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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13525

FusionGeneSummary for FKBP5_FKBP5

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP5_FKBP5
Fusion gene ID: 13525
HgeneTgene
Gene symbol

FKBP5

FKBP5

Gene ID

2289

2289

Gene nameFK506 binding protein 5FK506 binding protein 5
SynonymsAIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10AIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10
Cytomap

6p21.31

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogen-regulated protein 6ppeptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogen-regulated protein 6p
Modification date2018052720180527
UniProtAcc

Q13451

Q13451

Ensembl transtripts involved in fusion geneENST00000539068, ENST00000536438, 
ENST00000357266, ENST00000540787, 
ENST00000542713, 		ENST00000539068, 
ENST00000536438, ENST00000357266, 
ENST00000540787, ENST00000542713, 
Fusion gene scores* DoF score9 X 10 X 6=54011 X 11 X 7=847
# samples 1217
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/847*10)=-2.3168272231945
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP5 [Title/Abstract] AND FKBP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFKBP5

GO:0061077

chaperone-mediated protein folding

11350175

TgeneFKBP5

GO:0061077

chaperone-mediated protein folding

11350175


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF818520FKBP5chr6

35547812

-FKBP5chr6

35544922

+
ChiTaRS3.1CA418117FKBP5chr6

35541902

+FKBP5chr6

35541893

-
ChiTaRS3.1BG960579FKBP5chr6

35565123

-FKBP5chr6

35544960

+
ChiTaRS3.1BU618494FKBP5chr6

35541902

+FKBP5chr6

35541893

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000539068ENST00000539068FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000539068ENST00000536438FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000539068ENST00000357266FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000539068ENST00000540787FKBP5chr6

35547812

-FKBP5chr6

35544922

+
5CDS-intronENST00000539068ENST00000542713FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000536438ENST00000539068FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000536438ENST00000536438FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000536438ENST00000357266FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000536438ENST00000540787FKBP5chr6

35547812

-FKBP5chr6

35544922

+
5CDS-intronENST00000536438ENST00000542713FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000357266ENST00000539068FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000357266ENST00000536438FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000357266ENST00000357266FKBP5chr6

35547812

-FKBP5chr6

35544922

+
In-frameENST00000357266ENST00000540787FKBP5chr6

35547812

-FKBP5chr6

35544922

+
5CDS-intronENST00000357266ENST00000542713FKBP5chr6

35547812

-FKBP5chr6

35544922

+
Frame-shiftENST00000540787ENST00000539068FKBP5chr6

35547812

-FKBP5chr6

35544922

+
Frame-shiftENST00000540787ENST00000536438FKBP5chr6

35547812

-FKBP5chr6

35544922

+
Frame-shiftENST00000540787ENST00000357266FKBP5chr6

35547812

-FKBP5chr6

35544922

+
Frame-shiftENST00000540787ENST00000540787FKBP5chr6

35547812

-FKBP5chr6

35544922

+
5CDS-intronENST00000540787ENST00000542713FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-3CDSENST00000542713ENST00000539068FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-3CDSENST00000542713ENST00000536438FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-3CDSENST00000542713ENST00000357266FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-3CDSENST00000542713ENST00000540787FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-intronENST00000542713ENST00000542713FKBP5chr6

35547812

-FKBP5chr6

35544922

+
intron-3UTRENST00000539068ENST00000539068FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000539068ENST00000536438FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000539068ENST00000357266FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000539068ENST00000540787FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000539068ENST00000542713FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000536438ENST00000539068FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000536438ENST00000536438FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000536438ENST00000357266FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000536438ENST00000540787FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000536438ENST00000542713FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000357266ENST00000539068FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000357266ENST00000536438FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000357266ENST00000357266FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000357266ENST00000540787FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000357266ENST00000542713FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000540787ENST00000539068FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000540787ENST00000536438FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000540787ENST00000357266FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000540787ENST00000540787FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000540787ENST00000542713FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000542713ENST00000539068FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000542713ENST00000536438FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3UTRENST00000542713ENST00000357266FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000542713ENST00000540787FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-intronENST00000542713ENST00000542713FKBP5chr6

35541902

+FKBP5chr6

35541893

-
intron-3CDSENST00000539068ENST00000539068FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000539068ENST00000536438FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000539068ENST00000357266FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000539068ENST00000540787FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-intronENST00000539068ENST00000542713FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000536438ENST00000539068FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000536438ENST00000536438FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000536438ENST00000357266FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000536438ENST00000540787FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-intronENST00000536438ENST00000542713FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000357266ENST00000539068FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000357266ENST00000536438FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000357266ENST00000357266FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000357266ENST00000540787FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-intronENST00000357266ENST00000542713FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000540787ENST00000539068FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000540787ENST00000536438FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000540787ENST00000357266FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000540787ENST00000540787FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-intronENST00000540787ENST00000542713FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000542713ENST00000539068FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000542713ENST00000536438FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000542713ENST00000357266FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-3CDSENST00000542713ENST00000540787FKBP5chr6

