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Fusion gene ID: 13285 |
FusionGeneSummary for FDCSP_RGAG1 |
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Fusion gene information | Fusion gene name: FDCSP_RGAG1 | Fusion gene ID: 13285 | Hgene | Tgene | Gene symbol | FDCSP | RGAG1 | Gene ID | 260436 |
Gene name | follicular dendritic cell secreted protein | ||
Synonyms | C4orf7|FDC-SP | ||
Cytomap | 4q13.3|4q13 | ||
Type of gene | protein-coding | ||
Description | follicular dendritic cell secreted peptideFDC secreted protein | ||
Modification date | 20180329 | ||
UniProtAcc | Q8NFU4 | ||
Ensembl transtripts involved in fusion gene | ENST00000317987, | ENST00000465301, ENST00000540313, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 3=48 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FDCSP [Title/Abstract] AND RGAG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-FU-A3TX-01A | FDCSP | chr4 | 71096968 | + | RGAG1 | chrX | 109662230 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000317987 | ENST00000465301 | FDCSP | chr4 | 71096968 | + | RGAG1 | chrX | 109662230 | + |
5CDS-intron | ENST00000317987 | ENST00000540313 | FDCSP | chr4 | 71096968 | + | RGAG1 | chrX | 109662230 | + |
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FusionProtFeatures for FDCSP_RGAG1 |
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Hgene | Tgene |
FDCSP | RGAG1 |
Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediatoracting upon B-cells. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FDCSP_RGAG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FDCSP_RGAG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FDCSP | RGAG1 | CBX6, HECW2, BTRC, CEP152, TEX33, PRDX2, HSF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FDCSP_RGAG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FDCSP_RGAG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |