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Fusion gene ID: 13333 |
FusionGeneSummary for FGB_HP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FGB_HP | Fusion gene ID: 13333 | Hgene | Tgene | Gene symbol | FGB | HP | Gene ID | 2244 | 10395 |
| Gene name | fibrinogen beta chain | DLC1 Rho GTPase activating protein | |
| Synonyms | HEL-S-78p | ARHGAP7|HP|STARD12|p122-RhoGAP | |
| Cytomap | 4q31.3 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide | rho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia | |
| Modification date | 20180520 | 20180519 | |
| UniProtAcc | P02675 | P00738 | |
| Ensembl transtripts involved in fusion gene | ENST00000302068, ENST00000509493, ENST00000502545, | ENST00000570083, ENST00000355906, ENST00000398131, ENST00000569639, ENST00000357763, ENST00000562526, ENST00000565574, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 6 X 4 X 1=24 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FGB [Title/Abstract] AND HP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FGB | GO:0007160 | cell-matrix adhesion | 10903502 |
| Hgene | FGB | GO:0031639 | plasminogen activation | 16846481 |
| Hgene | FGB | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 |
| Hgene | FGB | GO:0034622 | cellular protein-containing complex assembly | 8910396 |
| Hgene | FGB | GO:0042730 | fibrinolysis | 16846481 |
| Hgene | FGB | GO:0043152 | induction of bacterial agglutination | 24367264 |
| Hgene | FGB | GO:0045907 | positive regulation of vasoconstriction | 15739255 |
| Hgene | FGB | GO:0045921 | positive regulation of exocytosis | 19193866 |
| Hgene | FGB | GO:0050714 | positive regulation of protein secretion | 19193866 |
| Hgene | FGB | GO:0051258 | protein polymerization | 12706644 |
| Hgene | FGB | GO:0051592 | response to calcium ion | 6777381 |
| Hgene | FGB | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502|19193866 |
| Hgene | FGB | GO:0070527 | platelet aggregation | 6281794 |
| Hgene | FGB | GO:0072378 | blood coagulation, fibrin clot formation | 16846481 |
| Hgene | FGB | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 |
| Hgene | FGB | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 |
| Hgene | FGB | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
| Tgene | HP | GO:0006915 | apoptotic process | 17292327 |
| Tgene | HP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 17888903 |
| Tgene | HP | GO:0008285 | negative regulation of cell proliferation | 12545165|17932950 |
| Tgene | HP | GO:0030336 | negative regulation of cell migration | 17932950|19158340 |
| Tgene | HP | GO:0035307 | positive regulation of protein dephosphorylation | 17292327 |
| Tgene | HP | GO:0051497 | negative regulation of stress fiber assembly | 17932950 |
| Tgene | HP | GO:0051895 | negative regulation of focal adhesion assembly | 19158340 |
| Tgene | HP | GO:1900119 | positive regulation of execution phase of apoptosis | 17888903 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-G3-A3CI-01A | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000302068 | ENST00000570083 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000302068 | ENST00000355906 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000302068 | ENST00000398131 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| Frame-shift | ENST00000302068 | ENST00000569639 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000302068 | ENST00000357763 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000302068 | ENST00000562526 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 5CDS-intron | ENST00000302068 | ENST00000565574 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000509493 | ENST00000570083 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000509493 | ENST00000355906 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000509493 | ENST00000398131 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| Frame-shift | ENST00000509493 | ENST00000569639 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000509493 | ENST00000357763 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| In-frame | ENST00000509493 | ENST00000562526 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 5CDS-intron | ENST00000509493 | ENST00000565574 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000570083 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000355906 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000398131 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000569639 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000357763 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-3CDS | ENST00000502545 | ENST00000562526 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
| 3UTR-intron | ENST00000502545 | ENST00000565574 | FGB | chr4 | 155489646 | + | HP | chr16 | 72093016 | + |
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FusionProtFeatures for FGB_HP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FGB | HP |
| Cleaved by the protease thrombin to yield monomerswhich, together with fibrinogen alpha (FGA) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. Fibrin has amajor function in hemostasis as one of the primary components ofblood clots. In addition, functions during the early stages ofwound repair to stabilize the lesion and guide cell migrationduring re-epithelialization. Was originally thought to beessential for platelet aggregation, based on in vitro studiesusing anticoagulated blood. However subsequent studies have shownthat it is not absolutely required for thrombus formation in vivo.Enhances expression of SELP in activated platelets. Maternalfibrinogen is essential for successful pregnancy. Fibrindeposition is also associated with infection, where it protectsagainst IFNG-mediated hemorrhage. May also facilitate theantibacterial immune response via both innate and T-cell mediatedpathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FGB | chr4:155489646 | chr16:72093016 | ENST00000302068 | + | 5 | 8 | 157_222 | 277 | 492 | Coiled coil | Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305 |
