	FusionGeneSummary
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Fusion gene ID: 13481

FusionGeneSummary for FIP1L1_FIP1L1

Fusion gene summary

Fusion gene information	Fusion gene name: FIP1L1_FIP1L1
	Fusion gene ID: 13481
		Hgene	Tgene
	Gene symbol	FIP1L1	FIP1L1
	Gene ID	81608	81608
	Gene name	factor interacting with PAPOLA and CPSF1	factor interacting with PAPOLA and CPSF1
	Synonyms	FIP1\|Rhe\|hFip1	FIP1\|Rhe\|hFip1
	Cytomap	4q12	4q12
	Type of gene	protein-coding	protein-coding
	Description	pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia	pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
	Modification date	20180523	20180523
	UniProtAcc	Q6UN15	Q6UN15
	Ensembl transtripts involved in fusion gene	ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668,	ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668,
Fusion gene scores	* DoF score	7 X 8 X 5=280	9 X 10 X 5=450
	# samples	10	13
	** MAII score	log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FIP1L1 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF763372	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
ChiTaRS3.1			AJ708056	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
ChiTaRS3.1			BF801893	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000507166	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507166	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507166	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507166	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507166	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-intron	ENST00000507166	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000358575	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000358575	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000358575	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000358575	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000358575	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
5CDS-intron	ENST00000358575	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000337488	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000337488	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000337488	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000337488	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000337488	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
5CDS-intron	ENST00000337488	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507922	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507922	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507922	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507922	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000507922	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-intron	ENST00000507922	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000306932	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000306932	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000306932	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000306932	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
Frame-shift	ENST00000306932	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
5CDS-intron	ENST00000306932	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000510668	ENST00000507166	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000510668	ENST00000358575	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000510668	ENST00000337488	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000510668	ENST00000507922	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-3CDS	ENST00000510668	ENST00000306932	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-intron	ENST00000510668	ENST00000510668	FIP1L1	chr4	54310271	+	FIP1L1	chr4	54292038	+
intron-intron	ENST00000507166	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507166	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507166	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507166	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507166	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507166	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000358575	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000337488	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000507922	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000306932	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000507166	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000358575	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000337488	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000507922	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000306932	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-intron	ENST00000510668	ENST00000510668	FIP1L1	chr4	54282394	+	FIP1L1	chr4	54262298	+
intron-3CDS	ENST00000507166	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507166	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507166	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507166	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000507166	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000507166	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000358575	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000358575	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000358575	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000358575	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000358575	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000358575	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000337488	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000337488	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000337488	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000337488	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000337488	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000337488	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507922	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507922	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507922	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000507922	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000507922	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000507922	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000306932	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000306932	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000306932	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
In-frame	ENST00000306932	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000306932	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
5CDS-intron	ENST00000306932	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000510668	ENST00000507166	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000510668	ENST00000358575	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000510668	ENST00000337488	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-3CDS	ENST00000510668	ENST00000507922	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000510668	ENST00000306932	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+
intron-intron	ENST00000510668	ENST00000510668	FIP1L1	chr4	54319300	+	FIP1L1	chr4	54280779	+

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FusionProtFeatures for FIP1L1_FIP1L1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FIP1L1 Q6UN15	FIP1L1 Q6UN15

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for FIP1L1_FIP1L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FIP1L1_FIP1L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
FIP1L1	CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1	FIP1L1	CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for FIP1L1_FIP1L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FIP1L1_FIP1L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FIP1L1	C1540912	Hypereosinophilic syndrome	1	CTD_human
Tgene	FIP1L1	C1540912	Hypereosinophilic syndrome	1	CTD_human

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Fusion gene ID: 13481

FusionGeneSummary for FIP1L1_FIP1L1

FusionProtFeatures for FIP1L1_FIP1L1

FusionGeneSequence for FIP1L1_FIP1L1

FusionGenePPI for FIP1L1_FIP1L1

RelatedDrugs for FIP1L1_FIP1L1

RelatedDiseases for FIP1L1_FIP1L1