|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 13358 |
FusionGeneSummary for FGD6_ARHGAP24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGD6_ARHGAP24 | Fusion gene ID: 13358 | Hgene | Tgene | Gene symbol | FGD6 | ARHGAP24 | Gene ID | 55785 | 83478 |
| Gene name | FYVE, RhoGEF and PH domain containing 6 | Rho GTPase activating protein 24 | |
| Synonyms | ZFYVE24 | FILGAP|RC-GAP72|RCGAP72|p73|p73RhoGAP | |
| Cytomap | 12q22 | 4q21.23-q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FYVE, RhoGEF and PH domain-containing protein 6zinc finger FYVE domain-containing protein 24 | rho GTPase-activating protein 24RAC1- and CDC42-specific GTPase-activating protein of 72 kDafilamin-A-associated RhoGAPrhoGAP of 73 kDasarcoma antigen NY-SAR-88 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6ZV73 | Q8N264 | |
| Ensembl transtripts involved in fusion gene | ENST00000343958, ENST00000546711, ENST00000549499, ENST00000550368, | ENST00000395184, ENST00000503995, ENST00000506421, ENST00000395183, ENST00000264343, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 4 X 3=48 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FGD6 [Title/Abstract] AND ARHGAP24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW749210 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - | ||
| ChiTaRS3.1 | AW749259 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000343958 | ENST00000395184 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000343958 | ENST00000503995 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000343958 | ENST00000506421 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000343958 | ENST00000395183 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000343958 | ENST00000264343 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-3CDS | ENST00000546711 | ENST00000395184 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000546711 | ENST00000503995 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000546711 | ENST00000506421 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000546711 | ENST00000395183 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000546711 | ENST00000264343 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-3CDS | ENST00000549499 | ENST00000395184 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000549499 | ENST00000503995 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000549499 | ENST00000506421 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000549499 | ENST00000395183 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000549499 | ENST00000264343 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-3CDS | ENST00000550368 | ENST00000395184 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000550368 | ENST00000503995 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000550368 | ENST00000506421 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000550368 | ENST00000395183 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
| intron-intron | ENST00000550368 | ENST00000264343 | FGD6 | chr12 | 95491480 | - | ARHGAP24 | chr4 | 86916061 | - |
Top |
FusionProtFeatures for FGD6_ARHGAP24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGD6 | ARHGAP24 |
| May activate CDC42, a member of the Ras-like family ofRho- and Rac proteins, by exchanging bound GDP for free GTP. Mayplay a role in regulating the actin cytoskeleton and cell shape(By similarity). {ECO:0000250}. | Rho GTPase-activating protein involved in cell polarity,cell morphology and cytoskeletal organization. Acts as a GTPaseactivator for the Rac-type GTPase by converting it to an inactiveGDP-bound state. Controls actin remodeling by inactivating Racdownstream of Rho leading to suppress leading edge protrusion andpromotes cell retraction to achieve cellular polarity. Able tosuppress RAC1 and CDC42 activity in vitro. Overexpression inducescell rounding with partial or complete disruption of actin stressfibers and formation of membrane ruffles, lamellipodia, andfilopodia. Isoform 2 is a vascular cell-specific GAP involved inmodulation of angiogenesis. {ECO:0000269|PubMed:15302923,ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FGD6_ARHGAP24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FGD6_ARHGAP24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FGD6_ARHGAP24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FGD6_ARHGAP24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FGD6 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | FGD6 | C2237660 | exudative macular degeneration | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|