NR3C1, NR3C2, AR, HSPA4, PTGES3, LRRK1, MAGEA11, APP, CLK3, CDK15, MAGED2, MCM3, MCM5, MGEA5, OGFR, TPM3, TRAP1, USP7, PRKAA1, AGO1, AHSA1, CDC37, CDC37L1, SUGT1, NUDCD3, HSP90AB1, ILK, NUDC, AGO2, CACYBP, CHUK, AURKB, ARAF, GLMN, TTC4, CHORDC1, LRRC40, IKBKG, KIAA1279, ANKMY2, EGLN1, HGH1, MCMBP, PDCD2, CDK4, CDK11A, TUBA1A, PNPLA2, DNAJB6, C14orf80, CXorf57, PYGL, MCM4, HSF4, IRS4, LIMK2, SGK2, TSSK6, ULK3, AGO3, MOS, PSKH2, PIPOX, SGK1, CDKL1, CDKL4, AURKC, CDK18, CDK7, CDK13, CDK3, RPS6KB2, DUT, TLE3, NTRK1, XRCC3, TINF2, FBXW7, DUSP2, DUSP8, AMACR, MAP3K6, PRKACB, AKT3, PDIK1L, STK35, NEK11, ABHD15, WDR90, CDK6, ATG7, TRIM25 | VPS54 | VPS52, VPS53, VPS51, STX6, CCDC132, TSSC1, SYN1, C10orf76, PTAR1, RAB1A, RAB1B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FKBP5_VPS54 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FKBP5_VPS54 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FKBP5 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Hgene | FKBP5 | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | FKBP5 | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | FKBP5 | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | FKBP5 | C0525045 | Mood Disorders | 5 | PSYGENET |
Hgene | FKBP5 | C1269683 | Major Depressive Disorder | 5 | CTD_human;PSYGENET |
Hgene | FKBP5 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | FKBP5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Hgene | FKBP5 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | FKBP5 | C0021290 | Neonatal disorder | 1 | CTD_human |
Hgene | FKBP5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | FKBP5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | FKBP5 | C0525041 | Neurobehavioral Manifestations | 1 | CTD_human |
Hgene | FKBP5 | C2362914 | clinical depression | 1 | PSYGENET |
Tgene | VPS54 | C0027746 | Nerve Degeneration | 1 | CTD_human |