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Fusion gene ID: 13379 |
FusionGeneSummary for FGF2_FREM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGF2_FREM3 | Fusion gene ID: 13379 | Hgene | Tgene | Gene symbol | FGF2 | FREM3 | Gene ID | 2258 | 166752 |
| Gene name | fibroblast growth factor 13 | FRAS1 related extracellular matrix 3 | |
| Synonyms | FGF-13|FGF2|FHF-2|FHF2 | - | |
| Cytomap | Xq26.3-q27.1 | 4q31.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibroblast growth factor 13fibroblast growth factor homologous factor 2 | FRAS1-related extracellular matrix protein 3 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | P09038 | P0C091 | |
| Ensembl transtripts involved in fusion gene | ENST00000264498, ENST00000608478, | ENST00000329798, ENST00000508899, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FGF2 [Title/Abstract] AND FREM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGF2 | GO:0000165 | MAPK cascade | 12244047 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1L1-01A | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000264498 | ENST00000329798 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| 5CDS-intron | ENST00000264498 | ENST00000508899 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| In-frame | ENST00000608478 | ENST00000329798 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
| 5CDS-intron | ENST00000608478 | ENST00000508899 | FGF2 | chr4 | 123748507 | + | FREM3 | chr4 | 144548913 | - |
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FusionProtFeatures for FGF2_FREM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGF2 | FREM3 |
| Extracellular matrix protein which may play a role incell adhesion. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FGF2 | chr4:123748507 | chr4:144548913 | ENST00000264498 | + | 1 | 3 | 179_181 | 192 | 289 | Motif | Cell attachment site%3B atypical |
| Tgene | >FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1764_1862 | 1758 | 2140 | Domain | Note=Calx-beta 1 |
| Tgene | >FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1875_1985 | 1758 | 2140 | Domain | Note=Calx-beta 2 |
| Tgene | >FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 2000_2106 | 1758 | 2140 | Domain | Note=Calx-beta 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FGF2 | chr4:123748507 | chr4:144548913 | ENST00000264498 | + | 1 | 3 | 221_223 | 192 | 289 | Motif | Cell attachment site%3B atypical |
| Hgene | >FGF2 | chr4:123748507 | chr4:144548913 | ENST00000264498 | + | 1 | 3 | 261_277 | 192 | 289 | Region | Heparin-binding |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1069_1171 | 1758 | 2140 | Repeat | CSPG 7 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1192_1285 | 1758 | 2140 | Repeat | CSPG 8 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1306_1404 | 1758 | 2140 | Repeat | CSPG 9 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1425_1516 | 1758 | 2140 | Repeat | CSPG 10 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1536_1625 | 1758 | 2140 | Repeat | CSPG 11 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 1659_1756 | 1758 | 2140 | Repeat | CSPG 12 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 306_409 | 1758 | 2140 | Repeat | CSPG 1 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 432_522 | 1758 | 2140 | Repeat | CSPG 2 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 543_677 | 1758 | 2140 | Repeat | CSPG 3 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 702_807 | 1758 | 2140 | Repeat | CSPG 4 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 828_920 | 1758 | 2140 | Repeat | CSPG 5 |
| Tgene | FREM3 | chr4:123748507 | chr4:144548913 | ENST00000329798 | - | 1 | 8 | 948_1040 | 1758 | 2140 | Repeat | CSPG 6 |
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FusionGeneSequence for FGF2_FREM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FGF2_ENST00000264498_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_574aa LVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPG GRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG RVDGVREKSDPHRGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQ TTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQ GSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQ >In-frame_FGF2_ENST00000608478_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_441aa MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHRGNKLTNQPFHLNWAWICLEKEYYIVDEDST FLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEI VDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLII DDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FGF2_ENST00000264498_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_1722nt CTGGTGGGTGTGGGGGGTGGAGATGTAGAAGATGTGACGCCGCGGCCCGGCGGGTGCCAGATTAGCGGACGCGGTGCCCGCGGTTGCAAC GGGATCCCGGGCGCTGCAGCTTGGGAGGCGGCTCTCCCCAGGCGGCGTCCGCGGAGACACCCATCCGTGAACCCCAGGTCCCGGGCCGCC GGCTCGCCGCGCACCAGGGGCCGGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGCTGGGGGACCGCGGGCGCGGCCGCGCGCTGCCGGGC GGGAGGCTGGGGGGCCGGGGCCGGGGCCGTGCCCCGGAGCGGGTCGGAGGCCGGGGCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCT CCAGCGGCTCGGGGATCCCGGCCGGGCCCCGCAGGGACCATGGCAGCCGGGAGCATCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGC AGCGGCGCCTTCCCGCCCGGCCACTTCAAGGACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGC CGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACAGAGGAAATAAACTAACAAATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGT TTGGAGAAAGAGTACTACATTGTGGATGAAGATTCCACATTCTTAGAAGTGACCCTTACACGCAGAGGATACCTTGGAGAAACATCATTT ATCAGCATTGGTACCAAAGATGAAACTGCAAAAAAAGACAAAGATTTCAAATGGAAGACCAATAAACAGATCCAGTTCAATCCTGGACAG ACTACAGCCACATGGAGGGTGAGAATTATACCTGACAATGAATATGAGACTTCAGAGACCTTCCAGATCATTCTGTCTGAACCTCTCATG GCTGTACTGGAGTTTCCAGAAATGGCAACGGTTGAAATTGTAGACCCTGGAGATGAATCAACAGTTTATATTCCAGAGGCGGAATACAAA ATAGAAGAGGACATTGGGGAACTTTTGATTCCAGTAAGACGATCTGGAGATGCAAGCCAGGAACTAATCGTCATTTGCTCCACACGTCAA GGTTCTGCCACAGGCACGATTTCTTCCACAGTGTTATTCTCTGATTACATCTCACGTCCAGAAGACCACACCAGCATCCTCCACTTTGAC AAGAATGAGACACAGAAGACCTGCCAGGTCCTGATCATTGATGACTCCCTTTATGAAGAGGAGGAATCCTTCAGCGTTTCACTTAGGCTG CCAGTGGGAGGACAGCTGGGAGCCAGATTCCCCACCACTAAGGTGACTATTCTGGCTGATCGTTATGATGAACCTGTCCTGCACTTTGGG GATGCTGAATATCACGTCAATGAAAGTGCTCGCTACGTGGAGGTTTGTGTTTGGAGAAGAGGCACTGATCTTTCCCAACCATCATCCATC GCCGTGCGCTCCAGAAAGTCAGAGCAGGAGTCAGCAGAAGCTGGAACAGATTATGTTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGC GTGCGCATGCAGACATTCCAAGTGACCATCCTTGATGACCTGGGACAGCCTACCTTGGAAGGCCCAGAGAAGTTTGAATTACTTCTTCAG ATGCCTATGGGTGCAGTGCTTGGAGAACCAAATAAAACTACCATTTTCATCGAGGACACCATCACGGACTGTAAGCAGAGTGCTTGTAGT >In-frame_FGF2_ENST00000608478_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_1323nt ATGGCAGCCGGGAGCATCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCCACTTCAAGGACCCCAAG CGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGCCGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACAGA GGAAATAAACTAACAAATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGTTTGGAGAAAGAGTACTACATTGTGGATGAAGATTCCACA TTCTTAGAAGTGACCCTTACACGCAGAGGATACCTTGGAGAAACATCATTTATCAGCATTGGTACCAAAGATGAAACTGCAAAAAAAGAC AAAGATTTCAAATGGAAGACCAATAAACAGATCCAGTTCAATCCTGGACAGACTACAGCCACATGGAGGGTGAGAATTATACCTGACAAT GAATATGAGACTTCAGAGACCTTCCAGATCATTCTGTCTGAACCTCTCATGGCTGTACTGGAGTTTCCAGAAATGGCAACGGTTGAAATT GTAGACCCTGGAGATGAATCAACAGTTTATATTCCAGAGGCGGAATACAAAATAGAAGAGGACATTGGGGAACTTTTGATTCCAGTAAGA CGATCTGGAGATGCAAGCCAGGAACTAATCGTCATTTGCTCCACACGTCAAGGTTCTGCCACAGGCACGATTTCTTCCACAGTGTTATTC TCTGATTACATCTCACGTCCAGAAGACCACACCAGCATCCTCCACTTTGACAAGAATGAGACACAGAAGACCTGCCAGGTCCTGATCATT GATGACTCCCTTTATGAAGAGGAGGAATCCTTCAGCGTTTCACTTAGGCTGCCAGTGGGAGGACAGCTGGGAGCCAGATTCCCCACCACT AAGGTGACTATTCTGGCTGATCGTTATGATGAACCTGTCCTGCACTTTGGGGATGCTGAATATCACGTCAATGAAAGTGCTCGCTACGTG GAGGTTTGTGTTTGGAGAAGAGGCACTGATCTTTCCCAACCATCATCCATCGCCGTGCGCTCCAGAAAGTCAGAGCAGGAGTCAGCAGAA GCTGGAACAGATTATGTTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGCGTGCGCATGCAGACATTCCAAGTGACCATCCTTGATGAC CTGGGACAGCCTACCTTGGAAGGCCCAGAGAAGTTTGAATTACTTCTTCAGATGCCTATGGGTGCAGTGCTTGGAGAACCAAATAAAACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FGF2_ENST00000264498_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_2099nt CGGCCCCAGAAAACCCGAGCGAGTAGGGGGCGGCGCGCAGGAGGGAGGAGAACTGGGGGCGCGGGAGGCTGGTGGGTGTGGGGGGTGGAG ATGTAGAAGATGTGACGCCGCGGCCCGGCGGGTGCCAGATTAGCGGACGCGGTGCCCGCGGTTGCAACGGGATCCCGGGCGCTGCAGCTT GGGAGGCGGCTCTCCCCAGGCGGCGTCCGCGGAGACACCCATCCGTGAACCCCAGGTCCCGGGCCGCCGGCTCGCCGCGCACCAGGGGCC GGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGCTGGGGGACCGCGGGCGCGGCCGCGCGCTGCCGGGCGGGAGGCTGGGGGGCCGGGGCC GGGGCCGTGCCCCGGAGCGGGTCGGAGGCCGGGGCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCTCCAGCGGCTCGGGGATCCCGGC CGGGCCCCGCAGGGACCATGGCAGCCGGGAGCATCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCC ACTTCAAGGACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGCCGAGTTGACGGGGTCCGGGAGA AGAGCGACCCTCACAGAGGAAATAAACTAACAAATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGTTTGGAGAAAGAGTACTACATTG TGGATGAAGATTCCACATTCTTAGAAGTGACCCTTACACGCAGAGGATACCTTGGAGAAACATCATTTATCAGCATTGGTACCAAAGATG AAACTGCAAAAAAAGACAAAGATTTCAAATGGAAGACCAATAAACAGATCCAGTTCAATCCTGGACAGACTACAGCCACATGGAGGGTGA GAATTATACCTGACAATGAATATGAGACTTCAGAGACCTTCCAGATCATTCTGTCTGAACCTCTCATGGCTGTACTGGAGTTTCCAGAAA TGGCAACGGTTGAAATTGTAGACCCTGGAGATGAATCAACAGTTTATATTCCAGAGGCGGAATACAAAATAGAAGAGGACATTGGGGAAC TTTTGATTCCAGTAAGACGATCTGGAGATGCAAGCCAGGAACTAATCGTCATTTGCTCCACACGTCAAGGTTCTGCCACAGGCACGATTT CTTCCACAGTGTTATTCTCTGATTACATCTCACGTCCAGAAGACCACACCAGCATCCTCCACTTTGACAAGAATGAGACACAGAAGACCT GCCAGGTCCTGATCATTGATGACTCCCTTTATGAAGAGGAGGAATCCTTCAGCGTTTCACTTAGGCTGCCAGTGGGAGGACAGCTGGGAG CCAGATTCCCCACCACTAAGGTGACTATTCTGGCTGATCGTTATGATGAACCTGTCCTGCACTTTGGGGATGCTGAATATCACGTCAATG AAAGTGCTCGCTACGTGGAGGTTTGTGTTTGGAGAAGAGGCACTGATCTTTCCCAACCATCATCCATCGCCGTGCGCTCCAGAAAGTCAG AGCAGGAGTCAGCAGAAGCTGGAACAGATTATGTTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGCGTGCGCATGCAGACATTCCAAG TGACCATCCTTGATGACCTGGGACAGCCTACCTTGGAAGGCCCAGAGAAGTTTGAATTACTTCTTCAGATGCCTATGGGTGCAGTGCTTG GAGAACCAAATAAAACTACCATTTTCATCGAGGACACCATCACGGACTGTAAGCAGAGTGCTTGTAGTTCCTTTGATTGAAAGACTTTAA GAGGGAAAAAAACAGCCAAGATATGTCTCCTAACAACAGAATGAAACTCTACTGTTTATAGATCTTAGCAATTCTGGGATATCAGTGATA TTGTACTGTCATTGGTGTTATATTCTGGTGATATGTGGAAATGTAATTTATATGACTGCATGGAGATAGAAATATATATACCTAGAAAAC ATTGAGCCCACAAATAATTAGACTGTGTTCATGTTCTTTTTCTATTTTGTTTTACTTTGTTTCTGAGGCAAGTAAGAAATCCACTGTGAT >In-frame_FGF2_ENST00000608478_chr4_123748507_+_FREM3_ENST00000329798_chr4_144548913_-_1976nt GCCAGATTAGCGGACGCGGTGCCCGCGGTTGCAACGGGATCCCGGGCGCTGCAGCTTGGGAGGCGGCTCTCCCCAGGCGGCGTCCGCGGA GACACCCATCCGTGAACCCCAGGTCCCGGGCCGCCGGCTCGCCGCGCACCAGGGGCCGGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGC TGGGGGACCGCGGGCGCGGCCGCGCGCTGCCGGGCGGGAGGCTGGGGGGCCGGGGCCGGGGCCGTGCCCCGGAGCGGGTCGGAGGCCGGG GCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCTCCAGCGGCTCGGGGATCCCGGCCGGGCCCCGCAGGGACCATGGCAGCCGGGAGCA TCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCCACTTCAAGGACCCCAAGCGGCTGTACTGCAAAA ACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGCCGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACAGAGGAAATAAACTAACAA ATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGTTTGGAGAAAGAGTACTACATTGTGGATGAAGATTCCACATTCTTAGAAGTGACCC TTACACGCAGAGGATACCTTGGAGAAACATCATTTATCAGCATTGGTACCAAAGATGAAACTGCAAAAAAAGACAAAGATTTCAAATGGA AGACCAATAAACAGATCCAGTTCAATCCTGGACAGACTACAGCCACATGGAGGGTGAGAATTATACCTGACAATGAATATGAGACTTCAG AGACCTTCCAGATCATTCTGTCTGAACCTCTCATGGCTGTACTGGAGTTTCCAGAAATGGCAACGGTTGAAATTGTAGACCCTGGAGATG AATCAACAGTTTATATTCCAGAGGCGGAATACAAAATAGAAGAGGACATTGGGGAACTTTTGATTCCAGTAAGACGATCTGGAGATGCAA GCCAGGAACTAATCGTCATTTGCTCCACACGTCAAGGTTCTGCCACAGGCACGATTTCTTCCACAGTGTTATTCTCTGATTACATCTCAC GTCCAGAAGACCACACCAGCATCCTCCACTTTGACAAGAATGAGACACAGAAGACCTGCCAGGTCCTGATCATTGATGACTCCCTTTATG AAGAGGAGGAATCCTTCAGCGTTTCACTTAGGCTGCCAGTGGGAGGACAGCTGGGAGCCAGATTCCCCACCACTAAGGTGACTATTCTGG CTGATCGTTATGATGAACCTGTCCTGCACTTTGGGGATGCTGAATATCACGTCAATGAAAGTGCTCGCTACGTGGAGGTTTGTGTTTGGA GAAGAGGCACTGATCTTTCCCAACCATCATCCATCGCCGTGCGCTCCAGAAAGTCAGAGCAGGAGTCAGCAGAAGCTGGAACAGATTATG TTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGCGTGCGCATGCAGACATTCCAAGTGACCATCCTTGATGACCTGGGACAGCCTACCT TGGAAGGCCCAGAGAAGTTTGAATTACTTCTTCAGATGCCTATGGGTGCAGTGCTTGGAGAACCAAATAAAACTACCATTTTCATCGAGG ACACCATCACGGACTGTAAGCAGAGTGCTTGTAGTTCCTTTGATTGAAAGACTTTAAGAGGGAAAAAAACAGCCAAGATATGTCTCCTAA CAACAGAATGAAACTCTACTGTTTATAGATCTTAGCAATTCTGGGATATCAGTGATATTGTACTGTCATTGGTGTTATATTCTGGTGATA TGTGGAAATGTAATTTATATGACTGCATGGAGATAGAAATATATATACCTAGAAAACATTGAGCCCACAAATAATTAGACTGTGTTCATG |
