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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13501

FusionGeneSummary for FKBP15_RET

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP15_RET
Fusion gene ID: 13501
HgeneTgene
Gene symbol

FKBP15

RET

Gene ID

23307

5979

Gene nameFK506 binding protein 15ret proto-oncogene
SynonymsFKBP133|KIAA0674|PPP1R76CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

9q32

10q11.21

Type of geneprotein-codingprotein-coding
DescriptionFK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2018052320180527
UniProtAcc

Q5T1M5

P07949

Ensembl transtripts involved in fusion geneENST00000238256, ENST00000493847, 
ENST00000355710, ENST00000340058, 
Fusion gene scores* DoF score4 X 5 X 3=6018 X 10 X 7=1260
# samples 665
** MAII scorelog2(6/60*10)=0log2(65/1260*10)=-0.954912110471462
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP15 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFKBP15

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLAMLTCGA-AB-2971-03AFKBP15chr9

115936842

-RETchr10

43607584

+
TCGARVTHCATCGA-ET-A3DQ-01AFKBP15chr9

115932802

-RETchr10

43612032

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000238256ENST00000355710FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000238256ENST00000340058FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000493847ENST00000355710FKBP15chr9

115936842

-RETchr10

43607584

+
intron-3CDSENST00000493847ENST00000340058FKBP15chr9

115936842

-RETchr10

43607584

+
In-frameENST00000238256ENST00000355710FKBP15chr9

115932802

-RETchr10

43612032

+
In-frameENST00000238256ENST00000340058FKBP15chr9

115932802

-RETchr10

43612032

+
intron-3CDSENST00000493847ENST00000355710FKBP15chr9

115932802

-RETchr10

43612032

+
intron-3CDSENST00000493847ENST00000340058FKBP15chr9

115932802

-RETchr10

43612032

+

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FusionProtFeatures for FKBP15_RET


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP15

Q5T1M5

RET

P07949

May be involved in the cytoskeletal organization ofneuronal growth cones. Seems to be inactive as a PPIase (Bysimilarity). Involved in the transport of early endosomes at thelevel of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. Receptor tyrosine-protein kinase involved in numerouscellular mechanisms including cell proliferation, neuronalnavigation, cell migration, and cell differentiation upon bindingwith glial cell derived neurotrophic factor family ligands.Phosphorylates PTK2/FAK1. Regulates both cell death/survivalbalance and positional information. Required for the molecularmechanisms orchestration during intestine organogenesis; involvedin the development of enteric nervous system and renalorganogenesis during embryonic life, and promotes the formation ofPeyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via itscleavage by caspase in sympathetic neurons and mediates cellmigration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner.Involved in the development of the neural crest. Active in theabsence of ligand, triggering apoptosis through a mechanism thatrequires receptor intracellular caspase cleavage. Acts as adependence receptor; in the presence of the ligand GDNF insomatotrophs (within pituitary), promotes survival and downregulates growth hormone (GH) production, but triggers apoptosisin absence of GDNF. Regulates nociceptor survival and size.Triggers the differentiation of rapidly adapting (RA)mechanoreceptors. Mediator of several diseases such asneuroendocrine cancers; these diseases are characterized byaberrant integrins-regulated cell migration. Mediates, throughinteraction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways(PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 incomplex with GFRAL induces higher activation of MAPK-signalingpathway than isoform 2 in complex with GFRAL (PubMed:28846099).{ECO:0000269|PubMed:20064382, ECO:0000269|PubMed:20616503,ECO:0000269|PubMed:20702524, ECO:0000269|PubMed:21357690,ECO:0000269|PubMed:21454698, ECO:0000269|PubMed:28846097,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528522_7899221220Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528818_8789221220Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528197_2909221220DomainPPIase FKBP-type
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-252872_1699221220RegionImportant for function in growth cone organization
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019724_10167121073DomainProtein kinase
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020724_10167121115DomainProtein kinase
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019730_7387121073Nucleotide bindingATP
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020730_7387121115Nucleotide bindingATP
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019805_8077121073RegionNote=Inhibitors binding
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020805_8077121115RegionNote=Inhibitors binding

