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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13327

FusionGeneSummary for FGA_NEU1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGA_NEU1
Fusion gene ID: 13327
HgeneTgene
Gene symbol

FGA

NEU1

Gene ID

2243

4758

Gene namefibrinogen alpha chainneuraminidase 1
SynonymsFib2NANH|NEU|SIAL1
Cytomap

4q31.3

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionfibrinogen alpha chainfibrinogen, A alpha polypeptidesialidase-1G9 sialidaseN-acetyl-alpha-neuraminidase 1acetylneuraminyl hydrolaseexo-alpha-sialidaselysosomal sialidasesialidase 1 (lysosomal sialidase)
Modification date2018052020180523
UniProtAcc

P02671

Q99519

Ensembl transtripts involved in fusion geneENST00000302053, ENST00000403106, 
ENST00000375631, ENST00000423382, 
ENST00000439648, ENST00000434496, 
ENST00000422978, ENST00000229725, 
ENST00000437432, ENST00000411774, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 3 X 1=6
# samples 53
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/6*10)=2.32192809488736
Context

PubMed: FGA [Title/Abstract] AND NEU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGA

GO:0007160

cell-matrix adhesion

10903502

HgeneFGA

GO:0031639

plasminogen activation

16846481

HgeneFGA

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

HgeneFGA

GO:0034622

cellular protein-containing complex assembly

8910396

HgeneFGA

GO:0042730

fibrinolysis

16846481

HgeneFGA

GO:0043152

induction of bacterial agglutination

24367264

HgeneFGA

GO:0045907

positive regulation of vasoconstriction

15739255

HgeneFGA

GO:0045921

positive regulation of exocytosis

19193866

HgeneFGA

GO:0050714

positive regulation of protein secretion

19193866

HgeneFGA

GO:0051258

protein polymerization

12706644

HgeneFGA

GO:0051592

response to calcium ion

6777381

HgeneFGA

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

HgeneFGA

GO:0070527

platelet aggregation

6281794

HgeneFGA

GO:0072378

blood coagulation, fibrin clot formation

16846481

HgeneFGA

GO:0090277

positive regulation of peptide hormone secretion

19193866

HgeneFGA

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

HgeneFGA

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA345305FGAchr4

155507732

-NEU1chr6

3160127

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000302053ENST00000375631FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000423382FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000439648FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000434496FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000422978FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000229725FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000302053ENST00000437432FGAchr4

155507732

-NEU1chr6

3160127

-
intron-3UTRENST00000302053ENST00000411774FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000375631FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000423382FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000439648FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000434496FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000422978FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000229725FGAchr4

155507732

-NEU1chr6

3160127

-
intron-intronENST00000403106ENST00000437432FGAchr4

155507732

-NEU1chr6

3160127

-
intron-3UTRENST00000403106ENST00000411774FGAchr4

155507732

-NEU1chr6

3160127

-

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FusionProtFeatures for FGA_NEU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGA

P02671

NEU1

Q99519

Cleaved by the protease thrombin to yield monomerswhich, together with fibrinogen beta (FGB) and fibrinogen gamma(FGG), polymerize to form an insoluble fibrin matrix. Fibrin has amajor function in hemostasis as one of the primary components ofblood clots. In addition, functions during the early stages ofwound repair to stabilize the lesion and guide cell migrationduring re-epithelialization. Was originally thought to beessential for platelet aggregation, based on in vitro studiesusing anticoagulated blood. However, subsequent studies have shownthat it is not absolutely required for thrombus formation in vivo.Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successfulpregnancy. Fibrin deposition is also associated with infection,where it protects against IFNG-mediated hemorrhage. May alsofacilitate the immune response via both innate and T-cell mediatedpathways. {ECO:0000250|UniProtKB:E9PV24}. Catalyzes the removal of sialic acid (N-acetylneuraminicacid) moities from glycoproteins and glycolipids. To be active, itis strictly dependent on its presence in the multienzyme complex.Appears to have a preference for alpha 2-3 and alpha 2-6 sialyllinkage. {ECO:0000269|PubMed:25153125,ECO:0000269|PubMed:8985184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGA_NEU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGA_NEU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGA_NEU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGAP02671DB00009AlteplaseFibrinogen alpha chainbiotechapproved
HgeneFGAP02671DB00029AnistreplaseFibrinogen alpha chainbiotechapproved
HgeneFGAP02671DB00031TenecteplaseFibrinogen alpha chainbiotechapproved
HgeneFGAP02671DB00364SucralfateFibrinogen alpha chainsmall moleculeapproved
HgeneFGAP02671DB00015ReteplaseFibrinogen alpha chainbiotechapproved|investigational
HgeneFGAP02671DB01593ZincFibrinogen alpha chainsmall moleculeapproved|investigational
HgeneFGAP02671DB05099AncrodFibrinogen alpha chainsmall moleculeapproved|investigational
HgeneFGAP02671DB13151Anti-inhibitor coagulant complexFibrinogen alpha chainbiotechapproved|investigational
TgeneNEU1Q99519DB00198OseltamivirSialidase-1small moleculeapproved

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RelatedDiseases for FGA_NEU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGAC0001733Afibrinogenemia4CTD_human
HgeneFGAC0022658Kidney Diseases2CTD_human;HPO
HgeneFGAC0272350Dysfibrinogenemia, Congenital2ORPHANET;UNIPROT
HgeneFGAC0740340Amyloidosis, Familial2CTD_human
HgeneFGAC0008370Cholestasis1CTD_human;HPO
HgeneFGAC0026640Mouth Neoplasms1CTD_human
HgeneFGAC0029456Osteoporosis1CTD_human
HgeneFGAC0034065Pulmonary Embolism1CTD_human
HgeneFGAC0040053Thrombosis1CTD_human
HgeneFGAC0041755Adverse reaction to drug1CTD_human
HgeneFGAC0268389Amyloidosis, familial visceral1CTD_human;UNIPROT
HgeneFGAC0398623Thrombophilia1CTD_human
HgeneFGAC1861172Venous Thromboembolism1CTD_human
HgeneFGAC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT
HgeneFGAC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneNEU1C0268228Neuraminidase 1 deficiency5CTD_human;UNIPROT
TgeneNEU1C0751778Myoclonic Epilepsies, Progressive1CTD_human