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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 13408

FusionGeneSummary for FGFR2_FRK

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2_FRK
Fusion gene ID: 13408
HgeneTgene
Gene symbol

FGFR2

FRK

Gene ID

2263

2444

Gene namefibroblast growth factor receptor 2fyn related Src family tyrosine kinase
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25GTK|PTK5|RAK
Cytomap

10q26.13

6q22.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14tyrosine-protein kinase FRKPTK5 protein tyrosine kinase 5fyn-related kinasenuclear tyrosine protein kinase RAKprotein-tyrosine kinase 5
Modification date2018052720180523
UniProtAcc

P21802

P42685

Ensembl transtripts involved in fusion geneENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
ENST00000606080, ENST00000538210, 
Fusion gene scores* DoF score18 X 10 X 9=16201 X 1 X 1=1
# samples 241
** MAII scorelog2(24/1620*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: FGFR2 [Title/Abstract] AND FRK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145

TgeneFRK

GO:0000122

negative regulation of transcription by RNA polymerase II

12837246


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCHOLTCGA-ZH-A8Y1-01AFGFR2chr10

123263304

-FRKchr6

116325161

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369061ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000369061ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000357555ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000357555ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000358487ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000358487ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000356226ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000356226ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000369060ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000369060ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000369059ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000369059ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
In-frameENST00000346997ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000346997ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000457416ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000457416ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000351936ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000351936ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000360144ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000360144ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
In-frameENST00000369056ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000369056ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
intron-3CDSENST00000490349ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
intron-intronENST00000490349ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
intron-3CDSENST00000359354ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
intron-intronENST00000359354ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-
Frame-shiftENST00000478859ENST00000606080FGFR2chr10

123263304

-FRKchr6

116325161

-
5CDS-intronENST00000478859ENST00000538210FGFR2chr10

123263304

-FRKchr6

116325161

-

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FusionProtFeatures for FGFR2_FRK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

FRK

P42685

Non-receptor tyrosine-protein kinase that negativelyregulates cell proliferation. Positively regulates PTEN proteinstability through phosphorylation of PTEN on 'Tyr-336', which inturn prevents its ubiquitination and degradation, possibly byreducing its binding to NEDD4. May function as a tumor suppressor.{ECO:0000269|PubMed:19345329}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917154_247477820DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917256_358477820DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-91725_125477820DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018154_247477786DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018256_358477786DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-101825_125477786DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816154_247362705DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816256_358362705DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-81625_125362705DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917154_247390708DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917256_358390708DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-91725_125390708DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018154_247479822DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018256_358479822DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-101825_125479822DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917154_247391681DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917256_358391681DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-91725_125391681DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917154_247480770DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917256_358480770DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-91725_125480770DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816154_247363706DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816256_358363706DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-81625_125363706DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715154_247367710DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715256_358367710DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-71525_125367710DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018154_247480823DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018256_358480823DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-101825_125480823DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917161_178477820RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018161_178477786RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816161_178362705RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917161_178390708RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018161_178479822RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917161_178391681RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917161_178480770RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816161_178363706RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715161_178367710RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018161_178480823RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-91722_377477820Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-101822_377477786Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-91722_377390708Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-101822_377479822Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-91722_377391681Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-91722_377480770Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-101822_377480823Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917378_398477820TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018378_398477786TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018378_398479822TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917378_398480770TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018378_398480823TransmembraneHelical
TgeneFRKchr10:123263304chr6:116325161ENST00000606080-08116_208114506DomainSH2
TgeneFRKchr10:123263304chr6:116325161ENST00000606080-08234_491114506DomainProtein kinase
TgeneFRKchr10:123263304chr6:116325161ENST00000606080-08240_248114506Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917481_770477820DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018481_770477786DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816481_770362705DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917481_770390708DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018481_770479822DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17154_247-163255DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17256_358-163255DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-1725_125-163255DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17481_770-163255DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917481_770391681DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917481_770480770DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816481_770363706DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715481_770367710DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018481_770480823DomainProtein kinase
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917487_495477820Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917565_567477820Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018487_495477786Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018565_567477786Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816487_495362705Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816565_567362705Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917487_495390708Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917565_567390708Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018487_495479822Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018565_567479822Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17487_495-163255Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17565_567-163255Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917487_495391681Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917565_567391681Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917487_495480770Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917565_567480770Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816487_495363706Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816565_567363706Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715487_495367710Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715565_567367710Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018487_495480823Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018565_567480823Nucleotide bindingATP
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17161_178-163255RegionNote=Heparin-binding
HgeneFGFR2chr10:123263304chr6:116325161ENST00000346997-917399_821477820Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000351936-1018399_821477786Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-81622_377362705Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816399_821362705Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917399_821390708Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000358487-1018399_821479822Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-1722_377-163255Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17399_821-163255Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917399_821391681Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369056-917399_821480770Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-81622_377363706Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816399_821363706Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-71522_377367710Topological domainExtracellular
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715399_821367710Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000457416-1018399_821480823Topological domainCytoplasmic
HgeneFGFR2chr10:123263304chr6:116325161ENST00000356226-816378_398362705TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000357555-917378_398390708TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000359354-17378_398-163255TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000360144-917378_398391681TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369060-816378_398363706TransmembraneHelical
HgeneFGFR2chr10:123263304chr6:116325161ENST00000369061-715378_398367710TransmembraneHelical
TgeneFRKchr10:123263304chr6:116325161ENST00000606080-0842_110114506DomainSH3


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FusionGeneSequence for FGFR2_FRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FGFR2_ENST00000369061_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_759aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYC
IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP
KWEFPRDKWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTS
DGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHP
KLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLAR
VFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIML

>In-frame_FGFR2_ENST00000346997_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_869aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFL
TRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPG
SMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAA
RNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLA

>In-frame_FGFR2_ENST00000369056_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_872aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG
FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTL
KPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRD
LAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FGFR2_ENST00000369061_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_2277nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGC
ATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAG
CCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACC
CCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCA
AAATGGGAGTTTCCAAGAGATAAGTGGTTCTTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAGACC
GGTTCCTTTCTAATCAGAGAAAGTGAAAGCCAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGAATT
AAAAGACTGGATGAAGGGGGATTTTTTCTCACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACAAGT
GACGGCCTGTGTGTCAAGCTGGGGAAACCATGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAATGG
GAGATAGACCGCAACTCCATACAGCTTCTGAAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACCACT
CCAGTAGCAGTGAAAACATTAAAACCAGGTTCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACATCCA
AAGCTTATCCAGCTTTATGCTGTTTGCACTTTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAATAT
CTCCAAAATGACACTGGATCAAAAATCCATCTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAGTCT
CGGAACTACATTCACAGAGATCTGGCTGCCAGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCCAGA
GTTTTTAAGGTAGATAATGAAGACATCTATGAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGTAGT
AATAAATTCAGCATTAAGTCCGATGTATGGTCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGTATG
ACAGGTGCCCAGGTAATCCAGATGTTGGCTCAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATGTTG
GAGTGCTGGAATGCAGAGCCTAAGGAACGACCTACATTTGAGACACTGCGTTGGAAACTTGAAGACTATTTTGAAACAGACTCTTCATAT

>In-frame_FGFR2_ENST00000346997_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_2607nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTTCTCTATATTCGG
AATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG
CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGT
ATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA
CGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGTGGTTC
TTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAGACCGGTTCCTTTCTAATCAGAGAAAGTGAAAGC
CAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGAATTAAAAGACTGGATGAAGGGGGATTTTTTCTC
ACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACAAGTGACGGCCTGTGTGTCAAGCTGGGGAAACCA
TGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAATGGGAGATAGACCGCAACTCCATACAGCTTCTG
AAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACCACTCCAGTAGCAGTGAAAACATTAAAACCAGGT
TCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACATCCAAAGCTTATCCAGCTTTATGCTGTTTGCACT
TTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAATATCTCCAAAATGACACTGGATCAAAAATCCAT
CTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAGTCTCGGAACTACATTCACAGAGATCTGGCTGCC
AGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCCAGAGTTTTTAAGGTAGATAATGAAGACATCTAT
GAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGTAGTAATAAATTCAGCATTAAGTCCGATGTATGG
TCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGTATGACAGGTGCCCAGGTAATCCAGATGTTGGCT
CAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATGTTGGAGTGCTGGAATGCAGAGCCTAAGGAACGA

>In-frame_FGFR2_ENST00000369056_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_2616nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCAGAAGTGCTGGCTCTGTTCAATGTG
ACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCTGCCTGGCTCACTGTCCTGCCAAAA
CAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCC
TGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACC
AAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACA
CGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGAT
AAGTGGTTCTTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAGACCGGTTCCTTTCTAATCAGAGAA
AGTGAAAGCCAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGAATTAAAAGACTGGATGAAGGGGGA
TTTTTTCTCACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACAAGTGACGGCCTGTGTGTCAAGCTG
GGGAAACCATGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAATGGGAGATAGACCGCAACTCCATA
CAGCTTCTGAAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACCACTCCAGTAGCAGTGAAAACATTA
AAACCAGGTTCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACATCCAAAGCTTATCCAGCTTTATGCT
GTTTGCACTTTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAATATCTCCAAAATGACACTGGATCA
AAAATCCATCTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAGTCTCGGAACTACATTCACAGAGAT
CTGGCTGCCAGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCCAGAGTTTTTAAGGTAGATAATGAA
GACATCTATGAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGTAGTAATAAATTCAGCATTAAGTCC
GATGTATGGTCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGTATGACAGGTGCCCAGGTAATCCAG
ATGTTGGCTCAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATGTTGGAGTGCTGGAATGCAGAGCCT
AAGGAACGACCTACATTTGAGACACTGCGTTGGAAACTTGAAGACTATTTTGAAACAGACTCTTCATATTCAGATGCAAATAACTTCATA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FGFR2_ENST00000369061_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_13692nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGTGGTTC
TTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAGACCGGTTCCTTTCTAATCAGAGAAAGTGAAAGC
CAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGAATTAAAAGACTGGATGAAGGGGGATTTTTTCTC
ACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACAAGTGACGGCCTGTGTGTCAAGCTGGGGAAACCA
TGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAATGGGAGATAGACCGCAACTCCATACAGCTTCTG
AAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACCACTCCAGTAGCAGTGAAAACATTAAAACCAGGT
TCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACATCCAAAGCTTATCCAGCTTTATGCTGTTTGCACT
TTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAATATCTCCAAAATGACACTGGATCAAAAATCCAT
CTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAGTCTCGGAACTACATTCACAGAGATCTGGCTGCC
AGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCCAGAGTTTTTAAGGTAGATAATGAAGACATCTAT
GAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGTAGTAATAAATTCAGCATTAAGTCCGATGTATGG
TCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGTATGACAGGTGCCCAGGTAATCCAGATGTTGGCT
CAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATGTTGGAGTGCTGGAATGCAGAGCCTAAGGAACGA
CCTACATTTGAGACACTGCGTTGGAAACTTGAAGACTATTTTGAAACAGACTCTTCATATTCAGATGCAAATAACTTCATAAGATGAACA
CTGGAGAAGAATATCAAATAATAAAGTAGCAAAACAAATTCAAATAATCCATTCCAAAATACAATGTTATCAACCAACTGCACAATCAGT
TTATCCTGACATATTCAAGTGATAGGATAAAGTTGGCCATGTATTATGAAAAAGATTATTTGTGCATTTTATTGACTGGGCAACACTGCA
GGACAGTCAAGGTGATATATAATTTCCTCACTGCCTGGTAAAATTAAGCACACTAAACCAAGTTATTTTTCTTTTTAAGAGATACTTACA
TTTCCATTTATTGTTTGAAATGTCGATCAAGAGAATCAACAGATGATAGTCCAATTTTTACTCAGTGACTGTTGTAGCATTTTCCTGTTT
ACTGATTAGAGTGGTTATTCATTATTCCTCAGATTGCTGAATCCCATCAGGCTGTTATTATGAAGGAATTTGATTGCTTTGCTGCACAGC
AGGACCTGTGCTTTGAGATTTTTTTTTCTCTTTTAAAATATCCTGTAACTACAATGATGGTAAAGCCATGTTAAATGACTTGATTGTACT
TGGAGTAATTGCACATTTTTTTCTATGCATAAAAAAATGATGCAGCTGTTGAGAAAACGAAGTCTTTTTCATTTTGCAGAAGGAAATGAT
GGAATTTTTCTGTACTTCAGTATGTGTCAACTGAGAGTCATATACATTAGTTTTAATCTCTTAATATTGAGAATCAGGTTGCAAAACGGA
TGAGTTATTATCTATGGAAATGTGAGAAATGTCTAATAGCCCATAAAGTCTGAGAAATAGGTATCAAAATAGTTTAGGAAAATGAGAGGA
GAACAGTAGGATTGCTGTGGCCTAGACTTCTGAGTAATTAATAAAGAAAAAGAAGTACCCTTTGGCCTACAGATCAGAGTTTTATTTATT
TTTTATTTTTTACTTTTTATTATAGTTTAAGTTCTGGGGTGCATGTGCAGAATGTGCAGTTTTGTTACATAGGTGTACAAGTGCCATGGT
GGTTTGCTGCACCCATCAACCCGTCGTCTACATTAGGCATTTCTCCTAGTGCTGTTCCTCCCCTAGCCCTCCATCCCCTGACAGGCCCCA
GTATGTGATGTTCCCCTCCTTGTGTCCATATGTTCTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGCTGTGTTTGGTTTTTTGTTC
TTGTGTTAGTTTGTTAAGAATGATGGTTTCCAGCTTTATCCATGTCCCTGTGAAGGACATGAACTCATCCTTTTTTATGGCTGCATAGTA
TTCCATAGTGTCTATGTGCCACATTTTCTTTATCCAGTCTATCGTTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAG
TGCCACAATAAACATGCATGTGTCTTTATAGCAGAATGATTTATAAGCCTTTAGGTACATACCCAGTAATGGGATCGCTGAGTCAAATGG
TATTTCTAGTTCTAGATCCTTGAGGAATTGCTACACTGTCCTCCACAATGGTTGAACTAATTTATACTCCCACCAACAGAGTAAAAGTGT
AAATGTGTTCCTATTTCTCCACATCCTCTTTGGCATCCAAAACAGCATCCTGTTGTTTCCTGACTTTTTAATGATCACCATTCTAACTGG
TGTGAGATGGTATCTCATTGTGGTTTTGATTTGGATTTCTCTAATGATCAGATGATGAGCTTTTTTTCATATGTCTGTTGGCTGCATAAA
TATCTTCTTTTGAAATGTGTCTGTTCAAATCCTTCGCCCACTTTTTGATGGGGTTGTTTGTTTTTTTCTTTTAAATTTGTTTATGTTCCT
TGTAGATTCTTGGTATTAGCCCTTTGTCAGATGGATAGCTTGCAAAAATTTTCTCCCATTCTGTAGGTTGCCTGTTCACTCTGATGATAG
TTTCTTTTGCTGTCTAGAAGCTCTTTAGTTTAATTAGATCCCATTTCTCAATTTGGGCTTTTGTTGCCATTGGTTTTTGTGTTTTAGTCA
TGATGTCTTTTCCAATGCCTATGTCCTGAATGGTGTTGCCTAGGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTTACATTTAAGTCTT
TAATCCATCTTGAGTTAATTTTTGTATAGGTGTAAGGAAGGGGTCCAGTTTCAGTTTTCTGCATATGGCTAGCTAGTTTTCCCAACACCA
TTTATTAAATAGGGAATCCTTTCCCCATTGGTTGTTTTTGTAAGGTTTGTCAAAGATCAGATGGTTGTAGATGTGTGGTGTTATTTCTGA
GGCCTCTGTTCTGTTCTGTTGGTCTAGATATCTGTTTTGGTACCACTACCATGCTGTTTTGTTTACTGTAGCCTTGTAGTATAGTTTGAA
GTCAGGTAGCATGATGCCTATAACTTTGTTCTTTTTGCTTAGAATTGTCTTGGCTATGCGGGCTCTTTTTTGATTCCATATGAAGTTTAA
AGTAGTTTTTTCCAATTCTGTGAAGAAAGTCAATGGTAGTTTGATGGGGATAGCACTGAATATATAAATTGCCTTGGGCAATATGGCCAT
TTTCACGATATTGATTCTTCCTATCCATGAGCATGGAATGTTTTTCCATTTATTTGTGTCCTCTCTTATTTCCTTGAGCAGTGGTTTGTA
GTTCTCCTTGAAGAGGTCCTTTGCATCCCTTGTAAGTTGTAATCCTAGATATTTCATTCTCTTTGTAGCAATTGTGAATGGGAGTTCACT
CATGATTTGGCTCTCTGTTTGTTATTGGTGTATAGGAATGTGTGTGATTTTTGCACATTGATTTTGTATCCTGAGACTTTGCTGAAGTTG
CTTATCAGCTTAAGGAGATTTTGGGCTGAGATGGTGGGGTTCCCTATATATACAATTCATATCATCTGCAAACAGAGACAATTTTACTTC
CTGTTTTCCTATTTGAATACCCTTTATTTCTTTCTCTTGCCTGATTGCCCTGGCCAGAACTTTCAATACTATTTTGAACAGGAGTGGTGA
GAGGGGGCATCCTTGTCTTGTGCCAGCTTTCAAAGGGAATGCTTCCAGGTTTACCCATTCAGTATGATATTGGCTGTGGTTTTGTCTTAA
ATCTGTCATTTTTTTTGAGCTACGTTCCATCAATACCTAGTTTATTGAGAGTTTTTAGTATGAAGGGGTGTTGAATTTTATCAAATTTTC
TGCATCTATTGAGATCATCATGTGGTTTTTGTCATTGGTTCTGTTTATGTGATGGATTGTGTTTATTGATTTGCGTATGTTGAACCAGCC
TTGTGTCTCAGGGATGAAGCCAACTTGATCGTGGTGGATAAGCTTTTTGATGTGCTGCTGCACTCAGTTTGCCAGTATTTTATTGAGGAT
TTTTGCATGGATGTTCGTCAGGGATACTGGCCTGAAATTTTCTCTCTTTTTTTTTTTTTGTTGTGTCTCTGCCAGGTTTTGGTTTCAGGA
TGATGCTGGCCTCATAAAATGAGTTAGGGAGGAGTCCCTCTTTTCCTATTGTTTGGAATAGTTTCAGAAAGAATAGTACTAGCTTTGTAC
CTCTTTGTACCTCTGGTAGAATTCGGCTGTGAATCTATCTGGTCCTGGACTTTTTTTGGTTGGTAGGCTATTAATTACTGCCTCAATTTC
AGAACTTGTTATTGGTCTATTTAGGGATTCATCTTCTTCCTGGTTTAGACTTGGGAGGGTGTATGTTTGCAGGAATTTACCCATTTCTTC
TAGATTTTCTAGTTTATTTGCTTAGAGGTATTTATAGTAATCTCTGATGGTATTTTGTATTTCTGTGGGATCAGTGGTGATCTCCGCTTT
ATCATTTTTTATTGTGTCTATTTGATTCTGCTCTCTTTTCTTCTTTATTAGTCTGGCTAGCATTCTATTTTGTTGATCTTTTCAAAAAAT
CAGATCCTGGATTCATTGATTTTTTGAAAGGTTTTTCATGTCTCTATCACCTTCAGTTCTGTTCTGATCTTAGTTATTTCTTGTCTTCTG
CTAGCTTTTGAATTTGTTTGCTCTTGCTTCTCTAGTACTTTTAATTGTGATATTAGGGTATAGATTTTAGTTCTTTCCTGATTCCTCTTG
TGGGCAGTTGGTGCTATAAATTTCCCTCTACACACTGCTTTAAATGTGTCCCAGAGATTCTGGTATGTTGTGTTTTTGTTCTCATTGGTT
TCAATGAACAACTTTATTTCTACCTTAATTTTATTATTTACCCAGTAGTCATTCAGGAGCAGGTTGTTCAGTTTCCAAGTAGTTGTTAGG
TTTTCTGTCAGTTTTAATCCTGAGTTCTAATTTGATTGCACTGTGGTCTTAGAGACTGTTTGTTATGACTTCCGTTCTTTTGCATTTGCT
GAGGAGTGTTTTACTTCCAATTATGTGATCACTTTTAGAATAAGTGCGATGAGGTGCTGAGAAGAATGTATATTCTGTTGATTTGGGGTA
GAGAATTCTGTAGATGTCTGTTAGGTCCACTTGGTCCAGAGCTGAGTTCAAGTTCTGAATATCTTTGTTAATTTTCTGTCTCATTTATCT
GTCTAATATTGACAGCAGGCTGTTAAAATTTCCCACTATTATTGTGTGGGAGTCTAAGTCTCTTTGTAGTTCTCTAAGAACTTGCTTTAT
GAATCTGGGTGCTTCTGTATTGGGTGTATATATATTTAGGATAGTTAGCTATTCTTGTTGCATTGATCTGTTTACCATTATGTAATGCCC
TTCTTTGTCTCTTTTGATCTTTGTTGATTTAAAGTCTGTTTTATCAGAGACTAGGATTGCAACCCCTGCTTTTTTTTTCTGCTTTCCGTT
TGCTTCGTAAATATTCCTCCATCCCTTTATCTTGAGCCTGTGTGTCTCTTTGCATGTGAGATGGGTCTCCTGAATACAGCACACTGATGG
GTCTTGAGTCTTTATCCAATTTGCCATTCTGTCTTTTACTTGGGGCATTCAGCCTGTTTACATTTAAGGTTAGTATTGTTATGTGTGAAT
TTGATTCTGTCATATGATGCTAGCTGGTTATTTTGCCCGAAAGTTGATGCAGGTTCTTCGTATCCTCGATGATCTTTACAATTTGGTATG
TTTTTGCAGTGGCTGGTATTGATTGTTCCTCTCTATGTTTAGTGCTTCCTTCAGGAGCTCTTTTAGGGCAGGCCTGGTGGTAACAAAATC
TCTCAGCATTTGCTTGTCTGTAAAGGATTTTATTTCTCCTTCGCTTATGAAACTGAGTTTGGTTGGATATGAAATTCTGGGTTGAAAATT
CTTTTCTTTAAGAATGTTGAATATTGGCCCCTACTCTATTCTGGCTTGTAAGGTGTCTGCAGAGAGATCCTCTGTTAGTCTGATGGGCTT
CCCTTTGTGGCTAACCTGACCTTTCTCTCTGGCTGCCCTTAACATTTTTTCCTTCATTTCAACCTTGGTGAATATGACGATTATATGTCT
TGGGGTTGCTCTGCTCGAGGAGTATCTTTGTGGCGTTCTCTGTATTTCCTTAATTTGAATGTTGACCTGTCTTGCTAGGTTGGGGATGTT
CTCCTGGATAATATCCTGAGGAGTGTTTTCCAACTTGGTTCCATTCTCCCCGTCACTTTCAGGTACACCAATCAAACGTAGACTTGGTGT
TTTCACATAATCCCATATTTCTTGGAGGCTTTGTTAGTTCCTTTTCACTCTTTTTTCTCTAATCTTGTCTTCTCCTTTATTTCATTAAGT
TGATCTTCAATCTTTGATATCCTTTCTTGTGCTTTATCGACTTGGCTATTGATAATTGTGTATGCTTCATGAAGTTCTCATGCTGTATTT
TTCAGCTCCATCAGGTCATTTATGTGCTTCTCTATACTTGTTATTCTAGTTAGCAATTCCTCTAATCTTTTTACAGTGTTCTTAACTTCC
TTGCATTGGGTTAGAACATGCTCCTTTAGCTTGGAGGAGTTTGTTATTACCCACCTTCTGAGGCCTACTTCTATCCATCCGTCAAACTCA
TTCTCCATCCAGTTTTATTCCCTTGCTGGCAAGGAGTTGTGATCCTTTGGAGGAGAAGAGGCATTCTGTTTTTTTGAATTTTCAGCTGTT
TTGCGCTGGTTTCTCCTCATCTTCCTGGATTTATCTACTTTTGGTCTTTGATCCTGCTGATGTTCGGATGGGGTCTCTGAGTGGACATAC
TATTCCTTTCTGTTTGTTAGTTTTCCTTCTAAGAGTTAGTGCCCTCTGCTGCAGGTCTGCTGGAGTTTGCTGGAGGTCCACTCCAGATGC
TGTTTGCCTTGGTGTCACGAGTGGAGGCTGCAGAACAGCAAAGATTGCTGCCTGTTCTTTCCTCTGGAAGCTTCGTCCCAGAGGGGCACC
CACTGGATGCCAGCCAGAGCTCTCCTGTATGAGGTGTCTGTTGGCCCCTACTGGGAGATATCTCCCAATCAGGATAAACGAGGGTCAGGG
ACCCACTTGAGGAGGCAGTCTGACTCTTACCAGAGCTCGAGCACTGTGCTGGGAAATCCACTACTCTCTTCAGAGCTGTCCGGCAGAGAT
ATTTAAGTCTGCTGAAGCTGCTCCCATATCCACCCCTTCCCACAGGTGCTCTGTCCCAGGGAGATGGGGTTTTATCTATTAGTCCCTGAC
TGCCTTTTTTTTAGAGTTGCCCTGCCCAGAGAGGAGGAATCTAGAGAGGCAGTCTGGCCAGAGTGGCCTTGCTGAGCTGAGGTGGTGGGC
TCTACCCAATTCGAACTCCCAGGCAGCTTTGTTTAGACTGTGAGGGTAAAATGCCTACTCAAGCTTCAGCAATGGCAGACGGCCCTCCTC
CCTCCAAGCTCGAGTGTCCCAGGTCGACCTCAGACTGCTGTGCTTGCAATGAGGATTTCAAGCCAGTGAATCTTAGCTTGCTGGGCTCCG
TGGGGGTGGGACCCGCCAAGCTAGACCACTTGGCTCCCTGGCTTCAGCCCCCCTTCCAGGGGAGTGAATGGTTCTGCCTTGCTGGCATTC
CAGGCACCACTGGGGTATGGAAAATAAAACTCCTGCAGCTAGTTCAGTGTCTGCCCAAATGGCTGCCCAGTTTTGTGCTTGACACCCAGG
GCCCCAGTGGCGTAGGCACCGGAGGGAATCTCCTGGTCTGCAGGTTTCAAAGACCATGGGAAAAGTGCAGTATCTGGGCTGGAGTGCACC
GTTCCTCAGGTACAGTCCCTCATGGCTTCCCTTGGGTAGAGGAGGTAGTTCCCTGACCCCTTGTGCTTCCTGGGTGAGGTGACACCCCAC
CCTGTTTCAGCTGGCCCTCCATGGGCTGCACCCACTGTCCAACCAGTCCCACTGATATGAACTGGGTACCTCAGTTGGAAATGCAGAAAT
CACCCGCCTTCTGCGTTGATCTCACTGGGAGCTGCAGACCAGAGCTGTTCCTATTTGGCCATCTTGCCAGCAATCAGACCAGAGTTTTAA
ATGGACTACAAAATAGGTCAAACTCTATTTCAGAACTAGAGGCTAGGAATAATGTCCAAACTTGGTTATGAAAGTTTTTTTTTTTTTTTG
GTCTGGTAGGATAAGAGGGTTTTTACTCATCTTAAGTTTGAATTAAACTTTGTAACAAAGTTATTGTTTTTTTAAACAATGCATGTATCA
AATTATCTGTCTCATTAGATAACTAGGTAGACTTTTCCAAGATGGTTTCAAAATCAAATATATATTCAAAGATCTTCCAGTGTAAAGCAA
TAGGAATGAAACAAGCCATGAGAAAGCAGAATATTTTGAGTATATTCTCATGCCTTTCTTTAAAGGAGAAGCGCCTATCTAAACAGTTAC
AGAAACCCAAATTCAAAGTAGATTAAACAAGAAGTAAATTTGTAAACTCTTTTAACTGGGAGACAGGAAGTAGGGAGGGCTCCAGGCACA
ATATCATTAGCAGTTCAATGTGAACGAAGACCCATGTCCTTTCCAAGCCTCCCTCTGCCATCAGCATTGCCCTCCTTCCCAGGGTCACAG
ATGGCTATCAATGGCAAAACTGGGGTTCCGCGTTCTCTTCTCCTCATCTGGCAAGAGAAAATGGGAAATCTCTATCCCAAGCTTGGATTA
AAAATTATTTTCATTTTTGTGTTCCAGCAAACTTGGGTCCTATGCCCAGCCATGGACCAAAAATAGGCTTAATGTGAATGTTATGTGCTG
ATTGGATTAAAATAAGTTCTGACTCTGAATCTGGGAATGTGGTCACCTTCCTCAGAGACAAGTTGAGAGGTTGGCTTATCTGAATAAAAG
CAGAGAATATGAGATGCTGGAGAGGTGTTCATTAAGGAGAACATTCCCTGAGGTGAATTAACGGTTAGAATTATCTATCTCTGTATTTAT
CTATCCACCCATCTATCATCATCATCACCTCATCTCCCTCCTTTCTCTCTCTCTAAATATATACATGCGGGTATGTTGAGTGTGTATATA
TTTATTTTTTTGTGTGTTTATATGGTGTGTGTGTGTGTGTATTCCAGGCAGATGTGTGCATATATACCCAAACTTTCCTGATGACCTTGA
AATTAAATGGGTCATGTGAAGCTAAAGATTATAGAACCCCTTGATTCCTTTATAAACAGTATTTCTAAGATAAGATCAACACTAATCTTT
CAAATTAGTTGACTGTGTATAGAACAACTTGTTTATTTAAAGTCATCTAGTCTAATGCAATCAAGGAGTAAATTATAAATAACCAGTTAG
CATAAATGGAAAGAAAATAGTTCCTTTTCTTTGAATTCATTTCATGTTTAATTTTTCTTGCGCACATATAGAAATGAATAGAAATATTCC
CATTTCAATATGCAAATTCAGCCACTATATAGTTTGTTTCTTTTTGGTAGCTAATAATAATAAATTTTTAAGTAAGATCTGATTTTGAAA
TATGAAAAGAAGTTTATCCTTTCCTGTTTTAATACCACCTGATACCCGTTTAACTTACTGTGTTTGATTCTTGGGGACATTTATGTTCAA
GGTTCTGTCAAAGCAATCTATTATTCTTGTTTTTACCTGATGGATCATGGAGAAAAATAATGGATTCAGTTATGAGAAACAGTAATAGAT
TTTTTTAACTGCCATAAATTTCTCTCCCTGTATTAAATAAAAGGATCAGGAAAAGATAAGTTGAATTTTCCTACAATGAGCCAGCTCTTC
TTAAATTTACCTCCCATAAATTGTAGCAAAGCACTTTTCATATAATGTTTTATTTATGTAATTCAGTTATTTGGAGATGGTGGTGAGGGA
TGTGAGTACATCATTTCATGTTGTATTTCAAATCTCTTTTGACAGAAACCCTAAGAATTTGCAATAAAGAAAATTCAATGTTCCATTAAG
TTTTTCTTTTTCTTTTTTTTTAAAAAGAGGGTAAGGAAGGAAATAAGGGAATAGATTTAAGTTACCTAAGGTCAAAAGAGGCACAGGGTA
GACTCTGAATAGTTGTGGAACCTGAATATTTTGTCATCAAAAACAAAGTTAAAGTCAGAGTGACCAGGAATCTGCAAACTGGCTGTGGGA
ATGGGTTGACTTAAAAGACAGACAAAGAACTAGCCTGTGGGGTAACATCAGGCTAGGCTCACCCTCAGCTTCTACCCACAATATCTGTAT
GATGACCATGTGGATCTAATGAACCAGGAGGGGCCCAAACTCTTCCGACTCTGTGGAGGCCTAAAGGAAACTGTTGCCATTGGAAGGATG
CCATACCACTACCCAGCTGGAGCTTCCTGAAGGAAGCAGAGCCCAGCTGGTGTTCCATGGTTTGTTAAGCATATGCCATACCTACAATCA
CTTTTTTCATGGTCTGGTTGAGCATATGATTTCTGAACCAAATAGCCTTTCTGGTATTGTGTCATTGGTGACTCATTATGATTCTTTAAA
AAGACACATTATGTGAGCTAGAATGGTGATGATTTGGGTACCTTATTCAAATTGCATCATCATTTAATTCAAGAGAAAGGCCATTCTTAA
AGTAAAAGTAAATGAGGTTTGTACACCTGGGTATTGGAATTGCCAGTGGGCTGATCTGACAATGTTTGATTCTTGTTTTTTCTGGAATTA
TTATGTAGAAGATTCAGTCTATAATCTTCAACATGATGCAAATATTCAGTGTCATAGGATCAAAAAAATGCTGGAAAGTATCTAAAAATC
TTTTAAATTCATATCTTAATTTTCAGTGTTATCCTCTTACTGCCTACATTCCCCCACTAAACTCTTAGATTTTTCTCTGCTTTTGTTAAG
AAAGTGATGTTAGTAGGCCTCTCAAGTTATTTATGAAATTTAGAAATATACTGGAGAACAAAGTAGTATATAAACCCTGAATTTCAAAAG
CCTTAACAAGTTTAGCTTCAATCTACATTCAGATGACACTATCTACAGAGATGTTATAAGATTAAATTACAAGAAAAGAGATGCCCAATT
ATTTCCATTTACTCTTCTTGCCTAGGTAGTTAATTTATCTATTATTCATTTGAAGCAACAGACGTCAATGTAACATCTTTTTCATTTTCA
TGGAGAATAATCAGCTTTTCCAGAAAAGGGTGCTATATCTCAAACACACCTCAAGTGTCCAGTTGGAAGTATTACCATGCAGAGGATTCA
AGTCATATTACCTAATAACCAGAAGTTGTATGTTGGGAAAAAGTGGTTAAAAGCAACTAAAACTGCCCTGTTTGGAAGAAACTAAATATT
GCTTTATAATGATTTTCTGATATTTTAGAATAGAGGCTTCAATTATACTATTTGTGAAAAAGAAAACTGCTTGGTATTAACCAAGTTACA
TTTAATTTTTATGGTCCACAAAATTTCAGAGTAGAAATATATCATAGCTTTTAATCAATTTTCAAAATCTATATTTAATTATTGATTCAA
AAAATAAGAAATAAAATCAATTAGCCAGATTTGTATACTTTAAAGCTACCACAGTGAGATTTTTCTCTTAAAAACATGCATGTTTTTATA
TTGTATTCTTTAATATTTATATTGTACAGTTACATGTGACACATATTACATATGACTAATTTATATGTAGCAACAGGGATTAAAGAAGAC
CTCTTTTAATTGTACCACTTGTTATAATGCTATTATTTACCCAGATTCAAATGTAACTACTTACAATTTTTAAACATTTTTATTTCTGTA
TTCTTTAAAATATTAAGGCAATGGTTTTTCTTGAAATTATATTTTGCCCTATGTATTCTATTTTTATTCACACTGGATTTATTATGATAA
TTATATCAAAGTGATTATTTTTACCCTGACTTTTAAAAGTCAACTGTTTCAGAAGTCAAGTTGATTGTGGATCTAAAATATAAATTCAAT