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-2528925_9519221220Coiled coilOntology_term=ECO:0000255
HgeneFKBP15chr9:115932802chr10:43612032ENST00000238256-25281208_12169221220Compositional biasNote=Poly-Asp
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019168_2727121073DomainCadherin
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020168_2727121115DomainCadherin
TgeneRETchr9:115932802chr10:43612032ENST00000340058+101929_6357121073Topological domainExtracellular
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019658_11147121073Topological domainCytoplasmic
TgeneRETchr9:115932802chr10:43612032ENST00000355710+102029_6357121115Topological domainExtracellular
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020658_11147121115Topological domainCytoplasmic
TgeneRETchr9:115932802chr10:43612032ENST00000340058+1019636_6577121073TransmembraneHelical
TgeneRETchr9:115932802chr10:43612032ENST00000355710+1020636_6577121115TransmembraneHelical


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FusionGeneSequence for FKBP15_RET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_1325aa
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHATRYTNGQT
VKQGKFGAAVLGNHTARETRILLTISQQQPVTVARIHVNFELMVRPNNTSTFTDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVATTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPTAGMQAYATPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRTVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPR

>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_1283aa
MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQATPKTAPATMSTPTILVATAVHATRYTNGQT
VKQGKFGAAVLGNHTARETRILLTISQQQPVTVARIHVNFELMVRPNNTSTFTDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVATTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKGWEDGMLGMKKGGKRLLIVPPACAVGSEGVI
GWTQATDSILVFEVEVRRVKFARDSGSDGHSVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALPQMTSQAPQPSVTGLQAPSAALMQVSSLDSH
SAVSGNAQSFQPTAGMQAYATPQASAVTSQLQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIERNQRTVEQSNLMMEKRNNSLQTATENTQAR
VLHAEQEKAKVTEELAAATAQVSHLQLKMTAHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLKKTRVSTDQAAAEQLSLVQAELQTQWEAKCE
HLLASAKDEHLQQYQEVCAQRDAYQQKLVQLQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
QVNHPHVIKLTGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQTLAEMKL
VHRDLAARNILVAEGRKMKISDFGLSRDVTEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPTPGIPPERL
FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLITDDGLSEEETPLVDCNNAPLPR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_3975nt
ATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATTGGCCTCACTTTTTGGACTGGATCAGGCA
GCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCAGGGAACGGCAGCAACAGGAAATCAGGCA
ACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCATGCATATCGATACACAAATGGTCAATAT
GTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGATTCTTCTTTATATCAGTCAACAACAGCCA
GTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCACCTTTTATGATGACCAGAGACAGAACTGG
TCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAAGTGCAACAGTACCTCTTCCCTGGATGCA
GTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGAAGTGGCCTATACCGGCTGGCTCTTTCAG
AATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAAGTTAGGATCAGGAAAAGTCATCAAGGGC
TGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGCCTGTGCTGTTGGCTCAGAAGGGGTAATA
GGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTTTGCCAGAGATTCTGGCTCTGATGGTCAC
AGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGCTGATCCTGTTGTGTCACCACCCACATCA
ATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACTTGCAATAAATACAAGTCCCGATGCAGTC
AAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACCACAGCTGGATTCCAATGATTCAGAAATC
GAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTCTCTTCATCCGGCCCATCCAGCGTTACCA
CAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTTAATGCAAGTGTCATCTCTCGATTCCCAC
TCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTATCCCCAGGCATCTGCCGTCACCTCCCAG
CTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATCAGGTGATATGGCTTCATTTCTCATGACT
GAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGATCATCTCATGACTAAGGTTGAAGAGTTA
CAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAGCATGATTATGAGCAACATCCAGCGAATC
ATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACAGAATGACAAGATTAGTGAACTAATTGAA
CGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCAGACAGCCACAGAAAACACACAGGCAAGA
GTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACAGGTCTCTCATCTGCAGCTGAAAATGACT
GCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGATCTTCTCAGGGGCCAGCTCACCAAAGTG
CAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGAAAAGCAGAACCGGAAACAACTGGAACTC
AAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAAGAACCTCTCAGAAAGGAAAAAGAAGTCA
GCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGAATTGGACAAACTTCGACAGCTCTTGAAA
AAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCTACAGACCCAGTGGGAAGCAAAATGTGAA
CATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAGAGATGCCTACCAGCAGAAGCTGGTACAA
CTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACAGCACATCAAGGAACTAGAGAAGAACAAG
TCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCATGAACCAGGTGTTCCAGTCCTTACGGAGA
GAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGGAGGATCCAAAGTGGGAATTCCCT
CGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCA
GGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAG
CAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGC
TCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCAC
CCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTC
GTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTAT
GAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACG
CAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTC
TTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAG
GAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCG
TCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGA
GCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGGAGAGAGTCCTGTACCACTCACGAGAGCT
GATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCTTTCACCCTCAGCGGCAAAATTAATGGAC

>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_3849nt
ATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATTGGCCTCACTTTTTGGACTGGATCAGGCA
GCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCAGGGAACGGCAGCAACAGGAAATCAGGCA
ACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCATGCATATCGATACACAAATGGTCAATAT
GTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGATTCTTCTTTATATCAGTCAACAACAGCCA
GTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCACCTTTTATGATGACCAGAGACAGAACTGG
TCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAAGTGCAACAGTACCTCTTCCCTGGATGCA
GTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGAAGTGGCCTATACCGGCTGGCTCTTTCAG
AATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAAGTTAGGATCAGGAAAAGTCATCAAGGGC
TGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGCCTGTGCTGTTGGCTCAGAAGGGGTAATA
GGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTTTGCCAGAGATTCTGGCTCTGATGGTCAC
AGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGCTGATCCTGTTGTGTCACCACCCACATCA
ATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACTTGCAATAAATACAAGTCCCGATGCAGTC
AAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACCACAGCTGGATTCCAATGATTCAGAAATC
GAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTCTCTTCATCCGGCCCATCCAGCGTTACCA
CAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTTAATGCAAGTGTCATCTCTCGATTCCCAC
TCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTATCCCCAGGCATCTGCCGTCACCTCCCAG
CTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATCAGGTGATATGGCTTCATTTCTCATGACT
GAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGATCATCTCATGACTAAGGTTGAAGAGTTA
CAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAGCATGATTATGAGCAACATCCAGCGAATC
ATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACAGAATGACAAGATTAGTGAACTAATTGAA
CGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCAGACAGCCACAGAAAACACACAGGCAAGA
GTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACAGGTCTCTCATCTGCAGCTGAAAATGACT
GCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGATCTTCTCAGGGGCCAGCTCACCAAAGTG
CAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGAAAAGCAGAACCGGAAACAACTGGAACTC
AAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAAGAACCTCTCAGAAAGGAAAAAGAAGTCA
GCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGAATTGGACAAACTTCGACAGCTCTTGAAA
AAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCTACAGACCCAGTGGGAAGCAAAATGTGAA
CATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAGAGATGCCTACCAGCAGAAGCTGGTACAA
CTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACAGCACATCAAGGAACTAGAGAAGAACAAG
TCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCATGAACCAGGTGTTCCAGTCCTTACGGAGA
GAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGGAGGATCCAAAGTGGGAATTCCCT
CGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGCAACGGCCTTCCATCTGAAAGGCAGAGCA
GGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGACCTGCTGTCAGAGTTCAACGTCCTGAAG
CAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCTCCTCATCGTGGAGTACGCCAAATACGGC
TCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGGCAGCCGCAACTCCAGCTCCCTGGACCAC
CCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGGGATGCAGTATCTGGCCGAGATGAAGCTC
GTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTCGGATTTCGGCTTGTCCCGAGATGTTTAT
GAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGAATCCCTTTTTGATCATATCTACACCACG
CAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCCCTATCCTGGGATTCCTCCTGAGCGGCTC
TTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTACCGCCTGATGCTGCAATGCTGGAAGCAG
GAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAAGAGGAGAGACTACTTGGACCTTGCGGCG
TCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGTGGACTGTAATAATGCCCCCCTCCCTCGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000355710_chr10_43612032_+_6175nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGCATGTCAGACCCGAACTGGCCTGG
AGAGAGTCCTGTACCACTCACGAGAGCTGATGGCACTAACACTGGGTTTCCAAGATATCCAAATGATAGTGTATATGCTAACTGGATGCT
TTCACCCTCAGCGGCAAAATTAATGGACACGTTTGATAGTTAACATTTCTTTGTGAAAGGTAATGGACTCACAAGGGGAAGAAACATGCT
GAGAATGGAAAGTCTACCGGCCCTTTCTTTGTGAACGTCACATTGGCCGAGCCGTGTTCAGTTCCCAGGTGGCAGACTCGTTTTTGGTAG
TTTGTTTTAACTTCCAAGGTGGTTTTACTTCTGATAGCCGGTGATTTTCCCTCCTAGCAGACATGCCACACCGGGTAAGAGCTCTGAGTC
TTAGTGGTTAAGCATTCCTTTCTCTTCAGTGCCCAGCAGCACCCAGTGTTGGTCTGTGTCCATCAGTGACCACCAACATTCTGTGTTCAC
ATGTGTGGGTCCAACACTTACTACCTGGTGTATGAAATTGGACCTGAACTGTTGGATTTTTCTAGTTGCCGCCAAACAAGGCAAAAAAAT
TTAAACATGAAGCACACACACAAAAAAGGCAGTAGGAAAAATGCTGGCCCTGATGACCTGTCCTTATTCAGAATGAGAGACTGCGGGGGG
GGCCTGGGGGTAGTGTCAATGCCCCTCCAGGGCTGGAGGGGAAGAGGGGCCCCGAGGATGGGCCTGGGCTCAGCATTCGAGATCTTGAGA
ATGATTTTTTTTAAATCATGCAACCTTTCCTTAGGAAGACATTTGGTTTTCATCATGATTAAGATGATTCCTAGATTTAGCACAATGGAG
AGATTCCATGCCATCTTTACTATGTGGATGGTGGTATCAGGGAAGAGGGCTCACAAGACACATTTGTCCCCCGGGCCCACCACATCATCC
TCACGTGTTCGGTACTGAGCAGCCACTACCCCTGATGAGAACAGTATGAAGAAAGGGGGCTGTTGGAGTCCCAGAATTGCTGACAGCAGA
GGCTTTGCTGCTGTGAATCCCACCTGCCACCAGCCTGCAGCACACCCCACAGCCAAGTAGAGGCGAAAGCAGTGGCTCATCCTACCTGTT
AGGAGCAGGTAGGGCTTGTACTCACTTTAATTTGAATCTTATCAACTTACTCATAAAGGGACAGGCTAGCTAGCTGTGTTAGAAGTAGCA
ATGACAATGACCAAGGACTGCTACACCTCTGATTACAATTCTGATGTGAAAAAGATGGTGTTTGGCTCTTATAGAGCCTGTGTGAAAGGC
CCATGGATCAGCTCTTCCTGTGTTTGTAATTTAATGCTGCTACAAGATGTTTCTGTTTCTTAGATTCTGACCATGACTCATAAGCTTCTT
GTCATTCTTCATTGCTTGTTTGTGGTCACAGATGCACAACACTCCTCCAGTCTTGTGGGGGCAGCTTTTGGGAAGTCTCAGCAGCTCTTC
TGGCTGTGTTGTCAGCACTGTAACTTCGCAGAAAAGAGTCGGATTACCAAAACACTGCCTGCTCTTCAGACTTAAAGCACTGATAGGACT
TAAAATAGTCTCATTCAAATACTGTATTTTATATAGGCATTTCACAAAAACAGCAAAATTGTGGCATTTTGTGAGGCCAAGGCTTGGATG
CGTGTGTAATAGAGCCTTGTGGTGTGTGCGCACACACCCAGAGGGAGAGTTTGAAAAATGCTTATTGGACACGTAACCTGGCTCTAATTT
GGGCTGTTTTTCAGATACACTGTGATAAGTTCTTTTACAAATATCTATAGACATGGTAAACTTTTGGTTTTCAGATATGCTTAATGATAG
TCTTACTAAATGCAGAAATAAGAATAAACTTTCTCAAATTATTAAAAATGCCTACACAGTAAGTGTGAATTGCTGCAACAGGTTTGTTCT
CAGGAGGGTAAGAACTCCAGGTCTAAACAGCTGACCCAGTGATGGGGAATTTATCCTTGACCAATTTATCCTTGACCAATAACCTAATTG
TCTATTCCTGAGTTATAAAAGTCCCCATCCTTATTAGCTCTACTGGAATTTTCATACACGTAAATGCAGAAGTTACTAAGTATTAAGTAT
TACTGAGTATTAAGTAGTAATCTGTCAGTTATTAAAATTTGTAAAATCTATTTATGAAAGGTCATTAAACCAGATCATGTTCCTTTTTTT

