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Fusion gene ID: 13365 |
FusionGeneSummary for FGF12_LAMP3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FGF12_LAMP3 | Fusion gene ID: 13365 | Hgene | Tgene | Gene symbol | FGF12 | LAMP3 | Gene ID | 2257 | 27074 |
Gene name | fibroblast growth factor 12 | lysosomal associated membrane protein 3 | |
Synonyms | EIEE47|FGF12B|FHF1 | CD208|DC LAMP|DC-LAMP|DCLAMP|LAMP|LAMP-3|TSC403 | |
Cytomap | 3q28-q29 | 3q27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | fibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factor | lysosome-associated membrane glycoprotein 3DC-lysosome-associated membrane glycoprotein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P61328 | Q9UQV4 | |
Ensembl transtripts involved in fusion gene | ENST00000445105, ENST00000264730, ENST00000454309, ENST00000450716, ENST00000430714, ENST00000466144, | ENST00000265598, ENST00000466939, ENST00000486686, | |
Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 2 X 1 X 2=4 |
# samples | 7 | 3 | |
** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: FGF12 [Title/Abstract] AND LAMP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-FG-5963-01A | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
TCGA | RV | LGG | TCGA-FG-5963-02A | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000445105 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-5UTR | ENST00000445105 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-intron | ENST00000445105 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
Frame-shift | ENST00000264730 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-5UTR | ENST00000264730 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-intron | ENST00000264730 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
intron-3CDS | ENST00000454309 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
intron-5UTR | ENST00000454309 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
intron-intron | ENST00000454309 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
In-frame | ENST00000450716 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-5UTR | ENST00000450716 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-intron | ENST00000450716 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
Frame-shift | ENST00000430714 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-5UTR | ENST00000430714 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5CDS-intron | ENST00000430714 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5UTR-3CDS | ENST00000466144 | ENST00000265598 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5UTR-5UTR | ENST00000466144 | ENST00000466939 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
5UTR-intron | ENST00000466144 | ENST00000486686 | FGF12 | chr3 | 192444970 | - | LAMP3 | chr3 | 182872179 | - |
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FusionProtFeatures for FGF12_LAMP3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FGF12 | LAMP3 |
Involved in nervous system development and function.Involved in the positive regulation of voltage-gated sodiumchannel activity. Promotes neuronal excitability by elevating thevoltage dependence of neuronal sodium channel SCN8A fastinactivation. {ECO:0000269|PubMed:27164707}. | May play a role in dendritic cell function and inadaptive immunity. {ECO:0000269|PubMed:9768752}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FGF12_LAMP3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_405aa MESKVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITY TLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAP GTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLL LNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGN |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_1215nt ATGGAGAGCAAAGTAATTTTGCACGATGGCAGTCAAATGAGAGCAAAAGCATTTCCAGAAACCAGAGATTATTCTCAACCTACTGCAGCA GCAACAGTACAGGACATAAAAAAACCTGTCCAGCAACCAGCTAAGCAAGCACCTCACCAAACTTTAGCAGCAAGATTCATGGATGGTCAT ATCACCTTTCAAACAGCGGCCACAGTAAAAATTCCAACAACTACCCCAGCGACTACAAAAAACACTGCAACCACCAGCCCAATTACCTAC ACCCTGGTCACAACCCAGGCCACACCCAACAACTCACACACAGCTCCTCCAGTTACTGAAGTTACAGTCGGCCCTAGCTTAGCCCCTTAT TCACTGCCACCCACCATCACCCCACCAGCTCATACAACTGGAACCAGTTCATCAACCGTCAGCCACACAACTGGGAACACCACTCAACCC AGTAACCAGACCACCCTTCCAGCAACTTTATCGATAGCACTGCACAAAAGCACAACCGGTCAGAAGCCTGTTCAACCCACCCATGCCCCA GGAACAACGGCAGCTGCCCACAATACCACCCGCACAGCTGCACCTGCCTCCACGGTTCCTGGGCCCACCCTTGCACCTCAGCCATCGTCA GTCAAGACTGGAATTTATCAGGTTCTAAACGGAAGCAGACTCTGTATAAAAGCAGAGATGGGGATACAGCTGATTGTTCAAGACAAGGAG TCGGTTTTTTCACCTCGGAGATACTTCAACATCGACCCCAACGCAACGCAAGCCTCTGGGAACTGTGGCACCCGAAAATCCAACCTTCTG TTGAATTTTCAGGGCGGATTTGTGAATCTCACATTTACCAAGGATGAAGAATCATATTATATCAGTGAAGTGGGAGCCTATTTGACCGTC TCAGATCCAGAGACAATTTACCAAGGAATCAAACATGCGGTGGTGATGTTCCAGACAGCAGTCGGGCATTCCTTCAAGTGCGTGAGTGAA CAGAGCCTCCAGTTGTCAGCCCACCTGCAGGTGAAAACAACCGATGTCCAACTTCAAGCCTTTGATTTTGAAGATGACCACTTTGGAAAT GTGGATGAGTGCTCGTCTGACTACACAATTGTGCTTCCTGTGATTGGGGCCATCGTGGTTGGTCTCTGCCTTATGGGTATGGGTGTCTAT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_3274nt TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGG GCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGGCCAACTTCCATTGAACTTCCCAGCACTCGA AAGGGACCGAAATGGAGAGCAAAGTAATTTTGCACGATGGCAGTCAAATGAGAGCAAAAGCATTTCCAGAAACCAGAGATTATTCTCAAC CTACTGCAGCAGCAACAGTACAGGACATAAAAAAACCTGTCCAGCAACCAGCTAAGCAAGCACCTCACCAAACTTTAGCAGCAAGATTCA TGGATGGTCATATCACCTTTCAAACAGCGGCCACAGTAAAAATTCCAACAACTACCCCAGCGACTACAAAAAACACTGCAACCACCAGCC CAATTACCTACACCCTGGTCACAACCCAGGCCACACCCAACAACTCACACACAGCTCCTCCAGTTACTGAAGTTACAGTCGGCCCTAGCT TAGCCCCTTATTCACTGCCACCCACCATCACCCCACCAGCTCATACAACTGGAACCAGTTCATCAACCGTCAGCCACACAACTGGGAACA CCACTCAACCCAGTAACCAGACCACCCTTCCAGCAACTTTATCGATAGCACTGCACAAAAGCACAACCGGTCAGAAGCCTGTTCAACCCA CCCATGCCCCAGGAACAACGGCAGCTGCCCACAATACCACCCGCACAGCTGCACCTGCCTCCACGGTTCCTGGGCCCACCCTTGCACCTC AGCCATCGTCAGTCAAGACTGGAATTTATCAGGTTCTAAACGGAAGCAGACTCTGTATAAAAGCAGAGATGGGGATACAGCTGATTGTTC AAGACAAGGAGTCGGTTTTTTCACCTCGGAGATACTTCAACATCGACCCCAACGCAACGCAAGCCTCTGGGAACTGTGGCACCCGAAAAT CCAACCTTCTGTTGAATTTTCAGGGCGGATTTGTGAATCTCACATTTACCAAGGATGAAGAATCATATTATATCAGTGAAGTGGGAGCCT ATTTGACCGTCTCAGATCCAGAGACAATTTACCAAGGAATCAAACATGCGGTGGTGATGTTCCAGACAGCAGTCGGGCATTCCTTCAAGT GCGTGAGTGAACAGAGCCTCCAGTTGTCAGCCCACCTGCAGGTGAAAACAACCGATGTCCAACTTCAAGCCTTTGATTTTGAAGATGACC ACTTTGGAAATGTGGATGAGTGCTCGTCTGACTACACAATTGTGCTTCCTGTGATTGGGGCCATCGTGGTTGGTCTCTGCCTTATGGGTA TGGGTGTCTATAAAATCCGCCTAAGGTGTCAATCATCTGGATACCAGAGAATCTAATTGTTGCCCGGGGGGAATGAAAATAATGGAATTT AGAGAACTCTTTCATCCCTTCCAGGATGGATGTTGGGAAATTCCCTCAGAGTGTGGGTCCTTCAAACAATGTAAACCACCATCTTCTATT CAAATGAAGTGAGTCATGTGTGATTTAAGTTCAGGCAGCACATCAATTTCTAAATACTTTTTGTTTATTTTATGAAAGATATAGTGAGCT GTTTATTTTCTAGTTTCCTTTAGAATATTTTAGCCACTCAAAGTCAACATTTGAGATATGTTGAATTAACATAATATATGTAAAGTAGAA TAAGCCTTCAAATTATAAACCAAGGGTCAATTGTAACTAATACTACTGTGTGTGCATTGAAGATTTTATTTTACCCTTGATCTTAACAAA GCCTTTGCTTTGTTATCAAATGGACTTTCAGTGCTTTTACTATCTGTGTTTTATGGTTTCATGTAACATACATATTCCTGGTGTAGCACT TAACTCCTTTTCCACTTTAAATTTGTTTTTGTTTTTTGAGACGGAGTTTCACTCTTGTCACCCAGGCTGGAGTACAGTGGCACGATCTCG GCTTATGGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCTTCAGCTTCCCGAGTAGCTGGGATTACAGGCACACACTACCACGCC TGGCTAATTTTTGTATTTTTATTATAGACGGGGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCTTGACCTCAGGTGATCCACCCACC TCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGCGCCCGGCCTTAAATGTTTTTTTTAATCATCAAAAAGAACAACATATCT CAGGTTGTCTAAGTGTTTTTATGTAAAACCAACAAAAAGAACAAATCAGCTTATATTTTTTATCTTGATGACTCCTGCTCCAGAATCGCT AGACTAAGAATTAGGTGGCTACAGATGGTAGAACTAAACAATAAGCAAGAGACAATAATAATGGCCCTTAATTATTAACAAAGTGCCAGA GTCTAGGCTAAGCACTTTATCTATATCTCATTTCATTCTCACAACTTATAGGTGAATGAGTAAACTGAGACTTAAGGGAACTGAATCACT TAAATGTCACCTGGCTAACTGATGGCAGAGCCAGAGCTTGAATTCATGTTGGTCTGACATCAAGGTCTTTGGTCTTCTCCCTACACCAAG TTACCTACAAGAACAATGACACCACACTCTGCCTGAAGGCTCACACCTCATACCAGCATACGCTCACCTTACAGGGAAATGGGTTTATCC AGGATCATGAGACATTAGGGTAGATGAAAGGAGAGCTTTGCAGATAACAAAATAGCCTATCCTTAATAAATCCTCCACTCTCTGGAAGGA GACTGAGGGGCTTTGTAAAACATTAGTCAGTTGCTCATTTTTATGGGATTGCTTAGCTGGGCTGTAAAGATGAAGGCATCAAATAAACTC AAAGTATTTTTAAATTTTTTTGATAATAGAGAAACTTCGCTAACCAACTGTTCTTTCTTGAGTGTATAGCCCCATCTTGTGGTAACTTGC TGCTTCTGCACTTCATATCCATATTTCCTATTGTTCACTTTATTCTGTAGAGCAGCCTGCCAAGAATTTTATTTCTGCTGTTTTTTTTGC TGCTAAAGAAAGGAACTAAGTCAGGATGTTAACAGAAAAGTCCACATAACCCTAGAATTCTTAGTCAAGGAATAATTCAAGTCAGCCTAG AGACCATGTTGACTTTCCTCATGTGTTTCCTTATGACTCAGTAAGTTGGCAAGGTCCTGACTTTAGTCTTAATAAAACATTGAATTGTAG |
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FusionGenePPI for FGF12_LAMP3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FGF12 | MAPK13, MAPK8IP2, NEDD4, NEDD4L, APP, SRPK2, SRPK1, DACH1, DCTD, COIL, IKZF1, ZNF460, LZTS2, DPPA2, SMURF1, YWHAE | LAMP3 | SGTB, GALNT4, MARCH5, NEK6, HUS1, NEK7, SEC14L1, MAPK8, ZRANB3, DOPEY2, INTS8, SEL1L3, SGPP1, NARS2, TAMM41, MAP2K7, FASTKD3, CAMK1D, MYADM, METTL15, COMMD2, HSPA12A, UGDH, ACOT9, HARS2, FASTKD1, KNTC1, ARFGEF2, TUBB3, UCKL1, JAK1, RNF213, ATP7A, COMMD3, CDC6, RAB39B, PDK1, INTS5, ARL8B, RABGGTA, DSTYK, ARFGEF1, MAD2L2, TBRG4, XRCC3, ARL8A, DARS2, RAB3B, TUBB2A, SLC25A14, ARL10, NEK4, LTN1, SLC22A18, PDS5A, UTP15, GALNT12, ATL3, HBS1L, HEATR1, RIF1, PCCA, TUBB2B, GLS |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FGF12_LAMP3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FGF12_LAMP3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LAMP3 | C0021400 | Influenza | 1 | CTD_human |