| Hgene | FGB | chr4:155489646 | chr16:72093016 | ENST00000302068 | + | 5 | 8 | 45_47 | 277 | 492 | Region | Note=Beta-chain polymerization%2C binding distal domain of another fibrin |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000355906 | + | 4 | 7 | 162_404 | 122 | 407 | Domain | Peptidase S1 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000398131 | + | 2 | 5 | 162_404 | 63 | 348 | Domain | Peptidase S1 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000398131 | + | 2 | 5 | 90_147 | 63 | 348 | Domain | Sushi 2 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000565574 | + | 0 | 5 | 162_404 | -8 | 348 | Domain | Peptidase S1 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000565574 | + | 0 | 5 | 31_88 | -8 | 348 | Domain | Sushi 1 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000565574 | + | 0 | 5 | 90_147 | -8 | 348 | Domain | Sushi 2 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000570083 | + | 2 | 5 | 162_404 | 63 | 348 | Domain | Peptidase S1 |
| Tgene | >HP | chr4:155489646 | chr16:72093016 | ENST00000570083 | + | 2 | 5 | 90_147 | 63 | 348 | Domain | Sushi 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FGB | chr4:155489646 | chr16:72093016 | ENST00000302068 | + | 5 | 8 | 232_488 | 277 | 492 | Domain | Fibrinogen C-terminal |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000355906 | + | 4 | 7 | 31_88 | 122 | 407 | Domain | Sushi 1 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000355906 | + | 4 | 7 | 90_147 | 122 | 407 | Domain | Sushi 2 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000398131 | + | 2 | 5 | 31_88 | 63 | 348 | Domain | Sushi 1 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000570083 | + | 2 | 5 | 31_88 | 63 | 348 | Domain | Sushi 1 |
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FusionGeneSequence for FGB_HP |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_562aa MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_562aa MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_562aa MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_562aa MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC DMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLF LNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDH LKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAE >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_307aa MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAP DAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQ LYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_343aa MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKN PANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQ VDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_343aa MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKN PANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQ VDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_343aa MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKN PANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQ VDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_343aa MEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKN PANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQ VDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPIL >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_88aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_1686nt ATGAAAAGGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCC CAAGGTGTCAACGACAATGAGGAGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGG CCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCT GATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAA AGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTG CTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAA TTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAA AAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAA TGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGT GACATGAATACAGAAAATGGAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGT GAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGG CAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTC CTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAG GTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATC TGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCAT CTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAG AGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCG GGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAG >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_1686nt ATGAAAAGGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCC CAAGGTGTCAACGACAATGAGGAGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGG CCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCT GATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAA AGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTG CTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAA TTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAA AAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAA TGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGT GACATGAATACAGAAAATGGAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGT GAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGG CAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTC CTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAG GTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATC TGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCAT CTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAG AGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCG GGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAG >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_1686nt ATGAAAAGGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCC CAAGGTGTCAACGACAATGAGGAGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGG CCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCT GATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAA AGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTG CTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAA TTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAA AAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAA TGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGT GACATGAATACAGAAAATGGAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGT GAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGG CAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTC CTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAG GTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATC TGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCAT CTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAG AGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCG GGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAG >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_1686nt ATGAAAAGGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCC CAAGGTGTCAACGACAATGAGGAGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGG CCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCT GATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAA AGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTG CTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAA TTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAA AAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAA TGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGT GACATGAATACAGAAAATGGAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGT GAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGG CAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTC CTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAG GTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATC TGCCTACCTTCAAAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCAT CTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAG AGCCCTGTAGGGGTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCG GGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAG >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_921nt ATGAAAAGGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCC CAAGGTGTCAACGACAATGAGGAGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGG CCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCT GATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAA AGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTG CTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAA TTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAA AAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAA TGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGT GACATGAATACAGAAAATGGAGGAGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGT >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_1029nt ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_1029nt ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_1029nt ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_1029nt ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_264nt ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_1914nt GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_1913nt GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_1913nt GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG AGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATC >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_1875nt GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAAT CCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAAT CTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCG AAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAG GTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCAGAA GTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCT GACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTG AATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTG GAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCC ATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAG >In-frame_FGB_ENST00000302068_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_1363nt GAAGTCATTCCTAGCAGAGGACTCAGATATATATAGGATTGAAGATCTCTCAGTTAAGTCTACATGAAAAGGATGGTTTCTTGGAGCTTC CACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTGTCAACGACAATGAGGAGGGT TTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGT GGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGAC CCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAG TTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAG AAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGC AATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAA ATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGT GAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGAGTG TACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGCCCATACTGAATGAACACAC CTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACAC CTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGGACTG GGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAAAGTG GACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATCAATAAAGAGCT >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000570083_chr16_72093016_+_1468nt GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000355906_chr16_72093016_+_1467nt GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000398131_chr16_72093016_+_1467nt GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG GAAGAGGGCAAAGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTC >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000357763_chr16_72093016_+_1429nt GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAA GAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCA TAATCTCACCACAGGTGCCACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAAC AGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTC CCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGC AGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGT GGCTGACCAAGACCAATGCATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCAT ACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGA CCTGGAGGAGGACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGAC TTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTG >In-frame_FGB_ENST00000509493_chr4_155489646_+_HP_ENST00000562526_chr16_72093016_+_917nt GGATGGTTTCTTGGAGCTTCCACAAACTTAAAACCATGAAACATCTATTATTGCTACTATTGTGTGTTTTTCTAGTTAAGTCCCAAGGTG TCAACGACAATGAGGAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAA TAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGC TCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGG AGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGG AGTGTACACCTTAAACAATGAGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGCCCATACTGAATGAAC ACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGG ACACCTGGTATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGG ACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAGGCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAA AGTGGACGGGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGCATTGCTGAGTCAATCAATAAAG |
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FusionGenePPI for FGB_HP |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FGB | CALR, FGG, FGA, NID1, FBLN1, LPA, KHDRBS2, MIS12, GRB7, AIMP2, TK1, CDKN1A, SMN1, PIK3R3, ANXA7, FN1, CSNK2B, ASB6, ASB7, ASCC1, DDX19B, TMEM237, ALDH2, HIST1H2BJ, SBDS, MAPK6, SNX27, SPR, ADK, NARS, OXSR1, RING1, NAA15, NME2, POU2F1, SLK, TCEA1, EIF2A, BLVRB, CTNNBL1, TBC1D24, MAP2K1, UBLCP1, SNX3, ARHGAP1, ATG3, CCNYL1, VRK1, PMVK, PPID, MCTS1, PUS7, C6orf211, EEF1A2, PIR, PAK2, ITPA, LZIC, DUSP3, HDLBP, ADSL, DENR, HMGCS1, KIF2A, ETF1, FEN1, UBE2T, GCA, LETM1, WIBG, PSME2, CTH, OTUB1, FTO, HDGFRP2, GPKOW, PNPO, VPS26A, NAA50, RBM12, KIAA1143, EIF3J, HSP90AA4P, PRKCI, SF3A1, RPRD1A, PAPSS1, TLN1, UBA1, RPRD1B, FARSB, NME2P1, USO1, DDAH1, PBK, CAB39, RHOA, PTPN11, TES, PYGB, DIS3, SCRN1, PAK1, GNAQ, SYAP1, SNX6, PAPOLA, LSM1, GLS, GTF2F1, GNL1 | HP | HBB, MIS12, GRB2, RBBP6, ELAVL1, ATP7B, VKORC1, ALB, GADD45G, TGM2, RPL11, LAMC3, SMAD3, TBL1X, TP63, WASL, MVP, GDPD1, DDX19B, ICE2, EXOSC9, SORT1, APOA1, DDX31, SNX27, MAPK6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000355906 | + | 4 | 7 | 318_323 | 122 | 407 | CD163 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000398131 | + | 2 | 5 | 318_323 | 63 | 348 | CD163 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000565574 | + | 0 | 5 | 318_323 | -8 | 348 | CD163 |
| Tgene | HP | chr4:155489646 | chr16:72093016 | ENST00000570083 | + | 2 | 5 | 318_323 | 63 | 348 | CD163 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FGB_HP |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FGB | P02675 | DB00364 | Sucralfate | Fibrinogen beta chain | small molecule | approved |
| Hgene | FGB | P02675 | DB13151 | Anti-inhibitor coagulant complex | Fibrinogen beta chain | biotech | approved|investigational |
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RelatedDiseases for FGB_HP |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FGB | C2584774 | Congenital hypofibrinogenemia | 4 | ORPHANET;UNIPROT |
| Hgene | FGB | C0029456 | Osteoporosis | 1 | CTD_human |
| Hgene | FGB | C0030567 | Parkinson Disease | 1 | CTD_human |
| Hgene | FGB | C0272350 | Dysfibrinogenemia, Congenital | 1 | ORPHANET;UNIPROT |
| Tgene | HP | C0041696 | Unipolar Depression | 4 | PSYGENET |
| Tgene | HP | C0011570 | Mental Depression | 3 | PSYGENET |
| Tgene | HP | C0011581 | Depressive disorder | 3 | PSYGENET |
| Tgene | HP | C0027051 | Myocardial Infarction | 3 | CTD_human |
| Tgene | HP | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
| Tgene | HP | C0024530 | Malaria | 2 | CTD_human |
| Tgene | HP | C0525045 | Mood Disorders | 2 | PSYGENET |
| Tgene | HP | C0001723 | Affective Disorders, Psychotic | 1 | PSYGENET |
| Tgene | HP | C0002871 | Anemia | 1 | CTD_human |
| Tgene | HP | C0002895 | Anemia, Sickle Cell | 1 | CTD_human |
| Tgene | HP | C0003864 | Arthritis | 1 | CTD_human |
| Tgene | HP | C0004153 | Atherosclerosis | 1 | CTD_human |
| Tgene | HP | C0004364 | Autoimmune Diseases | 1 | CTD_human |
| Tgene | HP | C0007222 | Cardiovascular Diseases | 1 | CTD_human |
| Tgene | HP | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
| Tgene | HP | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | HP | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
| Tgene | HP | C0017416 | Genital Neoplasms, Female | 1 | CTD_human |
| Tgene | HP | C0018995 | Hemochromatosis | 1 | CTD_human |
| Tgene | HP | C0019054 | Hemolysis (disorder) | 1 | CTD_human |
| Tgene | HP | C0019163 | Hepatitis B | 1 | CTD_human |
| Tgene | HP | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | HP | C0020517 | Hypersensitivity | 1 | CTD_human |
| Tgene | HP | C0020538 | Hypertensive disease | 1 | CTD_human |
| Tgene | HP | C0023418 | leukemia | 1 | CTD_human |
| Tgene | HP | C0035305 | Retinal Detachment | 1 | CTD_human |
| Tgene | HP | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | HP | C0041296 | Tuberculosis | 1 | CTD_human |
| Tgene | HP | C0085397 | Pasteurellaceae Infections | 1 | CTD_human |
| Tgene | HP | C0242339 | Dyslipidemias | 1 | CTD_human |
| Tgene | HP | C0342257 | Complications of Diabetes Mellitus | 1 | CTD_human |
| Tgene | HP | C0524909 | Hepatitis B, Chronic | 1 | CTD_human |
| Tgene | HP | C0524910 | Hepatitis C, Chronic | 1 | CTD_human |
| Tgene | HP | C0679360 | Foodborne Disease | 1 | CTD_human |
| Tgene | HP | C0852036 | Pregnancy associated hypertension | 1 | CTD_human |
| Tgene | HP | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | HP | C3279786 | ANHAPTOGLOBINEMIA | 1 | UNIPROT |
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