>In-frame_FKBP15_ENST00000238256_chr9_115932802_-_RET_ENST00000340058_chr10_43612032_+_4717nt
AGTTCGCCCTGCCGGAAAGCAGCACGCCGCCGCGGCATTTTACGACGTCGGCGGTGACAGGCCCTGGGACTCTGGGAATACCCAGCTTCC
TCCCCGCAACCCGGTGAAAGCCAACGCAATGTTCGGTGCGGGGGACGAGGACGACACCGATTTCCTCTCGCCGAGCGGCGGTGCCAGATT
GGCCTCACTTTTTGGACTGGATCAGGCAGCTGCTGGCCATGGAAATGAATTTTTCCAGTACACAGCCCCAAAACAGCCTAAGAAAGGCCA
GGGAACGGCAGCAACAGGAAATCAGGCAACACCAAAAACAGCACCAGCCACCATGAGCACTCCCACAATACTGGTCGCAACAGCAGTCCA
TGCATATCGATACACAAATGGTCAATATGTAAAGCAGGGCAAATTTGGTGCTGCAGTTCTGGGGAACCACACAGCCAGAGAGTATAGGAT
TCTTCTTTATATCAGTCAACAACAGCCAGTTACGGTTGCTAGGATTCATGTGAACTTTGAGCTAATGGTTCGGCCCAATAACTATAGCAC
CTTTTATGATGACCAGAGACAGAACTGGTCCATCATGTTTGAGTCGGAAAAGGCTGCTGTGGAGTTCAATAAGCAGGTGTGCATTGCTAA
GTGCAACAGTACCTCTTCCCTGGATGCAGTGCTCTCCCAGGACCTCATTGTGGCAGACGGCCCTGCTGTAGAAGTTGGAGATTCTTTGGA
AGTGGCCTATACCGGCTGGCTCTTTCAGAATCATGTGCTGGGCCAGGTTTTCGACTCCACTGCTAACAAAGATAAGTTGCTTCGCTTGAA
GTTAGGATCAGGAAAAGTCATCAAGGGCTGGGAGGATGGAATGCTGGGCATGAAAAAAGGAGGAAAGCGATTGCTTATTGTCCCTCCAGC
CTGTGCTGTTGGCTCAGAAGGGGTAATAGGCTGGACTCAAGCAACGGACTCGATCCTGGTGTTCGAGGTGGAGGTTAGGCGGGTGAAGTT
TGCCAGAGATTCTGGCTCTGATGGTCACAGTGTTAGTTCCCGCGATTCTGCAGCTCCGTCTCCCATCCCTGGTGCTGACAACCTCTCTGC
TGATCCTGTTGTGTCACCACCCACATCAATACCTTTCAAATCAGGGGAGCCAGCTCTTCGTACCAAATCTAACTCCCTCAGTGAACAACT
TGCAATAAATACAAGTCCCGATGCAGTCAAAGCCAAGTTGATCTCTCGGATGGCTAAAATGGGCCAGCCCATGCTGCCCATCCTTCCACC
ACAGCTGGATTCCAATGATTCAGAAATCGAAGATGTGAACACTCTGCAAGGAGGTGGGCAGCCTGTGGTGACTCCGTCCGTCCAGCCCTC
TCTTCATCCGGCCCATCCAGCGTTACCACAGATGACCTCACAGGCACCTCAGCCATCTGTTACTGGGCTCCAGGCACCTTCTGCTGCCTT
AATGCAAGTGTCATCTCTCGATTCCCACTCAGCTGTATCTGGAAATGCCCAATCCTTTCAGCCCTATGCAGGTATGCAAGCCTACGCTTA
TCCCCAGGCATCTGCCGTCACCTCCCAGCTGCAGCCCGTTCGGCCTTTGTACCCAGCACCGCTCTCTCAGCCTCCCCATTTCCAAGGATC
AGGTGATATGGCTTCATTTCTCATGACTGAAGCCCGGCAACATAACACTGAAATTCGAATGGCAGTCAGCAAAGTGGCTGATAAAATGGA
TCATCTCATGACTAAGGTTGAAGAGTTACAGAAACATAGTGCTGGCAATTCCATGCTTATTCCTAGCATGTCAGTTACAATGGAAACAAG
CATGATTATGAGCAACATCCAGCGAATCATTCAGGAAAATGAAAGATTGAAGCAAGAGATCCTTGAAAAGAGCAATCGGATAGAAGAACA
GAATGACAAGATTAGTGAACTAATTGAACGAAATCAGAGGTATGTTGAGCAGAGTAACCTGATGATGGAGAAGAGGAACAACTCACTTCA
GACAGCCACAGAAAACACACAGGCAAGAGTATTGCATGCTGAACAAGAGAAGGCCAAGGTGACAGAGGAGTTAGCAGCGGCCACTGCACA
GGTCTCTCATCTGCAGCTGAAAATGACTGCTCACCAAAAAAAGGAAACAGAGCTGCAGATGCAGCTGACAGAAAGCCTGAAGGAGACAGA
TCTTCTCAGGGGCCAGCTCACCAAAGTGCAGGCAAAGCTCTCAGAGCTCCAAGAAACCTCTGAGCAAGCACAGTCCAAATTCAAAAGTGA
AAAGCAGAACCGGAAACAACTGGAACTCAAGGTGACATCCCTGGAGGAGGAACTGACTGACCTTCGAGTTGAGAAGGAGTCCTTGGAAAA
GAACCTCTCAGAAAGGAAAAAGAAGTCAGCTCAAGAGCGTTCTCAGGCCGAGGAGGAGATAGATGAAATTCGCAAGTCATACCAGGAGGA
ATTGGACAAACTTCGACAGCTCTTGAAAAAGACTCGAGTGTCCACAGACCAAGCAGCTGCAGAGCAGCTGTCTTTAGTACAGGCTGAGCT
ACAGACCCAGTGGGAAGCAAAATGTGAACATTTGTTGGCCTCCGCCAAGGATGAGCACCTGCAGCAGTACCAGGAGGTGTGCGCACAGAG
AGATGCCTACCAGCAGAAGCTGGTACAACTTCAGGAAAAGTGTTTAGCCCTCCAGGCCCAAATCACAGCTCTCACCAAGCAAAATGAACA
GCACATCAAGGAACTAGAGAAGAACAAGTCCCAGATGTCTGGGGTTGAAGCTGCTGCATCTGACCCCTCAGAGAAGGTCAAGAAGATCAT
GAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGAT
CAAGGAGGATCCAAAGTGGGAATTCCCTCGGAAGAACTTGGTTCTTGGAAAAACTCTAGGAGAAGGCGAATTTGGAAAAGTGGTCAAGGC
AACGGCCTTCCATCTGAAAGGCAGAGCAGGGTACACCACGGTGGCCGTGAAGATGCTGAAAGAGAACGCCTCCCCGAGTGAGCTGCGAGA
CCTGCTGTCAGAGTTCAACGTCCTGAAGCAGGTCAACCACCCACATGTCATCAAATTGTATGGGGCCTGCAGCCAGGATGGCCCGCTCCT
CCTCATCGTGGAGTACGCCAAATACGGCTCCCTGCGGGGCTTCCTCCGCGAGAGCCGCAAAGTGGGGCCTGGCTACCTGGGCAGTGGAGG
CAGCCGCAACTCCAGCTCCCTGGACCACCCGGATGAGCGGGCCCTCACCATGGGCGACCTCATCTCATTTGCCTGGCAGATCTCACAGGG
GATGCAGTATCTGGCCGAGATGAAGCTCGTTCATCGGGACTTGGCAGCCAGAAACATCCTGGTAGCTGAGGGGCGGAAGATGAAGATTTC
GGATTTCGGCTTGTCCCGAGATGTTTATGAAGAGGATTCCTACGTGAAGAGGAGCCAGGGTCGGATTCCAGTTAAATGGATGGCAATTGA
ATCCCTTTTTGATCATATCTACACCACGCAAAGTGATGTATGGTCTTTTGGTGTCCTGCTGTGGGAGATCGTGACCCTAGGGGGAAACCC
CTATCCTGGGATTCCTCCTGAGCGGCTCTTCAACCTTCTGAAGACCGGCCACCGGATGGAGAGGCCAGACAACTGCAGCGAGGAGATGTA
CCGCCTGATGCTGCAATGCTGGAAGCAGGAGCCGGACAAAAGGCCGGTGTTTGCGGACATCAGCAAAGACCTGGAGAAGATGATGGTTAA
GAGGAGAGACTACTTGGACCTTGCGGCGTCCACTCCATCTGACTCCCTGATTTATGACGACGGCCTCTCAGAGGAGGAGACACCGCTGGT
GGACTGTAATAATGCCCCCCTCCCTCGAGCCCTCCCTTCCACATGGATTGAAAACAAACTCTATGGTAGAATTTCCCATGCATTTACTAG
ATTCTAGCACCGCTGTCCCCTTTGCACTATCCTTCCTCTCTGTGATGCTTTTTAAAAATGTTTCTGGTCTGAACAAAACCAAAGTCTGCT
CTGAACCTTTTTATTTGTAAATGTCTGACTTTGCATCCAGTTTACATTTAGGCATTATTGCAACTATGTTTTTCTAAAAGGATGTGAAAA
TAAGTGTAATTACCACATTGCCCAGCAACTTAGGATGGTAGAGGAAAAAACAGATCAGGGCGGAACTCTCAGGGGAGACCAAGAACAGGT
TGAATAAGGCGCTTCTGGGGTGGGAATCAAGTCATAGTACTTCTACTTTAACTAAGTGGATAAATATACAAATCTGGGGAGGTATTCAGT
TGAGAAAGGAGCCACCAGCACCACTCAGCCTGCACTGGGAGCACAGCCAGGTTCCCCCAGACCCCTCCTGGGCAGGCAGGTGCCTCTCAG
AGGCCACCCGGCACTGGCGAGCAGCCACTGGCCAAGCCTCAGCCCCAGTCCCAGCCACATGTCCTCCATCAGGGGTAGCGAGGTTGCAGG
AGCTGGCTGGCCCTGGGAGGACGCACCCCCACTGCTGTTTTCACATCCTTTCCCTTACCCACCTTCAGGACGGTTGTCACTTATGAAGTC
AGTGCTAAAGCTGGAGCAGTTGCTTTTTGAAAGAACATGGTCTGTGGTGCTGTGGTCTTACAATGGACAGTAAATATGGTTCTTGCCAAA


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FusionGenePPI for FKBP15_RET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FKBP15SP1, FAM21C, CDK19, VCP, STRN3, RPA1, RPA2, RPA3, LGR4, SNAP29, SSFA2, NUDT12, FBF1, XPO1, PRPF4, VPS26A, CTR9, VPS26B, KIAA0196, KIAA1033, TTBK2, UBC, MCM2, RHOU, WWOX, EXOC1, COMMD10, ZYX, ATP6V0D2, SERPINB2, STX11, C1orf87, AIPL1, MIOS, FGFR1OP, PDE5A, VPS29, HDAC6RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP15_RET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRETP07949DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved
TgeneRETP07949DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational
TgeneRETP07949DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000305}small moleculeapproved|investigational

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RelatedDiseases for FKBP15_RET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFKBP15C0236733Amphetamine-Related Disorders1CTD_human
HgeneFKBP15C0236969Substance-Related Disorders1CTD_human
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 115UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a14CTD_human;ORPHANET;UNIPROT
TgeneRETC1833921Familial medullary thyroid carcinoma14CTD_human;ORPHANET;UNIPROT
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b8CTD_human;ORPHANET;UNIPROT
TgeneRETC1275808Congenital central hypoventilation4CTD_human;ORPHANET;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human;HPO;ORPHANET
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia1CTD_human
TgeneRETC0031511Pheochromocytoma1CTD_human;HPO;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CTD_human;HPO
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;ORPHANET