>In-frame_FGFR2_ENST00000346997_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_13884nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGTGGTTCTTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAGACCGGTTCCTTTCTAATCAGA
GAAAGTGAAAGCCAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGAATTAAAAGACTGGATGAAGGG
GGATTTTTTCTCACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACAAGTGACGGCCTGTGTGTCAAG
CTGGGGAAACCATGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAATGGGAGATAGACCGCAACTCC
ATACAGCTTCTGAAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACCACTCCAGTAGCAGTGAAAACA
TTAAAACCAGGTTCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACATCCAAAGCTTATCCAGCTTTAT
GCTGTTTGCACTTTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAATATCTCCAAAATGACACTGGA
TCAAAAATCCATCTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAGTCTCGGAACTACATTCACAGA
GATCTGGCTGCCAGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCCAGAGTTTTTAAGGTAGATAAT
GAAGACATCTATGAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGTAGTAATAAATTCAGCATTAAG
TCCGATGTATGGTCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGTATGACAGGTGCCCAGGTAATC
CAGATGTTGGCTCAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATGTTGGAGTGCTGGAATGCAGAG
CCTAAGGAACGACCTACATTTGAGACACTGCGTTGGAAACTTGAAGACTATTTTGAAACAGACTCTTCATATTCAGATGCAAATAACTTC
ATAAGATGAACACTGGAGAAGAATATCAAATAATAAAGTAGCAAAACAAATTCAAATAATCCATTCCAAAATACAATGTTATCAACCAAC
TGCACAATCAGTTTATCCTGACATATTCAAGTGATAGGATAAAGTTGGCCATGTATTATGAAAAAGATTATTTGTGCATTTTATTGACTG
GGCAACACTGCAGGACAGTCAAGGTGATATATAATTTCCTCACTGCCTGGTAAAATTAAGCACACTAAACCAAGTTATTTTTCTTTTTAA
GAGATACTTACATTTCCATTTATTGTTTGAAATGTCGATCAAGAGAATCAACAGATGATAGTCCAATTTTTACTCAGTGACTGTTGTAGC
ATTTTCCTGTTTACTGATTAGAGTGGTTATTCATTATTCCTCAGATTGCTGAATCCCATCAGGCTGTTATTATGAAGGAATTTGATTGCT
TTGCTGCACAGCAGGACCTGTGCTTTGAGATTTTTTTTTCTCTTTTAAAATATCCTGTAACTACAATGATGGTAAAGCCATGTTAAATGA
CTTGATTGTACTTGGAGTAATTGCACATTTTTTTCTATGCATAAAAAAATGATGCAGCTGTTGAGAAAACGAAGTCTTTTTCATTTTGCA
GAAGGAAATGATGGAATTTTTCTGTACTTCAGTATGTGTCAACTGAGAGTCATATACATTAGTTTTAATCTCTTAATATTGAGAATCAGG
TTGCAAAACGGATGAGTTATTATCTATGGAAATGTGAGAAATGTCTAATAGCCCATAAAGTCTGAGAAATAGGTATCAAAATAGTTTAGG
AAAATGAGAGGAGAACAGTAGGATTGCTGTGGCCTAGACTTCTGAGTAATTAATAAAGAAAAAGAAGTACCCTTTGGCCTACAGATCAGA
GTTTTATTTATTTTTTATTTTTTACTTTTTATTATAGTTTAAGTTCTGGGGTGCATGTGCAGAATGTGCAGTTTTGTTACATAGGTGTAC
AAGTGCCATGGTGGTTTGCTGCACCCATCAACCCGTCGTCTACATTAGGCATTTCTCCTAGTGCTGTTCCTCCCCTAGCCCTCCATCCCC
TGACAGGCCCCAGTATGTGATGTTCCCCTCCTTGTGTCCATATGTTCTCATTGTTCAGCTCCCACTTATGAGTGAGAACATGCTGTGTTT
GGTTTTTTGTTCTTGTGTTAGTTTGTTAAGAATGATGGTTTCCAGCTTTATCCATGTCCCTGTGAAGGACATGAACTCATCCTTTTTTAT
GGCTGCATAGTATTCCATAGTGTCTATGTGCCACATTTTCTTTATCCAGTCTATCGTTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGC
TATTGTGAATAGTGCCACAATAAACATGCATGTGTCTTTATAGCAGAATGATTTATAAGCCTTTAGGTACATACCCAGTAATGGGATCGC
TGAGTCAAATGGTATTTCTAGTTCTAGATCCTTGAGGAATTGCTACACTGTCCTCCACAATGGTTGAACTAATTTATACTCCCACCAACA
GAGTAAAAGTGTAAATGTGTTCCTATTTCTCCACATCCTCTTTGGCATCCAAAACAGCATCCTGTTGTTTCCTGACTTTTTAATGATCAC
CATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGGATTTCTCTAATGATCAGATGATGAGCTTTTTTTCATATGTCTGT
TGGCTGCATAAATATCTTCTTTTGAAATGTGTCTGTTCAAATCCTTCGCCCACTTTTTGATGGGGTTGTTTGTTTTTTTCTTTTAAATTT
GTTTATGTTCCTTGTAGATTCTTGGTATTAGCCCTTTGTCAGATGGATAGCTTGCAAAAATTTTCTCCCATTCTGTAGGTTGCCTGTTCA
CTCTGATGATAGTTTCTTTTGCTGTCTAGAAGCTCTTTAGTTTAATTAGATCCCATTTCTCAATTTGGGCTTTTGTTGCCATTGGTTTTT
GTGTTTTAGTCATGATGTCTTTTCCAATGCCTATGTCCTGAATGGTGTTGCCTAGGTTTTCTTCTAGGGTTTTTATGGTTTTAGGTCTTA
CATTTAAGTCTTTAATCCATCTTGAGTTAATTTTTGTATAGGTGTAAGGAAGGGGTCCAGTTTCAGTTTTCTGCATATGGCTAGCTAGTT
TTCCCAACACCATTTATTAAATAGGGAATCCTTTCCCCATTGGTTGTTTTTGTAAGGTTTGTCAAAGATCAGATGGTTGTAGATGTGTGG
TGTTATTTCTGAGGCCTCTGTTCTGTTCTGTTGGTCTAGATATCTGTTTTGGTACCACTACCATGCTGTTTTGTTTACTGTAGCCTTGTA
GTATAGTTTGAAGTCAGGTAGCATGATGCCTATAACTTTGTTCTTTTTGCTTAGAATTGTCTTGGCTATGCGGGCTCTTTTTTGATTCCA
TATGAAGTTTAAAGTAGTTTTTTCCAATTCTGTGAAGAAAGTCAATGGTAGTTTGATGGGGATAGCACTGAATATATAAATTGCCTTGGG
CAATATGGCCATTTTCACGATATTGATTCTTCCTATCCATGAGCATGGAATGTTTTTCCATTTATTTGTGTCCTCTCTTATTTCCTTGAG
CAGTGGTTTGTAGTTCTCCTTGAAGAGGTCCTTTGCATCCCTTGTAAGTTGTAATCCTAGATATTTCATTCTCTTTGTAGCAATTGTGAA
TGGGAGTTCACTCATGATTTGGCTCTCTGTTTGTTATTGGTGTATAGGAATGTGTGTGATTTTTGCACATTGATTTTGTATCCTGAGACT
TTGCTGAAGTTGCTTATCAGCTTAAGGAGATTTTGGGCTGAGATGGTGGGGTTCCCTATATATACAATTCATATCATCTGCAAACAGAGA
CAATTTTACTTCCTGTTTTCCTATTTGAATACCCTTTATTTCTTTCTCTTGCCTGATTGCCCTGGCCAGAACTTTCAATACTATTTTGAA
CAGGAGTGGTGAGAGGGGGCATCCTTGTCTTGTGCCAGCTTTCAAAGGGAATGCTTCCAGGTTTACCCATTCAGTATGATATTGGCTGTG
GTTTTGTCTTAAATCTGTCATTTTTTTTGAGCTACGTTCCATCAATACCTAGTTTATTGAGAGTTTTTAGTATGAAGGGGTGTTGAATTT
TATCAAATTTTCTGCATCTATTGAGATCATCATGTGGTTTTTGTCATTGGTTCTGTTTATGTGATGGATTGTGTTTATTGATTTGCGTAT
GTTGAACCAGCCTTGTGTCTCAGGGATGAAGCCAACTTGATCGTGGTGGATAAGCTTTTTGATGTGCTGCTGCACTCAGTTTGCCAGTAT
TTTATTGAGGATTTTTGCATGGATGTTCGTCAGGGATACTGGCCTGAAATTTTCTCTCTTTTTTTTTTTTTGTTGTGTCTCTGCCAGGTT
TTGGTTTCAGGATGATGCTGGCCTCATAAAATGAGTTAGGGAGGAGTCCCTCTTTTCCTATTGTTTGGAATAGTTTCAGAAAGAATAGTA
CTAGCTTTGTACCTCTTTGTACCTCTGGTAGAATTCGGCTGTGAATCTATCTGGTCCTGGACTTTTTTTGGTTGGTAGGCTATTAATTAC
TGCCTCAATTTCAGAACTTGTTATTGGTCTATTTAGGGATTCATCTTCTTCCTGGTTTAGACTTGGGAGGGTGTATGTTTGCAGGAATTT
ACCCATTTCTTCTAGATTTTCTAGTTTATTTGCTTAGAGGTATTTATAGTAATCTCTGATGGTATTTTGTATTTCTGTGGGATCAGTGGT
GATCTCCGCTTTATCATTTTTTATTGTGTCTATTTGATTCTGCTCTCTTTTCTTCTTTATTAGTCTGGCTAGCATTCTATTTTGTTGATC
TTTTCAAAAAATCAGATCCTGGATTCATTGATTTTTTGAAAGGTTTTTCATGTCTCTATCACCTTCAGTTCTGTTCTGATCTTAGTTATT
TCTTGTCTTCTGCTAGCTTTTGAATTTGTTTGCTCTTGCTTCTCTAGTACTTTTAATTGTGATATTAGGGTATAGATTTTAGTTCTTTCC
TGATTCCTCTTGTGGGCAGTTGGTGCTATAAATTTCCCTCTACACACTGCTTTAAATGTGTCCCAGAGATTCTGGTATGTTGTGTTTTTG
TTCTCATTGGTTTCAATGAACAACTTTATTTCTACCTTAATTTTATTATTTACCCAGTAGTCATTCAGGAGCAGGTTGTTCAGTTTCCAA
GTAGTTGTTAGGTTTTCTGTCAGTTTTAATCCTGAGTTCTAATTTGATTGCACTGTGGTCTTAGAGACTGTTTGTTATGACTTCCGTTCT
TTTGCATTTGCTGAGGAGTGTTTTACTTCCAATTATGTGATCACTTTTAGAATAAGTGCGATGAGGTGCTGAGAAGAATGTATATTCTGT
TGATTTGGGGTAGAGAATTCTGTAGATGTCTGTTAGGTCCACTTGGTCCAGAGCTGAGTTCAAGTTCTGAATATCTTTGTTAATTTTCTG
TCTCATTTATCTGTCTAATATTGACAGCAGGCTGTTAAAATTTCCCACTATTATTGTGTGGGAGTCTAAGTCTCTTTGTAGTTCTCTAAG
AACTTGCTTTATGAATCTGGGTGCTTCTGTATTGGGTGTATATATATTTAGGATAGTTAGCTATTCTTGTTGCATTGATCTGTTTACCAT
TATGTAATGCCCTTCTTTGTCTCTTTTGATCTTTGTTGATTTAAAGTCTGTTTTATCAGAGACTAGGATTGCAACCCCTGCTTTTTTTTT
CTGCTTTCCGTTTGCTTCGTAAATATTCCTCCATCCCTTTATCTTGAGCCTGTGTGTCTCTTTGCATGTGAGATGGGTCTCCTGAATACA
GCACACTGATGGGTCTTGAGTCTTTATCCAATTTGCCATTCTGTCTTTTACTTGGGGCATTCAGCCTGTTTACATTTAAGGTTAGTATTG
