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Fusion gene ID: 13309 |
FusionGeneSummary for FENDRR_PSMB8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FENDRR_PSMB8 | Fusion gene ID: 13309 | Hgene | Tgene | Gene symbol | FENDRR | PSMB8 | Gene ID | 400550 | 5696 |
| Gene name | FOXF1 adjacent non-coding developmental regulatory RNA | proteasome subunit beta 8 | |
| Synonyms | FOXF1-AS1|FOXF1AS1|TCONS_00024240|lincFOXF1|onco-lncRNA-21 | ALDD|D6S216|D6S216E|JMP|LMP7|NKJO|PSMB5i|RING10 | |
| Cytomap | 16q24.1 | 6p21.32 | |
| Type of gene | ncRNA | protein-coding | |
| Description | FOXF1 antisense RNA 1 (head to head)FOXF1 antisense RNA 1 (non-protein coding) | proteasome subunit beta type-8low molecular mass protein 7low molecular weight protein 7macropain subunit C13multicatalytic endopeptidase complex subunit C13protease component C13proteasome (prosome, macropain) subunit, beta type, 8 (large multifunc | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | P28062 | ||
| Ensembl transtripts involved in fusion gene | ENST00000595886, | ENST00000395339, ENST00000374882, ENST00000374881, ENST00000446855, ENST00000455660, ENST00000436627, ENST00000457261, ENST00000447073, ENST00000416134, ENST00000449883, ENST00000446762, ENST00000441960, ENST00000546794, ENST00000425784, ENST00000429645, ENST00000416564, ENST00000399630, ENST00000383236, ENST00000383238, ENST00000427919, ENST00000421445, ENST00000452573, ENST00000458543, ENST00000438442, ENST00000435978, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: FENDRR [Title/Abstract] AND PSMB8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF850322 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000595886 | ENST00000395339 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000374882 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000374881 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000446855 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000455660 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000436627 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000457261 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000447073 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000416134 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000449883 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000446762 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000441960 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000546794 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000425784 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000429645 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000416564 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000399630 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000383236 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000383238 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000427919 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000421445 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000452573 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000458543 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000438442 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
| intron-intron | ENST00000595886 | ENST00000435978 | FENDRR | chr16 | 86538435 | + | PSMB8 | chr6 | 4240264 | + |
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FusionProtFeatures for FENDRR_PSMB8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FENDRR | PSMB8 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | The proteasome is a multicatalytic proteinase complexwhich is characterized by its ability to cleave peptides with Arg,Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral orslightly basic pH. The proteasome has an ATP-dependent proteolyticactivity. This subunit is involved in antigen processing togenerate class I binding peptides. Replacement of PSMB5 by PSMB8increases the capacity of the immunoproteasome to cleave modelpeptides after hydrophobic and basic residues. Acts as a majorcomponent of interferon gamma-induced sensitivity. Plays a keyrole in apoptosis via the degradation of the apoptotic inhibitorMCL1. May be involved in the inflammatory response pathway. Incancer cells, substitution of isoform 1 (E2) by isoform 2 (E1)results in immunoproteasome deficiency. Required for thedifferentiation of preadipocytes into adipocytes.{ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843,ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:8163024}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FENDRR_PSMB8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FENDRR_PSMB8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FENDRR_PSMB8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | PSMB8 | P28062 | DB08889 | Carfilzomib | Proteasome subunit beta type-8 | small molecule | approved|investigational |
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RelatedDiseases for FENDRR_PSMB8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PSMB8 | C1850568 | Nakajo syndrome | 2 | ORPHANET;UNIPROT |
| Tgene | PSMB8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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