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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13434

FusionGeneSummary for FGG_TSPAN5

check button Fusion gene summary
Fusion gene informationFusion gene name: FGG_TSPAN5
Fusion gene ID: 13434
HgeneTgene
Gene symbol

FGG

TSPAN5

Gene ID

2266

10098

Gene namefibrinogen gamma chaintetraspanin 5
Synonyms-NET-4|NET4|TM4SF9|TSPAN-5
Cytomap

4q32.1

4q23

Type of geneprotein-codingprotein-coding
Descriptionfibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8
Modification date2018051920180523
UniProtAcc

P02679

P62079

Ensembl transtripts involved in fusion geneENST00000404648, ENST00000405164, 
ENST00000336098, ENST00000407946, 
ENST00000305798, ENST00000505184, 
ENST00000509168, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: FGG [Title/Abstract] AND TSPAN5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGG

GO:0007160

cell-matrix adhesion

10903502

HgeneFGG

GO:0031639

plasminogen activation

16846481

HgeneFGG

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

HgeneFGG

GO:0034622

cellular protein-containing complex assembly

8910396

HgeneFGG

GO:0042730

fibrinolysis

16846481

HgeneFGG

GO:0045907

positive regulation of vasoconstriction

15739255

HgeneFGG

GO:0045921

positive regulation of exocytosis

19193866

HgeneFGG

GO:0050714

positive regulation of protein secretion

19193866

HgeneFGG

GO:0051592

response to calcium ion

6777381

HgeneFGG

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

HgeneFGG

GO:0070527

platelet aggregation

6281794

HgeneFGG

GO:0072378

blood coagulation, fibrin clot formation

16846481

HgeneFGG

GO:0090277

positive regulation of peptide hormone secretion

19193866

HgeneFGG

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

HgeneFGG

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI207493FGGchr4

155531291

-TSPAN5chr4

99496210

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000404648ENST00000305798FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000404648ENST00000505184FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000404648ENST00000509168FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000405164ENST00000305798FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000405164ENST00000505184FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000405164ENST00000509168FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000336098ENST00000305798FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000336098ENST00000505184FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000336098ENST00000509168FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000407946ENST00000305798FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000407946ENST00000505184FGGchr4

155531291

-TSPAN5chr4

99496210

+
intron-intronENST00000407946ENST00000509168FGGchr4

155531291

-TSPAN5chr4

99496210

+

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FusionProtFeatures for FGG_TSPAN5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGG

P02679

TSPAN5

P62079

Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGG_TSPAN5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGG_TSPAN5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGG_TSPAN5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGGP02679DB00364SucralfateFibrinogen gamma chainsmall moleculeapproved

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RelatedDiseases for FGG_TSPAN5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGGC0272350Dysfibrinogenemia, Congenital7ORPHANET;UNIPROT
HgeneFGGC0022548Keloid1CTD_human
HgeneFGGC0038356Stomach Neoplasms1CTD_human
HgeneFGGC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT