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Fusion gene ID: 13501 |
FusionGeneSummary for FKBP15_RET |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FKBP15_RET | Fusion gene ID: 13501 | Hgene | Tgene | Gene symbol | FKBP15 | RET | Gene ID | 23307 | 5979 |
| Gene name | FK506 binding protein 15 | ret proto-oncogene | |
| Synonyms | FKBP133|KIAA0674|PPP1R76 | CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1 | |
| Cytomap | 9q32 | 10q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76 | proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q5T1M5 | P07949 | |
| Ensembl transtripts involved in fusion gene | ENST00000238256, ENST00000493847, | ENST00000355710, ENST00000340058, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 18 X 10 X 7=1260 |
| # samples | 6 | 65 | |
| ** MAII score | log2(6/60*10)=0 | log2(65/1260*10)=-0.954912110471462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FKBP15 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FKBP15 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Tgene | RET | GO:0030155 | regulation of cell adhesion | 21357690 |
| Tgene | RET | GO:0030335 | positive regulation of cell migration | 20702524 |
| Tgene | RET | GO:0033619 | membrane protein proteolysis | 21357690 |
| Tgene | RET | GO:0033630 | positive regulation of cell adhesion mediated by integrin | 20702524 |
| Tgene | RET | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Tgene | RET | GO:0043410 | positive regulation of MAPK cascade | 28846099 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LAML | TCGA-AB-2971-03A | FKBP15 | chr9 | 115936842 | - | RET | chr10 | 43607584 | + |
| TCGA | RV | THCA | TCGA-ET-A3DQ-01A | FKBP15 | chr9 | 115932802 | - | RET | chr10 | 43612032 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000238256 | ENST00000355710 | FKBP15 | chr9 | 115936842 | - | RET | chr10 | 43607584 | + |
| intron-3CDS | ENST00000238256 | ENST00000340058 | FKBP15 | chr9 | 115936842 | - | RET | chr10 | 43607584 | + |
| intron-3CDS | ENST00000493847 | ENST00000355710 | FKBP15 | chr9 | 115936842 | - | RET | chr10 | 43607584 | + |
| intron-3CDS | ENST00000493847 | ENST00000340058 | FKBP15 | chr9 | 115936842 | - | RET | chr10 | 43607584 | + |
| In-frame | ENST00000238256 | ENST00000355710 | FKBP15 | chr9 | 115932802 | - | RET | chr10 | 43612032 | + |
| In-frame | ENST00000238256 | ENST00000340058 | FKBP15 | chr9 | 115932802 | - | RET | chr10 | 43612032 | + |
| intron-3CDS | ENST00000493847 | ENST00000355710 | FKBP15 | chr9 | 115932802 | - | RET | chr10 | 43612032 | + |
| intron-3CDS | ENST00000493847 | ENST00000340058 | FKBP15 | chr9 | 115932802 | - | RET | chr10 | 43612032 | + |
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FusionProtFeatures for FKBP15_RET |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FKBP15 | RET |
| May be involved in the cytoskeletal organization ofneuronal growth cones. Seems to be inactive as a PPIase (Bysimilarity). Involved in the transport of early endosomes at thelevel of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. | Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 522_789 | 922 | 1220 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 818_878 | 922 | 1220 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 197_290 | 922 | 1220 | Domain | PPIase FKBP-type |
| Hgene | FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 72_169 | 922 | 1220 | Region | Important for function in growth cone organization |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 724_1016 | 712 | 1073 | Domain | Protein kinase |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 724_1016 | 712 | 1115 | Domain | Protein kinase |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 730_738 | 712 | 1073 | Nucleotide binding | ATP |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 730_738 | 712 | 1115 | Nucleotide binding | ATP |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 805_807 | 712 | 1073 | Region | Note=Inhibitors binding |
| Tgene | >RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 805_807 | 712 | 1115 | Region | Note=Inhibitors binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 925_951 | 922 | 1220 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >FKBP15 | chr9:115932802 | chr10:43612032 | ENST00000238256 | - | 25 | 28 | 1208_1216 | 922 | 1220 | Compositional bias | Note=Poly-Asp |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 168_272 | 712 | 1073 | Domain | Cadherin |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 168_272 | 712 | 1115 | Domain | Cadherin |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 29_635 | 712 | 1073 | Topological domain | Extracellular |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 658_1114 | 712 | 1073 | Topological domain | Cytoplasmic |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 29_635 | 712 | 1115 | Topological domain | Extracellular |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 658_1114 | 712 | 1115 | Topological domain | Cytoplasmic |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000340058 | + | 10 | 19 | 636_657 | 712 | 1073 | Transmembrane | Helical |
| Tgene | RET | chr9:115932802 | chr10:43612032 | ENST00000355710 | + | 10 | 20 | 636_657 | 712 | 1115 | Transmembrane | Helical |
