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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13435

FusionGeneSummary for FGR_EFCAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: FGR_EFCAB2
Fusion gene ID: 13435
HgeneTgene
Gene symbol

FGR

EFCAB2

Gene ID

2268

84288

Gene nameFGR proto-oncogene, Src family tyrosine kinaseEF-hand calcium binding domain 2
SynonymsSRC2|c-fgr|c-src2|p55-Fgr|p55c-fgr|p58-Fgr|p58c-fgrCFAP200|DRC8
Cytomap

1p35.3

1q44

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologc-fgr protooncogenec-src-2 proto-oncogenefeline Gardner-Rasheed sarcoma viral oncogene homologp55-c-fgr proteinproto-oncogene c-Fgrproto-oncogene tyrosine-protedynein regulatory complex protein 8EF-hand calcium-binding domain-containing protein 2dynein regulatory complex subunit 8
Modification date2018052320180522
UniProtAcc

P09769

Q5VUJ9

Ensembl transtripts involved in fusion geneENST00000374005, ENST00000399173, 
ENST00000545953, ENST00000374004, 
ENST00000468038, 
ENST00000366523, 
ENST00000366522, ENST00000447569, 
ENST00000487845, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 2 X 1=4
# samples 22
** MAII scorelog2(2/4*10)=2.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: FGR [Title/Abstract] AND EFCAB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGR

GO:0018108

peptidyl-tyrosine phosphorylation

7519620|8327512

HgeneFGR

GO:0046777

protein autophosphorylation

2181286|8327512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC002836FGRchr1

27939139

-EFCAB2chr1

245250923

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000374005ENST00000366523FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374005ENST00000366522FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374005ENST00000447569FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374005ENST00000487845FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-3UTRENST00000399173ENST00000366523FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000399173ENST00000366522FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000399173ENST00000447569FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000399173ENST00000487845FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-3UTRENST00000545953ENST00000366523FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000545953ENST00000366522FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000545953ENST00000447569FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000545953ENST00000487845FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-3UTRENST00000374004ENST00000366523FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374004ENST00000366522FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374004ENST00000447569FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000374004ENST00000487845FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-3UTRENST00000468038ENST00000366523FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000468038ENST00000366522FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000468038ENST00000447569FGRchr1

27939139

-EFCAB2chr1

245250923

+
intron-intronENST00000468038ENST00000487845FGRchr1

27939139

-EFCAB2chr1

245250923

+

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FusionProtFeatures for FGR_EFCAB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGR

P09769

EFCAB2

Q5VUJ9

Non-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity andcontributes to the regulation of immune responses, includingneutrophil, monocyte, macrophage and mast cell functions,cytoskeleton remodeling in response to extracellular stimuli,phagocytosis, cell adhesion and migration. Promotes mast celldegranulation, release of inflammatory cytokines and IgE-mediatedanaphylaxis. Acts downstream of receptors that bind the Fc regionof immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B.Acts downstream of ITGB1 and ITGB2, and regulates actincytoskeleton reorganization, cell spreading and adhesion.Depending on the context, activates or inhibits cellularresponses. Functions as negative regulator of ITGB2 signaling,phagocytosis and SYK activity in monocytes. Required for normalITGB1 and ITGB2 signaling, normal cell spreading and adhesion inneutrophils and macrophages. Functions as positive regulator ofcell migration and regulates cytoskeleton reorganization via RAC1activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling.Phosphorylates PLD2 in antigen-stimulated mast cells, leading toPLD2 activation and the production of the signaling moleculeslysophosphatidic acid and diacylglycerol. Promotes activation ofPIK3R1. Phosphorylates FASLG, and thereby regulates itsubiquitination and subsequent internalization. PhosphorylatesABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1,PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already beenphosphorylated by SYK, but not unphosphorylated HCLS1.{ECO:0000269|PubMed:10739672, ECO:0000269|PubMed:17164290,ECO:0000269|PubMed:1737799, ECO:0000269|PubMed:7519620}. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility whichmaintains the alignment and integrity of the distal axoneme andregulates microtubule sliding in motile axonemes.{ECO:0000250|UniProtKB:A8J3A0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGR_EFCAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGR_EFCAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGR_EFCAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGRP09769DB01254DasatinibTyrosine-protein kinase Fgrsmall moleculeapproved|investigational

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RelatedDiseases for FGR_EFCAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGRC0023893Liver Cirrhosis, Experimental1CTD_human