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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13496

FusionGeneSummary for FKBP11_TENM3

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP11_TENM3
Fusion gene ID: 13496
HgeneTgene
Gene symbol

FKBP11

TENM3

Gene ID

51303

55714

Gene nameFK506 binding protein 11teneurin transmembrane protein 3
SynonymsFKBP19MCOPCB9|ODZ3|TNM3|Ten-m3|ten-3
Cytomap

12q13.12

4q34.3-q35.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP1119 kDa FK506-binding protein19 kDa FKBPFK506 binding protein 11, 19 kDaFKBP-11FKBP-19PPIase FKBP11rotamaseteneurin-3ODZ3-like proteinodz, odd Oz/ten-m homolog 3protein Odd Oz/ten-m homolog 3tenascin-M3testicular tissue protein Li 195
Modification date2018052220180523
UniProtAcc

Q9NYL4

Q9P273

Ensembl transtripts involved in fusion geneENST00000444214, ENST00000550765, 
ENST00000552878, ENST00000453172, 
ENST00000511685, ENST00000406950, 
ENST00000502950, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 2=32
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FKBP11 [Title/Abstract] AND TENM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF964329FKBP11chr12

49316146

+TENM3chr4

183723933

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000444214ENST00000511685FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000444214ENST00000406950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000444214ENST00000502950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-3UTRENST00000550765ENST00000511685FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000550765ENST00000406950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000550765ENST00000502950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-3UTRENST00000552878ENST00000511685FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000552878ENST00000406950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000552878ENST00000502950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-3UTRENST00000453172ENST00000511685FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000453172ENST00000406950FKBP11chr12

49316146

+TENM3chr4

183723933

+
intron-intronENST00000453172ENST00000502950FKBP11chr12

49316146

+TENM3chr4

183723933

+

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FusionProtFeatures for FKBP11_TENM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP11

Q9NYL4

TENM3

Q9P273

PPIases accelerate the folding of proteins duringprotein synthesis. Involved in neural development by regulating theestablishment of proper connectivity within the nervous system.Acts in both pre- and postsynaptic neurons in the hippocampus tocontrol the assembly of a precise topographic projection: requiredin both CA1 and subicular neurons for the precise targeting ofproximal CA1 axons to distal subiculum, probably by promotinghomophilic cell adhesion. Required for proper dendritemorphogenesis and axon targeting in the vertebrate visual system,thereby playing a key role in the development of the visualpathway. Regulates the formation in ipsilateral retinal mapping toboth the dorsal lateral geniculate nucleus (dLGN) and the superiorcolliculus (SC). May also be involved in the differentiation ofthe fibroblast-like cells in the superficial layer of mandibularcondylar cartilage into chondrocytes.{ECO:0000250|UniProtKB:Q9WTS6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP11_TENM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP11_TENM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP11_TENM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP11_TENM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTENM3C0236736Cocaine-Related Disorders1CTD_human
TgeneTENM3C0264423Asthma, Occupational1CTD_human