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Fusion gene ID: 13378 |
FusionGeneSummary for FGF20_RP1 |
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Fusion gene information | Fusion gene name: FGF20_RP1 | Fusion gene ID: 13378 | Hgene | Tgene | Gene symbol | FGF20 | RP1 | Gene ID | 26281 | 10982 |
Gene name | fibroblast growth factor 20 | microtubule associated protein RP/EB family member 2 | |
Synonyms | FGF-20|RHDA2 | CSCSC2|EB1|EB2|RP1 | |
Cytomap | 8p22 | 18q12.1-q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fibroblast growth factor 20 | microtubule-associated protein RP/EB family member 2APC-binding protein EB1APC-binding protein EB2T-cell activation protein, EB1 familyend-binding protein 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NP95 | P56715 | |
Ensembl transtripts involved in fusion gene | ENST00000180166, | ENST00000220676, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 5=100 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGF20 [Title/Abstract] AND RP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FGF20 | GO:0043524 | negative regulation of neuron apoptotic process | 16988046 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-AJ-A3BH-01A | FGF20 | chr8 | 16853164 | - | RP1 | chr8 | 55651503 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000180166 | ENST00000220676 | FGF20 | chr8 | 16853164 | - | RP1 | chr8 | 55651503 | + |
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FusionProtFeatures for FGF20_RP1 |
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Hgene | Tgene |
FGF20 | RP1 |
Neurotrophic factor that regulates central nervousdevelopment and function. {ECO:0000269|PubMed:16597617}. | Microtubule-associated protein regulating the stabilityand length of the microtubule-based axoneme of photoreceptors.Required for the differentiation of photoreceptor cells, it playsa role in the organization of the outer segment of rod and conephotoreceptors ensuring the correct orientation and higher-orderstacking of outer segment disks along the photoreceptor axoneme(By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FGF20_RP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FGF20_RP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FGF20 | FGF9 | RP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FGF20_RP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FGF20_RP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FGF20 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | FGF20 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | FGF20 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | RP1 | C0220701 | RETINITIS PIGMENTOSA 1 | 5 | CTD_human;UNIPROT |