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Fusion gene ID: 13297 |
FusionGeneSummary for FDPS_TGIF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FDPS_TGIF2 | Fusion gene ID: 13297 | Hgene | Tgene | Gene symbol | FDPS | TGIF2 | Gene ID | 2224 | 60436 |
| Gene name | farnesyl diphosphate synthase | TGFB induced factor homeobox 2 | |
| Synonyms | FPPS|FPS|POROK9 | - | |
| Cytomap | 1q22 | 20q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | farnesyl pyrophosphate synthase(2E,6E)-farnesyl diphosphate synthaseFPP synthaseFPP synthetasefarnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase | homeobox protein TGIF25'-TG-3' interacting factor 2TGF(beta)-induced transcription factor 2TGFB-induced factor 2 (TALE family homeobox)transcription growth factor-beta-induced factor 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P14324 | Q9GZN2 | |
| Ensembl transtripts involved in fusion gene | ENST00000447866, ENST00000368356, ENST00000487002, ENST00000356657, | ENST00000373874, ENST00000373872, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 3 X 2=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FDPS [Title/Abstract] AND TGIF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF928396 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000447866 | ENST00000373874 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| 5CDS-intron | ENST00000447866 | ENST00000373872 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| 5CDS-intron | ENST00000368356 | ENST00000373874 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| 5CDS-intron | ENST00000368356 | ENST00000373872 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| intron-intron | ENST00000487002 | ENST00000373874 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| intron-intron | ENST00000487002 | ENST00000373872 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| 5CDS-intron | ENST00000356657 | ENST00000373874 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
| 5CDS-intron | ENST00000356657 | ENST00000373872 | FDPS | chr1 | 155289617 | - | TGIF2 | chr20 | 35215858 | - |
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FusionProtFeatures for FDPS_TGIF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FDPS | TGIF2 |
| Key enzyme in isoprenoid biosynthesis which catalyzesthe formation of farnesyl diphosphate (FPP), a precursor forseveral classes of essential metabolites including sterols,dolichols, carotenoids, and ubiquinones. FPP also serves assubstrate for protein farnesylation and geranylgeranylation.Catalyzes the sequential condensation of isopentenyl pyrophosphatewith the allylic pyrophosphates, dimethylallyl pyrophosphate, andthen with the resultant geranylpyrophosphate to the ultimateproduct farnesyl pyrophosphate. | Transcriptional repressor, which probably represstranscription by binding directly the 5'-CTGTCAA-3' DNA sequenceor by interacting with TGF-beta activated SMAD proteins. Probablyrepresses transcription via the recruitment of histone deacetylaseproteins. {ECO:0000269|PubMed:11427533}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FDPS_TGIF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FDPS_TGIF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FDPS_TGIF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FDPS | P14324 | DB00282 | Pamidronate | Farnesyl pyrophosphate synthase | small molecule | approved |
| Hgene | FDPS | P14324 | DB00399 | Zoledronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
| Hgene | FDPS | P14324 | DB00630 | Alendronic acid | Farnesyl pyrophosphate synthase | small molecule | approved |
| Hgene | FDPS | P14324 | DB00710 | Ibandronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
| Hgene | FDPS | P14324 | DB00884 | Risedronate | Farnesyl pyrophosphate synthase | small molecule | approved|investigational |
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RelatedDiseases for FDPS_TGIF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FDPS | C4225262 | POROKERATOSIS 9, MULTIPLE TYPES | 1 | UNIPROT |
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