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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 13420

FusionGeneSummary for FGFR3_TACC3

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR3_TACC3
Fusion gene ID: 13420
HgeneTgene
Gene symbol

FGFR3

TACC3

Gene ID

2261

10460

Gene namefibroblast growth factor receptor 3transforming acidic coiled-coil containing protein 3
SynonymsACH|CD333|CEK2|HSFGFR3EX|JTK4ERIC-1|ERIC1
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3 variant 4hydroxyaryl-protein kinasetyrosine kinase JTK4transforming acidic coiled-coil-containing protein 3
Modification date2018052320180523
UniProtAcc

P22607

Q9Y6A5

Ensembl transtripts involved in fusion geneENST00000481110, ENST00000440486, 
ENST00000412135, ENST00000340107, 
ENST00000260795, ENST00000352904, 
ENST00000474521, 		ENST00000313288, 
Fusion gene scores* DoF score7 X 9 X 14=8826 X 10 X 13=780
# samples 4542
** MAII scorelog2(45/882*10)=-0.970853654340483
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(42/780*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR3 [Title/Abstract] AND TACC3 [Title/Abstract] AND fusion [Title/Abstract]

The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma (pmid: 23298836)
Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR3

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR3

GO:0018108

peptidyl-tyrosine phosphorylation

11294897

HgeneFGFR3

GO:0046777

protein autophosphorylation

11294897


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-CF-A47T-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-CF-A3MF-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-XF-AAMZ-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-CF-A8HY-01AFGFR3chr4

1808661

+TACC3chr4

1737458

+
TCGARVBLCATCGA-XF-AAMX-01AFGFR3chr4

1795770

+TACC3chr4

1746245

+
TCGARVBLCATCGA-E7-A5KE-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-CF-A3MG-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-CF-A3MH-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVBLCATCGA-CF-A47S-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGALDBLCATCGA-CF-A3MF-01AFGFR3chr4

1808925

+TACC3chr4

1741371

+
TCGARVCESCTCGA-LP-A7HU-01AFGFR3chr4

1808661

+TACC3chr4

1737458

+
TCGARVCESCTCGA-DS-A3LQ-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVCESCTCGA-VS-A9UD-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVCESCTCGA-WL-A834-01AFGFR3chr4

1808661

+TACC3chr4

1737458

+
TCGARVCESCTCGA-ZJ-AAXT-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGALDCESCTCGA-Q1-A73R-01AFGFR3chr4

1808947

+TACC3chr4

1742621

+
TCGARVESCATCGA-LN-A5U5-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVESCATCGA-LN-A9FO-01AFGFR3chr4

1808661

+TACC3chr4

1737458

+
TCGARVGBMTCGA-14-1823-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVGBMTCGA-06-2567-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVGBMTCGA-14-1829-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVGBMTCGA-14-0789-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGALDGBMTCGA-27-1835-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVHNSCTCGA-CR-6473-01AFGFR3chr4

1808661

+TACC3chr4

1739325

+
TCGARVHNSCTCGA-CV-7100-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVKIRPTCGA-DW-7839-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVKIRPTCGA-A4-7287-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGALDLAMLTCGA-AB-2920-03BFGFR3chr4

1807798

+TACC3chr4

1729971

+
TCGARVLGGTCGA-P5-A72U-01AFGFR3chr4

1808661

+TACC3chr4

1732899

+
TCGARVLGGTCGA-FG-7643-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVLIHCTCGA-DD-A1EK-01AFGFR3chr4

1801539

+TACC3chr4

1746245

+
TCGALDLIHCTCGA-CC-A3M9-01AFGFR3chr4

1801539

+TACC3chr4

1746245

+
TCGARVLUADTCGA-38-4630-01AFGFR3chr4

1803470

+TACC3chr4

1746245

+
TCGALDLUADTCGA-38-4630-01AFGFR3chr4

1801250

+TACC3chr4

1729435

+
TCGARVLUSCTCGA-63-7022-01AFGFR3chr4

1808661

+TACC3chr4

1746245

+
TCGARVLUSCTCGA-34-2608-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVLUSCTCGA-22-4607-01AFGFR3chr4

1808661

+TACC3chr4

1737000

+
TCGARVLUSCTCGA-92-8065-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVLUSCTCGA-39-5024-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGARVLUSCTCGA-66-2786-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
TCGALDSTADTCGA-BR-8058-01AFGFR3chr4

1808661

+TACC3chr4

1741429

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
In-frameENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
In-frameENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
In-frameENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1741429

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
In-frameENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
In-frameENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
In-frameENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737458