TTATGTGTGAATTTGATTCTGTCATATGATGCTAGCTGGTTATTTTGCCCGAAAGTTGATGCAGGTTCTTCGTATCCTCGATGATCTTTA
CAATTTGGTATGTTTTTGCAGTGGCTGGTATTGATTGTTCCTCTCTATGTTTAGTGCTTCCTTCAGGAGCTCTTTTAGGGCAGGCCTGGT
GGTAACAAAATCTCTCAGCATTTGCTTGTCTGTAAAGGATTTTATTTCTCCTTCGCTTATGAAACTGAGTTTGGTTGGATATGAAATTCT
GGGTTGAAAATTCTTTTCTTTAAGAATGTTGAATATTGGCCCCTACTCTATTCTGGCTTGTAAGGTGTCTGCAGAGAGATCCTCTGTTAG
TCTGATGGGCTTCCCTTTGTGGCTAACCTGACCTTTCTCTCTGGCTGCCCTTAACATTTTTTCCTTCATTTCAACCTTGGTGAATATGAC
GATTATATGTCTTGGGGTTGCTCTGCTCGAGGAGTATCTTTGTGGCGTTCTCTGTATTTCCTTAATTTGAATGTTGACCTGTCTTGCTAG
GTTGGGGATGTTCTCCTGGATAATATCCTGAGGAGTGTTTTCCAACTTGGTTCCATTCTCCCCGTCACTTTCAGGTACACCAATCAAACG
TAGACTTGGTGTTTTCACATAATCCCATATTTCTTGGAGGCTTTGTTAGTTCCTTTTCACTCTTTTTTCTCTAATCTTGTCTTCTCCTTT
ATTTCATTAAGTTGATCTTCAATCTTTGATATCCTTTCTTGTGCTTTATCGACTTGGCTATTGATAATTGTGTATGCTTCATGAAGTTCT
CATGCTGTATTTTTCAGCTCCATCAGGTCATTTATGTGCTTCTCTATACTTGTTATTCTAGTTAGCAATTCCTCTAATCTTTTTACAGTG
TTCTTAACTTCCTTGCATTGGGTTAGAACATGCTCCTTTAGCTTGGAGGAGTTTGTTATTACCCACCTTCTGAGGCCTACTTCTATCCAT
CCGTCAAACTCATTCTCCATCCAGTTTTATTCCCTTGCTGGCAAGGAGTTGTGATCCTTTGGAGGAGAAGAGGCATTCTGTTTTTTTGAA
TTTTCAGCTGTTTTGCGCTGGTTTCTCCTCATCTTCCTGGATTTATCTACTTTTGGTCTTTGATCCTGCTGATGTTCGGATGGGGTCTCT
GAGTGGACATACTATTCCTTTCTGTTTGTTAGTTTTCCTTCTAAGAGTTAGTGCCCTCTGCTGCAGGTCTGCTGGAGTTTGCTGGAGGTC
CACTCCAGATGCTGTTTGCCTTGGTGTCACGAGTGGAGGCTGCAGAACAGCAAAGATTGCTGCCTGTTCTTTCCTCTGGAAGCTTCGTCC
CAGAGGGGCACCCACTGGATGCCAGCCAGAGCTCTCCTGTATGAGGTGTCTGTTGGCCCCTACTGGGAGATATCTCCCAATCAGGATAAA
CGAGGGTCAGGGACCCACTTGAGGAGGCAGTCTGACTCTTACCAGAGCTCGAGCACTGTGCTGGGAAATCCACTACTCTCTTCAGAGCTG
TCCGGCAGAGATATTTAAGTCTGCTGAAGCTGCTCCCATATCCACCCCTTCCCACAGGTGCTCTGTCCCAGGGAGATGGGGTTTTATCTA
TTAGTCCCTGACTGCCTTTTTTTTAGAGTTGCCCTGCCCAGAGAGGAGGAATCTAGAGAGGCAGTCTGGCCAGAGTGGCCTTGCTGAGCT
GAGGTGGTGGGCTCTACCCAATTCGAACTCCCAGGCAGCTTTGTTTAGACTGTGAGGGTAAAATGCCTACTCAAGCTTCAGCAATGGCAG
ACGGCCCTCCTCCCTCCAAGCTCGAGTGTCCCAGGTCGACCTCAGACTGCTGTGCTTGCAATGAGGATTTCAAGCCAGTGAATCTTAGCT
TGCTGGGCTCCGTGGGGGTGGGACCCGCCAAGCTAGACCACTTGGCTCCCTGGCTTCAGCCCCCCTTCCAGGGGAGTGAATGGTTCTGCC
TTGCTGGCATTCCAGGCACCACTGGGGTATGGAAAATAAAACTCCTGCAGCTAGTTCAGTGTCTGCCCAAATGGCTGCCCAGTTTTGTGC
TTGACACCCAGGGCCCCAGTGGCGTAGGCACCGGAGGGAATCTCCTGGTCTGCAGGTTTCAAAGACCATGGGAAAAGTGCAGTATCTGGG
CTGGAGTGCACCGTTCCTCAGGTACAGTCCCTCATGGCTTCCCTTGGGTAGAGGAGGTAGTTCCCTGACCCCTTGTGCTTCCTGGGTGAG
GTGACACCCCACCCTGTTTCAGCTGGCCCTCCATGGGCTGCACCCACTGTCCAACCAGTCCCACTGATATGAACTGGGTACCTCAGTTGG
AAATGCAGAAATCACCCGCCTTCTGCGTTGATCTCACTGGGAGCTGCAGACCAGAGCTGTTCCTATTTGGCCATCTTGCCAGCAATCAGA
CCAGAGTTTTAAATGGACTACAAAATAGGTCAAACTCTATTTCAGAACTAGAGGCTAGGAATAATGTCCAAACTTGGTTATGAAAGTTTT
TTTTTTTTTTTGGTCTGGTAGGATAAGAGGGTTTTTACTCATCTTAAGTTTGAATTAAACTTTGTAACAAAGTTATTGTTTTTTTAAACA
ATGCATGTATCAAATTATCTGTCTCATTAGATAACTAGGTAGACTTTTCCAAGATGGTTTCAAAATCAAATATATATTCAAAGATCTTCC
AGTGTAAAGCAATAGGAATGAAACAAGCCATGAGAAAGCAGAATATTTTGAGTATATTCTCATGCCTTTCTTTAAAGGAGAAGCGCCTAT
CTAAACAGTTACAGAAACCCAAATTCAAAGTAGATTAAACAAGAAGTAAATTTGTAAACTCTTTTAACTGGGAGACAGGAAGTAGGGAGG
GCTCCAGGCACAATATCATTAGCAGTTCAATGTGAACGAAGACCCATGTCCTTTCCAAGCCTCCCTCTGCCATCAGCATTGCCCTCCTTC
CCAGGGTCACAGATGGCTATCAATGGCAAAACTGGGGTTCCGCGTTCTCTTCTCCTCATCTGGCAAGAGAAAATGGGAAATCTCTATCCC
AAGCTTGGATTAAAAATTATTTTCATTTTTGTGTTCCAGCAAACTTGGGTCCTATGCCCAGCCATGGACCAAAAATAGGCTTAATGTGAA
TGTTATGTGCTGATTGGATTAAAATAAGTTCTGACTCTGAATCTGGGAATGTGGTCACCTTCCTCAGAGACAAGTTGAGAGGTTGGCTTA
TCTGAATAAAAGCAGAGAATATGAGATGCTGGAGAGGTGTTCATTAAGGAGAACATTCCCTGAGGTGAATTAACGGTTAGAATTATCTAT
CTCTGTATTTATCTATCCACCCATCTATCATCATCATCACCTCATCTCCCTCCTTTCTCTCTCTCTAAATATATACATGCGGGTATGTTG
AGTGTGTATATATTTATTTTTTTGTGTGTTTATATGGTGTGTGTGTGTGTGTATTCCAGGCAGATGTGTGCATATATACCCAAACTTTCC
TGATGACCTTGAAATTAAATGGGTCATGTGAAGCTAAAGATTATAGAACCCCTTGATTCCTTTATAAACAGTATTTCTAAGATAAGATCA
ACACTAATCTTTCAAATTAGTTGACTGTGTATAGAACAACTTGTTTATTTAAAGTCATCTAGTCTAATGCAATCAAGGAGTAAATTATAA
ATAACCAGTTAGCATAAATGGAAAGAAAATAGTTCCTTTTCTTTGAATTCATTTCATGTTTAATTTTTCTTGCGCACATATAGAAATGAA
TAGAAATATTCCCATTTCAATATGCAAATTCAGCCACTATATAGTTTGTTTCTTTTTGGTAGCTAATAATAATAAATTTTTAAGTAAGAT
CTGATTTTGAAATATGAAAAGAAGTTTATCCTTTCCTGTTTTAATACCACCTGATACCCGTTTAACTTACTGTGTTTGATTCTTGGGGAC
ATTTATGTTCAAGGTTCTGTCAAAGCAATCTATTATTCTTGTTTTTACCTGATGGATCATGGAGAAAAATAATGGATTCAGTTATGAGAA
ACAGTAATAGATTTTTTTAACTGCCATAAATTTCTCTCCCTGTATTAAATAAAAGGATCAGGAAAAGATAAGTTGAATTTTCCTACAATG
AGCCAGCTCTTCTTAAATTTACCTCCCATAAATTGTAGCAAAGCACTTTTCATATAATGTTTTATTTATGTAATTCAGTTATTTGGAGAT
GGTGGTGAGGGATGTGAGTACATCATTTCATGTTGTATTTCAAATCTCTTTTGACAGAAACCCTAAGAATTTGCAATAAAGAAAATTCAA
TGTTCCATTAAGTTTTTCTTTTTCTTTTTTTTTAAAAAGAGGGTAAGGAAGGAAATAAGGGAATAGATTTAAGTTACCTAAGGTCAAAAG
AGGCACAGGGTAGACTCTGAATAGTTGTGGAACCTGAATATTTTGTCATCAAAAACAAAGTTAAAGTCAGAGTGACCAGGAATCTGCAAA
CTGGCTGTGGGAATGGGTTGACTTAAAAGACAGACAAAGAACTAGCCTGTGGGGTAACATCAGGCTAGGCTCACCCTCAGCTTCTACCCA
CAATATCTGTATGATGACCATGTGGATCTAATGAACCAGGAGGGGCCCAAACTCTTCCGACTCTGTGGAGGCCTAAAGGAAACTGTTGCC
ATTGGAAGGATGCCATACCACTACCCAGCTGGAGCTTCCTGAAGGAAGCAGAGCCCAGCTGGTGTTCCATGGTTTGTTAAGCATATGCCA
TACCTACAATCACTTTTTTCATGGTCTGGTTGAGCATATGATTTCTGAACCAAATAGCCTTTCTGGTATTGTGTCATTGGTGACTCATTA
TGATTCTTTAAAAAGACACATTATGTGAGCTAGAATGGTGATGATTTGGGTACCTTATTCAAATTGCATCATCATTTAATTCAAGAGAAA
GGCCATTCTTAAAGTAAAAGTAAATGAGGTTTGTACACCTGGGTATTGGAATTGCCAGTGGGCTGATCTGACAATGTTTGATTCTTGTTT
TTTCTGGAATTATTATGTAGAAGATTCAGTCTATAATCTTCAACATGATGCAAATATTCAGTGTCATAGGATCAAAAAAATGCTGGAAAG
TATCTAAAAATCTTTTAAATTCATATCTTAATTTTCAGTGTTATCCTCTTACTGCCTACATTCCCCCACTAAACTCTTAGATTTTTCTCT
GCTTTTGTTAAGAAAGTGATGTTAGTAGGCCTCTCAAGTTATTTATGAAATTTAGAAATATACTGGAGAACAAAGTAGTATATAAACCCT
GAATTTCAAAAGCCTTAACAAGTTTAGCTTCAATCTACATTCAGATGACACTATCTACAGAGATGTTATAAGATTAAATTACAAGAAAAG
AGATGCCCAATTATTTCCATTTACTCTTCTTGCCTAGGTAGTTAATTTATCTATTATTCATTTGAAGCAACAGACGTCAATGTAACATCT
TTTTCATTTTCATGGAGAATAATCAGCTTTTCCAGAAAAGGGTGCTATATCTCAAACACACCTCAAGTGTCCAGTTGGAAGTATTACCAT
GCAGAGGATTCAAGTCATATTACCTAATAACCAGAAGTTGTATGTTGGGAAAAAGTGGTTAAAAGCAACTAAAACTGCCCTGTTTGGAAG
AAACTAAATATTGCTTTATAATGATTTTCTGATATTTTAGAATAGAGGCTTCAATTATACTATTTGTGAAAAAGAAAACTGCTTGGTATT
AACCAAGTTACATTTAATTTTTATGGTCCACAAAATTTCAGAGTAGAAATATATCATAGCTTTTAATCAATTTTCAAAATCTATATTTAA
TTATTGATTCAAAAAATAAGAAATAAAATCAATTAGCCAGATTTGTATACTTTAAAGCTACCACAGTGAGATTTTTCTCTTAAAAACATG
CATGTTTTTATATTGTATTCTTTAATATTTATATTGTACAGTTACATGTGACACATATTACATATGACTAATTTATATGTAGCAACAGGG
ATTAAAGAAGACCTCTTTTAATTGTACCACTTGTTATAATGCTATTATTTACCCAGATTCAAATGTAACTACTTACAATTTTTAAACATT
TTTATTTCTGTATTCTTTAAAATATTAAGGCAATGGTTTTTCTTGAAATTATATTTTGCCCTATGTATTCTATTTTTATTCACACTGGAT
TTATTATGATAATTATATCAAAGTGATTATTTTTACCCTGACTTTTAAAAGTCAACTGTTTCAGAAGTCAAGTTGATTGTGGATCTAAAA

