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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1346

FusionGeneSummary for AKAP7_AKAP7

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP7_AKAP7
Fusion gene ID: 1346
HgeneTgene
Gene symbol

AKAP7

AKAP7

Gene ID

9465

9465

Gene nameA-kinase anchoring protein 7A-kinase anchoring protein 7
SynonymsAKAP15|AKAP18AKAP15|AKAP18
Cytomap

6q23.2

6q23.2

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchoring protein 7A kinase (PRKA) anchor protein 7A-kinase anchor protein 18 kDaA-kinase anchor protein 9 kDaAKAP 18A-kinase anchoring protein 7A kinase (PRKA) anchor protein 7A-kinase anchor protein 18 kDaA-kinase anchor protein 9 kDaAKAP 18
Modification date2018052320180523
UniProtAcc

Q9P0M2

Q9P0M2

Ensembl transtripts involved in fusion geneENST00000431975, ENST00000541650, 
ENST00000366358, ENST00000368123, 
ENST00000537868, ENST00000263050, 
ENST00000342266, ENST00000474850, 
ENST00000431975, ENST00000541650, 
ENST00000366358, ENST00000368123, 
ENST00000537868, ENST00000263050, 
ENST00000342266, ENST00000474850, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AKAP7 [Title/Abstract] AND AKAP7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV333231AKAP7chr6

131582062

+AKAP7chr6

131577931

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000431975ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000431975ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000541650ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000366358ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000368123ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000537868ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000263050ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000342266ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000431975AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000541650AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000366358AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000368123AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000537868AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000263050AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000342266AKAP7chr6

131582062

+AKAP7chr6

131577931

+
intron-intronENST00000474850ENST00000474850AKAP7chr6

131582062

+AKAP7chr6

131577931

+

Top

FusionProtFeatures for AKAP7_AKAP7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP7

Q9P0M2

AKAP7

Q9P0M2

Probably targets cAMP-dependent protein kinase (PKA) tothe cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity,whereas the free cytoplasmic form may negatively regulate ENaCchannel feedback inhibition by intracellular sodium.{ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820}. Probably targets cAMP-dependent protein kinase (PKA) tothe cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity,whereas the free cytoplasmic form may negatively regulate ENaCchannel feedback inhibition by intracellular sodium.{ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP7_AKAP7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP7_AKAP7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AKAP7_AKAP7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AKAP7_AKAP7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP7C0236969Substance-Related Disorders1CTD_human
TgeneAKAP7C0236969Substance-Related Disorders1CTD_human