FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13394

FusionGeneSummary for FGFR1_TACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR1_TACC1
Fusion gene ID: 13394
HgeneTgene
Gene symbol

FGFR1

TACC1

Gene ID

2260

6867

Gene namefibroblast growth factor receptor 1transforming acidic coiled-coil containing protein 1
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1Ga55
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrtransforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2018052720180523
UniProtAcc

P11362

O75410

Ensembl transtripts involved in fusion geneENST00000425967, ENST00000397091, 
ENST00000447712, ENST00000341462, 
ENST00000532791, ENST00000397113, 
ENST00000356207, ENST00000335922, 
ENST00000326324, ENST00000397103, 
ENST00000397108, ENST00000496629, 
ENST00000519416, ENST00000520615, 
ENST00000443286, ENST00000520340, 
ENST00000518415, ENST00000522752, 
ENST00000348567, ENST00000330691, 
ENST00000317827, ENST00000379931, 
ENST00000276520, ENST00000520973, 
ENST00000520611, 
Fusion gene scores* DoF score11 X 9 X 5=49514 X 13 X 8=1456
# samples 1215
** MAII scorelog2(12/495*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR1 [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A1HO-01AFGFR1chr8

38275746

-TACC1chr8

38646222

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000425967ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000425967ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000425967ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000425967ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000425967ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000425967ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000425967ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397091ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397091ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000447712ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000447712ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000341462ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000341462ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000532791ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000532791ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397113ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397113ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000356207ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000356207ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000335922ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000335922ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000326324ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000326324ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397103ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397103ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-5UTRENST00000397108ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
5CDS-intronENST00000397108ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000519416FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000520615FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000443286FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000520340FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000518415FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000522752FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000348567FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000330691FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000317827FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000379931FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000276520FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-5UTRENST00000496629ENST00000520973FGFR1chr8

38275746

-TACC1chr8

38646222

+
intron-intronENST00000496629ENST00000520611FGFR1chr8

38275746

-TACC1chr8

38646222

+

Top

FusionProtFeatures for FGFR1_TACC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

P11362

TACC1

O75410


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FGFR1_TACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FGFR1_TACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1TACC1YEATS4, AURKB, AURKA, LSM7, TDRD7, CKAP5, SNRPG, BARD1, KAT2A, ITSN2, NIF3L1, S100A11, SLC9A3R1, C12orf57, PLXNB2, HTT, KDM1A, FBXW11, PRKRIR, STX5, BTRC, MEMO1, SH2D4A, DTNBP1, VAPB, LYST, VAPA, BRD3, RB1CC1, TACC2, BAIAP2L1, STAT2, RNF41, POC1B, KNSTRN, RPN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FGFR1_TACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR1P11362DB00039PaliferminFibroblast growth factor receptor 1biotechapproved
HgeneFGFR1P11362DB08896RegorafenibFibroblast growth factor receptor 1small moleculeapproved
HgeneFGFR1P11362DB09079NintedanibFibroblast growth factor receptor 1small moleculeapproved
HgeneFGFR1P11362DB00398SorafenibFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB01109HeparinFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB08901PonatinibFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB09078LenvatinibFibroblast growth factor receptor 1small moleculeapproved|investigational

Top

RelatedDiseases for FGFR1_TACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)14ORPHANET;UNIPROT
HgeneFGFR1C0011570Mental Depression5PSYGENET
HgeneFGFR1C0011581Depressive disorder5CTD_human;HPO;PSYGENET
HgeneFGFR1C0005586Bipolar Disorder3PSYGENET
HgeneFGFR1C0041696Unipolar Depression3PSYGENET
HgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
HgeneFGFR1C0027022Myeloproliferative disease2CTD_human
HgeneFGFR1C0220658Pfeiffer Syndrome2UNIPROT
HgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis2ORPHANET;UNIPROT
HgeneFGFR1C0432283Osteoglophonic dwarfism2CTD_human;ORPHANET;UNIPROT
HgeneFGFR1C1458155Mammary Neoplasms2CTD_human
HgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate2ORPHANET;UNIPROT
HgeneFGFR1C0004114Astrocytoma1CTD_human
HgeneFGFR1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneFGFR1C0007137Squamous cell carcinoma1CTD_human
HgeneFGFR1C0008924Cleft Lip1CTD_human;HPO
HgeneFGFR1C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR1C0017638Glioma1CTD_human
HgeneFGFR1C0024121Lung Neoplasms1CTD_human
HgeneFGFR1C0036341Schizophrenia1CTD_human
HgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
HgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
HgeneFGFR1C0432122Interfrontal craniofaciosynostosis1CTD_human;UNIPROT