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FusionGenePPI for FGF2_FREM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FGF2 | SDC1, SDC2, SDC4, CSNK2A1, CSNK2A2, CSNK2B, GPC3, RPS19, VTN, FGFBP1, SDC3, FGFR1, GPC4, RPL6, THBS1, CRYAB, PRMT1, TUBG1, TMEFF1, IFI16, COMT, FGFR2, PRKACA, CD44, TES | FREM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FGF2_FREM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FGF2 | P09038 | DB00364 | Sucralfate | Fibroblast growth factor 2 | small molecule | approved |
| Hgene | FGF2 | P09038 | DB00686 | Pentosan Polysulfate | Fibroblast growth factor 2 | small molecule | approved |
| Hgene | FGF2 | P09038 | DB00877 | Sirolimus | Fibroblast growth factor 2 | small molecule | approved|investigational |
| Hgene | FGF2 | P09038 | DB01109 | Heparin | Fibroblast growth factor 2 | small molecule | approved|investigational |
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RelatedDiseases for FGF2_FREM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FGF2 | C0525045 | Mood Disorders | 3 | PSYGENET |
| Hgene | FGF2 | C0151744 | Myocardial Ischemia | 2 | CTD_human |
| Hgene | FGF2 | C0008924 | Cleft Lip | 1 | CTD_human |
| Hgene | FGF2 | C0008925 | Cleft Palate | 1 | CTD_human |
| Hgene | FGF2 | C0011581 | Depressive disorder | 1 | CTD_human |
| Hgene | FGF2 | C0014549 | Tonic-Clonic Epilepsy | 1 | CTD_human |
| Hgene | FGF2 | C0017638 | Glioma | 1 | CTD_human |
| Hgene | FGF2 | C0017639 | Gliosis | 1 | CTD_human |
| Hgene | FGF2 | C0018800 | Cardiomegaly | 1 | CTD_human |
| Hgene | FGF2 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| Hgene | FGF2 | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | FGF2 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | FGF2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | FGF2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | FGF2 | C0025500 | Mesothelioma | 1 | CTD_human |
| Hgene | FGF2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Hgene | FGF2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | FGF2 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
| Hgene | FGF2 | C0031030 | Periapical Periodontitis | 1 | CTD_human |
| Hgene | FGF2 | C0033054 | Prenatal Exposure Delayed Effects | 1 | CTD_human |
| Hgene | FGF2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | FGF2 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Hgene | FGF2 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | FGF2 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | FGF2 | C0036572 | Seizures | 1 | CTD_human |
| Hgene | FGF2 | C0040028 | Thrombocythemia, Essential | 1 | CTD_human |
| Hgene | FGF2 | C0085109 | Corneal Neovascularization | 1 | CTD_human |
| Hgene | FGF2 | C0085207 | Gestational Diabetes | 1 | CTD_human |
| Hgene | FGF2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Hgene | FGF2 | C0751955 | Brain Infarction | 1 | CTD_human |
| Tgene | FREM3 | C1269683 | Major Depressive Disorder | 2 | CTD_human;PSYGENET |
| Tgene | FREM3 | C0041696 | Unipolar Depression | 1 | PSYGENET |
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