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1795770

+TACC3chr4

1746245

+
5CDS-intronENST00000481110ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
5CDS-intronENST00000440486ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
5CDS-intronENST00000412135ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
5CDS-intronENST00000340107ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
5CDS-intronENST00000260795ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
5CDS-intronENST00000352904ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
intron-intronENST00000474521ENST00000313288FGFR3chr4

1808925

+TACC3chr4

1741371

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808947

+TACC3chr4

1742621

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
In-frameENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
In-frameENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
In-frameENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1739325

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1807798

+TACC3chr4

1729971

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
In-frameENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
In-frameENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
In-frameENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1732899

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1801539

+TACC3chr4

1746245

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
3UTR-3CDSENST00000474521ENST00000313288FGFR3chr4

1803470

+TACC3chr4

1746245

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1801250

+TACC3chr4

1729435

+
Frame-shiftENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1746245

+
In-frameENST00000481110ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
Frame-shiftENST00000440486ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
Frame-shiftENST00000412135ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
Frame-shiftENST00000340107ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
Frame-shiftENST00000260795ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
Frame-shiftENST00000352904ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+
intron-3CDSENST00000474521ENST00000313288FGFR3chr4

1808661

+TACC3chr4

1737000

+

Top

FusionProtFeatures for FGFR3_TACC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR3

P22607

TACC3

Q9Y6A5

Tyrosine-protein kinase that acts as cell-surfacereceptor for fibroblast growth factors and plays an essential rolein the regulation of cell proliferation, differentiation andapoptosis. Plays an essential role in the regulation ofchondrocyte differentiation, proliferation and apoptosis, and isrequired for normal skeleton development. Regulates bothosteogenesis and postnatal bone mineralization by osteoblasts.Promotes apoptosis in chondrocytes, but can also promote cancercell proliferation. Required for normal development of the innerear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads tothe activation of several signaling cascades. Activation of PLCG1leads to the production of the cellular signaling moleculesdiacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylationof FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, andmediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAPkinase signaling pathway, as well as of the AKT1 signalingpathway. Plays a role in the regulation of vitamin D metabolism.Mutations that lead to constitutive kinase activation or impairnormal FGFR3 maturation, internalization and degradation lead toaberrant signaling. Over-expressed or constitutively activatedFGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A andSTAT5B. Secreted isoform 3 retains its capacity to bind FGF1 andFGF2 and hence may interfere with FGF signaling.{ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897,ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538,ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617,ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277,ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467,ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672,ECO:0000269|PubMed:8663044}. Plays a role in the microtubule-dependent coupling ofthe nucleus and the centrosome. Involved in the processes thatregulate centrosome-mediated interkinetic nuclear migration (INM)of neural progenitors (By similarity). Acts as component of theTACC3/ch-TOG/clathrin complex proposed to contribute tostabilization of kinetochore fibers of the mitotic spindle byacting as inter-microtubule bridge. The TACC3/ch-TOG/clathrincomplex is required for the maintenance of kinetochore fibertension (PubMed:21297582, PubMed:23532825). May be involved in thecontrol of cell growth and differentiation. May contribute tocancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11,ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582,ECO:0000269|PubMed:23532825}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617151_244758807DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+161724_126758807DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617253_355758807DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617472_761758807DomainProtein kinase
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718151_244760809DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+171824_126760809DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718253_355760809DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718472_761760809DomainProtein kinase
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415151_244646695DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+141524_126646695DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415253_355646695DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516151_244646695DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+151624_126646695DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516253_355646695DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718151_244758807DomainNote=Ig-like C2-type 2
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+171824_126758807DomainNote=Ig-like C2-type 1
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718253_355758807DomainNote=Ig-like C2-type 3
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718472_761758807DomainProtein kinase
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617478_486758807Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718478_486760809Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415478_486646695Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516478_486646695Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718478_486758807Nucleotide bindingATP
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+161723_375758807Topological domainExtracellular
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+171823_375760809Topological domainExtracellular
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+141523_375646695Topological domainExtracellular
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+151623_375646695Topological domainExtracellular
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+171823_375758807Topological domainExtracellular
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617376_396758807TransmembraneHelical
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718376_396760809TransmembraneHelical
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415376_396646695TransmembraneHelical
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516376_396646695TransmembraneHelical
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718376_396758807TransmembraneHelical
TgeneTACC3chr4:1808661chr4:1737000ENST00000313288+516637_837530839Coiled coilOntology_term=ECO:0000255
TgeneTACC3chr4:1808661chr4:1737000ENST00000313288+516594_838530839RegionNecessary but not sufficient for spindle localization

