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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13370

FusionGeneSummary for FGF12_ZNF595

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF12_ZNF595
Fusion gene ID: 13370
HgeneTgene
Gene symbol

FGF12

ZNF595

Gene ID

2257

152687

Gene namefibroblast growth factor 12zinc finger protein 595
SynonymsEIEE47|FGF12B|FHF1-
Cytomap

3q28-q29

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factorzinc finger protein 595
Modification date2018051920180522
UniProtAcc

P61328

Ensembl transtripts involved in fusion geneENST00000445105, ENST00000264730, 
ENST00000454309, ENST00000450716, 
ENST00000430714, ENST00000466144, 
ENST00000339368, ENST00000509152, 
ENST00000526473, 
Fusion gene scores* DoF score6 X 3 X 4=727 X 1 X 7=49
# samples 77
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/49*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGF12 [Title/Abstract] AND ZNF595 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-NK-A5CR-01AFGF12chr3

192444970

-ZNF595chr4

59323

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000445105ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000445105ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000445105ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000264730ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000264730ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000264730ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+
intron-3UTRENST00000454309ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
intron-3UTRENST00000454309ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
intron-3UTRENST00000454309ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000450716ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000450716ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000450716ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000430714ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000430714ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
5CDS-3UTRENST00000430714ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+
5UTR-3UTRENST00000466144ENST00000339368FGF12chr3

192444970

-ZNF595chr4

59323

+
5UTR-3UTRENST00000466144ENST00000509152FGF12chr3

192444970

-ZNF595chr4

59323

+
5UTR-3UTRENST00000466144ENST00000526473FGF12chr3

192444970

-ZNF595chr4

59323

+

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FusionProtFeatures for FGF12_ZNF595


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF12

P61328

ZNF595

Involved in nervous system development and function.Involved in the positive regulation of voltage-gated sodiumchannel activity. Promotes neuronal excitability by elevating thevoltage dependence of neuronal sodium channel SCN8A fastinactivation. {ECO:0000269|PubMed:27164707}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGF12_ZNF595


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGF12_ZNF595


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGF12MAPK13, MAPK8IP2, NEDD4, NEDD4L, APP, SRPK2, SRPK1, DACH1, DCTD, COIL, IKZF1, ZNF460, LZTS2, DPPA2, SMURF1, YWHAEZNF595JUNB, TRIM28


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGF12_ZNF595


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGF12_ZNF595


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource