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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13459

FusionGeneSummary for FHL2_TNKS1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FHL2_TNKS1BP1
Fusion gene ID: 13459
HgeneTgene
Gene symbol

FHL2

TNKS1BP1

Gene ID

2274

85456

Gene namefour and a half LIM domains 2tankyrase 1 binding protein 1
SynonymsAAG11|DRAL|FHL-2|SLIM-3|SLIM3TAB182
Cytomap

2q12.2

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionfour and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3182 kDa tankyrase-1-binding proteintankyrase 1 binding protein 1, 182kDatankyrase 1-binding protein of 182 kDatestis secretory sperm-binding protein Li 206a
Modification date2018052320180522
UniProtAcc

Q14192

Q9C0C2

Ensembl transtripts involved in fusion geneENST00000393352, ENST00000336660, 
ENST00000607522, ENST00000409177, 
ENST00000344213, ENST00000393353, 
ENST00000322142, ENST00000358129, 
ENST00000409807, ENST00000408995, 
ENST00000358252, ENST00000532437, 
ENST00000530920, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 6 X 2=72
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FHL2 [Title/Abstract] AND TNKS1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFHL2

GO:0000122

negative regulation of transcription by RNA polymerase II

15692560

HgeneFHL2

GO:0043066

negative regulation of apoptotic process

15692560


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF844047FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000393352ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000393352ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000393352ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000336660ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000336660ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000336660ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000607522ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000607522ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000607522ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000409177ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000409177ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000409177ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000344213ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000344213ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000344213ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000393353ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000393353ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000393353ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000322142ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000322142ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000322142ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000358129ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000358129ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000358129ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000409807ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000409807ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000409807ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000408995ENST00000358252FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-3UTRENST00000408995ENST00000532437FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-
intron-intronENST00000408995ENST00000530920FHL2chr2

106025429

+TNKS1BP1chr11

57067473

-

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FusionProtFeatures for FHL2_TNKS1BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FHL2

Q14192

TNKS1BP1

Q9C0C2

May function as a molecular transmitter linking varioussignaling pathways to transcriptional regulation. Negativelyregulates the transcriptional repressor E4F1 and may function incell growth. Inhibits the transcriptional activity of FOXO1 andits apoptotic function by enhancing the interaction of FOXO1 withSIRT1 and FOXO1 deacetylation. Negatively regulates thecalcineurin/NFAT signaling pathway in cardiomyocytes(PubMed:28717008). {ECO:0000269|PubMed:15692560,ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468,ECO:0000269|PubMed:28717008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FHL2_TNKS1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FHL2_TNKS1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FHL2_TNKS1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FHL2_TNKS1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHL2C0018800Cardiomegaly1CTD_human
HgeneFHL2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneFHL2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFHL2C1458155Mammary Neoplasms1CTD_human