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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13414

FusionGeneSummary for FGFR2_USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2_USP10
Fusion gene ID: 13414
HgeneTgene
Gene symbol

FGFR2

USP10

Gene ID

2263

84669

Gene namefibroblast growth factor receptor 2ubiquitin specific peptidase 32
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25NY-REN-60|USP10
Cytomap

10q26.13

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2018052720180523
UniProtAcc

P21802

Q14694

Ensembl transtripts involved in fusion geneENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
ENST00000219473, ENST00000570191, 
ENST00000562743, 
Fusion gene scores* DoF score18 X 10 X 9=16206 X 5 X 5=150
# samples 246
** MAII scorelog2(24/1620*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR2 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-24-1424-01AFGFR2chr10

123353223

-USP10chr16

84792322

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000369061ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369061ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369061ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000357555ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000357555ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000357555ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000358487ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000358487ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000358487ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000356226ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000356226ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000356226ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369060ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369060ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369060ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369059ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369059ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369059ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000346997ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000346997ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000346997ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000457416ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000457416ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000457416ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000351936ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000351936ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000351936ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000360144ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000360144ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000360144ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369056ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000369056ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000369056ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-3CDSENST00000490349ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-3CDSENST00000490349ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5UTR-intronENST00000490349ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000359354ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
Frame-shiftENST00000359354ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
5CDS-intronENST00000359354ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-3CDSENST00000478859ENST00000219473FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-3CDSENST00000478859ENST00000570191FGFR2chr10

123353223

-USP10chr16

84792322

+
intron-intronENST00000478859ENST00000562743FGFR2chr10

123353223

-USP10chr16

84792322

+

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FusionProtFeatures for FGFR2_USP10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

USP10

Q14694

Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGFR2_USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGFR2_USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3USP10G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGFR2_USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
HgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn

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RelatedDiseases for FGFR2_USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
HgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
HgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0038356Stomach Neoplasms2CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0003090Ankylosis1CTD_human
HgeneFGFR2C0005586Bipolar Disorder1PSYGENET
HgeneFGFR2C0008924Cleft Lip1CTD_human
HgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
HgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
HgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
HgeneFGFR2C0023890Liver Cirrhosis1CTD_human
HgeneFGFR2C0024121Lung Neoplasms1CTD_human
HgeneFGFR2C0026613Motor Skills Disorders1CTD_human
HgeneFGFR2C0033975Psychotic Disorders1PSYGENET
HgeneFGFR2C0037268Skin Abnormalities1CTD_human
HgeneFGFR2C0037274Dermatologic disorders1CTD_human
HgeneFGFR2C0040427Tooth Abnormalities1CTD_human
HgeneFGFR2C0080178Spina Bifida1CTD_human
HgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
HgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
HgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
HgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO