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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13458

FusionGeneSummary for FHL2_RPL31

check button Fusion gene summary
Fusion gene informationFusion gene name: FHL2_RPL31
Fusion gene ID: 13458
HgeneTgene
Gene symbol

FHL2

RPL31

Gene ID

2274

6160

Gene namefour and a half LIM domains 2ribosomal protein L31
SynonymsAAG11|DRAL|FHL-2|SLIM-3|SLIM3L31
Cytomap

2q12.2

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionfour and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 360S ribosomal protein L31large ribosomal subunit protein eL31
Modification date2018052320180523
UniProtAcc

Q14192

P62899

Ensembl transtripts involved in fusion geneENST00000393352, ENST00000336660, 
ENST00000607522, ENST00000409177, 
ENST00000344213, ENST00000393353, 
ENST00000322142, ENST00000358129, 
ENST00000409807, ENST00000408995, 
ENST00000264258, ENST00000409000, 
ENST00000409028, ENST00000409320, 
ENST00000409733, ENST00000409650, 
ENST00000409038, ENST00000409711, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: FHL2 [Title/Abstract] AND RPL31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFHL2

GO:0000122

negative regulation of transcription by RNA polymerase II

15692560

HgeneFHL2

GO:0043066

negative regulation of apoptotic process

15692560

TgeneRPL31

GO:0002181

cytoplasmic translation

25957688


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AB024057FHL2chr2

106002816

-RPL31chr2

101676003

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000393352ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393352ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000336660ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
intron-intronENST00000607522ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409177ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000344213ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000393353ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000322142ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000358129ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000409807ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000264258FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409000FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409028FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409320FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409733FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409650FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409038FHL2chr2

106002816

-RPL31chr2

101676003

-
5CDS-intronENST00000408995ENST00000409711FHL2chr2

106002816

-RPL31chr2

101676003

-

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FusionProtFeatures for FHL2_RPL31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FHL2

Q14192

RPL31

P62899

May function as a molecular transmitter linking varioussignaling pathways to transcriptional regulation. Negativelyregulates the transcriptional repressor E4F1 and may function incell growth. Inhibits the transcriptional activity of FOXO1 andits apoptotic function by enhancing the interaction of FOXO1 withSIRT1 and FOXO1 deacetylation. Negatively regulates thecalcineurin/NFAT signaling pathway in cardiomyocytes(PubMed:28717008). {ECO:0000269|PubMed:15692560,ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468,ECO:0000269|PubMed:28717008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FHL2_RPL31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FHL2_RPL31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FHL2_RPL31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FHL2_RPL31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHL2C0018800Cardiomegaly1CTD_human
HgeneFHL2C0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneFHL2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFHL2C1458155Mammary Neoplasms1CTD_human
TgeneRPL31C1458155Mammary Neoplasms1CTD_human