35565123

-FKBP5chr6

35544960

+
intron-intronENST00000542713ENST00000542713FKBP5chr6

35565123

-FKBP5chr6

35544960

+

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FusionProtFeatures for FKBP5_FKBP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP5

Q13451

FKBP5

Q13451

Immunophilin protein with PPIase and co-chaperoneactivities. Component of unligated steroid receptorsheterocomplexes through interaction with heat-shock protein 90(HSP90). Plays a role in the intracellular trafficking ofheterooligomeric forms of steroid hormone receptors maintainingthe complex into the cytoplasm when unliganded. Immunophilin protein with PPIase and co-chaperoneactivities. Component of unligated steroid receptorsheterocomplexes through interaction with heat-shock protein 90(HSP90). Plays a role in the intracellular trafficking ofheterooligomeric forms of steroid hormone receptors maintainingthe complex into the cytoplasm when unliganded.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFKBP5chr6:35547812chr6:35544922ENST00000357266-011157_243-51458DomainPPIase FKBP-type 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000357266-01142_130-51458DomainPPIase FKBP-type 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000536438-012157_243-106458DomainPPIase FKBP-type 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000536438-01242_130-106458DomainPPIase FKBP-type 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000539068-011157_243-68458DomainPPIase FKBP-type 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000539068-01142_130-68458DomainPPIase FKBP-type 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000542713-07157_243-53269DomainPPIase FKBP-type 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000542713-0742_130-53269DomainPPIase FKBP-type 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000357266-011268_301-51458RepeatNote=TPR 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000357266-011317_350-51458RepeatNote=TPR 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000357266-011351_384-51458RepeatNote=TPR 3
TgeneFKBP5chr6:35547812chr6:35544922ENST00000536438-012268_301-106458RepeatNote=TPR 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000536438-012317_350-106458RepeatNote=TPR 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000536438-012351_384-106458RepeatNote=TPR 3
TgeneFKBP5chr6:35547812chr6:35544922ENST00000539068-011268_301-68458RepeatNote=TPR 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000539068-011317_350-68458RepeatNote=TPR 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000539068-011351_384-68458RepeatNote=TPR 3
TgeneFKBP5chr6:35547812chr6:35544922ENST00000542713-07268_301-53269RepeatNote=TPR 1
TgeneFKBP5chr6:35547812chr6:35544922ENST00000542713-07317_350-53269RepeatNote=TPR 2
TgeneFKBP5chr6:35547812chr6:35544922ENST00000542713-07351_384-53269RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP5_FKBP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP5_FKBP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FKBP5_FKBP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP5_FKBP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFKBP5C0005586Bipolar Disorder5PSYGENET
HgeneFKBP5C0011570Mental Depression5PSYGENET
HgeneFKBP5C0011581Depressive disorder5PSYGENET
HgeneFKBP5C0041696Unipolar Depression5PSYGENET
HgeneFKBP5C0525045Mood Disorders5PSYGENET
HgeneFKBP5C1269683Major Depressive Disorder5CTD_human;PSYGENET
HgeneFKBP5C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneFKBP5C0003873Rheumatoid Arthritis1CTD_human
HgeneFKBP5C0014175Endometriosis1CTD_human
HgeneFKBP5C0021290Neonatal disorder1CTD_human
HgeneFKBP5C0033975Psychotic Disorders1PSYGENET
HgeneFKBP5C0349204Nonorganic psychosis1PSYGENET
HgeneFKBP5C0525041Neurobehavioral Manifestations1CTD_human
HgeneFKBP5C2362914clinical depression1PSYGENET
TgeneFKBP5C0005586Bipolar Disorder5PSYGENET
TgeneFKBP5C0011570Mental Depression5PSYGENET
TgeneFKBP5C0011581Depressive disorder5PSYGENET
TgeneFKBP5C0041696Unipolar Depression5PSYGENET
TgeneFKBP5C0525045Mood Disorders5PSYGENET
TgeneFKBP5C1269683Major Depressive Disorder5CTD_human;PSYGENET
TgeneFKBP5C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneFKBP5C0003873Rheumatoid Arthritis1CTD_human
TgeneFKBP5C0014175Endometriosis1CTD_human
TgeneFKBP5C0021290Neonatal disorder1CTD_human
TgeneFKBP5C0033975Psychotic Disorders1PSYGENET
TgeneFKBP5C0349204Nonorganic psychosis1PSYGENET
TgeneFKBP5C0525041Neurobehavioral Manifestations1CTD_human
TgeneFKBP5C2362914clinical depression1PSYGENET