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FusionGeneSequence for FKBP15_RET |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_1325aa MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_1283aa MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHAYRYTNGQY VKQGKFGAAVLGNHTAREYRILLYISQQQPVTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH SAVSGNAQSFQPYAGMQAYAYPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRYVEQSNLMMEKRNNSLQTATENTQAR VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_3975nt ATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATTGGCCTCACTTTTTGGACTGGATCAGGCA GCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCAGGGAACGGCAGCAACAGGAAATCAGGCA ACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCATGCATATCGATACACAAATGGTCAATAT GTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGATTCTTCTTTATATCAGTCAACAACAGCCA GTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCACCTTTTATGATGACCAGAGACAGAACTGG TCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAAGTGCAACAGTACCTCTTCCCTGGATGCA GTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGAAGTGGCCTATACCGGCTGGCTCTTTCAG AATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAAGTTAGGATCAGGAAAAGTCATCAAGGGC TGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGCCTGTGCTGTTGGCTCAGAAGGGGTAATA GGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTTTGCCAGAGATTCTGGCTCTGATGGTCAC AGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGCTGATCCTGTTGTGTCACCACCCACATCA ATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACTTGCAATAAATACAAGTCCCGATGCAGTC AAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACCACAGCTGGATTCCAATGATTCAGAAATC GAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTCTCTTCATCCGGCCCATCCAGCGTTACCA CAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTTAATGCAAGTGTCATCTCTCGATTCCCAC TCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTATCCCCAGGCATCTGCCGTCACCTCCCAG CTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATCAGGTGATATGGCTTCATTTCTCATGACT GAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGATCATCTCATGACTAAGGTTGAAGAGTTA CAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAGCATGATTATGAGCAACATCCAGCGAATC ATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACAGAATGACAAGATTAGTGAACTAATTGAA CGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCAGACAGCCACAGAAAACACACAGGCAAGA GTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACAGGTCTCTCATCTGCAGCTGAAAATGACT GCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGATCTTCTCAGGGGCCAGCTCACCAAAGTG CAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGAAAAGCAGAACCGGAAACAACTGGAACTC AAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAAGAACCTCTCAGAAAGGAAAAAGAAGTCA GCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGAATTGGACAAACTTCGACAGCTCTTGAAA AAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCTACAGACCCAGTGGGAAGCAAAATGTGAA CATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAGAGATGCCTACCAGCAGAAGCTGGTACAA CTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACAGCACATCAAGGAACTAGAGAAGAACAAG TCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCATGAACCAGGTGTTCCAGTCCTTACGGAGA GAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGGAGGATCCAAAGTGGGAATTCCCT CGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCA GGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAG CAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGC TCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCAC CCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTC GTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTAT GAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACG CAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTC TTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAG GAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCG TCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGA GCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCT GATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGAC >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_3849nt ATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATTGGCCTCACTTTTTGGACTGGATCAGGCA GCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCAGGGAACGGCAGCAACAGGAAATCAGGCA ACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCATGCATATCGATACACAAATGGTCAATAT GTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGATTCTTCTTTATATCAGTCAACAACAGCCA GTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCACCTTTTATGATGACCAGAGACAGAACTGG TCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAAGTGCAACAGTACCTCTTCCCTGGATGCA GTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGAAGTGGCCTATACCGGCTGGCTCTTTCAG AATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAAGTTAGGATCAGGAAAAGTCATCAAGGGC TGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGCCTGTGCTGTTGGCTCAGAAGGGGTAATA GGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTTTGCCAGAGATTCTGGCTCTGATGGTCAC AGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGCTGATCCTGTTGTGTCACCACCCACATCA ATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACTTGCAATAAATACAAGTCCCGATGCAGTC AAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACCACAGCTGGATTCCAATGATTCAGAAATC GAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTCTCTTCATCCGGCCCATCCAGCGTTACCA CAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTTAATGCAAGTGTCATCTCTCGATTCCCAC TCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTATCCCCAGGCATCTGCCGTCACCTCCCAG CTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATCAGGTGATATGGCTTCATTTCTCATGACT GAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGATCATCTCATGACTAAGGTTGAAGAGTTA CAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAGCATGATTATGAGCAACATCCAGCGAATC ATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACAGAATGACAAGATTAGTGAACTAATTGAA CGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCAGACAGCCACAGAAAACACACAGGCAAGA GTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACAGGTCTCTCATCTGCAGCTGAAAATGACT GCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGATCTTCTCAGGGGCCAGCTCACCAAAGTG CAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGAAAAGCAGAACCGGAAACAACTGGAACTC AAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAAGAACCTCTCAGAAAGGAAAAAGAAGTCA GCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGAATTGGACAAACTTCGACAGCTCTTGAAA AAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCTACAGACCCAGTGGGAAGCAAAATGTGAA CATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAGAGATGCCTACCAGCAGAAGCTGGTACAA CTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACAGCACATCAAGGAACTAGAGAAGAACAAG TCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCATGAACCAGGTGTTCCAGTCCTTACGGAGA GAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGGAGGATCCAAAGTGGGAATTCCCT CGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCA GGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAG CAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGC TCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCAC CCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTC GTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTAT GAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACG CAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTC TTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAG GAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCG TCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_6175nt AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGG AGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCT TTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCT GAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAG TTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTC TTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCAC ATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAAT TTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGG GGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGA ATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAG AGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCC TCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGA GGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTT AGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCA ATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGC CCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTT GTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTC TGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACT TAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATG CGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTT GGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAG TCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCT CAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTG TCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTAT TACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTT >In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_4717nt AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAG ATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCT CTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAA TAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGT TGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGT TGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAG AGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGG AGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTC AGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAA |
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FusionGenePPI for FKBP15_RET |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FKBP15 | SP1, FAM21C, CDK19, VCP, STRN3, RPA1, RPA2, RPA3, LGR4, SNAP29, SSFA2, NUDT12, FBF1, XPO1, PRPF4, VPS26A, CTR9, VPS26B, KIAA0196, KIAA1033, TTBK2, UBC, MCM2, RHOU, WWOX, EXOC1, COMMD10, ZYX, ATP6V0D2, SERPINB2, STX11, C1orf87, AIPL1, MIOS, FGFR1OP, PDE5A, VPS29, HDAC6 | RET | STAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FKBP15_RET |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RET | P07949 | DB05294 | Vandetanib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved |
| Tgene | RET | P07949 | DB08896 | Regorafenib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved |
| Tgene | RET | P07949 | DB00398 | Sorafenib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
| Tgene | RET | P07949 | DB08875 | Cabozantinib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
| Tgene | RET | P07949 | DB08901 | Ponatinib | Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305} | small molecule | approved|investigational |
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RelatedDiseases for FKBP15_RET |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FKBP15 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Hgene | FKBP15 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Tgene | RET | C3888239 | HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1 | 15 | UNIPROT |
| Tgene | RET | C0025268 | Multiple Endocrine Neoplasia Type 2a | 14 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C1833921 | Familial medullary thyroid carcinoma | 14 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C0025269 | Multiple Endocrine Neoplasia Type 2b | 8 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C1275808 | Congenital central hypoventilation | 4 | CTD_human;ORPHANET;UNIPROT |
| Tgene | RET | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | RET | C0019569 | Hirschsprung Disease | 2 | CTD_human;HPO;ORPHANET |
| Tgene | RET | C0006413 | Burkitt Lymphoma | 1 | CTD_human |
| Tgene | RET | C0027662 | Multiple Endocrine Neoplasia | 1 | CTD_human |
| Tgene | RET | C0031511 | Pheochromocytoma | 1 | CTD_human;HPO;UNIPROT |
| Tgene | RET | C0038220 | Status Epilepticus | 1 | CTD_human |
| Tgene | RET | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
| Tgene | RET | C0206693 | Medullary carcinoma | 1 | CTD_human |
| Tgene | RET | C0238462 | Medullary carcinoma of thyroid | 1 | CTD_human;HPO |
| Tgene | RET | C0740340 | Amyloidosis, Familial | 1 | CTD_human |
| Tgene | RET | C1609433 | Congenital absence of kidneys syndrome | 1 | CTD_human;ORPHANET |
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