>In-frame_FGFR2_ENST00000369056_chr10_123263304_-_FRK_ENST00000606080_chr6_116325161_-_13905nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGTGGTTCTTTGGAGCAATCGGAAGATCAGATGCAGAGAAACAACTATTATATTCAGAAAACAAG
ACCGGTTCCTTTCTAATCAGAGAAAGTGAAAGCCAAAAAGGAGAATTCTCTCTTTCAGTTTTAGATGGAGCAGTTGTAAAACACTACAGA
ATTAAAAGACTGGATGAAGGGGGATTTTTTCTCACGCGAAGAAGAATCTTTTCAACACTGAACGAATTTGTGAGCCACTACACCAAGACA
AGTGACGGCCTGTGTGTCAAGCTGGGGAAACCATGCTTAAAGATCCAGGTCCCAGCTCCATTTGATTTGTCGTATAAAACCGTGGACCAA
TGGGAGATAGACCGCAACTCCATACAGCTTCTGAAGCGATTGGGATCTGGTCAGTTTGGCGAAGTATGGGAAGGTCTGTGGAACAATACC
ACTCCAGTAGCAGTGAAAACATTAAAACCAGGTTCAATGGATCCAAATGACTTCCTGAGGGAGGCACAGATAATGAAGAACCTAAGACAT
CCAAAGCTTATCCAGCTTTATGCTGTTTGCACTTTAGAAGATCCAATTTATATTATTACAGAGTTGATGAGACATGGAAGTCTGCAAGAA
TATCTCCAAAATGACACTGGATCAAAAATCCATCTGACTCAACAGGTAGACATGGCGGCACAGGTTGCCTCTGGAATGGCCTATCTGGAG
TCTCGGAACTACATTCACAGAGATCTGGCTGCCAGAAATGTCCTCGTTGGTGAACATAATATCTACAAAGTAGCAGATTTTGGACTTGCC
AGAGTTTTTAAGGTAGATAATGAAGACATCTATGAATCTAGACACGAAATAAAGCTGCCGGTGAAGTGGACTGCGCCCGAAGCCATTCGT
AGTAATAAATTCAGCATTAAGTCCGATGTATGGTCATTTGGAATCCTTCTTTATGAAATCATTACTTATGGCAAAATGCCTTACAGTGGT
ATGACAGGTGCCCAGGTAATCCAGATGTTGGCTCAAAACTATAGACTTCCGCAACCATCCAACTGTCCACAGCAATTTTACAACATCATG
TTGGAGTGCTGGAATGCAGAGCCTAAGGAACGACCTACATTTGAGACACTGCGTTGGAAACTTGAAGACTATTTTGAAACAGACTCTTCA
TATTCAGATGCAAATAACTTCATAAGATGAACACTGGAGAAGAATATCAAATAATAAAGTAGCAAAACAAATTCAAATAATCCATTCCAA
AATACAATGTTATCAACCAACTGCACAATCAGTTTATCCTGACATATTCAAGTGATAGGATAAAGTTGGCCATGTATTATGAAAAAGATT
ATTTGTGCATTTTATTGACTGGGCAACACTGCAGGACAGTCAAGGTGATATATAATTTCCTCACTGCCTGGTAAAATTAAGCACACTAAA
CCAAGTTATTTTTCTTTTTAAGAGATACTTACATTTCCATTTATTGTTTGAAATGTCGATCAAGAGAATCAACAGATGATAGTCCAATTT
TTACTCAGTGACTGTTGTAGCATTTTCCTGTTTACTGATTAGAGTGGTTATTCATTATTCCTCAGATTGCTGAATCCCATCAGGCTGTTA
TTATGAAGGAATTTGATTGCTTTGCTGCACAGCAGGACCTGTGCTTTGAGATTTTTTTTTCTCTTTTAAAATATCCTGTAACTACAATGA
TGGTAAAGCCATGTTAAATGACTTGATTGTACTTGGAGTAATTGCACATTTTTTTCTATGCATAAAAAAATGATGCAGCTGTTGAGAAAA
CGAAGTCTTTTTCATTTTGCAGAAGGAAATGATGGAATTTTTCTGTACTTCAGTATGTGTCAACTGAGAGTCATATACATTAGTTTTAAT
CTCTTAATATTGAGAATCAGGTTGCAAAACGGATGAGTTATTATCTATGGAAATGTGAGAAATGTCTAATAGCCCATAAAGTCTGAGAAA
TAGGTATCAAAATAGTTTAGGAAAATGAGAGGAGAACAGTAGGATTGCTGTGGCCTAGACTTCTGAGTAATTAATAAAGAAAAAGAAGTA
CCCTTTGGCCTACAGATCAGAGTTTTATTTATTTTTTATTTTTTACTTTTTATTATAGTTTAAGTTCTGGGGTGCATGTGCAGAATGTGC
AGTTTTGTTACATAGGTGTACAAGTGCCATGGTGGTTTGCTGCACCCATCAACCCGTCGTCTACATTAGGCATTTCTCCTAGTGCTGTTC
CTCCCCTAGCCCTCCATCCCCTGACAGGCCCCAGTATGTGATGTTCCCCTCCTTGTGTCCATATGTTCTCATTGTTCAGCTCCCACTTAT
GAGTGAGAACATGCTGTGTTTGGTTTTTTGTTCTTGTGTTAGTTTGTTAAGAATGATGGTTTCCAGCTTTATCCATGTCCCTGTGAAGGA
CATGAACTCATCCTTTTTTATGGCTGCATAGTATTCCATAGTGTCTATGTGCCACATTTTCTTTATCCAGTCTATCGTTGATGGGCATTT
GGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCACAATAAACATGCATGTGTCTTTATAGCAGAATGATTTATAAGCCTTTAGGTA
CATACCCAGTAATGGGATCGCTGAGTCAAATGGTATTTCTAGTTCTAGATCCTTGAGGAATTGCTACACTGTCCTCCACAATGGTTGAAC
TAATTTATACTCCCACCAACAGAGTAAAAGTGTAAATGTGTTCCTATTTCTCCACATCCTCTTTGGCATCCAAAACAGCATCCTGTTGTT
TCCTGACTTTTTAATGATCACCATTCTAACTGGTGTGAGATGGTATCTCATTGTGGTTTTGATTTGGATTTCTCTAATGATCAGATGATG
AGCTTTTTTTCATATGTCTGTTGGCTGCATAAATATCTTCTTTTGAAATGTGTCTGTTCAAATCCTTCGCCCACTTTTTGATGGGGTTGT
TTGTTTTTTTCTTTTAAATTTGTTTATGTTCCTTGTAGATTCTTGGTATTAGCCCTTTGTCAGATGGATAGCTTGCAAAAATTTTCTCCC
ATTCTGTAGGTTGCCTGTTCACTCTGATGATAGTTTCTTTTGCTGTCTAGAAGCTCTTTAGTTTAATTAGATCCCATTTCTCAATTTGGG
CTTTTGTTGCCATTGGTTTTTGTGTTTTAGTCATGATGTCTTTTCCAATGCCTATGTCCTGAATGGTGTTGCCTAGGTTTTCTTCTAGGG
TTTTTATGGTTTTAGGTCTTACATTTAAGTCTTTAATCCATCTTGAGTTAATTTTTGTATAGGTGTAAGGAAGGGGTCCAGTTTCAGTTT
TCTGCATATGGCTAGCTAGTTTTCCCAACACCATTTATTAAATAGGGAATCCTTTCCCCATTGGTTGTTTTTGTAAGGTTTGTCAAAGAT
CAGATGGTTGTAGATGTGTGGTGTTATTTCTGAGGCCTCTGTTCTGTTCTGTTGGTCTAGATATCTGTTTTGGTACCACTACCATGCTGT
TTTGTTTACTGTAGCCTTGTAGTATAGTTTGAAGTCAGGTAGCATGATGCCTATAACTTTGTTCTTTTTGCTTAGAATTGTCTTGGCTAT
GCGGGCTCTTTTTTGATTCCATATGAAGTTTAAAGTAGTTTTTTCCAATTCTGTGAAGAAAGTCAATGGTAGTTTGATGGGGATAGCACT
GAATATATAAATTGCCTTGGGCAATATGGCCATTTTCACGATATTGATTCTTCCTATCCATGAGCATGGAATGTTTTTCCATTTATTTGT
GTCCTCTCTTATTTCCTTGAGCAGTGGTTTGTAGTTCTCCTTGAAGAGGTCCTTTGCATCCCTTGTAAGTTGTAATCCTAGATATTTCAT
TCTCTTTGTAGCAATTGTGAATGGGAGTTCACTCATGATTTGGCTCTCTGTTTGTTATTGGTGTATAGGAATGTGTGTGATTTTTGCACA
TTGATTTTGTATCCTGAGACTTTGCTGAAGTTGCTTATCAGCTTAAGGAGATTTTGGGCTGAGATGGTGGGGTTCCCTATATATACAATT
CATATCATCTGCAAACAGAGACAATTTTACTTCCTGTTTTCCTATTTGAATACCCTTTATTTCTTTCTCTTGCCTGATTGCCCTGGCCAG
AACTTTCAATACTATTTTGAACAGGAGTGGTGAGAGGGGGCATCCTTGTCTTGTGCCAGCTTTCAAAGGGAATGCTTCCAGGTTTACCCA
TTCAGTATGATATTGGCTGTGGTTTTGTCTTAAATCTGTCATTTTTTTTGAGCTACGTTCCATCAATACCTAGTTTATTGAGAGTTTTTA
GTATGAAGGGGTGTTGAATTTTATCAAATTTTCTGCATCTATTGAGATCATCATGTGGTTTTTGTCATTGGTTCTGTTTATGTGATGGAT
TGTGTTTATTGATTTGCGTATGTTGAACCAGCCTTGTGTCTCAGGGATGAAGCCAACTTGATCGTGGTGGATAAGCTTTTTGATGTGCTG
CTGCACTCAGTTTGCCAGTATTTTATTGAGGATTTTTGCATGGATGTTCGTCAGGGATACTGGCCTGAAATTTTCTCTCTTTTTTTTTTT
TTGTTGTGTCTCTGCCAGGTTTTGGTTTCAGGATGATGCTGGCCTCATAAAATGAGTTAGGGAGGAGTCCCTCTTTTCCTATTGTTTGGA
ATAGTTTCAGAAAGAATAGTACTAGCTTTGTACCTCTTTGTACCTCTGGTAGAATTCGGCTGTGAATCTATCTGGTCCTGGACTTTTTTT
GGTTGGTAGGCTATTAATTACTGCCTCAATTTCAGAACTTGTTATTGGTCTATTTAGGGATTCATCTTCTTCCTGGTTTAGACTTGGGAG
GGTGTATGTTTGCAGGAATTTACCCATTTCTTCTAGATTTTCTAGTTTATTTGCTTAGAGGTATTTATAGTAATCTCTGATGGTATTTTG
TATTTCTGTGGGATCAGTGGTGATCTCCGCTTTATCATTTTTTATTGTGTCTATTTGATTCTGCTCTCTTTTCTTCTTTATTAGTCTGGC
TAGCATTCTATTTTGTTGATCTTTTCAAAAAATCAGATCCTGGATTCATTGATTTTTTGAAAGGTTTTTCATGTCTCTATCACCTTCAGT
TCTGTTCTGATCTTAGTTATTTCTTGTCTTCTGCTAGCTTTTGAATTTGTTTGCTCTTGCTTCTCTAGTACTTTTAATTGTGATATTAGG
GTATAGATTTTAGTTCTTTCCTGATTCCTCTTGTGGGCAGTTGGTGCTATAAATTTCCCTCTACACACTGCTTTAAATGTGTCCCAGAGA
TTCTGGTATGTTGTGTTTTTGTTCTCATTGGTTTCAATGAACAACTTTATTTCTACCTTAATTTTATTATTTACCCAGTAGTCATTCAGG
AGCAGGTTGTTCAGTTTCCAAGTAGTTGTTAGGTTTTCTGTCAGTTTTAATCCTGAGTTCTAATTTGATTGCACTGTGGTCTTAGAGACT
GTTTGTTATGACTTCCGTTCTTTTGCATTTGCTGAGGAGTGTTTTACTTCCAATTATGTGATCACTTTTAGAATAAGTGCGATGAGGTGC
TGAGAAGAATGTATATTCTGTTGATTTGGGGTAGAGAATTCTGTAGATGTCTGTTAGGTCCACTTGGTCCAGAGCTGAGTTCAAGTTCTG
AATATCTTTGTTAATTTTCTGTCTCATTTATCTGTCTAATATTGACAGCAGGCTGTTAAAATTTCCCACTATTATTGTGTGGGAGTCTAA
GTCTCTTTGTAGTTCTCTAAGAACTTGCTTTATGAATCTGGGTGCTTCTGTATTGGGTGTATATATATTTAGGATAGTTAGCTATTCTTG
TTGCATTGATCTGTTTACCATTATGTAATGCCCTTCTTTGTCTCTTTTGATCTTTGTTGATTTAAAGTCTGTTTTATCAGAGACTAGGAT
TGCAACCCCTGCTTTTTTTTTCTGCTTTCCGTTTGCTTCGTAAATATTCCTCCATCCCTTTATCTTGAGCCTGTGTGTCTCTTTGCATGT
GAGATGGGTCTCCTGAATACAGCACACTGATGGGTCTTGAGTCTTTATCCAATTTGCCATTCTGTCTTTTACTTGGGGCATTCAGCCTGT
TTACATTTAAGGTTAGTATTGTTATGTGTGAATTTGATTCTGTCATATGATGCTAGCTGGTTATTTTGCCCGAAAGTTGATGCAGGTTCT
TCGTATCCTCGATGATCTTTACAATTTGGTATGTTTTTGCAGTGGCTGGTATTGATTGTTCCTCTCTATGTTTAGTGCTTCCTTCAGGAG
CTCTTTTAGGGCAGGCCTGGTGGTAACAAAATCTCTCAGCATTTGCTTGTCTGTAAAGGATTTTATTTCTCCTTCGCTTATGAAACTGAG
TTTGGTTGGATATGAAATTCTGGGTTGAAAATTCTTTTCTTTAAGAATGTTGAATATTGGCCCCTACTCTATTCTGGCTTGTAAGGTGTC
TGCAGAGAGATCCTCTGTTAGTCTGATGGGCTTCCCTTTGTGGCTAACCTGACCTTTCTCTCTGGCTGCCCTTAACATTTTTTCCTTCAT
TTCAACCTTGGTGAATATGACGATTATATGTCTTGGGGTTGCTCTGCTCGAGGAGTATCTTTGTGGCGTTCTCTGTATTTCCTTAATTTG
AATGTTGACCTGTCTTGCTAGGTTGGGGATGTTCTCCTGGATAATATCCTGAGGAGTGTTTTCCAACTTGGTTCCATTCTCCCCGTCACT
TTCAGGTACACCAATCAAACGTAGACTTGGTGTTTTCACATAATCCCATATTTCTTGGAGGCTTTGTTAGTTCCTTTTCACTCTTTTTTC
TCTAATCTTGTCTTCTCCTTTATTTCATTAAGTTGATCTTCAATCTTTGATATCCTTTCTTGTGCTTTATCGACTTGGCTATTGATAATT
GTGTATGCTTCATGAAGTTCTCATGCTGTATTTTTCAGCTCCATCAGGTCATTTATGTGCTTCTCTATACTTGTTATTCTAGTTAGCAAT
TCCTCTAATCTTTTTACAGTGTTCTTAACTTCCTTGCATTGGGTTAGAACATGCTCCTTTAGCTTGGAGGAGTTTGTTATTACCCACCTT
CTGAGGCCTACTTCTATCCATCCGTCAAACTCATTCTCCATCCAGTTTTATTCCCTTGCTGGCAAGGAGTTGTGATCCTTTGGAGGAGAA
GAGGCATTCTGTTTTTTTGAATTTTCAGCTGTTTTGCGCTGGTTTCTCCTCATCTTCCTGGATTTATCTACTTTTGGTCTTTGATCCTGC
TGATGTTCGGATGGGGTCTCTGAGTGGACATACTATTCCTTTCTGTTTGTTAGTTTTCCTTCTAAGAGTTAGTGCCCTCTGCTGCAGGTC
TGCTGGAGTTTGCTGGAGGTCCACTCCAGATGCTGTTTGCCTTGGTGTCACGAGTGGAGGCTGCAGAACAGCAAAGATTGCTGCCTGTTC
TTTCCTCTGGAAGCTTCGTCCCAGAGGGGCACCCACTGGATGCCAGCCAGAGCTCTCCTGTATGAGGTGTCTGTTGGCCCCTACTGGGAG
ATATCTCCCAATCAGGATAAACGAGGGTCAGGGACCCACTTGAGGAGGCAGTCTGACTCTTACCAGAGCTCGAGCACTGTGCTGGGAAAT
CCACTACTCTCTTCAGAGCTGTCCGGCAGAGATATTTAAGTCTGCTGAAGCTGCTCCCATATCCACCCCTTCCCACAGGTGCTCTGTCCC
AGGGAGATGGGGTTTTATCTATTAGTCCCTGACTGCCTTTTTTTTAGAGTTGCCCTGCCCAGAGAGGAGGAATCTAGAGAGGCAGTCTGG
CCAGAGTGGCCTTGCTGAGCTGAGGTGGTGGGCTCTACCCAATTCGAACTCCCAGGCAGCTTTGTTTAGACTGTGAGGGTAAAATGCCTA
CTCAAGCTTCAGCAATGGCAGACGGCCCTCCTCCCTCCAAGCTCGAGTGTCCCAGGTCGACCTCAGACTGCTGTGCTTGCAATGAGGATT
TCAAGCCAGTGAATCTTAGCTTGCTGGGCTCCGTGGGGGTGGGACCCGCCAAGCTAGACCACTTGGCTCCCTGGCTTCAGCCCCCCTTCC
AGGGGAGTGAATGGTTCTGCCTTGCTGGCATTCCAGGCACCACTGGGGTATGGAAAATAAAACTCCTGCAGCTAGTTCAGTGTCTGCCCA
AATGGCTGCCCAGTTTTGTGCTTGACACCCAGGGCCCCAGTGGCGTAGGCACCGGAGGGAATCTCCTGGTCTGCAGGTTTCAAAGACCAT
GGGAAAAGTGCAGTATCTGGGCTGGAGTGCACCGTTCCTCAGGTACAGTCCCTCATGGCTTCCCTTGGGTAGAGGAGGTAGTTCCCTGAC
CCCTTGTGCTTCCTGGGTGAGGTGACACCCCACCCTGTTTCAGCTGGCCCTCCATGGGCTGCACCCACTGTCCAACCAGTCCCACTGATA
TGAACTGGGTACCTCAGTTGGAAATGCAGAAATCACCCGCCTTCTGCGTTGATCTCACTGGGAGCTGCAGACCAGAGCTGTTCCTATTTG
GCCATCTTGCCAGCAATCAGACCAGAGTTTTAAATGGACTACAAAATAGGTCAAACTCTATTTCAGAACTAGAGGCTAGGAATAATGTCC
AAACTTGGTTATGAAAGTTTTTTTTTTTTTTTGGTCTGGTAGGATAAGAGGGTTTTTACTCATCTTAAGTTTGAATTAAACTTTGTAACA
AAGTTATTGTTTTTTTAAACAATGCATGTATCAAATTATCTGTCTCATTAGATAACTAGGTAGACTTTTCCAAGATGGTTTCAAAATCAA
ATATATATTCAAAGATCTTCCAGTGTAAAGCAATAGGAATGAAACAAGCCATGAGAAAGCAGAATATTTTGAGTATATTCTCATGCCTTT
CTTTAAAGGAGAAGCGCCTATCTAAACAGTTACAGAAACCCAAATTCAAAGTAGATTAAACAAGAAGTAAATTTGTAAACTCTTTTAACT
GGGAGACAGGAAGTAGGGAGGGCTCCAGGCACAATATCATTAGCAGTTCAATGTGAACGAAGACCCATGTCCTTTCCAAGCCTCCCTCTG
CCATCAGCATTGCCCTCCTTCCCAGGGTCACAGATGGCTATCAATGGCAAAACTGGGGTTCCGCGTTCTCTTCTCCTCATCTGGCAAGAG
AAAATGGGAAATCTCTATCCCAAGCTTGGATTAAAAATTATTTTCATTTTTGTGTTCCAGCAAACTTGGGTCCTATGCCCAGCCATGGAC
CAAAAATAGGCTTAATGTGAATGTTATGTGCTGATTGGATTAAAATAAGTTCTGACTCTGAATCTGGGAATGTGGTCACCTTCCTCAGAG
ACAAGTTGAGAGGTTGGCTTATCTGAATAAAAGCAGAGAATATGAGATGCTGGAGAGGTGTTCATTAAGGAGAACATTCCCTGAGGTGAA
TTAACGGTTAGAATTATCTATCTCTGTATTTATCTATCCACCCATCTATCATCATCATCACCTCATCTCCCTCCTTTCTCTCTCTCTAAA
TATATACATGCGGGTATGTTGAGTGTGTATATATTTATTTTTTTGTGTGTTTATATGGTGTGTGTGTGTGTGTATTCCAGGCAGATGTGT
GCATATATACCCAAACTTTCCTGATGACCTTGAAATTAAATGGGTCATGTGAAGCTAAAGATTATAGAACCCCTTGATTCCTTTATAAAC
AGTATTTCTAAGATAAGATCAACACTAATCTTTCAAATTAGTTGACTGTGTATAGAACAACTTGTTTATTTAAAGTCATCTAGTCTAATG
CAATCAAGGAGTAAATTATAAATAACCAGTTAGCATAAATGGAAAGAAAATAGTTCCTTTTCTTTGAATTCATTTCATGTTTAATTTTTC
TTGCGCACATATAGAAATGAATAGAAATATTCCCATTTCAATATGCAAATTCAGCCACTATATAGTTTGTTTCTTTTTGGTAGCTAATAA
TAATAAATTTTTAAGTAAGATCTGATTTTGAAATATGAAAAGAAGTTTATCCTTTCCTGTTTTAATACCACCTGATACCCGTTTAACTTA
CTGTGTTTGATTCTTGGGGACATTTATGTTCAAGGTTCTGTCAAAGCAATCTATTATTCTTGTTTTTACCTGATGGATCATGGAGAAAAA
TAATGGATTCAGTTATGAGAAACAGTAATAGATTTTTTTAACTGCCATAAATTTCTCTCCCTGTATTAAATAAAAGGATCAGGAAAAGAT
AAGTTGAATTTTCCTACAATGAGCCAGCTCTTCTTAAATTTACCTCCCATAAATTGTAGCAAAGCACTTTTCATATAATGTTTTATTTAT
GTAATTCAGTTATTTGGAGATGGTGGTGAGGGATGTGAGTACATCATTTCATGTTGTATTTCAAATCTCTTTTGACAGAAACCCTAAGAA
TTTGCAATAAAGAAAATTCAATGTTCCATTAAGTTTTTCTTTTTCTTTTTTTTTAAAAAGAGGGTAAGGAAGGAAATAAGGGAATAGATT
TAAGTTACCTAAGGTCAAAAGAGGCACAGGGTAGACTCTGAATAGTTGTGGAACCTGAATATTTTGTCATCAAAAACAAAGTTAAAGTCA
GAGTGACCAGGAATCTGCAAACTGGCTGTGGGAATGGGTTGACTTAAAAGACAGACAAAGAACTAGCCTGTGGGGTAACATCAGGCTAGG
CTCACCCTCAGCTTCTACCCACAATATCTGTATGATGACCATGTGGATCTAATGAACCAGGAGGGGCCCAAACTCTTCCGACTCTGTGGA
GGCCTAAAGGAAACTGTTGCCATTGGAAGGATGCCATACCACTACCCAGCTGGAGCTTCCTGAAGGAAGCAGAGCCCAGCTGGTGTTCCA
TGGTTTGTTAAGCATATGCCATACCTACAATCACTTTTTTCATGGTCTGGTTGAGCATATGATTTCTGAACCAAATAGCCTTTCTGGTAT
TGTGTCATTGGTGACTCATTATGATTCTTTAAAAAGACACATTATGTGAGCTAGAATGGTGATGATTTGGGTACCTTATTCAAATTGCAT
CATCATTTAATTCAAGAGAAAGGCCATTCTTAAAGTAAAAGTAAATGAGGTTTGTACACCTGGGTATTGGAATTGCCAGTGGGCTGATCT
GACAATGTTTGATTCTTGTTTTTTCTGGAATTATTATGTAGAAGATTCAGTCTATAATCTTCAACATGATGCAAATATTCAGTGTCATAG
GATCAAAAAAATGCTGGAAAGTATCTAAAAATCTTTTAAATTCATATCTTAATTTTCAGTGTTATCCTCTTACTGCCTACATTCCCCCAC
TAAACTCTTAGATTTTTCTCTGCTTTTGTTAAGAAAGTGATGTTAGTAGGCCTCTCAAGTTATTTATGAAATTTAGAAATATACTGGAGA
ACAAAGTAGTATATAAACCCTGAATTTCAAAAGCCTTAACAAGTTTAGCTTCAATCTACATTCAGATGACACTATCTACAGAGATGTTAT
AAGATTAAATTACAAGAAAAGAGATGCCCAATTATTTCCATTTACTCTTCTTGCCTAGGTAGTTAATTTATCTATTATTCATTTGAAGCA
ACAGACGTCAATGTAACATCTTTTTCATTTTCATGGAGAATAATCAGCTTTTCCAGAAAAGGGTGCTATATCTCAAACACACCTCAAGTG
TCCAGTTGGAAGTATTACCATGCAGAGGATTCAAGTCATATTACCTAATAACCAGAAGTTGTATGTTGGGAAAAAGTGGTTAAAAGCAAC
TAAAACTGCCCTGTTTGGAAGAAACTAAATATTGCTTTATAATGATTTTCTGATATTTTAGAATAGAGGCTTCAATTATACTATTTGTGA
AAAAGAAAACTGCTTGGTATTAACCAAGTTACATTTAATTTTTATGGTCCACAAAATTTCAGAGTAGAAATATATCATAGCTTTTAATCA
ATTTTCAAAATCTATATTTAATTATTGATTCAAAAAATAAGAAATAAAATCAATTAGCCAGATTTGTATACTTTAAAGCTACCACAGTGA
GATTTTTCTCTTAAAAACATGCATGTTTTTATATTGTATTCTTTAATATTTATATTGTACAGTTACATGTGACACATATTACATATGACT
AATTTATATGTAGCAACAGGGATTAAAGAAGACCTCTTTTAATTGTACCACTTGTTATAATGCTATTATTTACCCAGATTCAAATGTAAC
TACTTACAATTTTTAAACATTTTTATTTCTGTATTCTTTAAAATATTAAGGCAATGGTTTTTCTTGAAATTATATTTTGCCCTATGTATT
CTATTTTTATTCACACTGGATTTATTATGATAATTATATCAAAGTGATTATTTTTACCCTGACTTTTAAAAGTCAACTGTTTCAGAAGTC


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FusionGenePPI for FGFR2_FRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3FRKRB1, PTEN, KHDRBS1, FYN, HSP90AA1, CSK, BNIP2, SF3B4, EGFR, PCBP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGFR2_FRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
HgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn
TgeneFRKP42685DB08896RegorafenibTyrosine-protein kinase FRKsmall moleculeapproved
TgeneFRKP42685DB01254DasatinibTyrosine-protein kinase FRKsmall moleculeapproved|investigational

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RelatedDiseases for FGFR2_FRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
HgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
HgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0038356Stomach Neoplasms2CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0003090Ankylosis1CTD_human
HgeneFGFR2C0005586Bipolar Disorder1PSYGENET
HgeneFGFR2C0008924Cleft Lip1CTD_human
HgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
HgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
HgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
HgeneFGFR2C0023890Liver Cirrhosis1CTD_human
HgeneFGFR2C0024121Lung Neoplasms1CTD_human
HgeneFGFR2C0026613Motor Skills Disorders1CTD_human
HgeneFGFR2C0033975Psychotic Disorders1PSYGENET
HgeneFGFR2C0037268Skin Abnormalities1CTD_human
HgeneFGFR2C0037274Dermatologic disorders1CTD_human
HgeneFGFR2C0040427Tooth Abnormalities1CTD_human
HgeneFGFR2C0080178Spina Bifida1CTD_human
HgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
HgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
HgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
HgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO
TgeneFRKC0271650Impaired glucose tolerance1CTD_human