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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13481

FusionGeneSummary for FIP1L1_FIP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: FIP1L1_FIP1L1
Fusion gene ID: 13481
HgeneTgene
Gene symbol

FIP1L1

FIP1L1

Gene ID

81608

81608

Gene namefactor interacting with PAPOLA and CPSF1factor interacting with PAPOLA and CPSF1
SynonymsFIP1|Rhe|hFip1FIP1|Rhe|hFip1
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophiliapre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2018052320180523
UniProtAcc

Q6UN15

Q6UN15

Ensembl transtripts involved in fusion geneENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
ENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
Fusion gene scores* DoF score7 X 8 X 5=2809 X 10 X 5=450
# samples 1013
** MAII scorelog2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/450*10)=-1.79141337818858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FIP1L1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF763372FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
ChiTaRS3.1AJ708056FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
ChiTaRS3.1BF801893FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000507166ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507166ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000358575ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000358575ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000337488ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000337488ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000507922ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
Frame-shiftENST00000306932ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
5CDS-intronENST00000306932ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000507166FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000358575FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000337488FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000507922FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-3CDSENST00000510668ENST00000306932FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54310271

+FIP1L1chr4

54292038

+
intron-intronENST00000507166ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000358575ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000337488ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000306932ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000507166FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000358575FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000337488FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000507922FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000306932FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54282394

+FIP1L1chr4

54262298

+
intron-3CDSENST00000507166ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507166ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507166ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507166ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000358575ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000358575ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000358575ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000337488ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000337488ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000337488ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000507922ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507922ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000507922ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
In-frameENST00000306932ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000306932ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
5CDS-intronENST00000306932ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000507166FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000358575FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000337488FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-3CDSENST00000510668ENST00000507922FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000510668ENST00000306932FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+
intron-intronENST00000510668ENST00000510668FIP1L1chr4

54319300

+FIP1L1chr4

54280779

+

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FusionProtFeatures for FIP1L1_FIP1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FIP1L1

Q6UN15

FIP1L1

Q6UN15


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FIP1L1_FIP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FIP1L1_FIP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FIP1L1CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1FIP1L1CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FIP1L1_FIP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FIP1L1_FIP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFIP1L1C1540912Hypereosinophilic syndrome1CTD_human
TgeneFIP1L1C1540912Hypereosinophilic syndrome1CTD_human