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Fusion gene ID: 13320 |
FusionGeneSummary for FER_COMMD10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FER_COMMD10 | Fusion gene ID: 13320 | Hgene | Tgene | Gene symbol | FER | COMMD10 | Gene ID | 2241 | 51397 |
| Gene name | FER tyrosine kinase | COMM domain containing 10 | |
| Synonyms | PPP1R74|TYK3|p94-Fer | PTD002 | |
| Cytomap | 5q21.3 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase Ferfeline encephalitis virus-related kinase FERfer (fps/fes related) tyrosine kinasefujinami poultry sarcoma/Feline sarcoma-related protein Ferphosphoprotein NCP94protein phosphatase 1, regulatory subunit 74proto-oncogene c-F | COMM domain-containing protein 10 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P16591 | Q9Y6G5 | |
| Ensembl transtripts involved in fusion gene | ENST00000536402, ENST00000281092, ENST00000502752, ENST00000438717, | ENST00000274458, ENST00000515539, ENST00000503424, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 1=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: FER [Title/Abstract] AND COMMD10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FER | GO:0007260 | tyrosine phosphorylation of STAT protein | 19147545 |
| Hgene | FER | GO:0010591 | regulation of lamellipodium assembly | 19738202 |
| Hgene | FER | GO:0018108 | peptidyl-tyrosine phosphorylation | 12972546|19738202 |
| Hgene | FER | GO:0046777 | protein autophosphorylation | 7623846 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BG-01A | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000536402 | ENST00000274458 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| Frame-shift | ENST00000536402 | ENST00000515539 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| 5CDS-intron | ENST00000536402 | ENST00000503424 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| Frame-shift | ENST00000281092 | ENST00000274458 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| Frame-shift | ENST00000281092 | ENST00000515539 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| 5CDS-intron | ENST00000281092 | ENST00000503424 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| 3UTR-3CDS | ENST00000502752 | ENST00000274458 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| 3UTR-3CDS | ENST00000502752 | ENST00000515539 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| 3UTR-intron | ENST00000502752 | ENST00000503424 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| intron-3CDS | ENST00000438717 | ENST00000274458 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| intron-3CDS | ENST00000438717 | ENST00000515539 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
| intron-intron | ENST00000438717 | ENST00000503424 | FER | chr5 | 108171508 | + | COMMD10 | chr5 | 115627214 | + |
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FusionProtFeatures for FER_COMMD10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FER | COMMD10 |
| Tyrosine-protein kinase that acts downstream of cellsurface receptors for growth factors and plays a role in theregulation of the actin cytoskeleton, microtubule assembly,lamellipodia formation, cell adhesion, cell migration andchemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Actsdownstream of EGFR to promote activation of NF-kappa-B and cellproliferation. May play a role in the regulation of the mitoticcell cycle. Plays a role in the insulin receptor signaling pathwayand in activation of phosphatidylinositol 3-kinase. Actsdownstream of the activated FCER1 receptor and plays a role inFCER1 (high affinity immunoglobulin epsilon receptor)-mediatedsignaling in mast cells. Plays a role in the regulation of mastcell degranulation. Plays a role in leukocyte recruitment anddiapedesis in response to bacterial lipopolysaccharide (LPS).Plays a role in synapse organization, trafficking of synapticvesicles, the generation of excitatory postsynaptic currents andneuron-neuron synaptic transmission. Plays a role in neuronal celldeath after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1,GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Canphosphorylate STAT3, but the biological relevance of this dependson cell type and stimulus. {ECO:0000269|PubMed:12972546,ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545,ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202,ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868,ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846,ECO:0000269|PubMed:9722593}. | May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FER_COMMD10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FER_COMMD10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FER | TMF1, CTNNB1, CDH1, CTTN, DNM1, DNM2, DNM3, FER, EGFR, HSP90AA1, ERBB2, ERBB3, CDC37, NXF1, KCTD4, PIK3R1, PIK3R3, PPP1R7, CRK, LIMA1, ARC | COMMD10 | COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FER_COMMD10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FER_COMMD10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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