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415472_761646695DomainProtein kinase
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516472_761646695DomainProtein kinase
HgeneFGFR3chr4:1808661chr4:1737000ENST00000260795+1617397_806758807Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr4:1737000ENST00000340107+1718397_806760809Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr4:1737000ENST00000352904+1415397_806646695Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr4:1737000ENST00000412135+1516397_806646695Topological domainCytoplasmic
HgeneFGFR3chr4:1808661chr4:1737000ENST00000440486+1718397_806758807Topological domainCytoplasmic
TgeneTACC3chr4:1808661chr4:1737000ENST00000313288+516155_160530839Compositional biasNote=Poly-Ser
TgeneTACC3chr4:1808661chr4:1737000ENST00000313288+516522_577530839RegionNecessary but not sufficient for spindle localization


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FusionGeneSequence for FGFR3_TACC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGFR3_TACC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR3C6orf47, SMG7, BORA, CCDC17, HBZ, HNRNPL, NDUFS6, RNF130, ATF3, ARAP1, CHGB, CTSK, RADIL, GTF3C1, KRT8, POLA2, KIAA1377, RPL8, SLC25A6, SH2B1, FGF9, FGF1, GRB2, FGF8, HSP90AA1, HSP90AB1, HSPA1B, HSPA8, CDC37, HSPA4, SOCS1, SOCS3, FGFR3, SNX11, TMEM231, ILKAP, SRPK2, PVRL1, BRD4, VHL, FNTA, CDK6, FGFR2, TMEM30B, ARRDC3, SDC2TACC3AKAP9, TTF2, NDEL1, MBD2, CKAP5, KAT2A, KAT2B, RAE1, AHCYL1, SRXN1, SEC23A, RAD23B, CPLX1, UBA2, RAD23A, RAB14, SSSCA1, PAICS, SEC24A, AURKA, ARNT2, VPS37C, TBC1D22B, KIZ, ASPSCR1, CIB3, SNX20, FZR1, SNAP29, PLEKHO2, C17orf59, MRE11A, NTRK1, ADAR, CALD1, CUX1, KIF11, PCDH7, VASP, SLBP, NFS1, XPR1, DHRS2, ZER1, SLAIN2, ARX, BOD1L1, ORC3, ENAH, METTL14, RNF123, PDF, PANK2, RNF135, KIAA1804, PRMT9, DEPDC7, RNF168, WDR90, C2orf69, PRR14L, FRYL, FAM111B, MIA3, CRISP2, CORO6, SPERT, EVL, HSPA8, MVK, HSPBP1, OIP5, GTF2E2, ZFC3H1, CDC27


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGFR3_TACC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR3P22607DB00039PaliferminFibroblast growth factor receptor 3biotechapproved
HgeneFGFR3P22607DB06589PazopanibFibroblast growth factor receptor 3small moleculeapproved
HgeneFGFR3P22607DB09079NintedanibFibroblast growth factor receptor 3small moleculeapproved
HgeneFGFR3P22607DB08901PonatinibFibroblast growth factor receptor 3small moleculeapproved|investigational
HgeneFGFR3P22607DB09078LenvatinibFibroblast growth factor receptor 3small moleculeapproved|investigational

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RelatedDiseases for FGFR3_TACC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR3C0022603Seborrheic keratosis21UNIPROT
HgeneFGFR3C0001080Achondroplasia8CTD_human;ORPHANET;UNIPROT
HgeneFGFR3C0410529Hypochondroplasia (disorder)8CTD_human;ORPHANET;UNIPROT
HgeneFGFR3C0334082NEVUS, EPIDERMAL (disorder)7CTD_human;UNIPROT
HgeneFGFR3C0005695Bladder Neoplasm4CTD_human
HgeneFGFR3C1864436Muenke Syndrome4CTD_human;ORPHANET;UNIPROT
HgeneFGFR3C0005684Malignant neoplasm of urinary bladder3UNIPROT
HgeneFGFR3C2677099CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)3CTD_human;ORPHANET;UNIPROT
HgeneFGFR3C0007138Carcinoma, Transitional Cell1CTD_human
HgeneFGFR3C0008924Cleft Lip1CTD_human
HgeneFGFR3C0008925Cleft Palate1CTD_human
HgeneFGFR3C0026764Multiple Myeloma1CTD_human
HgeneFGFR3C0036631Seminoma1CTD_human
HgeneFGFR3C0039743Thanatophoric Dysplasia1CTD_human
HgeneFGFR3C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
HgeneFGFR3C1864852CATSHL syndrome1CTD_human;ORPHANET;UNIPROT
TgeneTACC3C0005695Bladder Neoplasm1CTD_human
TgeneTACC3C0007138Carcinoma, Transitional Cell1CTD_human