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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13484

FusionGeneSummary for FIP1L1_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: FIP1L1_SCFD2
Fusion gene ID: 13484
HgeneTgene
Gene symbol

FIP1L1

SCFD2

Gene ID

81608

152579

Gene namefactor interacting with PAPOLA and CPSF1sec1 family domain containing 2
SynonymsFIP1|Rhe|hFip1STXBP1L1
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophiliasec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018052320180519
UniProtAcc

Q6UN15

Q8WU76

Ensembl transtripts involved in fusion geneENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
ENST00000401642, ENST00000388940, 
Fusion gene scores* DoF score7 X 8 X 5=28010 X 8 X 10=800
# samples 1011
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FIP1L1 [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-7707-01AFIP1L1chr4

54266006

+SCFD2chr4

54179930

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000507166ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000507166ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000358575ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000358575ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000337488ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000337488ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000507922ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000507922ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000306932ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
In-frameENST00000306932ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
intron-3CDSENST00000510668ENST00000401642FIP1L1chr4

54266006

+SCFD2chr4

54179930

-
intron-3CDSENST00000510668ENST00000388940FIP1L1chr4

54266006

+SCFD2chr4

54179930

-

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FusionProtFeatures for FIP1L1_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FIP1L1

Q6UN15

SCFD2

Q8WU76

May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000306932+815356_406233521Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000306932+815456_562233521Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000306932+815478_594233521Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000337488+1018356_406271595Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000337488+1018456_562271595Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000337488+1018478_594271595Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000358575+918356_406256589Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000358575+918456_562256589Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000358575+918478_594256589Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507166+1024356_406271850Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507166+1024456_562271850Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507166+1024478_594271850Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507922+912356_406256379Compositional biasNote=Pro-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507922+912456_562256379Compositional biasNote=Arg-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507922+912478_594256379Compositional biasNote=Glu-rich
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000306932+8151_356233521RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000306932+815457_490233521RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000337488+10181_356271595RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000337488+1018457_490271595RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000358575+9181_356256589RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000358575+918457_490256589RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507166+10241_356271850RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507166+1024457_490271850RegionArg/Asp/Glu-rich domain
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507922+9121_356256379RegionNote=Necessary for stimulating PAPOLA activity
HgeneFIP1L1chr4:54266006chr4:54179930ENST00000507922+912457_490256379RegionArg/Asp/Glu-rich domain
TgeneSCFD2chr4:54266006chr4:54179930ENST00000388940-18120_124335640Compositional biasNote=Poly-Ala
TgeneSCFD2chr4:54266006chr4:54179930ENST00000401642-19120_124335685Compositional biasNote=Poly-Ala


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FusionGeneSequence for FIP1L1_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FIP1L1_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FIP1L1CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FIP1L1_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FIP1L1_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFIP1L1C1540912Hypereosinophilic syndrome1CTD_human