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Fusion gene ID: 13414 |
FusionGeneSummary for FGFR2_USP10 |
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Fusion gene information | Fusion gene name: FGFR2_USP10 | Fusion gene ID: 13414 | Hgene | Tgene | Gene symbol | FGFR2 | USP10 | Gene ID | 2263 | 84669 |
Gene name | fibroblast growth factor receptor 2 | ubiquitin specific peptidase 32 | |
Synonyms | BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25 | NY-REN-60|USP10 | |
Cytomap | 10q26.13 | 17q23.1-q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14 | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P21802 | Q14694 | |
Ensembl transtripts involved in fusion gene | ENST00000369061, ENST00000357555, ENST00000358487, ENST00000356226, ENST00000369060, ENST00000369059, ENST00000346997, ENST00000457416, ENST00000351936, ENST00000360144, ENST00000369056, ENST00000490349, ENST00000359354, ENST00000478859, | ENST00000219473, ENST00000570191, ENST00000562743, | |
Fusion gene scores | * DoF score | 18 X 10 X 9=1620 | 6 X 5 X 5=150 |
# samples | 24 | 6 | |
** MAII score | log2(24/1620*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGFR2 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FGFR2 | GO:0008284 | positive regulation of cell proliferation | 8663044 |
Hgene | FGFR2 | GO:0008543 | fibroblast growth factor receptor signaling pathway | 8663044|15629145 |
Hgene | FGFR2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 15629145|16844695 |
Hgene | FGFR2 | GO:0046777 | protein autophosphorylation | 15629145 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-24-1424-01A | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000369061 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369061 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000369061 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000357555 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000357555 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000357555 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000358487 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000358487 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000358487 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000356226 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000356226 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000356226 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369060 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369060 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000369060 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369059 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369059 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000369059 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000346997 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000346997 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000346997 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000457416 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000457416 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000457416 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000351936 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000351936 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000351936 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000360144 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000360144 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000360144 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369056 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000369056 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000369056 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5UTR-3CDS | ENST00000490349 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5UTR-3CDS | ENST00000490349 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5UTR-intron | ENST00000490349 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000359354 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
Frame-shift | ENST00000359354 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
5CDS-intron | ENST00000359354 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
intron-3CDS | ENST00000478859 | ENST00000219473 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
intron-3CDS | ENST00000478859 | ENST00000570191 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
intron-intron | ENST00000478859 | ENST00000562743 | FGFR2 | chr10 | 123353223 | - | USP10 | chr16 | 84792322 | + |
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FusionProtFeatures for FGFR2_USP10 |
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Hgene | Tgene |
FGFR2 | USP10 |
Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FGFR2_USP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FGFR2_USP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FGFR2 | FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3 | USP10 | G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FGFR2_USP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | FGFR2 | P21802 | DB00039 | Palifermin | Fibroblast growth factor receptor 2 | biotech | approved |
Hgene | FGFR2 | P21802 | DB08896 | Regorafenib | Fibroblast growth factor receptor 2 | small molecule | approved |
Hgene | FGFR2 | P21802 | DB09079 | Nintedanib | Fibroblast growth factor receptor 2 | small molecule | approved |
Hgene | FGFR2 | P21802 | DB01109 | Heparin | Fibroblast growth factor receptor 2 | small molecule | approved|investigational |
Hgene | FGFR2 | P21802 | DB08901 | Ponatinib | Fibroblast growth factor receptor 2 | small molecule | approved|investigational |
Hgene | FGFR2 | P21802 | DB09078 | Lenvatinib | Fibroblast growth factor receptor 2 | small molecule | approved|investigational |
Hgene | FGFR2 | P21802 | DB01041 | Thalidomide | Fibroblast growth factor receptor 2 | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for FGFR2_USP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FGFR2 | C2931196 | Craniofacial dysostosis type 1 | 21 | ORPHANET;UNIPROT |
Hgene | FGFR2 | C0220658 | Pfeiffer Syndrome | 10 | UNIPROT |
Hgene | FGFR2 | C0001193 | Apert syndrome | 8 | ORPHANET;UNIPROT |
Hgene | FGFR2 | C1510455 | Acrocephalosyndactylia | 4 | CTD_human |
Hgene | FGFR2 | C0010278 | Craniosynostosis | 3 | CTD_human;HPO |
Hgene | FGFR2 | C0036341 | Schizophrenia | 3 | PSYGENET |
Hgene | FGFR2 | C0376634 | Craniofacial Abnormalities | 3 | CTD_human |
Hgene | FGFR2 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
Hgene | FGFR2 | C0011570 | Mental Depression | 2 | PSYGENET |
Hgene | FGFR2 | C0011581 | Depressive disorder | 2 | PSYGENET |
Hgene | FGFR2 | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Hgene | FGFR2 | C1865070 | SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | FGFR2 | C0003090 | Ankylosis | 1 | CTD_human |
Hgene | FGFR2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | FGFR2 | C0008924 | Cleft Lip | 1 | CTD_human |
Hgene | FGFR2 | C0008925 | Cleft Palate | 1 | CTD_human;HPO |
Hgene | FGFR2 | C0010273 | Craniofacial Dysostosis | 1 | CTD_human;HPO |
Hgene | FGFR2 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | FGFR2 | C0018553 | Hamartoma Syndrome, Multiple | 1 | CTD_human |
Hgene | FGFR2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | FGFR2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | FGFR2 | C0026613 | Motor Skills Disorders | 1 | CTD_human |
Hgene | FGFR2 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Hgene | FGFR2 | C0037268 | Skin Abnormalities | 1 | CTD_human |
Hgene | FGFR2 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | FGFR2 | C0040427 | Tooth Abnormalities | 1 | CTD_human |
Hgene | FGFR2 | C0080178 | Spina Bifida | 1 | CTD_human |
Hgene | FGFR2 | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | FGFR2 | C0206762 | Limb Deformities, Congenital | 1 | CTD_human |
Hgene | FGFR2 | C0265269 | Lacrimoauriculodentodigital syndrome | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | FGFR2 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Hgene | FGFR2 | C1450010 | Plagiocephaly, Nonsynostotic | 1 | CTD_human;HPO |
Hgene | FGFR2 | C1852406 | Cutis Gyrata Syndrome of Beare And Stevenson | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | FGFR2 | C2350233 | Antley-Bixler Syndrome Phenotype | 1 | CTD_human |
Hgene | FGFR2 | C3281247 | BENT BONE DYSPLASIA SYNDROME | 1 | ORPHANET;UNIPROT |
Hgene | FGFR2 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |