FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13365

FusionGeneSummary for FGF12_LAMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF12_LAMP3
Fusion gene ID: 13365
HgeneTgene
Gene symbol

FGF12

LAMP3

Gene ID

2257

27074

Gene namefibroblast growth factor 12lysosomal associated membrane protein 3
SynonymsEIEE47|FGF12B|FHF1CD208|DC LAMP|DC-LAMP|DCLAMP|LAMP|LAMP-3|TSC403
Cytomap

3q28-q29

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factorlysosome-associated membrane glycoprotein 3DC-lysosome-associated membrane glycoprotein
Modification date2018051920180519
UniProtAcc

P61328

Q9UQV4

Ensembl transtripts involved in fusion geneENST00000445105, ENST00000264730, 
ENST00000454309, ENST00000450716, 
ENST00000430714, ENST00000466144, 
ENST00000265598, ENST00000466939, 
ENST00000486686, 
Fusion gene scores* DoF score6 X 3 X 4=722 X 1 X 2=4
# samples 73
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/4*10)=2.90689059560852
Context

PubMed: FGF12 [Title/Abstract] AND LAMP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-FG-5963-01AFGF12chr3

192444970

-LAMP3chr3

182872179

-
TCGARVLGGTCGA-FG-5963-02AFGF12chr3

192444970

-LAMP3chr3

182872179

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000445105ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-5UTRENST00000445105ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-intronENST00000445105ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-
Frame-shiftENST00000264730ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-5UTRENST00000264730ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-intronENST00000264730ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-
intron-3CDSENST00000454309ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
intron-5UTRENST00000454309ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
intron-intronENST00000454309ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-
In-frameENST00000450716ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-5UTRENST00000450716ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-intronENST00000450716ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-
Frame-shiftENST00000430714ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-5UTRENST00000430714ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
5CDS-intronENST00000430714ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-
5UTR-3CDSENST00000466144ENST00000265598FGF12chr3

192444970

-LAMP3chr3

182872179

-
5UTR-5UTRENST00000466144ENST00000466939FGF12chr3

192444970

-LAMP3chr3

182872179

-
5UTR-intronENST00000466144ENST00000486686FGF12chr3

192444970

-LAMP3chr3

182872179

-

Top

FusionProtFeatures for FGF12_LAMP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF12

P61328

LAMP3

Q9UQV4

Involved in nervous system development and function.Involved in the positive regulation of voltage-gated sodiumchannel activity. Promotes neuronal excitability by elevating thevoltage dependence of neuronal sodium channel SCN8A fastinactivation. {ECO:0000269|PubMed:27164707}. May play a role in dendritic cell function and inadaptive immunity. {ECO:0000269|PubMed:9768752}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FGF12_LAMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_405aa
MESKVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITY
TLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAP
GTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLL
LNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_1215nt
ATGGAGAGCAAAGTAATTTTGCACGATGGCAGTCAAATGAGAGCAAAAGCATTTCCAGAAACCAGAGATTATTCTCAACCTACTGCAGCA
GCAACAGTACAGGACATAAAAAAACCTGTCCAGCAACCAGCTAAGCAAGCACCTCACCAAACTTTAGCAGCAAGATTCATGGATGGTCAT
ATCACCTTTCAAACAGCGGCCACAGTAAAAATTCCAACAACTACCCCAGCGACTACAAAAAACACTGCAACCACCAGCCCAATTACCTAC
ACCCTGGTCACAACCCAGGCCACACCCAACAACTCACACACAGCTCCTCCAGTTACTGAAGTTACAGTCGGCCCTAGCTTAGCCCCTTAT
TCACTGCCACCCACCATCACCCCACCAGCTCATACAACTGGAACCAGTTCATCAACCGTCAGCCACACAACTGGGAACACCACTCAACCC
AGTAACCAGACCACCCTTCCAGCAACTTTATCGATAGCACTGCACAAAAGCACAACCGGTCAGAAGCCTGTTCAACCCACCCATGCCCCA
GGAACAACGGCAGCTGCCCACAATACCACCCGCACAGCTGCACCTGCCTCCACGGTTCCTGGGCCCACCCTTGCACCTCAGCCATCGTCA
GTCAAGACTGGAATTTATCAGGTTCTAAACGGAAGCAGACTCTGTATAAAAGCAGAGATGGGGATACAGCTGATTGTTCAAGACAAGGAG
TCGGTTTTTTCACCTCGGAGATACTTCAACATCGACCCCAACGCAACGCAAGCCTCTGGGAACTGTGGCACCCGAAAATCCAACCTTCTG
TTGAATTTTCAGGGCGGATTTGTGAATCTCACATTTACCAAGGATGAAGAATCATATTATATCAGTGAAGTGGGAGCCTATTTGACCGTC
TCAGATCCAGAGACAATTTACCAAGGAATCAAACATGCGGTGGTGATGTTCCAGACAGCAGTCGGGCATTCCTTCAAGTGCGTGAGTGAA
CAGAGCCTCCAGTTGTCAGCCCACCTGCAGGTGAAAACAACCGATGTCCAACTTCAAGCCTTTGATTTTGAAGATGACCACTTTGGAAAT
GTGGATGAGTGCTCGTCTGACTACACAATTGTGCTTCCTGTGATTGGGGCCATCGTGGTTGGTCTCTGCCTTATGGGTATGGGTGTCTAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_FGF12_ENST00000450716_chr3_192444970_-_LAMP3_ENST00000265598_chr3_182872179_-_3274nt
TTAAAGCAGGAGCCTTGAGAGCCTGATAAGCTGTTGACACAAGTGCTTTTGAGAATAGCAGGAAGCCTGAGGGGAAGGAAGGAAGTACGG
GCGAAATCATCAGATTGGCTTCCCAGATTTGGGAATCTGAAGCGGGCCCACATCTTCCGGCCAACTTCCATTGAACTTCCCAGCACTCGA
AAGGGACCGAAATGGAGAGCAAAGTAATTTTGCACGATGGCAGTCAAATGAGAGCAAAAGCATTTCCAGAAACCAGAGATTATTCTCAAC
CTACTGCAGCAGCAACAGTACAGGACATAAAAAAACCTGTCCAGCAACCAGCTAAGCAAGCACCTCACCAAACTTTAGCAGCAAGATTCA
TGGATGGTCATATCACCTTTCAAACAGCGGCCACAGTAAAAATTCCAACAACTACCCCAGCGACTACAAAAAACACTGCAACCACCAGCC
CAATTACCTACACCCTGGTCACAACCCAGGCCACACCCAACAACTCACACACAGCTCCTCCAGTTACTGAAGTTACAGTCGGCCCTAGCT
TAGCCCCTTATTCACTGCCACCCACCATCACCCCACCAGCTCATACAACTGGAACCAGTTCATCAACCGTCAGCCACACAACTGGGAACA
CCACTCAACCCAGTAACCAGACCACCCTTCCAGCAACTTTATCGATAGCACTGCACAAAAGCACAACCGGTCAGAAGCCTGTTCAACCCA
CCCATGCCCCAGGAACAACGGCAGCTGCCCACAATACCACCCGCACAGCTGCACCTGCCTCCACGGTTCCTGGGCCCACCCTTGCACCTC
AGCCATCGTCAGTCAAGACTGGAATTTATCAGGTTCTAAACGGAAGCAGACTCTGTATAAAAGCAGAGATGGGGATACAGCTGATTGTTC
AAGACAAGGAGTCGGTTTTTTCACCTCGGAGATACTTCAACATCGACCCCAACGCAACGCAAGCCTCTGGGAACTGTGGCACCCGAAAAT
CCAACCTTCTGTTGAATTTTCAGGGCGGATTTGTGAATCTCACATTTACCAAGGATGAAGAATCATATTATATCAGTGAAGTGGGAGCCT
ATTTGACCGTCTCAGATCCAGAGACAATTTACCAAGGAATCAAACATGCGGTGGTGATGTTCCAGACAGCAGTCGGGCATTCCTTCAAGT
GCGTGAGTGAACAGAGCCTCCAGTTGTCAGCCCACCTGCAGGTGAAAACAACCGATGTCCAACTTCAAGCCTTTGATTTTGAAGATGACC
ACTTTGGAAATGTGGATGAGTGCTCGTCTGACTACACAATTGTGCTTCCTGTGATTGGGGCCATCGTGGTTGGTCTCTGCCTTATGGGTA
TGGGTGTCTATAAAATCCGCCTAAGGTGTCAATCATCTGGATACCAGAGAATCTAATTGTTGCCCGGGGGGAATGAAAATAATGGAATTT
AGAGAACTCTTTCATCCCTTCCAGGATGGATGTTGGGAAATTCCCTCAGAGTGTGGGTCCTTCAAACAATGTAAACCACCATCTTCTATT
CAAATGAAGTGAGTCATGTGTGATTTAAGTTCAGGCAGCACATCAATTTCTAAATACTTTTTGTTTATTTTATGAAAGATATAGTGAGCT
GTTTATTTTCTAGTTTCCTTTAGAATATTTTAGCCACTCAAAGTCAACATTTGAGATATGTTGAATTAACATAATATATGTAAAGTAGAA
TAAGCCTTCAAATTATAAACCAAGGGTCAATTGTAACTAATACTACTGTGTGTGCATTGAAGATTTTATTTTACCCTTGATCTTAACAAA
GCCTTTGCTTTGTTATCAAATGGACTTTCAGTGCTTTTACTATCTGTGTTTTATGGTTTCATGTAACATACATATTCCTGGTGTAGCACT
TAACTCCTTTTCCACTTTAAATTTGTTTTTGTTTTTTGAGACGGAGTTTCACTCTTGTCACCCAGGCTGGAGTACAGTGGCACGATCTCG
GCTTATGGCAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCTTCAGCTTCCCGAGTAGCTGGGATTACAGGCACACACTACCACGCC
TGGCTAATTTTTGTATTTTTATTATAGACGGGGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCTTGACCTCAGGTGATCCACCCACC
TCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCATTGCGCCCGGCCTTAAATGTTTTTTTTAATCATCAAAAAGAACAACATATCT
CAGGTTGTCTAAGTGTTTTTATGTAAAACCAACAAAAAGAACAAATCAGCTTATATTTTTTATCTTGATGACTCCTGCTCCAGAATCGCT
AGACTAAGAATTAGGTGGCTACAGATGGTAGAACTAAACAATAAGCAAGAGACAATAATAATGGCCCTTAATTATTAACAAAGTGCCAGA
GTCTAGGCTAAGCACTTTATCTATATCTCATTTCATTCTCACAACTTATAGGTGAATGAGTAAACTGAGACTTAAGGGAACTGAATCACT
TAAATGTCACCTGGCTAACTGATGGCAGAGCCAGAGCTTGAATTCATGTTGGTCTGACATCAAGGTCTTTGGTCTTCTCCCTACACCAAG
TTACCTACAAGAACAATGACACCACACTCTGCCTGAAGGCTCACACCTCATACCAGCATACGCTCACCTTACAGGGAAATGGGTTTATCC
AGGATCATGAGACATTAGGGTAGATGAAAGGAGAGCTTTGCAGATAACAAAATAGCCTATCCTTAATAAATCCTCCACTCTCTGGAAGGA
GACTGAGGGGCTTTGTAAAACATTAGTCAGTTGCTCATTTTTATGGGATTGCTTAGCTGGGCTGTAAAGATGAAGGCATCAAATAAACTC
AAAGTATTTTTAAATTTTTTTGATAATAGAGAAACTTCGCTAACCAACTGTTCTTTCTTGAGTGTATAGCCCCATCTTGTGGTAACTTGC
TGCTTCTGCACTTCATATCCATATTTCCTATTGTTCACTTTATTCTGTAGAGCAGCCTGCCAAGAATTTTATTTCTGCTGTTTTTTTTGC
TGCTAAAGAAAGGAACTAAGTCAGGATGTTAACAGAAAAGTCCACATAACCCTAGAATTCTTAGTCAAGGAATAATTCAAGTCAGCCTAG
AGACCATGTTGACTTTCCTCATGTGTTTCCTTATGACTCAGTAAGTTGGCAAGGTCCTGACTTTAGTCTTAATAAAACATTGAATTGTAG


Top

FusionGenePPI for FGF12_LAMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGF12MAPK13, MAPK8IP2, NEDD4, NEDD4L, APP, SRPK2, SRPK1, DACH1, DCTD, COIL, IKZF1, ZNF460, LZTS2, DPPA2, SMURF1, YWHAELAMP3SGTB, GALNT4, MARCH5, NEK6, HUS1, NEK7, SEC14L1, MAPK8, ZRANB3, DOPEY2, INTS8, SEL1L3, SGPP1, NARS2, TAMM41, MAP2K7, FASTKD3, CAMK1D, MYADM, METTL15, COMMD2, HSPA12A, UGDH, ACOT9, HARS2, FASTKD1, KNTC1, ARFGEF2, TUBB3, UCKL1, JAK1, RNF213, ATP7A, COMMD3, CDC6, RAB39B, PDK1, INTS5, ARL8B, RABGGTA, DSTYK, ARFGEF1, MAD2L2, TBRG4, XRCC3, ARL8A, DARS2, RAB3B, TUBB2A, SLC25A14, ARL10, NEK4, LTN1, SLC22A18, PDS5A, UTP15, GALNT12, ATL3, HBS1L, HEATR1, RIF1, PCCA, TUBB2B, GLS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FGF12_LAMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FGF12_LAMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLAMP3C0021400Influenza1CTD_human